Výsledky vyhľadávania - "West, Alison C."

Gasdermin D promotes hyperinflammation and immunopathology during severe influenza A virus infection Autor Rosli, Sarah, Harpur, Christopher M., Lam, Maggie, West, Alison C., Hodges, Christopher, Mansell, Ashley, Lawlor, Kate E., Tate, Michelle D.

“…Excessive inflammation and tissue damage during severe influenza A virus (IAV) infection can lead to the development of fatal pulmonary disease. Pyroptosis is…”
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Serine-Phosphorylated STAT3 Promotes Tumorigenesis via Modulation of RNA Polymerase Transcriptional Activity Autor Balic, Jesse J, Garama, Daniel J, Saad, Mohamed I, Yu, Liang, West, Alison C, West, Alice J, Livis, Thaleia, Bhathal, Prithi S, Gough, Daniel J, Jenkins, Brendan J

“…Deregulated activation of the latent oncogenic transcription factor STAT3 in many human epithelial malignancies, including gastric cancer, has invariably been…”
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Constitutive STAT3 Serine Phosphorylation Promotes Helicobacter-Mediated Gastric Disease Autor Balic, Jesse J, Saad, Mohamed I, Dawson, Ruby, West, Alice J, McLeod, Louise, West, Alison C, D'Costa, Kimberley, Deswaerte, Virginie, Dev, Anouk, Sievert, William, Gough, Daniel J, Bhathal, Prithi S, Ferrero, Richard L, Jenkins, Brendan J

“…Gastric cancer is associated with chronic inflammation (gastritis) triggered by persistent Helicobacter pylori (H. pylori) infection. Elevated tyrosine…”
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Gasdermin E deficiency limits inflammation and lung damage during influenza virus infection Autor Rosli, Sarah, Ambrose, Rebecca L., Harpur, Christopher M., Lam, Maggie, Hodges, Christopher, Barry, Kristian T., West, Alison C., Mansell, Ashley, Lawlor, Kate E., Tate, Michelle D.

“…Severe influenza A virus (IAV) infections are associated with hyperinflammation and significant lung damage. Gasdermin E (GSDME) mediates pyroptosis, a lytic…”
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NLRP3 deficiency abrogates silica-induced neutrophil infiltration, pulmonary damage and fibrosis Autor Lam, Maggie, Barry, Kristian T., Hodges, Christopher J., Harpur, Christopher M., Ong, James D. H., Rosli, Sarah, West, Alison C., Dousha, Lovisa, Hertzog, Paul J., Mansell, Ashley, Tate, Michelle D.

“…Background Silicosis is a progressive and often fatal occupational lung disease. The NLRP3 inflammasome is an innate immune sensor that is activated by silica…”
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The anticancer effects of HDAC inhibitors require the immune system Autor West, Alison C, Smyth, Mark J, Johnstone, Ricky W

“…Histone deacetylase inhibitors (HDACis) are known to exert immunomodulatory effects. We have recently demonstrated that the therapeutic efficacy of HDACis…”
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New and emerging HDAC inhibitors for cancer treatment Autor West, Alison C., Johnstone, Ricky W.

“…Epigenetic enzymes are often dysregulated in human tumors through mutation, altered expression, or inappropriate recruitment to certain loci. The…”
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Inflammatory and non-inflammatory roles for Toll-like receptors in gastrointestinal cancer Autor West, Alison C, Jenkins, Brendan J

“…Collectively, cancers of the gastrointestinal (GI) tract (including the esophagus, stomach, duodenum, colon, rectum, liver, gall bladder and bile ducts) are…”
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Inflammasome-Associated Gastric Tumorigenesis Is Independent of the NLRP3 Pattern Recognition Receptor Autor West, Alice J., Deswaerte, Virginie, West, Alison C., Gearing, Linden J., Tan, Patrick, Jenkins, Brendan J.

“…Inflammasomes are important multiprotein regulatory complexes of innate immunity and have recently emerged as playing divergent roles in numerous…”
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NKT cell adjuvant-based tumor vaccine for treatment of myc oncogene-driven mouse B-cell lymphoma Autor Mattarollo, Stephen R, West, Alison C, Steegh, Kim, Duret, Helene, Paget, Christophe, Martin, Ben, Matthews, Geoffrey M, Shortt, Jake, Chesi, Marta, Bergsagel, P Leif, Bots, Michael, Zuber, Johannes, Lowe, Scott W, Johnstone, Ricky W, Smyth, Mark J

“…Immunomodulators are effective in controlling hematologic malignancy by initiating or reactivating host antitumor immunity to otherwise poorly immunogenic and…”
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Toll-like Receptor 9 Promotes Initiation of Gastric Tumorigenesis by Augmenting Inflammation and Cellular Proliferation Autor Tang, Ke, McLeod, Louise, Livis, Thaleia, West, Alison C., Dawson, Ruby, Yu, Liang, Balic, Jesse J., Chonwerawong, Michelle, Wray-McCann, Georgie, Oshima, Hiroko, Oshima, Masanobu, Deswaerte, Virginie, Ferrero, Richard L., Jenkins, Brendan J.

“…Gastric cancer (GC) is strongly linked with chronic gastritis after Helicobacter pylori infection. Toll-like receptors (TLRs) are key innate immune pathogenic…”
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Naturally derived cytokine peptides limit virus replication and severe disease during influenza A virus infection Autor Harpur, Christopher M, West, Alison C, Le Page, Mélanie A, Lam, Maggie, Hodges, Christopher, Oseghale, Osezua, Gearing, Andrew J, Tate, Michelle D

“…Objectives Novel host‐targeted therapeutics could treat severe influenza A virus (IAV) infections, with reduced risk of drug resistance. LAT8881 is a synthetic…”
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An intact immune system is required for the anticancer activities of histone deacetylase inhibitors Autor West, Alison C, Mattarollo, Stephen R, Shortt, Jake, Cluse, Leonie A, Christiansen, Ailsa J, Smyth, Mark J, Johnstone, Ricky W

“…Cell-intrinsic effects such as induction of apoptosis and/or inhibition of cell proliferation have been proposed as the major antitumor responses to histone…”
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STAT3-mediated upregulation of the AIM2 DNA sensor links innate immunity with cell migration to promote epithelial tumourigenesis Autor Dawson, Ruby E, Deswaerte, Virginie, West, Alison C, Tang, Ke, West, Alice J, Balic, Jesse J, Gearing, Linden J, Saad, Mohamed I, Yu, Liang, Wu, Yonghui, Bhathal, Prithi S, Kumar, Beena, Chakrabarti, Jayati T, Zavros, Yana, Oshima, Hiroko, Klinman, Dennis M, Oshima, Masanobu, Tan, Patrick, Jenkins, Brendan J

“…ObjectiveThe absent in melanoma 2 (AIM2) cytosolic pattern recognition receptor and DNA sensor promotes the pathogenesis of autoimmune and chronic inflammatory…”
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Blockade of the protease ADAM17 ameliorates experimental pancreatitis Autor Saad, Mohamed I, Weng, Teresa, Lundy, Joanne, Gearing, Linden J, West, Alison C, Harpur, Christopher M, Alanazi, Mohammad, Hodges, Christopher, Croagh, Daniel, Kumar, Beena, Sagi, Irit, Rose-John, Stefan, Jenkins, Brendan J

“…Acute and chronic pancreatitis, the latter associated with fibrosis, are multifactorial inflammatory disorders and leading causes of gastrointestinal…”
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The combination of histone deacetylase inhibitors with immune-stimulating antibodies has potent anti-cancer effects Autor West, Alison C., Christiansen, Ailsa J., Smyth, Mark J., Johnstone, Ricky W.

“…The use of immunotherapy to treat cancer is rapidly gaining momentum. Using pre-clinical mouse models, we have recently demonstrated potent and long lasting…”
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Harnessing Endogenous Peptide Compounds as Potential Therapeutics for Severe Influenza Autor West, Alison C, Harpur, Christopher M, Le Page, Mélanie A, Lam, Maggie, Hodges, Christopher, Ely, Lauren K, Gearing, Andrew J, Tate, Michelle D

“…Abstract Background Excessive pulmonary inflammation and damage are characteristic features of severe influenza virus infections. LAT8881 is a synthetic…”
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Cross-talk between IL-6 trans-signaling and AIM2 inflammasome/IL-1β axes bridge innate immunity and epithelial apoptosis to promote emphysema Autor Ruwanpura, Saleela M, McLeod, Louise, Dousha, Lovisa F, Seow, Huei J, West, Alison C, West, Alice J, Weng, Teresa, Alanazi, Mohammad, MacDonald, Martin, King, Paul T, Bardin, Philip G, Gabay, Cem, Klinman, Dennis M, Bozinovski, Steven, Vlahos, Ross, Anderson, Gary P, Rose-John, Stefan, Saad, Mohamed I, Jenkins, Brendan J

“…Pulmonary emphysema is associated with dysregulated innate immune responses that promote chronic pulmonary inflammation and alveolar apoptosis, culminating in…”
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TLR2 activation promotes tumour growth and associates with patient survival and chemotherapy response in pancreatic ductal adenocarcinoma Autor Lundy, Joanne, Gearing, Linden J., Gao, Hugh, West, Alison C., McLeod, Louise, Deswaerte, Virginie, Yu, Liang, Porazinski, Sean, Pajic, Marina, Hertzog, Paul J., Croagh, Daniel, Jenkins, Brendan J.

“…Pancreatic ductal adenocarcinoma (PDAC) has an extremely poor prognosis, and is plagued by a paucity of targeted treatment options and tumour resistance to…”
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The cytosolic DNA sensor AIM2 promotes Helicobacter‐induced gastric pathology via the inflammasome Autor Dawson, Ruby E, Deswaerte, Virginie, West, Alison C, Sun, Ekimei, Wray‐McCann, Georgie, Livis, Thaleia, Kumar, Beena, Rodriguez, Emiliana, Gabay, Cem, Ferrero, Richard L, Jenkins, Brendan J

“…Helicobacter pylori (H. pylori) infection can trigger chronic gastric inflammation perpetuated by overactivation of the innate immune system, leading to a…”
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