Výsledky vyhľadávania - "Weinshilboum, Richard M"

The Role of the Aryl Hydrocarbon Receptor (AHR) in Immune and Inflammatory Diseases Autor Neavin, Drew R, Liu, Duan, Ray, Balmiki, Weinshilboum, Richard M

“…The aryl hydrocarbon receptor (AHR) is a nuclear receptor that modulates the response to environmental stimuli. It was recognized historically for its role in…”
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Metabolomics: a global biochemical approach to drug response and disease Autor Kaddurah-Daouk, Rima, Kristal, Bruce S, Weinshilboum, Richard M

“…Metabolomics is the study of metabolism at the global level. This rapidly developing new discipline has important potential implications for pharmacologic…”
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Genome-wide association studies of drug response and toxicity: an opportunity for genome medicine Autor Giacomini, Kathleen M., Yee, Sook Wah, Mushiroda, Taisei, Weinshilboum, Richard M., Ratain, Mark J., Kubo, Michiaki

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Targeting MTAP increases PARP inhibitor susceptibility in triple-negative breast cancer through a feed-forward loop Autor Zeng, Xiangyu, Zhao, Fei, Tu, Xinyi, Zhang, Yong, Yang, Wen, Hou, Jing, Jiang, Qi, Zhu, Shouhai, Wu, Zheming, Hao, Yalan, Zhang, Lingxin, Weinshilboum, Richard M., Tao, Kaixiong, Wang, Liewei, Lou, Zhenkun

“…Triple-negative breast cancer (TNBC) represents the most malignant subtype of breast cancer. The clinical application of PARP inhibitors (PARPi) is limited by…”
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Glucocorticoids unmask silent non-coding genetic risk variants for common diseases Autor Nguyen, Thanh Thanh L, Gao, Huanyao, Liu, Duan, Philips, Trudy Janice, Ye, Zhenqing, Lee, Jeong-Heon, Shi, Geng-xian, Copenhaver, Kaleigh, Zhang, Lingxin, Wei, Lixuan, Yu, Jia, Zhang, Huan, Barath, Abhijeet, Luong, Maggie, Zhang, Cheng, Gaspar-Maia, Alexandre, Li, Hu, Wang, Liewei, Ordog, Tamas, Weinshilboum, Richard M

“…Understanding the function of non-coding genomic sequence variants represents a challenge for biomedicine. Many diseases are products of gene-by-environment…”
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The lncRNA MIR2052HG regulates ERα levels and aromatase inhibitor resistance through LMTK3 by recruiting EGR1 Autor Cairns, Junmei, Ingle, James N., Kalari, Krishna R., Shepherd, Lois E., Kubo, Michiaki, Goetz, Matthew P., Weinshilboum, Richard M., Wang, Liewei

“…Background Our previous genome-wide association study using the MA.27 aromatase inhibitors adjuvant trial identified SNPs in the long noncoding RNA MIR2052HG…”
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SLCO1B1 : Application and Limitations of Deep Mutational Scanning for Genomic Missense Variant Function Autor Zhang, Lingxin, Sarangi, Vivekananda, Ho, Ming-Fen, Moon, Irene, Kalari, Krishna R, Wang, Liewei, Weinshilboum, Richard M

“…( ) is an important transmembrane hepatic uptake transporter. Genetic variants in the gene have been associated with altered protein folding, resulting in…”
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Ketamine and Active Ketamine Metabolites Regulate STAT3 and the Type I Interferon Pathway in Human Microglia: Molecular Mechanisms Linked to the Antidepressant Effects of Ketamine Autor Ho, Ming-Fen, Zhang, Cheng, Zhang, Lingxin, Li, Hu, Weinshilboum, Richard M.

“…Inflammation is an important biological process which contributes to risk for depression, in part as a result of the production of proinflammatory cytokines…”
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Acylcarnitine metabolomic profiles inform clinically-defined major depressive phenotypes Autor Ahmed, Ahmed T., MahmoudianDehkordi, Siamak, Bhattacharyya, Sudeepa, Arnold, Matthias, Liu, Duan, Neavin, Drew, Moseley, M. Arthur, Thompson, J. Will, Williams, Lisa St John, Louie, Gregory, Skime, Michelle K., Wang, Liewei, Riva-Posse, Patricio, McDonald, William M., Bobo, William V., Craighead, W. Edward, Krishnan, Ranga, Weinshilboum, Richard M., Dunlop, Boadie W., Millington, David S., Rush, A. John, Frye, Mark A., Kaddurah-Daouk, Rima

“…•This study was to assess whether three symptomatically defined phenotypes of MDD, (core depression, neurovegetative of melancholia and anxiety), could be…”
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TCF7L2 lncRNA: a link between bipolar disorder and body mass index through glucocorticoid signaling Autor Liu, Duan, Nguyen, Thanh Thanh Le, Gao, Huanyao, Huang, Huaizhi, Kim, Daniel C, Sharp, Brenna, Ye, Zhenqing, Lee, Jeong-Heon, Coombes, Brandon J, Ordog, Tamas, Wang, Liewei, Biernacka, Joanna M, Frye, Mark A, Weinshilboum, Richard M

“…Bipolar disorder (BD) and obesity are highly comorbid. We previously performed a genome-wide association study (GWAS) for BD risk accounting for the effect of…”
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TSPYL Family Regulates CYP17A1 and CYP3A4 Expression: Potential Mechanism Contributing to Abiraterone Response in Metastatic Castration‐Resistant Prostate Cancer Autor Qin, Sisi, Liu, Duan, Kohli, Manish, Wang, Liguo, Vedell, Peter T., Hillman, David W., Niu, Nifang, Yu, Jia, Weinshilboum, Richard M., Wang, Liewei

“…The testis‐specific Y‐encoded‐like protein (TSPYL) gene family includes TSPYL1 to TSPYL6. We previously reported that TSPYL5 regulates cytochrome P450 (CYP)…”
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Androgen receptor-mediated pharmacogenomic expression quantitative trait loci: implications for breast cancer response to AR-targeting therapy Autor Gao, Huanyao, Wei, Lixuan, Indulkar, Shreya, Nguyen, Thanh Thanh. L., Liu, Duan, Ho, Ming-Fen, Zhang, Cheng, Li, Hu, Weinshilboum, Richard M., Ingle, James N., Wang, Liewei

“…Background Endocrine therapy is the most important treatment modality of breast cancer patients whose tumors express the estrogen receptor α (ERα). The…”
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Metabolomic signature of exposure and response to citalopram/escitalopram in depressed outpatients Autor Bhattacharyya, Sudeepa, Ahmed, Ahmed T., Arnold, Matthias, Liu, Duan, Luo, Chunqiao, Zhu, Hongjie, Mahmoudiandehkordi, Siamak, Neavin, Drew, Louie, Gregory, Dunlop, Boadie W., Frye, Mark A., Wang, Liewei, Weinshilboum, Richard M., Krishnan, Ranga R., Rush, A. John, Kaddurah-Daouk, Rima

“…Metabolomics provides valuable tools for the study of drug effects, unraveling the mechanism of action and variation in response due to treatment. In this…”
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Testis- specific Y-encoded- like protein 1 and cholesterol metabolism: Regulation of CYP1B1 expression through Wnt signaling Autor Zhu, Xiujuan, Gao, Huanyao, Qin, Sisi, Liu, Duan, Cairns, Junmei, Gu, Yayun, Yu, Jia, Weinshilboum, Richard M., Wang, Liewei

“…The cytochromes P450 (CYPs) represent a large gene superfamily that plays an important role in the metabolism of both exogenous and endogenous compounds. We…”
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ERICH3: vesicular association and antidepressant treatment response Autor Liu, Duan, Zhuang, Yongxian, Zhang, Lingxin, Gao, Huanyao, Neavin, Drew, Carrillo-Roa, Tania, Wang, Yani, Yu, Jia, Qin, Sisi, Kim, Daniel C, Liu, Erica, Nguyen, Thanh Thanh Le, Biernacka, Joanna M, Kaddurah-Daouk, Rima, Dunlop, Boadie W, Craighead, W Edward, Mayberg, Helen S, Binder, Elisabeth B, Frye, Mark A, Wang, Liewei, Weinshilboum, Richard M

“…Selective serotonin reuptake inhibitors (SSRIs) are standard of care for major depressive disorder (MDD) pharmacotherapy, but only approximately half of these…”
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Knowledge-guided analysis of "omics" data using the KnowEnG cloud platform Autor Blatti, Charles, Emad, Amin, Berry, Matthew J., Gatzke, Lisa, Epstein, Milt, Lanier, Daniel, Rizal, Pramod, Ge, Jing, Liao, Xiaoxia, Sobh, Omar, Lambert, Mike, Post, Corey S., Xiao, Jinfeng, Groves, Peter, Epstein, Aidan T., Chen, Xi, Srinivasan, Subhashini, Lehnert, Erik, Kalari, Krishna R., Wang, Liewei, Weinshilboum, Richard M., Song, Jun S., Jongeneel, C. Victor, Han, Jiawei, Ravaioli, Umberto, Sobh, Nahil, Bushell, Colleen B., Sinha, Saurabh

“…We present Knowledge Engine for Genomics (KnowEnG), a free-to-use computational system for analysis of genomics data sets, designed to accelerate biomedical…”
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Multidisciplinary model to implement pharmacogenomics at the point of care Autor Caraballo, Pedro J., Hodge, Lucy S., Bielinski, Suzette J., Stewart, A. Keith, Farrugia, Gianrico, Schultz, Cloann G., Rohrer-Vitek, Carolyn R., Olson, Janet E., St. Sauver, Jennifer L., Roger, Veronique L., Parkulo, Mark A., Kullo, Iftikhar J., Nicholson, Wayne T., Elliott, Michelle A., Black, John L., Weinshilboum, Richard M.

“…Despite potential clinical benefits, implementation of pharmacogenomics (PGx) faces many technical and clinical challenges. These challenges can be overcome…”
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CYP2D6 metabolism and patient outcome in the Austrian Breast and Colorectal Cancer Study Group trial (ABCSG) 8 Autor Goetz, Matthew P, Suman, Vera J, Hoskin, Tanya L, Gnant, Michael, Filipits, Martin, Safgren, Stephanie L, Kuffel, Mary, Jakesz, Raimund, Rudas, Margaretha, Greil, Richard, Dietze, Otto, Lang, Alois, Offner, Felix, Reynolds, Carol A, Weinshilboum, Richard M, Ames, Matthew M, Ingle, James N

“…Controversy exists about CYP2D6 genotype and tamoxifen efficacy. A matched case-control study was conducted using the Austrian Breast and Colorectal Cancer…”
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Citalopram and escitalopram plasma drug and metabolite concentrations: genome‐wide associations Autor Ji, Yuan, Schaid, Daniel J., Desta, Zeruesenay, Kubo, Michiaki, Batzler, Anthony J., Snyder, Karen, Mushiroda, Taisei, Kamatani, Naoyuki, Ogburn, Evan, Hall‐Flavin, Daniel, Flockhart, David, Nakamura, Yusuke, Mrazek, David A., Weinshilboum, Richard M.

“…Aims Citalopram (CT) and escitalopram (S‐CT) are among the most widely prescribed selective serotonin reuptake inhibitors used to treat major depressive…”
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Genome-wide associations and functional genomic studies of musculoskeletal adverse events in women receiving aromatase inhibitors Autor Ingle, James N, Schaid, Daniel J, Goss, Paul E, Liu, Mohan, Mushiroda, Taisei, Chapman, Judy-Anne W, Kubo, Michiaki, Jenkins, Gregory D, Batzler, Anthony, Shepherd, Lois, Pater, Joseph, Wang, Liewei, Ellis, Matthew J, Stearns, Vered, Rohrer, Daniel C, Goetz, Matthew P, Pritchard, Kathleen I, Flockhart, David A, Nakamura, Yusuke, Weinshilboum, Richard M

“…We performed a case-control genome-wide association study (GWAS) to identify single nucleotide polymorphisms (SNPs) associated with musculoskeletal adverse…”
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