Suchergebnisse - "Wilson, James F"

A genetic atlas of human admixture history von Hellenthal, Garrett, Busby, George B J, Band, Gavin, Wilson, James F, Capelli, Cristian, Falush, Daniel, Myers, Simon

“… Modern genetic data combined with appropriate statistical methods have the potential to contribute substantially to our understanding of human history. We have …”
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Multivariate genomic scan implicates novel loci and haem metabolism in human ageing von Timmers, Paul R. H. J., Wilson, James F., Joshi, Peter K., Deelen, Joris

“… Ageing phenotypes, such as years lived in good health (healthspan), total years lived (lifespan), and survival until an exceptional old age (longevity), are of …”
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A General Approach for Haplotype Phasing across the Full Spectrum of Relatedness von O'Connell, Jared, Gurdasani, Deepti, Delaneau, Olivier, Pirastu, Nicola, Ulivi, Sheila, Cocca, Massimiliano, Traglia, Michela, Huang, Jie, Huffman, Jennifer E., Rudan, Igor, McQuillan, Ruth, Fraser, Ross M., Campbell, Harry, Polasek, Ozren, Asiki, Gershim, Ekoru, Kenneth, Hayward, Caroline, Wright, Alan F., Vitart, Veronique, Navarro, Pau, Zagury, Jean-Francois, Wilson, James F., Toniolo, Daniela, Gasparini, Paolo, Soranzo, Nicole, Sandhu, Manjinder S., Marchini, Jonathan

“… Many existing cohorts contain a range of relatedness between genotyped individuals, either by design or by chance. Haplotype estimation in such cohorts is a …”
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Genomic Runs of Homozygosity Record Population History and Consanguinity von Kirin, Mirna, McQuillan, Ruth, Franklin, Christopher S., Campbell, Harry, McKeigue, Paul M., Wilson, James F.

“… The human genome is characterised by many runs of homozygous genotypes, where identical haplotypes were inherited from each parent. The length of each run is …”
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Abundant pleiotropy in human complex diseases and traits von Sivakumaran, Shanya, Agakov, Felix, Theodoratou, Evropi, Prendergast, James G, Zgaga, Lina, Manolio, Teri, Rudan, Igor, McKeigue, Paul, Wilson, James F, Campbell, Harry

“… We present a systematic review of pleiotropy among SNPs and genes reported to show genome-wide association with common complex diseases and traits. We find …”
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International Photographic Classification and Grading System for Myopic Maculopathy von Ohno-Matsui, Kyoko, Kawasaki, Ryo, Jonas, Jost B., Cheung, Chui Ming Gemmy, Saw, Seang-Mei, Verhoeven, Virginie J.M., Klaver, Caroline C.W., Moriyama, Muka, Shinohara, Kosei, Kawasaki, Yumiko, Yamazaki, Mai, Meuer, Stacy, Ishibashi, Tatsuro, Yasuda, Miho, Yamashita, Hidetoshi, Sugano, Akira, Wang, Jie Jin, Mitchell, Paul, Wong, Tien Yin, Ohno-Matsui, Kyoko, Moriyama, Muka, Shinohara, Kosei, Kawasaki, Ryo, Kawasaki, Yumiko, Yamazaki, Mai, Jonas, Jost B., Cheung, Chui-Ming Gemmy, Saw, Seang-Mei, Wong, Tien Yin, Verhoeven, Virginie J.M., Klaver, Caroline C.W., Meuer, Stacy, Klein, Ronald, Klein, Barbara E., Ishibashi, Tatsuro, Yasuda, Miho, Sugano, Akira, Yamashita, Hidetoshi, Wang, Jie Jin, Mitchell, Paul, Wang, Ning Li, Hashemi, Hassan, Fotouhi, Akbar, Polašek, Ozren, Vitart, Veronique, Wilson, James F., Fleck, Brian

“… To develop a classification and grading system for myopic maculopathy. Development and evaluation of a classification system for myopic maculopathy based on …”
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Coffee Consumption and Kidney Function: A Mendelian Randomization Study von Kennedy, Oliver J, Pirastu, Nicola, Poole, Robin, Fallowfield, Jonathan A, Hayes, Peter C, Grzeszkowiak, Eryk J, Taal, Maarten W, Wilson, James F, Parkes, Julie, Roderick, Paul J

“… Chronic kidney disease (CKD) is a leading cause of morbidity and mortality worldwide, with limited strategies for prevention and treatment. Coffee is a complex …”
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Characterisation of pharmacogenomic variation in the Shetland and Orkney Isles in Scotland von Twesigomwe, David, Aitman, Timothy J., Wilson, James F.

“… Genetic variation is partly responsible for variability in drug response across populations. However, the full catalogue of pharmacogenetic variants and their …”
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Large-scale GWAS of food liking reveals genetic determinants and genetic correlations with distinct neurophysiological traits von May-Wilson, Sebastian, Matoba, Nana, Wade, Kaitlin H., Hottenga, Jouke-Jan, Concas, Maria Pina, Mangino, Massimo, Grzeszkowiak, Eryk J., Menni, Cristina, Gasparini, Paolo, Timpson, Nicholas J., Veldhuizen, Maria G., de Geus, Eco, Wilson, James F., Pirastu, Nicola

“… We present the results of a GWAS of food liking conducted on 161,625 participants from the UK-Biobank. Liking was assessed over 139 specific foods using a …”
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Limited Effect of Y Chromosome Variation on Coronary Artery Disease and Mortality in UK Biobank-Brief Report von Timmers, Paul R H J, Wilson, James F

“… The effect of genetic variation in the male-specific region of the Y chromosome (MSY) on coronary artery disease and cardiovascular risk factors has been …”
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Genome-Wide Association Analyses in 128,266 Individuals Identifies New Morningness and Sleep Duration Loci von Jones, Samuel E., Tyrrell, Jessica, Wood, Andrew R., Beaumont, Robin N., Ruth, Katherine S., Tuke, Marcus A., Yaghootkar, Hanieh, Hu, Youna, Teder-Laving, Maris, Hayward, Caroline, Roenneberg, Till, Wilson, James F., Del Greco, Fabiola, Hicks, Andrew A., Shin, Chol, Yun, Chang-Ho, Lee, Seung Ku, Metspalu, Andres, Byrne, Enda M., Gehrman, Philip R., Tiemeier, Henning, Allebrandt, Karla V., Freathy, Rachel M., Murray, Anna, Hinds, David A., Frayling, Timothy M., Weedon, Michael N.

“… Disrupted circadian rhythms and reduced sleep duration are associated with several human diseases, particularly obesity and type 2 diabetes, but until …”
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Genetic adaptation of fatty-acid metabolism: a human-specific haplotype increasing the biosynthesis of long-chain omega-3 and omega-6 fatty acids von Ameur, Adam, Enroth, Stefan, Johansson, Asa, Zaboli, Ghazal, Igl, Wilmar, Johansson, Anna C V, Rivas, Manuel A, Daly, Mark J, Schmitz, Gerd, Hicks, Andrew A, Meitinger, Thomas, Feuk, Lars, van Duijn, Cornelia, Oostra, Ben, Pramstaller, Peter P, Rudan, Igor, Wright, Alan F, Wilson, James F, Campbell, Harry, Gyllensten, Ulf

“… Omega-3 and omega-6 long-chain polyunsaturated fatty acids (LC-PUFAs) are essential for the development and function of the human brain. They can be obtained …”
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Using genetic variation to disentangle the complex relationship between food intake and health outcomes von Pirastu, Nicola, McDonnell, Ciara, Grzeszkowiak, Eryk J., Mounier, Ninon, Imamura, Fumiaki, Merino, Jordi, Day, Felix R., Zheng, Jie, Taba, Nele, Concas, Maria Pina, Repetto, Linda, Kentistou, Katherine A., Robino, Antonietta, Esko, Tõnu, Joshi, Peter K., Fischer, Krista, Ong, Ken K., Gaunt, Tom R., Kutalik, Zoltán, Perry, John R. B., Wilson, James F.

“… Diet is considered as one of the most important modifiable factors influencing human health, but efforts to identify foods or dietary patterns associated with …”
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Mapping the serum proteome to neurological diseases using whole genome sequencing von Png, Grace, Barysenka, Andrei, Repetto, Linda, Navarro, Pau, Shen, Xia, Pietzner, Maik, Wheeler, Eleanor, Wareham, Nicholas J., Langenberg, Claudia, Tsafantakis, Emmanouil, Karaleftheri, Maria, Dedoussis, George, Mälarstig, Anders, Wilson, James F., Gilly, Arthur, Zeggini, Eleftheria

“… Despite the increasing global burden of neurological disorders, there is a lack of effective diagnostic and therapeutic biomarkers. Proteins are often …”
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Regionally enriched rare deleterious exonic variants in the UK and Ireland von Halachev, Mihail, Gountouna, Viktoria-Eleni, Meynert, Alison, Tzoneva, Gannie, Shuldiner, Alan R., Semple, Colin A., Wilson, James F.

“… It is unclear how patterns of regional genetic differentiation in the UK and Ireland might impact the protein-coding fraction of the genome. We exploit UK …”
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Variants near CHRNA3/5 and APOE have age- and sex-related effects on human lifespan von Joshi, Peter K., Fischer, Krista, Schraut, Katharina E., Campbell, Harry, Esko, Tõnu, Wilson, James F.

“… Lifespan is a trait of enormous personal interest. Research into the biological basis of human lifespan, however, is hampered by the long time to death. Using …”
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High throughput isolation and glycosylation analysis of IgG-variability and heritability of the IgG glycome in three isolated human populations von Pucić, Maja, Knezević, Ana, Vidic, Jana, Adamczyk, Barbara, Novokmet, Mislav, Polasek, Ozren, Gornik, Olga, Supraha-Goreta, Sandra, Wormald, Mark R, Redzić, Irma, Campbell, Harry, Wright, Alan, Hastie, Nicholas D, Wilson, James F, Rudan, Igor, Wuhrer, Manfred, Rudd, Pauline M, Josić, Djuro, Lauc, Gordan

“… All immunoglobulin G molecules carry N-glycans, which modulate their biological activity. Changes in N-glycosylation of IgG associate with various diseases and …”
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Genetic regulation of post-translational modification of two distinct proteins von Landini, Arianna, Trbojević-Akmačić, Irena, Navarro, Pau, Tsepilov, Yakov A., Sharapov, Sodbo Z., Vučković, Frano, Polašek, Ozren, Hayward, Caroline, Petrović, Tea, Vilaj, Marija, Aulchenko, Yurii S., Lauc, Gordan, Wilson, James F., Klarić, Lucija

“… Post-translational modifications diversify protein functions and dynamically coordinate their signalling networks, influencing most aspects of cell physiology …”
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GWAS for male-pattern baldness identifies 71 susceptibility loci explaining 38% of the risk von Pirastu, Nicola, Joshi, Peter K., de Vries, Paul S., Cornelis, Marilyn C., McKeigue, Paul M., Keum, NaNa, Franceschini, Nora, Colombo, Marco, Giovannucci, Edward L., Spiliopoulou, Athina, Franke, Lude, North, Kari E., Kraft, Peter, Morrison, Alanna C., Esko, Tõnu, Wilson, James F.

“… Male pattern baldness (MPB) or androgenetic alopecia is one of the most common conditions affecting men, reaching a prevalence of ~50% by the age of 50; …”
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Multivariate discovery and replication of five novel loci associated with Immunoglobulin G N-glycosylation von Shen, Xia, Klarić, Lucija, Sharapov, Sodbo, Mangino, Massimo, Ning, Zheng, Wu, Di, Trbojević-Akmačić, Irena, Pučić-Baković, Maja, Rudan, Igor, Polašek, Ozren, Hayward, Caroline, Spector, Timothy D., Wilson, James F., Lauc, Gordan, Aulchenko, Yurii S.

“… Joint modeling of a number of phenotypes using multivariate methods has often been neglected in genome-wide association studies and if used, replication has …”
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