Výsledky vyhľadávania - "Wilkinson, Patrick"

The Polyploid State Restricts Hepatocyte Proliferation and Liver Regeneration in Mice Autor Wilkinson, Patrick D., Delgado, Evan R., Alencastro, Frances, Leek, Madeleine P., Roy, Nairita, Weirich, Matthew P., Stahl, Elizabeth C., Otero, P. Anthony, Chen, Maelee I., Brown, Whitney K., Duncan, Andrew W.

“…The liver contains a mixture of hepatocytes with diploid or polyploid (tetraploid, octaploid, etc.) nuclear content. Polyploid hepatocytes are commonly found…”
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Differential Roles for Diploid and Polyploid Hepatocytes in Acute and Chronic Liver Injury Autor Wilkinson, Patrick D, Duncan, Andrew W

“…Hepatocytes are the primary functional cells of the liver that perform essential roles in homeostasis, regeneration, and injury. Most mammalian somatic cells…”
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Macrophage-derived tumor necrosis factor-α mediates diabetic renal injury Autor Awad, Alaa S., You, Hanning, Gao, Ting, Cooper, Timothy K., Nedospasov, Sergei A., Vacher, Jean, Wilkinson, Patrick F., Farrell, Francis X., Brian Reeves, W.

“…Monocyte/macrophage recruitment correlates strongly with the progression of diabetic nephropathy. Tumor necrosis factor-α (TNF-α) is produced by…”
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RORγt and RORα signature genes in human Th17 cells Autor Castro, Glenda, Liu, Xuejun, Ngo, Karen, De Leon-Tabaldo, Aimee, Zhao, Shanrong, Luna-Roman, Rosa, Yu, Jingxue, Cao, Tinghua, Kuhn, Robert, Wilkinson, Patrick, Herman, Krystal, Nelen, Marina I., Blevitt, Jonathan, Xue, Xiaohua, Fourie, Anne, Fung-Leung, Wai-Ping

“…RORγt and RORα are transcription factors of the RAR-related orphan nuclear receptor (ROR) family. They are expressed in Th17 cells and have been suggested to…”
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Polyploid Hepatocytes Facilitate Adaptation and Regeneration to Chronic Liver Injury Autor Wilkinson, Patrick D, Alencastro, Frances, Delgado, Evan R, Leek, Madeleine P, Weirich, Matthew P, Otero, P Anthony, Roy, Nairita, Brown, Whitney K, Oertel, Michael, Duncan, Andrew W

“…The liver contains diploid and polyploid hepatocytes (tetraploid, octaploid, etc.), with polyploids comprising ≥90% of the hepatocyte population in adult mice…”
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Inflammation and Ectopic Fat Deposition in the Aging Murine Liver Is Influenced by CCR2 Autor Stahl, Elizabeth C, Delgado, Evan R, Alencastro, Frances, LoPresti, Samuel T, Wilkinson, Patrick D, Roy, Nairita, Haschak, Martin J, Skillen, Clint D, Monga, Satdarshan P, Duncan, Andrew W, Brown, Bryan N

“…Aging is associated with inflammation and metabolic syndrome, which manifests in the liver as nonalcoholic fatty liver disease (NAFLD). NAFLD can range in…”
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Residual DNA impurities in AAV vectors—nature and transcription Autor Jen, Hsin-I, Wilkinson, Patrick, Lu, Xiaohui, Zhang, Wei

“…Recombinant adeno-associated viruses (rAAVs) produced by transfecting DNA plasmids into mammalian cells can inadvertently package host cell DNA (hcDNA) and…”
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Adenosine Signaling Increases Proinflammatory and Profibrotic Mediators through Activation of a Functional Adenosine 2B Receptor in Renal Fibroblasts Autor Wilkinson, Patrick F, Farrell, Francis X, Morel, Diane, Law, William, Murphy, Suzanne

“…Interstitial renal fibrosis is a major pathophysiological manifestation of patients diagnosed with Chronic Kidney Disease (CKD), Diabetic Nephropathy (DN) and…”
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Repeated exposure of house dust mite induces progressive airway inflammation in mice: Differential roles of CCL17 and IL‐13 Autor Malaviya, Ravi, Zhou, Zhao, Raymond, Holly, Wertheimer, Josh, Jones, Brian, Bunting, Rachel, Wilkinson, Patrick, Madireddy, Lohith, Hall, LeRoy, Ryan, Mary, Rao, Tadimeti S.

“…We conducted a systematic evaluation of lung inflammation indued by repeated intranasal exposure (for 10 consecutive days) to a human aeroallergen, house dust…”
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Relationship of microparticles to progenitor cells as a measure of vascular health in a diabetic population Autor Curtis, Anne M., Zhang, Lifeng, Medenilla, Elizabeth, Gui, Ming, Wilkinson, Patrick F., Hu, Erding, Giri, Jay, Doraiswamy, Vijay, Gunda, Sampath, Burgert, Mark E., Moore, Jonni S, Edelberg, Jay M., Mohler, Emile R.

“…Objective: Quantitative measures are needed to identify diabetic patients at higher risk for CV events. Cell‐derived microparticles (MPs) are submicron…”
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Analysis of classical neutrophils and polymorphonuclear myeloid-derived suppressor cells in cancer patients and tumor-bearing mice Autor Veglia, Filippo, Hashimoto, Ayumi, Dweep, Harsh, Sanseviero, Emilio, De Leo, Alessandra, Tcyganov, Evgenii, Kossenkov, Andrew, Mulligan, Charles, Nam, Brian, Masters, Gregory, Patel, Jaymala, Bhargava, Vipul, Wilkinson, Patrick, Smirnov, Denis, Sepulveda, Manuel A, Singhal, Sunil, Eruslanov, Evgeniy B, Cristescu, Razvan, Loboda, Andrey, Nefedova, Yulia, Gabrilovich, Dmitry I

“…In this study, using single-cell RNA-seq, cell mass spectrometry, flow cytometry, and functional analysis, we characterized the heterogeneity of…”
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Calreticulin mutant myeloproliferative neoplasms induce MHC-I skewing, which can be overcome by an optimized peptide cancer vaccine Autor Gigoux, Mathieu, Holmström, Morten O, Zappasodi, Roberta, Park, Joseph J, Pourpe, Stephane, Bozkus, Cansu Cimen, Mangarin, Levi M B, Redmond, David, Verma, Svena, Schad, Sara, George, Mariam M, Venkatesh, Divya, Ghosh, Arnab, Hoyos, David, Molvi, Zaki, Kamaz, Baransel, Marneth, Anna E, Duke, William, Leventhal, Matthew J, Jan, Max, Ho, Vincent T, Hobbs, Gabriela S, Knudsen, Trine Alma, Skov, Vibe, Kjær, Lasse, Larsen, Thomas Stauffer, Hansen, Dennis Lund, Lindsley, R Coleman, Hasselbalch, Hans, Grauslund, Jacob H, Lisle, Thomas L, Met, Özcan, Wilkinson, Patrick, Greenbaum, Benjamin, Sepulveda, Manuel A, Chan, Timothy, Rampal, Raajit, Andersen, Mads H, Abdel-Wahab, Omar, Bhardwaj, Nina, Wolchok, Jedd D, Mullally, Ann, Merghoub, Taha

“…The majority of JAK2 -negative myeloproliferative neoplasms (MPNs) have disease-initiating frameshift mutations in calreticulin ( ), resulting in a common…”
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Serum Inflammatory and Immune Mediators Are Elevated in Early Stage Diabetic Nephropathy Autor Perlman, Alan S, Chevalier, James M, Wilkinson, Patrick, Liu, Hao, Parker, Thomas, Levine, Daniel M, Sloan, Betty Jo, Gong, Anna, Sherman, Raymond, Farrell, Francis X

“…Diabetes is the leading cause of end stage renal disease (ESRD) in the United States, representing 44% of incident cases [1]. In this study, serum and…”
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The polyploid state restricts hepatocyte proliferation and liver regeneration Autor Wilkinson, Patrick D., Delgado, Evan R., Alencastro, Frances, Leek, Madeleine P., Roy, Nairita, Weirich, Matthew P., Stahl, Elizabeth C., Otero, P. Anthony, Chen, Maelee I., Brown, Whitney K., Duncan, Andrew W.

“…The liver contains a mixture of hepatocytes with diploid or polyploid (tetraploid, octaploid, etc.) nuclear content. Polyploid hepatocytes are commonly found…”
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Functional Adenosine Receptor 2B Drives Profibrotic and Proinflammatory Signaling in Renal Fibroblasts Through Modulation of TGFβ Receptor Signaling Autor Wilkinson, Patrick

“…Extracellular adenosine signaling via the adenosine receptor 2B (AR 2B) is a potent profibrotic and proinflammatory molecule that has been shown to contribute…”
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ROR[gamma]t and ROR[alpha] signature genes in human Th17 cells Autor Castro, Glenda, Liu, Xuejun, Ngo, Karen, De Leon-Tabaldo, Aimee, Zhao, Shanrong, Luna-Roman, Rosa, Yu, Jingxue, Cao, Tinghua, Kuhn, Robert, Wilkinson, Patrick, Herman, Krystal, Nelen, Marina I, Blevitt, Jonathan, Xue, Xiaohua, Fourie, Anne, Fung-Leung, Wai-Ping

“…ROR[gamma]t and ROR[alpha] are transcription factors of the RAR-related orphan nuclear receptor (ROR) family. They are expressed in Th17 cells and have been…”
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Macrophage-derived tumor necrosis factor-[alpha] mediates diabetic renal injury Autor Awad, Alaa S, You, Hanning, Gao, Ting, Cooper, Timothy K, Nedospasov, Sergei A, Vacher, Jean, Wilkinson, Patrick F, Farrell, Francis X, Brian Reeves, W

“…Monocyte/macrophage recruitment correlates strongly with the progression of diabetic nephropathy. Tumor necrosis factor-α (TNF-α) is produced by…”
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Cave Vodou in Haiti: The Use of Caves as Sacred Space in Modern Haitian Ritual Autor Wilkinson, Patrick Richard

“…Haitian Vodou is a syncretic religion that combines elements of West African beliefs and indigenous Taíno culture with a rigid framework of forced Catholicism…”
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Polyploidy in Liver Regeneration and Adaptation to Chronic Liver Injury Autor Wilkinson, Patrick David

“…The liver contains diploid and polyploid hepatocytes (tetraploid, octaploid, etc.), with polyploids comprising ≥90% of the hepatocyte population in adult mice…”
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Development of cell-based immunoassays to measure type I collagen in cultured fibroblasts Autor Jones, Brian, Bucks, Christine, Wilkinson, Patrick, Pratta, Michael, Farrell, Francis, Sivakumar, Pitchumani

“…Excessive deposition of type I collagen by activated fibroblasts is a hallmark of scarring and fibrotic pathologies. Quantitation of collagen I at the protein…”
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