Výsledky vyhľadávania - "Zaratzian, Anaiis"

miR-139-5p Modulates Radiotherapy Resistance in Breast Cancer by Repressing Multiple Gene Networks of DNA Repair and ROS Defense Autor Pajic, Marina, Froio, Danielle, Daly, Sheridan, Doculara, Louise, Millar, Ewan, Graham, Peter H, Drury, Alison, Steinmann, Angela, de Bock, Charles E, Boulghourjian, Alice, Zaratzian, Anaiis, Carroll, Susan, Toohey, Joanne, O'Toole, Sandra A, Harris, Adrian L, Buffa, Francesca M, Gee, Harriet E, Hollway, Georgina E, Molloy, Timothy J

“…Radiotherapy is essential to the treatment of most solid tumors and acquired or innate resistance to this therapeutic modality is a major clinical problem…”
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Temporal profiling of the breast tumour microenvironment reveals collagen XII as a driver of metastasis Autor Papanicolaou, Michael, Parker, Amelia L., Yam, Michelle, Filipe, Elysse C., Wu, Sunny Z., Chitty, Jessica L., Wyllie, Kaitlin, Tran, Emmi, Mok, Ellie, Nadalini, Audrey, Skhinas, Joanna N., Lucas, Morghan C., Herrmann, David, Nobis, Max, Pereira, Brooke A., Law, Andrew M. K., Castillo, Lesley, Murphy, Kendelle J., Zaratzian, Anaiis, Hastings, Jordan F., Croucher, David R., Lim, Elgene, Oliver, Brian G., Mora, Fatima Valdes, Parker, Benjamin L., Gallego-Ortega, David, Swarbrick, Alexander, O’Toole, Sandra, Timpson, Paul, Cox, Thomas R.

“…The tumour stroma, and in particular the extracellular matrix (ECM), is a salient feature of solid tumours that plays a crucial role in shaping their…”
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Intravital Imaging to Monitor Therapeutic Response in Moving Hypoxic Regions Resistant to PI3K Pathway Targeting in Pancreatic Cancer Autor Conway, James R.W., Warren, Sean C., Herrmann, David, Murphy, Kendelle J., Cazet, Aurélie S., Vennin, Claire, Shearer, Robert F., Killen, Monica J., Magenau, Astrid, Mélénec, Pauline, Pinese, Mark, Nobis, Max, Zaratzian, Anaiis, Boulghourjian, Alice, Da Silva, Andrew M., del Monte-Nieto, Gonzalo, Adam, Arne S.A., Harvey, Richard P., Haigh, Jody J., Wang, Yingxiao, Croucher, David R., Sansom, Owen J., Pajic, Marina, Caldon, C. Elizabeth, Morton, Jennifer P., Timpson, Paul

“…Application of advanced intravital imaging facilitates dynamic monitoring of pathway activity upon therapeutic inhibition. Here, we assess resistance to…”
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Three-dimensional organotypic matrices from alternative collagen sources as pre-clinical models for cell biology Autor Conway, James R. W., Vennin, Claire, Cazet, Aurélie S., Herrmann, David, Murphy, Kendelle J., Warren, Sean C., Wullkopf, Lena, Boulghourjian, Alice, Zaratzian, Anaiis, Da Silva, Andrew M., Pajic, Marina, Morton, Jennifer P., Cox, Thomas R., Timpson, Paul

“…Organotypic co-cultures bridge the gap between standard two-dimensional culture and mouse models. Such assays increase the fidelity of pre-clinical studies, to…”
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Intravital imaging technology guides FAK-mediated priming in pancreatic cancer precision medicine according to Merlin status Autor Murphy, Kendelle J., Reed, Daniel A., Vennin, Claire, Conway, James R. W., Nobis, Max, Yin, Julia X., Chambers, Cecilia R., Pereira, Brooke A., Lee, Victoria, Filipe, Elysse C., Trpceski, Michael, Ritchie, Shona, Lucas, Morghan C., Warren, Sean C., Skhinas, Joanna N., Magenau, Astrid, Metcalf, Xanthe L., Stoehr, Janett, Major, Gretel, Parkin, Ashleigh, Bidanel, Romain, Lyons, Ruth J., Zaratzian, Anaiis, Tayao, Michael, Da Silva, Andrew, Abdulkhalek, Lea, Gill, Anthony J., Johns, Amber L., Biankin, Andrew V., Samra, Jaswinder, Grimmond, Sean M., Chou, Angela, Goetz, Jacky G., Samuel, Michael S., Lyons, J. Guy, Burgess, Andrew, Caldon, C. Elizabeth, Horvath, Lisa G., Daly, Roger J., Gadegaard, Nikolaj, Wang, Yingxiao, Sansom, Owen J., Morton, Jennifer P., Cox, Thomas R., Pajic, Marina, Herrmann, David, Timpson, Paul

“…Intravital imaging guides a personalized medicine approach to target mechanoreciprocity in pancreatic cancer. Pancreatic ductal adenocarcinoma (PDAC) is a…”
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Targeting the NPY/NPY1R signaling axis in mutant p53–dependent pancreatic cancer impairs metastasis Autor Chambers, Cecilia R., Watakul, Supitchaya, Schofield, Peter, Howell, Anna E., Zhu, Jessie, Tran, Alice M. H., Kuepper, Nadia, Reed, Daniel A., Murphy, Kendelle J., Channon, Lily M., Pereira, Brooke A., Tyma, Victoria M., Lee, Victoria, Trpceski, Michael, Henry, Jake, Melenec, Pauline, Abdulkhalek, Lea, Nobis, Max, Metcalf, Xanthe L., Ritchie, Shona, Cadell, Antonia, Stoehr, Janett, Magenau, Astrid, Chacon-Fajardo, Diego, Chitty, Jessica L., O’Connell, Savannah, Zaratzian, Anaiis, Tayao, Michael, Da Silva, Andrew, Lyons, Ruth J., Goldstein, Leonard D., Dale, Ashleigh, Rookyard, Alexander, Connolly, Angela, Crossett, Ben, Tran, Yen T. H., Kaltzis, Peter, Vennin, Claire, Dinevska, Marija, Croucher, David R., Samra, Jaswinder, Mittal, Anubhav, Weatheritt, Robert J., Philp, Andrew, Del Monte-Nieto, Gonzalo, Zhang, Lei, Enriquez, Ronaldo F., Cox, Thomas R., Shi, Yan-Chuan C., Pinese, Mark, Waddell, Nicola, Sim, Hao-Wen, Chtanova, Tatyana, Wang, Yingxiao, Joshua, Anthony M., Chantrill, Lorraine, Evans, Thomas R. Jeffry, Gill, Anthony J., Morton, Jennifer P., Pajic, Marina, Christ, Daniel, Herzog, Herbert, Timpson, Paul, Herrmann, David

“…Pancreatic cancer (PC) is a highly metastatic malignancy. More than 80% of patients with PC present with advanced-stage disease, preventing potentially…”
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The Mini‐Organo: A rapid high‐throughput 3D coculture organotypic assay for oncology screening and drug development Autor Chitty, Jessica L., Skhinas, Joanna N., Filipe, Elysse C., Wang, Shan, Cupello, Carmen Rodriguez, Grant, Rhiannon D., Yam, Michelle, Papanicolaou, Michael, Major, Gretel, Zaratzian, Anaiis, Da Silva, Andrew M., Tayao, Michael, Vennin, Claire, Timpson, Paul, Madsen, Chris D., Cox, Thomas R.

“…Background The use of in vitro cell cultures is a powerful tool for obtaining key insights into the behaviour and response of cells to interventions in normal…”
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