Výsledky vyhledávání - "bioRxiv"

Selective packaging of mitochondrial proteins into extracellular vesicles prevents the release of mitochondrial DAMPs Autor Todkar, Kiran, Chikhi, Lilia, Desjardins, Véronique, El-Mortada, Firas, Pépin, Geneviève, Germain, Marc

“…Most cells constitutively secrete mitochondrial DNA and proteins in extracellular vesicles (EVs). While EVs are small vesicles that transfer material between…”
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STING Polymer Structure Reveals Mechanisms for Activation, Hyperactivation, and Inhibition Autor Ergun, Sabrina L, Fernandez, Daniel, Weiss, Thomas M, Li, Lingyin

“…How the central innate immune protein, STING, is activated by its ligands remains unknown. Here, using structural biology and biochemistry, we report that the…”
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PspA adopts an ESCRT-III-like fold and remodels bacterial membranes Autor Junglas, Benedikt, Huber, Stefan T., Heidler, Thomas, Schlösser, Lukas, Mann, Daniel, Hennig, Raoul, Clarke, Mairi, Hellmann, Nadja, Schneider, Dirk, Sachse, Carsten

“…PspA is the main effector of the phage shock protein (Psp) system and preserves the bacterial inner membrane integrity and function. Here, we present the 3.6 Å…”
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Metrics for graph comparison: A practitioner’s guide Autor Wills, Peter, Meyer, François G.

“…Comparison of graph structure is a ubiquitous task in data analysis and machine learning, with diverse applications in fields such as neuroscience, cyber…”
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Pulsatile dynamics propagate crystalline order in the developing Drosophila eye Autor Couturier, Lydie, Luna-Escalante, Juan, Mazouni, Khallil, Mestdagh, Claire, Phan, Minh-Son, Tinevez, Jean-Yves, Schweisguth, François, Corson, Francis

“…Pattern formation in developing tissues often involves self-organization guided by positional information. In most tissues, however, its dynamics, and…”
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Optimized husbandry and targeted gene-editing for the cnidarian Nematostella vectensis Autor Carvalho, João E., Burtin, Maxence, Detournay, Olivier, Amiel, Aldine R., Röttinger, Eric

“…Optimized laboratory conditions for research models are crucial for the success of scientific projects. This includes the control of the entire life cycle,…”
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E4F1 COORDINATES PYRUVATE METABOLISM AND THE ACTIVITY OF THE ELONGATOR COMPLEX TO ENSURE TRANSLATION FIDELITY DURING BRAIN DEVELOPMENT Autor Michela, Di Michele, Aurore, Attina, Pierre-François, Roux, Imène, Tabet, Sophie, Laguesse, Javier, Florido, Morane, Houdeville, Armelle, Choquet, Betty, Encislai, Giuseppe, Arena, Carlo, De Blasio, Olivia, Wendling, Francois-Xavier, Frenois, Laura, Papon, Lucille, Stuani, Maryse, Fuentes, Céline, Jahanault-Tagliani, Mélanie, Rousseau, Justine, Guégan, Yoan, Buscail, Pierrick, Dupré, Henri-Alexandre, Michaud, Geneviève, Rodier, Floriant, Bellvert, Hanna, Kulyk, Carole, Ferraro Peyret, Hugo, Mathieu, Pierre, Close, Francesca, Rapino, Cédric, Chaveroux, Nelly, Pirot, Lucie, Rubio, Adeline, Torro, Tania, Sorg, Fabrice, Ango, Christophe, Hirtz, Vincent, Compan, Elise, Lebigot, Andrea, Legati, Daniele, Ghezzi, Laurent, Nguyen, Alexandre, David, Claude, Sardet, Matthieu, Lacroix, Laurent, Le Cam

“…Pyruvate metabolism defects lead to severe neuropathies such as the Leigh syndrome (LS) but the molecular mechanisms underlying neuronal cell death remain…”
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Toxoplasma gondii chronic infection decreases visceral nociception through peripheral opioid receptor signaling Autor Audibert, Alexis, Mas-Orea, Xavier, Rey, Léa, Belloy, Marcy, Bassot, Emilie, Marodon, Gilles, Masson, Frederick, Cenac, Nicolas, Dietrich, Gilles, Bonnart, Chrystelle, Blanchard, Nicolas

“…By eliciting immune activation in the digestive tract, intestinal pathogens may perturb gut homeostasis. Some gastrointestinal infections can indeed increase…”
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Assessing in vivo the impact of gene context on transcription through DNA supercoiling Autor Boulas, Ihab, Bruno, Lisa, Rimsky, Sylvie, Espeli, Olivier, Junier, Ivan, Rivoire, Olivier

“…Gene context can have significant impact on gene expression but is currently not integrated in quantitative models of gene regulation despite known biophysical…”
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Nuclear and cytoplasmic huntingtin inclusions exhibit distinct biochemical composition, interactome and ultrastructural properties Autor Riguet, Nathan, Mahul-Mellier, Anne-Laure, Maharjan, Niran, Burtscher, Johannes, Croisier, Marie, Knott, Graham, Hastings, Janna, Patin, Alice, Reiterer, Veronika, Farhan, Hesso, Nasarov, Sergey, Lashuel, Hilal A.

“…Despite the strong evidence linking the aggregation of the Huntingtin protein (Htt) to the pathogenesis of Huntington’s disease (HD), the mechanisms underlying…”
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The interpeduncular nucleus blunts the rewarding effect of nicotine Autor Jehl, Joachim, Ciscato, Maria, Vicq, Eléonore, Dejean de la Batie, Gabrielle, Guyon, Nicolas, Mondoloni, Sarah, Frangieh, Jacinthe, Nguyen, Claire, Hardelin, Jean-Pierre, Marti, Fabio, Corringer, Pierre-Jean, Faure, Philippe, Mourot, Alexandre

“…Nicotine, by stimulating ventral tegmental area (VTA) dopaminergic neurons, has a rewarding effect that drives tobacco consumption. In turn, the…”
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CSF1R regulates monocyte subset differentiation and intracellular metabolism Autor Gallerand, Alexandre, Merlin, Johanna, Caillot, Zakariya, Delaby, Chloé, Bord, Elisa, Han, Jichang, Dolfi, Bastien, Castiglione, Alexia, Grenet, Sacha, Franceschini, Maxime, Jarretou, Gisèle, Zair, Fairouz N, Boré, Evy, Tuffin, Florian, Dombrowicz, David, Guinamard, Rodolphe R, Randolph, Gwendalyn J, Bertola, Adeline, Auberger, Patrick, Jacquel, Arnaud, Hume, David A, Williams, Jesse W, Bajénoff, Marc, Neels, Jaap G, Ivanov, Stoyan

“…Monocytes are key circulating effectors of vascular homeostasis, innate immunity and inflammation. Following their generation in mouse bone marrow, classical…”
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Distortion correction of diffusion weighted MRI without reverse phase-encoding scans or field-maps Autor Schilling, Kurt G., Blaber, Justin, Hansen, Colin, Cai, Leon, Rogers, Baxter, Anderson, Adam W., Smith, Seth, Kanakaraj, Praitayini, Rex, Tonia, Resnick, Susan M., Shafer, Andrea T., Cutting, Laurie E., Woodward, Neil, Zald, David, Landman, Bennett A.

“…Diffusion magnetic resonance images may suffer from geometric distortions due to susceptibility induced off resonance fields, which cause geometric mismatch…”
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Complementary killing activities of Pbunavirus LS1 and Bruynoghevirus LUZ24 phages on planktonic and sessile Pseudomonas aeruginosa PAO1 derivatives Autor Billaud, Maud, Plantady, Clarisse, Lerouge, Benoît, Ollivier, Emma, Lossouarn, Julien, Moncaut, Elisabeth, Deschamps, Julien, Briandet, Romain, Cleret, Aurore, Fevre, Cindy, Demarre, Gaëlle, Petit, Marie-Agnès

“…Four P. aeruginosa phages active against a representative panel of strains, and with complementary spectra of action were chosen with the goal of using them…”
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Shape matters: the relationship between cell geometry and diversity in phytoplankton Autor Ryabov, Alexey, Kerimoglu, Onur, Litchman, Elena, Olenina, Irina, Roselli, Leonilde, Basset, Alberto, Stanca, Elena, Blasius, Bernd, Chase, Jonathan

“…Size and shape profoundly influence an organism’s ecophysiological performance and evolutionary fitness, suggesting a link between morphology and diversity…”
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Investigating the role of urban vegetation alongside other environmental variables in shaping Aedes albopictus presence and abundance in Montpellier, France Autor Bartholomée, Colombine, Taconet, Paul, Mercat, Mathilde, Grail, Coralie, Bouhsira, Emilie, Fournet, Florence, Moiroux, Nicolas

“…Urban greening helps address urbanization challenges and provides health benefits, but it may also favor mosquito species, vectors of pathogens causing human…”
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Marangoni-like tissue flows enhance symmetry breaking of embryonic organoids Autor Gsell, Simon, Tlili, Sham, Merkel, Matthias, Lenne, Pierre-François

“…During early development of multi-cellular animals, cells self-organize to set up the body axes, such as the primary head-to-tail axis, based on which the…”
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A vesicle microrheometer for high-throughput viscosity measurements of lipid and polymer membranes Autor Faizi, Hammad A, Dimova, Rumiana, Vlahovska, Petia M

“…Viscosity is a key property of cell membranes that controls mobility of embedded proteins and membrane remodeling. Measuring it is challenging because existing…”
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Metal–Organic Framework Encapsulated Whole-Cell Vaccines Enhance Humoral Immunity against Bacterial Infection Autor Luzuriaga, Michael A, Herbert, Fabian C, Brohlin, Olivia R, Gadhvi, Jashkaran, Howlett, Thomas, Shahrivarkevishahi, Arezoo, Wijesundara, Yalini H, Venkitapathi, Sundharamani, Veera, Kavya, Ehrman, Ryanne, Benjamin, Candace E, Popal, Sarah, Burton, Michael D, Ingersoll, Molly A, De Nisco, Nicole J, Gassensmith, Jeremiah J

“…The increasing rate of resistance of bacterial infection against antibiotics requires next generation approaches to fight potential pandemic spread. The…”
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PspA adopts an ESCRT-III-like fold and remodels bacterial membranes Autor Junglas, Benedikt, Huber, Stefan T, Heidler, Thomas, Schlösser, Lukas, Mann, Daniel, Hennig, Raoul, Clarke, Mairi, Hellmann, Nadja, Schneider, Dirk, Sachse, Carsten

“…PspA is the main effector of the phage shock protein (Psp) system and preserves the bacterial inner membrane integrity and function. Here, we present the 3.6 Å…”
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