Suchergebnisse - "Weiner, Howard L"

The challenge of multiple sclerosis: How do we cure a chronic heterogeneous disease? von Weiner, Howard L.

“… Multiple sclerosis is (MS) a T‐cell autoimmune disease characterized by a relapsing‐remitting followed by a progressive phase. Relapses are driven by the …”
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Blood neurofilament light: a critical review of its application to neurologic disease von Barro, Christian, Chitnis, Tanuja, Weiner, Howard L.

“… Neuronal injury is a universal event that occurs in disease processes that affect both the central and peripheral nervous systems. A blood biomarker linked to …”
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The Host Shapes the Gut Microbiota via Fecal MicroRNA von Liu, Shirong, da Cunha, Andre Pires, Rezende, Rafael M, Cialic, Ron, Wei, Zhiyun, Bry, Lynn, Comstock, Laurie E, Gandhi, Roopali, Weiner, Howard L

“… The host gut microbiota varies across species and individuals but is relatively stable over time within an individual. How the host selectively shapes the …”
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Therapeutic anti-CD3 monoclonal antibodies: from bench to bedside von Kuhn, Chantal, Weiner, Howard L

“… The induction of tolerance is a major goal of immunotherapy. Investigations over the last 20 years have shown that anti-CD3 monoclonal antibodies (mAbs) …”
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Oral tolerance von Weiner, Howard L., da Cunha, Andre Pires, Quintana, Francisco, Wu, Henry

“… The gut‐associated lymphoid tissue is the largest immune organ in the body and is the primary route by which we are exposed to antigens. Tolerance induction is …”
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The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases von Krasemann, Susanne, Madore, Charlotte, Cialic, Ron, Baufeld, Caroline, Calcagno, Narghes, El Fatimy, Rachid, Beckers, Lien, O'Loughlin, Elaine, Xu, Yang, Fanek, Zain, Greco, David J, Smith, Scott T, Tweet, George, Humulock, Zachary, Zrzavy, Tobias, Conde-Sanroman, Patricia, Gacias, Mar, Weng, Zhiping, Chen, Hao, Tjon, Emily, Mazaheri, Fargol, Hartmann, Kristin, Madi, Asaf, Ulrich, Jason D, Glatzel, Markus, Worthmann, Anna, Heeren, Joerg, Budnik, Bogdan, Lemere, Cynthia, Ikezu, Tsuneya, Heppner, Frank L, Litvak, Vladimir, Holtzman, David M, Lassmann, Hans, Weiner, Howard L, Ochando, Jordi, Haass, Christian, Butovsky, Oleg

“… Microglia play a pivotal role in the maintenance of brain homeostasis but lose homeostatic function during neurodegenerative disorders. We identified a …”
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MicroRNAs are universal regulators of differentiation, activation, and polarization of microglia and macrophages in normal and diseased CNS von Ponomarev, Eugene D., Veremeyko, Tatiana, Weiner, Howard L.

“… MicroRNAs (miRNAs) are a class of small (∼22 nucleotides) noncoding RNAs involved in the regulation of gene expression at the post‐translational level. It is …”
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Exploration of machine learning techniques in predicting multiple sclerosis disease course von Zhao, Yijun, Healy, Brian C., Rotstein, Dalia, Guttmann, Charles R. G., Bakshi, Rohit, Weiner, Howard L., Brodley, Carla E., Chitnis, Tanuja

“… To explore the value of machine learning methods for predicting multiple sclerosis disease course. 1693 CLIMB study patients were classified as increased …”
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A shift from adaptive to innate immunity: a potential mechanism of disease progression in multiple sclerosis von Weiner, Howard L.

“… Multiple sclerosis is postulated to be a T cell-mediated autoimmune disease characterised by a relapsing-remitting stage followed by a secondary progressive …”
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A probiotic modulates the microbiome and immunity in multiple sclerosis von Tankou, Stephanie K., Regev, Keren, Healy, Brian C., Tjon, Emily, Laghi, Luca, Cox, Laura M., Kivisäkk, Pia, Pierre, Isabelle V., Hrishikesh, Lokhande, Gandhi, Roopali, Cook, Sandra, Glanz, Bonnie, Stankiewicz, James, Weiner, Howard L.

“… Objective Effect of a probiotic on the gut microbiome and peripheral immune function in healthy controls and relapsing‐remitting multiple sclerosis (MS) …”
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Oral Administration of miR-30d from Feces of MS Patients Suppresses MS-like Symptoms in Mice by Expanding Akkermansia muciniphila von Liu, Shirong, Rezende, Rafael M, Moreira, Thais G, Tankou, Stephanie K, Cox, Laura M, Wu, Meng, Song, Anya, Dhang, Fyonn H, Wei, Zhiyun, Costamagna, Gianluca, Weiner, Howard L

“… Fecal transfer from healthy donors is being explored as a microbiome modality. MicroRNAs (miRNAs) have been found to affect the microbiome. Multiple sclerosis …”
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Gut Microbiome in Progressive Multiple Sclerosis von Cox, Laura M., Maghzi, Amir Hadi, Liu, Shirong, Tankou, Stephanie K., Dhang, Fyonn H., Willocq, Valerie, Song, Anya, Wasén, Caroline, Tauhid, Shahamat, Chu, Renxin, Anderson, Mark C., De Jager, Philip L., Polgar‐Turcsanyi, Mariann, Healy, Brian C., Glanz, Bonnie I., Bakshi, Rohit, Chitnis, Tanuja, Weiner, Howard L.

“… Objective This study was undertaken to investigate the gut microbiome in progressive multiple sclerosis (MS) and how it relates to clinical disease. Methods We …”
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Silencing microRNA-155 ameliorates experimental autoimmune encephalomyelitis von Murugaiyan, Gopal, Beynon, Vanessa, Mittal, Akanksha, Joller, Nicole, Weiner, Howard L

“… IFN-γ-producing Th1 and IL-17-producing Th17 cells are the key participants in various autoimmune diseases, including multiple sclerosis and its animal model, …”
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Alterations of the human gut microbiome in multiple sclerosis von Jangi, Sushrut, Gandhi, Roopali, Cox, Laura M., Li, Ning, von Glehn, Felipe, Yan, Raymond, Patel, Bonny, Mazzola, Maria Antonietta, Liu, Shirong, Glanz, Bonnie L., Cook, Sandra, Tankou, Stephanie, Stuart, Fiona, Melo, Kirsy, Nejad, Parham, Smith, Kathleen, Topçuolu, Begüm D., Holden, James, Kivisäkk, Pia, Chitnis, Tanuja, De Jager, Philip L., Quintana, Francisco J., Gerber, Georg K., Bry, Lynn, Weiner, Howard L.

“… The gut microbiome plays an important role in immune function and has been implicated in several autoimmune disorders. Here we use 16S rRNA sequencing to …”
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Dominant role of microglial and macrophage innate immune responses in human ischemic infarcts von Zrzavy, Tobias, Machado‐Santos, Joana, Christine, Sheren, Baumgartner, Christoph, Weiner, Howard L., Butovsky, Oleg, Lassmann, Hans

“… Inflammatory mechanisms, involving granulocytes, T‐cells, B‐cells, macrophages and activated microglia, have been suggested to play a pathogenic role in …”
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Nanoparticle-mediated codelivery of myelin antigen and a tolerogenic small molecule suppresses experimental autoimmune encephalomyelitis von Yeste, Ada, Nadeau, Meghan, Burns, Evan J, Weiner, Howard L, Quintana, Francisco J

“… The immune response is normally controlled by regulatory T cells (Tregs). However, Treg deficits are found in autoimmune diseases, and therefore the induction …”
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Unraveling the dual nature of brain CD8+ T cells in Alzheimer’s disease von Hu, Dan, Weiner, Howard L.

“… Keywords: Alzheimer's disease, CD8.sup.+ T cells, Microglia …”
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MicroRNA-21 promotes Th17 differentiation and mediates experimental autoimmune encephalomyelitis von Murugaiyan, Gopal, da Cunha, Andre Pires, Ajay, Amrendra K., Joller, Nicole, Garo, Lucien P., Kumaradevan, Sowmiya, Yosef, Nir, Vaidya, Vishal S., Weiner, Howard L.

“… Accumulation of IL-17-producing Th17 cells is associated with the development of multiple autoimmune diseases; however, the contribution of microRNA (miRNA) …”
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Microglia inhibit photoreceptor cell death and regulate immune cell infiltration in response to retinal detachment von Okunuki, Yoko, Mukai, Ryo, Pearsall, Elizabeth A, Klokman, Garrett, Husain, Deeba, Park, Dong-Ho, Korobkina, Ekaterina, Weiner, Howard L, Butovsky, Oleg, Ksander, Bruce R, Miller, Joan W, Connor, Kip M

“… Retinal detachment (RD) is a sight-threatening complication common in many highly prevalent retinal disorders. RD rapidly leads to photoreceptor cell death …”
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The innate immune system in demyelinating disease von Mayo, Lior, Quintana, Francisco J., Weiner, Howard L.

“… Demyelinating diseases such as multiple sclerosis are chronic inflammatory autoimmune diseases with a heterogeneous clinical presentation and course. Both the …”
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