Výsledky vyhľadávania - "Wilting, Roel H"

Overlapping functions of Hdac1 and Hdac2 in cell cycle regulation and haematopoiesis Autor Wilting, Roel H, Yanover, Eva, Heideman, Marinus R, Jacobs, Heinz, Horner, James, van der Torre, Jaco, DePinho, Ronald A, Dannenberg, Jan-Hermen

“…Histone deacetylases (HDACs) counterbalance acetylation of lysine residues, a protein modification involved in numerous biological processes. Here, Hdac1 and…”
Získať plný text

Epigenetic mechanisms in tumorigenesis, tumor cell heterogeneity and drug resistance Autor Wilting, Roel H., Dannenberg, Jan-Hermen

“…Resistance of cancer cells to chemotherapeutics and emerging targeted drugs is a devastating problem in the treatment of cancer patients. Multiple mechanisms…”
Získať plný text

Attenuation of melanoma invasion by a secreted variant of activated leukocyte cell adhesion molecule Autor van Kilsdonk, Jeroen W J, Wilting, Roel H, Bergers, Mieke, van Muijen, Goos N P, Schalkwijk, Joost, van Kempen, Léon C L T, Swart, Guido W M

“…Activated leukocyte cell adhesion molecule (ALCAM/CD166/MEMD), a marker of various cancers and mesenchymal stem cells, is involved in melanoma metastasis. We…”
Zistit podrobnosti o prístupe

Dosage-dependent tumor suppression by histone deacetylases 1 and 2 through regulation of c-Myc collaborating genes and p53 function Autor Heideman, Marinus R, Wilting, Roel H, Yanover, Eva, Velds, Arno, de Jong, Johann, Kerkhoven, Ron M, Jacobs, Heinz, Wessels, Lodewyk F, Dannenberg, Jan-Hermen

“…Histone deacetylases (HDACs) are epigenetic erasers of lysine-acetyl marks. Inhibition of HDACs using small molecule inhibitors (HDACi) is a potential strategy…”
Zistit podrobnosti o prístupe