Suchergebnisse - "Zhao, Nancy Q"

Natural killer cell phenotype is altered in HIV-exposed seronegative women von Zhao, Nancy Q., Vendrame, Elena, Ferreira, Anne-Maud, Seiler, Christof, Ranganath, Thanmayi, Alary, Michel, Labbé, Annie-Claude, Guédou, Fernand, Poudrier, Johanne, Holmes, Susan, Roger, Michel, Blish, Catherine A.

“… Highly exposed seronegative (HESN) individuals present a unique setting to study mechanisms of protection against HIV acquisition. As natural killer (NK) cell …”
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Treated HIV Infection Alters Phenotype but Not HIV-Specific Function of Peripheral Blood Natural Killer Cells von Zhao, Nancy Q., Ferreira, Anne-Maud, Grant, Philip M., Holmes, Susan, Blish, Catherine A.

“… Natural killer (NK) cells are the predominant antiviral cells of the innate immune system, and may play an important role in acquisition and disease …”
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NKG2A-Expressing Natural Killer Cells Dominate the Response to Autologous Lymphoblastoid Cells Infected with Epstein–Barr Virus von Hatton, Olivia, Strauss-Albee, Dara Marie, Zhao, Nancy Q., Haggadone, Mikel D., Pelpola, Judith Shanika, Krams, Sheri M., Martinez, Olivia M., Blish, Catherine A.

“… Epstein-Barr virus (EBV) is a human γ-herpesvirus that establishes latency and lifelong infection in host B cells while achieving a balance with the host …”
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NKp30 and NKG2D contribute to natural killer cell-mediated recognition of HIV-infected cells von Pi, Ruoxi, Zhao, Nancy Q., Bien, Allison J., Ranganath, Thanmayi, Seiler, Christof, Holmes, Susan, Marson, Alexander, Nguyen, David N., Blish, Catherine A.

“… Natural killer (NK) cells respond rapidly in early HIV-1 infection. HIV-1 prevention and control strategies harnessing NK cells could be enabled by mechanistic …”
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Natural Killer Cell Receptors and Ligands Are Associated With Markers of HIV-1 Persistence in Chronically Infected ART Suppressed Patients von Ivison, Geoffrey T., Vendrame, Elena, Martínez-Colón, Giovanny J., Ranganath, Thanmayi, Vergara, Rosemary, Zhao, Nancy Q., Martin, Maureen P., Bendall, Sean C., Carrington, Mary, Cyktor, Joshua C., McMahon, Deborah K., Eron, Joseph, Jones, R. Brad, Mellors, John W., Bosch, Ronald J., Gandhi, Rajesh T., Holmes, Susan, Blish, Catherine A.

“… The latent HIV-1 reservoir represents a major barrier to achieving a long-term antiretroviral therapy (ART)-free remission or cure for HIV-1. Natural Killer …”
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A single-cell atlas of the peripheral immune response in patients with severe COVID-19 von Wilk, Aaron J., Rustagi, Arjun, Zhao, Nancy Q., Roque, Jonasel, Martínez-Colón, Giovanny J., McKechnie, Julia L., Ivison, Geoffrey T., Ranganath, Thanmayi, Vergara, Rosemary, Hollis, Taylor, Simpson, Laura J., Grant, Philip, Subramanian, Aruna, Rogers, Angela J., Blish, Catherine A.

“… There is an urgent need to better understand the pathophysiology of Coronavirus disease 2019 (COVID-19), the global pandemic caused by SARS-CoV-2, which has …”
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Multi-omic profiling reveals widespread dysregulation of innate immunity and hematopoiesis in COVID-19 von Wilk, Aaron J, Lee, Madeline J, Wei, Bei, Parks, Benjamin, Pi, Ruoxi, Martínez-Colón, Giovanny J, Ranganath, Thanmayi, Zhao, Nancy Q, Taylor, Shalina, Becker, Winston, Jimenez-Morales, David, Blomkalns, Andra L, O'Hara, Ruth, Ashley, Euan A, Nadeau, Kari C, Yang, Samuel, Holmes, Susan, Rabinovitch, Marlene, Rogers, Angela J, Greenleaf, William J, Blish, Catherine A

“… Our understanding of protective versus pathological immune responses to SARS-CoV-2, the virus that causes coronavirus disease 2019 (COVID-19), is limited by …”
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TIGIT is upregulated by HIV-1 infection and marks a highly functional adaptive and mature subset of natural killer cells von Vendrame, Elena, Seiler, Christof, Ranganath, Thanmayi, Zhao, Nancy Q, Vergara, Rosemary, Alary, Michel, Labbé, Annie-Claude, Guédou, Fernand, Poudrier, Johanne, Holmes, Susan, Roger, Michel, Blish, Catherine A

“… Our objective was to investigate the mechanisms that govern natural killer (NK)-cell responses to HIV, with a focus on specific receptor--ligand interactions …”
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Enhancing natural killer cell function with gp41-targeting bispecific antibodies to combat HIV infection von Ramadoss, Nitya S, Zhao, Nancy Q, Richardson, Barbra A, Grant, Philip M, Kim, Peter S, Blish, Catherine A

“… The aim of this study was to develop and evaluate the activity of bispecific antibodies (bsAbs) to enhance natural killer (NK) cell antibody-dependent cellular …”
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Profiling of the Human Natural Killer Cell Receptor-Ligand Repertoire von Vendrame, Elena, McKechnie, Julia L., Ranganath, Thanmayi, Zhao, Nancy Q., Rustagi, Arjun, Vergara, Rosemary, Ivison, Geoffrey T., Kronstad, Lisa M., Simpson, Laura J., Blish, Catherine A.

“… Natural killer (NK) cells are among the first responders to viral infections. The ability of NK cells to rapidly recognize and kill virally infected cells is …”
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NKp30 and NKG2D contribute to natural killer recognition of HIV-infected cells von Zhao, Nancy Q, Pi, Ruoxi, Nguyen, David N, Ranganath, Thanmayi, Seiler, Christof, Holmes, Susan, Marson, Alexander, Blish, Catherine A

“… Natural killer (NK) cells respond rapidly in early HIV-1 infection. HIV-1 prevention and control strategies harnessing NK cells could be enabled by mechanistic …”
Volltext

A single-cell atlas of the peripheral immune response to severe COVID-19 von Wilk, Aaron J, Rustagi, Arjun, Zhao, Nancy Q, Roque, Jonasel, Martinez-Colon, Giovanny J, McKechnie, Julia L, Ivison, Geoffrey T, Ranganath, Thanmayi, Vergara, Rosemary, Hollis, Taylor, Simpson, Laura J, Grant, Philip, Subramanian, Aruna, Rogers, Angela J, Blish, Catherine A

“… There is an urgent need to better understand the pathophysiology of Coronavirus disease 2019 (COVID-19), the global pandemic caused by SARS-CoV-2. Here, we …”
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Prior vaccination prevents overactivation of innate immune responses during COVID-19 breakthrough infection von Chan, Leslie, Pinedo, Kassandra, Stabile, Mikayla A, Hamlin, Rebecca E, Pienkos, Shaun M, Ratnasiri, Kalani, Yang, Samuel, Blomkalns, Andra L, Nadeau, Kari C, Pulendran, Bali, O'Hara, Ruth, Rogers, Angela J, Holmes, Susan P, Blish, Catherine A

“… At this stage in the COVID-19 pandemic, most infections are "breakthrough" infections that occur in individuals with prior severe acute respiratory syndrome …”
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Treated HIV Infection Alters Phenotype But Not HIV-specific Function of Peripheral Blood Natural Killer Cells von Zhao, Nancy Q, Ferreira, Anne-Maud, Grant, Philip M, Holmes, Susan, Blish, Catherine A

“… Natural killer (NK) cells are the predominant antiviral cells of the innate immune system, and may play an important role in acquisition and disease …”
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Additional analyses exploring the hypothesized transdifferentiation of plasmablasts to developing neutrophils in severe COVID-19 von Wilk, Aaron J, Rustagi, Arjun, Zhao, Nancy Q, Martin, Beth A, Rogers, Angela J, Blish, Catherine A

“… Abstract We thank Alquicira-Hernandez et al. for their reanalysis of our single-cell transcriptomic dataset profiling peripheral immune responses to severe …”
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TIGIT is upregulated by HIV-1 infection and marks a highly functional adaptive and mature subset of natural killer cells von Vendrame, Elena, Seiler, Christof, Ranganath, Thanmayi, Zhao, Nancy Q, Vergara, Rosemary, Alary, Michel, Labbé, Annie Claude, Guédou, Fernand, Poudrier, Johanne, Holmes, Susan, Michel, Roger, Blish, Catherine A

“… Objective: Our objective was to investigate the mechanisms that govern natural killer (NK) cell responses to HIV, with a focus on specific receptor-ligand …”
Volltext

Enhancing natural killer cell function with gp41-targeting bispecific antibodies to combat HIV infection von Ramadoss, Nitya S, Zhao, Nancy Q, Richardson, Barbra A, Grant, Philip M, Kim, Peter S, Blish, Catherine A

“… Objective(s): To develop and evaluate the activity of bispecific antibodies (bsAbs) to enhance NK cell antibody-dependent cellular cytotoxicity (ADCC) against …”
Volltext

Multi-omic profiling reveals widespread dysregulation of innate immunity and hematopoiesis in COVID-19 von Wilk, Aaron J, Lee, Madeline J, Wei, Bei, Parks, Benjamin, Pi, Ruoxi, Martínez-Colón, Giovanny J, Ranganath, Thanmayi, Zhao, Nancy Q, Taylor, Shalina, Becker, Winston, Stanford Covid-19 Biobank, Jimenez-Morales, David, Blomkalns, Andra L, Ruth O’hara, Ashley, Euan A, Nadeau, Kari C, Yang, Samuel, Holmes, Susan, Rabinovitch, Marlene, Rogers, Angela J, Greenleaf, William J, Blish, Catherine A

“… ABSTRACT Our understanding of protective vs. pathologic immune responses to SARS-CoV-2, the virus that causes Coronavirus disease 2019 (COVID-19), is limited …”
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Characterization of the impact of daclizumab beta on circulating natural killer cells by mass cytometry von Ranganath, Thanmayi, Simpson, Laura Jane, Seiler, Christof, Ferreira, Anne-Maud, Vendrame, Elena, Zhao, Nancy Q, Fontenot, Jason D, Holmes, Susan P, Blish, Catherine A

“… Daclizumab beta is a humanized monoclonal antibody that binds to CD25 and selectively inhibits high-affinity IL-2 receptor signaling. As a former treatment for …”
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