Suchergebnisse - "Wezel, Anouk"

Stress-induced mast cell activation contributes to atherosclerotic plaque destabilization von Lagraauw, H. Maxime, Wezel, Anouk, van der Velden, Daniël, Kuiper, Johan, Bot, Ilze

“… Mast cells accumulate in the perivascular tissue during atherosclerotic plaque progression and contribute to plaque destabilization. However, the specific …”
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Mast cells mediate neutrophil recruitment during atherosclerotic plaque progression von Wezel, Anouk, Lagraauw, H. Maxime, van der Velden, Daniël, de Jager, Saskia C.A., Quax, Paul H.A., Kuiper, Johan, Bot, Ilze

“… Activated mast cells have been identified in the intima and perivascular tissue of human atherosclerotic plaques. As mast cells have been described to release …”
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Systematic Evaluation of the Cellular Innate Immune Response During the Process of Human Atherosclerosis von Dijk, Rogier A., Rijs, Kevin, Wezel, Anouk, Hamming, Jaap F., Kolodgie, Frank D., Virmani, Renu, Schaapherder, Alexander F., Lindeman, Jan H. N.

“… Background The concept of innate immunity is well recognized within the spectrum of atherosclerosis, which is primarily dictated by macrophages. Although …”
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Mast cell depletion in the preclinical phase of collagen-induced arthritis reduces clinical outcome by lowering the inflammatory cytokine profile von van der Velden, Daniël, Lagraauw, H. Maxime, Wezel, Anouk, Launay, Pierre, Kuiper, Johan, Huizinga, Tom W. J., Toes, René E. M., Bot, Ilze, Stoop, Jeroen N.

“… Background Rheumatoid arthritis (RA) is a multifactorial autoimmune disease, which is characterized by inflammation of synovial joints leading to the …”
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Vascular neuropeptide Y contributes to atherosclerotic plaque progression and perivascular mast cell activation von Lagraauw, H. Maxime, Westra, Marijke M., Bot, Martine, Wezel, Anouk, van Santbrink, Peter J., Pasterkamp, Gerard, Biessen, Erik A.L., Kuiper, Johan, Bot, Ilze

“… Neuropeptide Y is an abundantly expressed neurotransmitter capable of modulating both immune and metabolic responses related to the development of …”
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Flow Cytometry-Based Characterization of Mast Cells in Human Atherosclerosis von Kritikou, Eva, Depuydt, Marie A.C., de Vries, Margreet R., Mulder, Kevin E., Govaert, Arthur M., Smit, Marrit D., van Duijn, Janine, Foks, Amanda C., Wezel, Anouk, Smeets, Harm J., Slütter, Bram, Quax, Paul H.A., Kuiper, Johan, Bot, Ilze

“… The presence of mast cells in human atherosclerotic plaques has been associated with adverse cardiovascular events. Mast cell activation, through the classical …”
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TLR4 Accessory Molecule RP105 (CD180) Regulates Monocyte-Driven Arteriogenesis in a Murine Hind Limb Ischemia Model von Bastiaansen, Antonius J. N. M., Karper, Jacco C., Wezel, Anouk, de Boer, Hetty C., Welten, Sabine M. J., de Jong, Rob C. M., Peters, Erna A. B., de Vries, Margreet R., van Oeveren-Rietdijk, Annemarie M., van Zonneveld, Anton Jan, Hamming, Jaap F., Nossent, A. Yaël, Quax, Paul H. A.

“… We investigated the role of the TLR4-accessory molecule RP105 (CD180) in post-ischemic neovascularization, i.e. arteriogenesis and angiogenesis. TLR4-mediated …”
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CD8+ T-cells contribute to lesion stabilization in advanced atherosclerosis by limiting macrophage content and CD4+ T-cell responses von van Duijn, Janine, Kritikou, Eva, Benne, Naomi, van der Heijden, Thomas, van Puijvelde, Gijs H, Kröner, Mara J, Schaftenaar, Frank H, Foks, Amanda C, Wezel, Anouk, Smeets, Harm, Yagita, Hideo, Bot, Ilze, Jiskoot, Wim, Kuiper, Johan, Slütter, Bram

“… T lymphocytes play an important role in atherosclerosis development, but the role of the CD8+ T-cell remains debated, especially in the clinically relevant …”
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Single-cell profiling reveals age-associated immunity in atherosclerosis von Smit, Virginia, de Mol, Jill, Schaftenaar, Frank H, Depuydt, Marie A C, Postel, Rimke J, Smeets, Diede, Verheijen, Fenne W M, Bogers, Laurens, van Duijn, Janine, Verwilligen, Robin A F, Grievink, Hendrika W, Bernabé Kleijn, Mireia N A, van Ingen, Eva, de Jong, Maaike J M, Goncalves, Lauren, Peeters, Judith A H M, Smeets, Harm J, Wezel, Anouk, Polansky, Julia K, de Winther, Menno P J, Binder, Christoph J, Tsiantoulas, Dimitrios, Bot, Ilze, Kuiper, Johan, Foks, Amanda C

“… Abstract Aims Aging is a dominant driver of atherosclerosis and induces a series of immunological alterations, called immunosenescence. Given the demographic …”
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Leukemia inhibitory factor receptor inhibition by EC359 reduces atherosclerotic stenosis grade in Ldlr−/− mice von Hemme, Esmeralda, Depuydt, Marie A.C., van Santbrink, Peter J., Wezel, Anouk, Smeets, Harm J., Foks, Amanda C., Kuiper, Johan, Bot, Ilze

“… Cytokines are involved in all stages of atherosclerosis, generally contributing to disease progression. Previously, members of the Interleukin (IL)-6 cytokine …”
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CD39 identifies a microenvironment-specific anti-inflammatory CD8+ T-cell population in atherosclerotic lesions von van Duijn, Janine, van Elsas, Marit, Benne, Naomi, Depuydt, Marie, Wezel, Anouk, Smeets, Harm, Bot, Ilze, Jiskoot, Wim, Kuiper, Johan, Slütter, Bram

“… CD8+ T-cells have been attributed both atherogenic and atheroprotective properties, but analysis of CD8+ T-cells has mostly been restricted to the circulation …”
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Virus-Associated CD8 + T-Cells Are Not Activated Through Antigen-Mediated Interaction Inside Atherosclerotic Lesions von de Jong, Maaike J M, Schaftenaar, Frank H, Depuydt, Marie A C, Lozano Vigario, Fernando, Janssen, George M C, Peeters, Judith A H M, Goncalves, Lauren, Wezel, Anouk, Smeets, Harm J, Kuiper, Johan, Bot, Ilze, van Veelen, Peter, Slütter, Bram

“… Viral infections have been associated with the progression of atherosclerosis and CD8 T-cells directed against common viruses, such as influenza, Epstein-Barr …”
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Resident Memory T Cells in the Atherosclerotic Lesion Associate With Reduced Macrophage Content and Increased Lesion Stability von de Jong, M J M, Depuydt, M A C, Schaftenaar, F H, Liu, K, Maters, D, Wezel, Anouk, Smeets, Harm J, Kuiper, J, Bot, I, van Gisbergen, K, Slütter, B

“… Tissue resident memory T (T ) cells are a T-cell subset that resides at the site of prior antigen recognition to protect the body against reoccurring …”
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CXCL12 Derived From ACKR1 + Intraplaque Neovessels Mediates CD8 + T Cell Recruitment in Human Atherosclerosis von Parma, Laura, Sachs, Nadja, Sobczak, Nikola, Li, Zhaolong, Merchant, Kevin, Pauli, Jessica, Depuydt, Marie A C, Wezel, Anouk, Smeets, Harm J, Bot, Ilze, Slütter, Bram, Maegdefessel, Lars, Weber, Christian, Duchêne, Johan, Megens, Remco T A

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Hypercholesterolemia Induces a Mast Cell-CD4 + T Cell Interaction in Atherosclerosis von Kritikou, Eva, van der Heijden, Thomas, Swart, Maarten, van Duijn, Janine, Slütter, Bram, Wezel, Anouk, Smeets, Harm J, Maffia, Pasquale, Kuiper, Johan, Bot, Ilze

“… Mast cells (MCs) are potent innate immune cells that aggravate atherosclerosis through the release of proinflammatory mediators inside atherosclerotic plaques …”
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B- and T-lymphocyte attenuator stimulation protects against atherosclerosis by regulating follicular B cells von Douna, Hidde, Amersfoort, Jacob, Schaftenaar, Frank H, Kröner, Mara J, Kiss, Máté G, Slütter, Bram, Depuydt, Marie A C, Bernabé Kleijn, Mireia N A, Wezel, Anouk, Smeets, Harm J, Yagita, Hideo, Binder, Christoph J, Bot, I, van Puijvelde, Gijs H M, Kuiper, Johan, Foks, Amanda C

“… Abstract Aims The immune system is strongly involved in atherosclerosis and immune regulation generally leads to attenuated atherosclerosis. B- and …”
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Single-cell T cell receptor sequencing of paired human atherosclerotic plaques and blood reveals autoimmune-like features of expanded effector T cells von Depuydt, Marie A. C., Schaftenaar, Frank H., Prange, Koen H. M., Boltjes, Arjan, Hemme, Esmeralda, Delfos, Lucie, de Mol, Jill, de Jong, Maaike J. M., Bernabé Kleijn, Mireia N. A., Peeters, Judith A. H. M., Goncalves, Lauren, Wezel, Anouk, Smeets, Harm J., de Borst, Gert J., Foks, Amanda C., Pasterkamp, Gerard, de Winther, Menno P. J., Kuiper, Johan, Bot, Ilze, Slütter, Bram

“… Atherosclerosis is a lipid-driven chronic inflammatory disease; however, whether it can be classified as an autoimmune disease remains unclear. In this study, …”
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Inhibition of MicroRNA-494 Reduces Carotid Artery Atherosclerotic Lesion Development and Increases Plaque Stability von Wezel, Anouk, Welten, Sabine M J, Razawy, Wida, Lagraauw, H Maxime, de Vries, Margreet R, Goossens, Eveline A C, Boonstra, Martin C, Hamming, Jaap F, Kandimalla, Ekambar R, Kuiper, Johan, Quax, Paul H A, Nossent, A Yaël, Bot, Ilze

“… Unstable atherosclerotic lesions in carotid arteries require surgical endarterectomy to reduce the risk of ischemic stroke. We aimed to identify microRNAs that …”
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Inhibition of 14q32 microRNA miR-495 reduces lesion formation, intimal hyperplasia and plasma cholesterol levels in experimental restenosis von Welten, Sabine M.J., de Jong, Rob C.M., Wezel, Anouk, de Vries, Margreet R., Boonstra, Martin C., Parma, Laura, Jukema, J. Wouter, van der Sluis, Tetje C., Arens, Ramon, Bot, Ilze, Agrawal, Sudhir, Quax, Paul H.A., Nossent, A. Yaël

“… We aimed at investigating the role of 14q32 microRNAs in intimal hyperplasia and accelerated atherosclerosis; two major contributors to restenosis. Restenosis …”
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Complement factor C5a induces atherosclerotic plaque disruptions von Wezel, Anouk, Vries, Margreet R., Lagraauw, H. Maxime, Foks, Amanda C., Kuiper, Johan, Quax, Paul H.A., Bot, Ilze

“… Complement factor C5a and its receptor C5aR are expressed in vulnerable atherosclerotic plaques; however, a causal relation between C5a and plaque rupture has …”
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