Suchergebnisse - "Zelcer, Noam"

LXR regulates cholesterol uptake through Idol-dependent ubiquitination of the LDL receptor von Zelcer, Noam, Hong, Cynthia, Boyadjian, Rima, Tontonoz, Peter

“… Cellular cholesterol levels reflect a balance between uptake, efflux, and endogenous synthesis. Here we show that the sterol-responsive nuclear liver X …”
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Orthogonal validation of PROTAC mediated degradation of the integral membrane proteins EGFR and c-MET von Ruffilli, Camilla, Röth, Sascha, Zelcer, Noam, Moreau, Kevin

“… Dysregulation of integral membrane proteins (IMPs) has been linked to a myriad of diseases, making these proteins an attractive target in drug research. Whilst …”
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Haploid genetic screens identify SPRING/C12ORF49 as a determinant of SREBP signaling and cholesterol metabolism von Loregger, Anke, Raaben, Matthijs, Nieuwenhuis, Joppe, Tan, Josephine M. E., Jae, Lucas T., van den Hengel, Lisa G., Hendrix, Sebastian, van den Berg, Marlene, Scheij, Saskia, Song, Ji-Ying, Huijbers, Ivo J., Kroese, Lona J., Ottenhoff, Roelof, van Weeghel, Michel, van de Sluis, Bart, Brummelkamp, Thijn, Zelcer, Noam

“… The sterol-regulatory element binding proteins (SREBP) are central transcriptional regulators of lipid metabolism. Using haploid genetic screens we identify …”
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(Pro)renin Receptor Inhibition Reprograms Hepatic Lipid Metabolism and Protects Mice From Diet-Induced Obesity and Hepatosteatosis von Ren, Liwei, Sun, Yuan, Lu, Hong, Ye, Dien, Han, Lijuan, Wang, Na, Daugherty, Alan, Li, Furong, Wang, Miaomiao, Su, Fengting, Tao, Wenjun, Sun, Jie, Zelcer, Noam, Mullick, Adam E, Danser, A H Jan, Jiang, Yizhou, He, Yongcheng, Ruan, Xiongzhong, Lu, Xifeng

“… An elevated level of plasma LDL (low-density lipoprotein) is an established risk factor for cardiovascular disease. Recently, we reported that the (pro)renin …”
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SPRING licenses S1P-mediated cleavage of SREBP2 by displacing an inhibitory pro-domain von Hendrix, Sebastian, Dartigue, Vincent, Hall, Hailee, Bawaria, Shrankhla, Kingma, Jenina, Bajaj, Bilkish, Zelcer, Noam, Kober, Daniel L.

“… Site-one protease (S1P) conducts the first of two cleavage events in the Golgi to activate Sterol regulatory element binding proteins (SREBPs) and upregulate …”
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Post-transcriptional regulation of lipoprotein receptors by the E3-ubiquitin ligase inducible degrader of the low-density lipoprotein receptor von Sorrentino, Vincenzo, Zelcer, Noam

“… The hepatic low-density lipoprotein receptor (LDLR) pathway is essential for clearing circulating LDL and is an important therapeutic target for treating …”
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Stearoyl-CoA desaturase-1 impairs the reparative properties of macrophages and microglia in the brain von Bogie, Jeroen F J, Grajchen, Elien, Wouters, Elien, Corrales, Aida Garcia, Dierckx, Tess, Vanherle, Sam, Mailleux, Jo, Gervois, Pascal, Wolfs, Esther, Dehairs, Jonas, Van Broeckhoven, Jana, Bowman, Andrew P, Lambrichts, Ivo, Gustafsson, Jan-Åke, Remaley, Alan T, Mulder, Monique, Swinnen, Johannes V, Haidar, Mansour, Ellis, Shane R, Ntambi, James M, Zelcer, Noam, Hendriks, Jerome J A

“… Failure of remyelination underlies the progressive nature of demyelinating diseases such as multiple sclerosis. Macrophages and microglia are crucially …”
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Nuclear Receptor Nur77 Limits the Macrophage Inflammatory Response through Transcriptional Reprogramming of Mitochondrial Metabolism von Koenis, Duco Steven, Medzikovic, Lejla, van Loenen, Pieter Bas, van Weeghel, Michel, Huveneers, Stephan, Vos, Mariska, Evers-van Gogh, Ingrid Johanna, Van den Bossche, Jan, Speijer, Dave, Kim, Yongsoo, Wessels, Lodewyk, Zelcer, Noam, Zwart, Wilbert, Kalkhoven, Eric, de Vries, Carlie Jacoba

“… Activation of macrophages by inflammatory stimuli induces reprogramming of mitochondrial metabolism to support the production of pro-inflammatory cytokines and …”
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Industrial Trans Fatty Acids Stimulate SREBP2‐Mediated Cholesterogenesis and Promote Non‐Alcoholic Fatty Liver Disease von Oteng, Antwi‐Boasiako, Loregger, Anke, Weeghel, Michel, Zelcer, Noam, Kersten, Sander

“… Scope The mechanisms underlying the deleterious effects of trans fatty acids on plasma cholesterol and non‐alcoholic fatty liver disease (NAFLD) are unclear …”
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Hepatic SREBP signaling requires SPRING to govern systemic lipid metabolism in mice and humans von Hendrix, Sebastian, Kingma, Jenina, Ottenhoff, Roelof, Valiloo, Masoud, Svecla, Monika, Zijlstra, Lobke F., Sachdev, Vinay, Kovac, Kristina, Levels, Johannes H. M., Jongejan, Aldo, de Boer, Jan F., Kuipers, Folkert, Rimbert, Antoine, Norata, Giuseppe D., Loregger, Anke, Zelcer, Noam

“… The sterol regulatory element binding proteins (SREBPs) are transcription factors that govern cholesterol and fatty acid metabolism. We recently identified …”
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Proteolysis Targeting Chimeras (PROTACs): A Perspective on Integral Membrane Protein Degradation von Ruffilli, Camilla, Roth, Sascha, Rodrigo, Monica, Boyd, Helen, Zelcer, Noam, Moreau, Kevin

“… Targeted protein degradation (TPD) is a promising therapeutic modality to modulate protein levels and its application promises to reduce the "undruggable" …”
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LXR signaling couples sterol metabolism to proliferation in the acquired immune response von Bensinger, Steven J, Bradley, Michelle N, Joseph, Sean B, Zelcer, Noam, Janssen, Edith M, Hausner, Mary Ann, Shih, Roger, Parks, John S, Edwards, Peter A, Jamieson, Beth D, Tontonoz, Peter

“… Cholesterol is essential for membrane synthesis; however, the mechanisms that link cellular lipid metabolism to proliferation are incompletely understood. We …”
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The UPS and downs of cholesterol homeostasis von Sharpe, Laura J., Cook, Emma C.L., Zelcer, Noam, Brown, Andrew J.

“… •The ubiquitin-proteasome system affects all aspects of cholesterol homeostasis.•Many E3 ligases have been shown to play a role in cholesterol …”
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NDRG1 functions in LDL receptor trafficking by regulating endosomal recycling and degradation von Pietiäinen, Vilja, Vassilev, Boris, Blom, Tomas, Wang, Wei, Nelson, Jessica, Bittman, Robert, Bäck, Nils, Zelcer, Noam, Ikonen, Elina

“… N-myc downstream-regulated gene 1 (NDRG1) mutations cause Charcot-Marie-Tooth disease type 4D (CMT4D). However, the cellular function of NDRG1 and how it …”
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Cholesterol biosynthesis as a drug-induced vulnerability in diffuse large B cell lymphoma insensitive to EZH2 inhibition von Niccolai, Rachele, Göbel, Camiel, Ndoj, Klevis, Kreft, Maaike, Kuiken, Hendrik J., Lieftink, Cor, Morris, Ben, Yska, Sietse D., Hendrix, Sebastian, van den Broek, Bram, Pappalardo, Vincent, Kersten, Marie José, Beijersbergen, Roderick L., Zelcer, Noam, van Leeuwen, Fred, Jacobs, Heinz

“… •GCB-DLBCL insensitive to EZH2 inhibition become dependent on cholesterol synthesis.•This dependency relates to altered LDLR subcellular localization and LDL …”
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The Deubiquitylase USP2 Regulates the LDLR Pathway by Counteracting the E3-Ubiquitin Ligase IDOL von Nelson, Jessica Kristine, Sorrentino, Vincenzo, Avagliano Trezza, Rossella, Heride, Claire, Urbe, Sylvie, Distel, Ben, Zelcer, Noam

“… The low-density lipoprotein (LDL) receptor (LDLR) is a central determinant of circulating LDL-cholesterol and as such subject to tight regulation. Recent …”
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UBE3A promotes foam cell formation and counters remyelination by targeting ABCA1 for proteasomal degradation von Loix, Melanie, Vanherle, Sam, Bolkaerts, Laura, Verberk, Sanne G. S., Punt, Mattijs, Wouters, Flore, Moonen, Brecht, Verhagen, Rob, Van Wouw, Suzanne A. E., Jongejan, Aldo, Distel, Ben, Elgersma, Ype, Haidar, Mansour, Zelcer, Noam, Hendriks, Jerome J. A., Bogie, Jeroen F. J.

“… The accumulation of foamy macrophages is a pathological hallmark of demyelinating brain disorders. Perturbed metabolism and efflux of intracellular lipids …”
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Attenuation of neuroinflammation and Alzheimer's disease pathology by liver x receptors von Zelcer, Noam, Khanlou, Negar, Clare, Ryan, Jiang, Qingguang, Reed-Geaghan, Erin G, Landreth, Gary E, Vinters, Harry V, Tontonoz, Peter

“… Alzheimer's disease (AD) is an age-dependent neurodegenerative disease that causes progressive cognitive impairment. The initiation and progression of AD has …”
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EEPD1 Is a Novel LXR Target Gene in Macrophages Which Regulates ABCA1 Abundance and Cholesterol Efflux von Nelson, Jessica Kristine, Koenis, Duco Steven, Scheij, Saskia, Cook, Emma Clare Laura, Moeton, Martina, Santos, Ana, Lobaccaro, Jean-Marc Adolphe, Baron, Silvere, Zelcer, Noam

“… The sterol-responsive nuclear receptors, liver X receptors α (LXRα, ) and β (LXRβ, ), are key determinants of cellular cholesterol homeostasis. LXRs are …”
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Haploid Mammalian Genetic Screen Identifies UBXD8 as a Key Determinant of HMGCR Degradation and Cholesterol Biosynthesis von Loregger, Anke, Raaben, Matthijs, Tan, Josephine, Scheij, Saskia, Moeton, Martina, van den Berg, Marlene, Gelberg-Etel, Hila, Stickel, Elmer, Roitelman, Joseph, Brummelkamp, Thijn, Zelcer, Noam

“… The cellular demand for cholesterol requires control of its biosynthesis by the mevalonate pathway. Regulation of HMGCR (3-hydroxy-3-methylglutaryl coenzyme A …”
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