Suchergebnisse - "Webb, David J"

Endothelins in cardiovascular biology and therapeutics von Dhaun, Neeraj, Webb, David J

“… Cardiovascular disease is a major contributor to global morbidity and mortality and is the common end point of many chronic diseases. The endothelins comprise …”
Volltext

Small interfering RNA: Discovery, pharmacology and clinical development—An introductory review von Ranasinghe, Priyanga, Addison, Melisande L., Dear, James W., Webb, David J.

“… Post‐transcriptional gene silencing targets and degrades mRNA transcripts, silencing the expression of specific genes. RNA interference technology, using …”
Volltext

Established and emerging therapeutic uses of PDE type 5 inhibitors in cardiovascular disease von Tzoumas, Nikolaos, Farrah, Tariq E., Dhaun, Neeraj, Webb, David J.

“… PDE type 5 inhibitors (PDE5Is), such as sildenafil, tadalafil and vardenafil, are a class of drugs used to prolong the physiological effects of NO/cGMP …”
Volltext

Zilebesiran, an RNA Interference Therapeutic Agent for Hypertension von Desai, Akshay S., Webb, David J., Taubel, Jorg, Casey, Sarah, Cheng, Yansong, Robbie, Gabriel J., Foster, Don, Huang, Stephen A., Rhyee, Sean, Sweetser, Marianne T., Bakris, George L.

“… In this phase 1 study involving persons with hypertension, zilebesiran (an RNA interference therapeutic agent) was associated with decreases in angiotensin …”
Volltext

Spironolactone versus placebo, bisoprolol, and doxazosin to determine the optimal treatment for drug-resistant hypertension (PATHWAY-2): a randomised, double-blind, crossover trial von Williams, Bryan, MacDonald, Thomas M, Morant, Steve, Webb, David J, Sever, Peter, McInnes, Gordon, Ford, Ian, Cruickshank, J Kennedy, Caulfield, Mark J, Salsbury, Jackie, Mackenzie, Isla, Padmanabhan, Sandosh, Brown, Morris J

“… Optimal drug treatment for patients with resistant hypertension is undefined. We aimed to test the hypotheses that resistant hypertension is most often caused …”
Volltext

Epilepsy, suicidality, and psychiatric disorders: A bidirectional association von Hesdorffer, Dale C., Ishihara, Lianna, Mynepalli, Lakshmi, Webb, David J., Weil, John, Hauser, W. Allen

“… Objective: A study was undertaken to determine whether psychiatric disorders associated with suicide are more common in incident epilepsy than in matched …”
Volltext

A high-fat meal induces low-grade endotoxemia: evidence of a novel mechanism of postprandial inflammation von Erridge, Clett, Attina, Teresa, Spickett, Corinne M, Webb, David J

“… Bacterial endotoxin is a potently inflammatory antigen that is abundant in the human gut. Endotoxin circulates at low concentrations in the blood of all …”
Weitere Angaben

Stress Sensitivity Analysis of Optical Fiber Bragg Grating-Based Fabry–Pérot Interferometric Sensors von Pospori, Andreas, Webb, David J.

“… A stress sensitivity analysis of optical fiber-based Fabry-Pérot (FP) sensors has been performed, taking into account the influence of fiber loss on the …”
Volltext

Blood Markers of Coagulation, Fibrinolysis, Endothelial Dysfunction and Inflammation in Lacunar Stroke versus Non-Lacunar Stroke and Non-Stroke: Systematic Review and Meta-Analysis von Wiseman, Stewart, Marlborough, Fergal, Doubal, Fergus, Webb, David J., Wardlaw, Joanna

“… Background: The cause of cerebral small vessel disease is not fully understood, yet it is important, accounting for about 25% of all strokes. It also increases …”
Volltext

Endothelin signalling mediates experience-dependent myelination in the CNS von Swire, Matthew, Kotelevtsev, Yuri, Webb, David J, Lyons, David A, ffrench-Constant, Charles

“… Experience and changes in neuronal activity can alter CNS myelination, but the signalling pathways responsible remain poorly understood. Here we define a …”
Volltext

Identification and proteomic profiling of exosomes in human cerebrospinal fluid von Street, Jonathan M, Barran, Perdita E, Mackay, C Logan, Weidt, Stefan, Balmforth, Craig, Walsh, Tim S, Chalmers, Rod TA, Webb, David J, Dear, James W

“… Background Exosomes are released from multiple cell types, contain protein and RNA species, and have been exploited as a novel reservoir for disease biomarker …”
Volltext

Mechanistic biomarkers provide early and sensitive detection of acetaminophen‐induced acute liver injury at first presentation to hospital von Antoine, Daniel J., Dear, James W., Lewis, Philip Starkey, Platt, Vivien, Coyle, Judy, Masson, Moyra, Thanacoody, Ruben H., Gray, Alasdair J., Webb, David J., Moggs, Jonathan G., Bateman, D. Nicholas, Goldring, Christopher E., Park, B. Kevin

“… Acetaminophen overdose is a common reason for hospital admission and the most frequent cause of hepatotoxicity in the Western world. Early identification would …”
Volltext

Multi-layered Spatial Transcriptomics Identify Secretory Factors Promoting Human Hematopoietic Stem Cell Development von Crosse, Edie I, Gordon-Keylock, Sabrina, Rybtsov, Stanislav, Binagui-Casas, Anahi, Felchle, Hannah, Nnadi, Nneka C, Kirschner, Kristina, Chandra, Tamir, Tamagno, Sara, Webb, David J, Rossi, Fiona, Anderson, Richard A, Medvinsky, Alexander

“… Hematopoietic stem cells (HSCs) first emerge in the embryonic aorta-gonad-mesonephros (AGM) region. Studies of model organisms defined intersecting signaling …”
Weitere Angaben

Medical students' perceptions and knowledge about antimicrobial stewardship: how are we educating our future prescribers? von Abbo, Lilian M, Cosgrove, Sara E, Pottinger, Paul S, Pereyra, Margaret, Sinkowitz-Cochran, Ronda, Srinivasan, Arjun, Webb, David J, Hooton, Thomas M

“… Better understanding of medical students' perceptions, attitudes, and knowledge about antimicrobial prescribing practices could facilitate more effective …”
Weitere Angaben

Small Interfering RNA Therapeutics in Hypertension: A Viewpoint on Vasopressor and Vasopressor‐Sparing Strategies for Counteracting Blood Pressure Lowering by Angiotensinogen–Targeting Small Interfering RNA von Ranasinghe, Priyanga, Addison, Melisande L., Webb, David J.

Volltext

Knowledge, attitudes, and practices related to hypertension among Sri Lankans: an online cross-sectional survey von Ranasinghe, Priyanga, Weerasekara, Pumudu, Manchanayake, Minura, Liyanage, Sandamini, Perera, Thilina, Silva, Minollie, Webb, David J.

“… Background Hypertension (HTN) is a major public health issue in Sri Lanka, influenced by genetic predisposition and lifestyle factors. Despite high general …”
Volltext

Choroidal and retinal thinning in chronic kidney disease independently associate with eGFR decline and are modifiable with treatment von Farrah, Tariq E., Pugh, Dan, Chapman, Fiona A., Godden, Emily, Balmforth, Craig, Oniscu, Gabriel C., Webb, David J., Dhillon, Baljean, Dear, James W., Bailey, Matthew A., Gallacher, Peter J., Dhaun, Neeraj

“… In patients with chronic kidney disease (CKD), there is an unmet need for novel biomarkers that reliably track kidney injury, demonstrate treatment-response, …”
Volltext

Attributing equity gaps to course structure in introductory physics von Webb, David J., Paul, Cassandra A.

“… We add to a growing literature suggesting that demographic grade gaps should be attributed to biases embedded in the courses themselves. Changes in the …”
Volltext

Endocrine and haemodynamic changes in resistant hypertension, and blood pressure responses to spironolactone or amiloride: the PATHWAY-2 mechanisms substudies von Williams, Bryan, MacDonald, Thomas M, Morant, Steve V, Webb, David J, Sever, Peter, McInnes, Gordon T, Ford, Ian, Cruickshank, J Kennedy, Caulfield, Mark J, Padmanabhan, Sandosh, Mackenzie, Isla S, Salsbury, Jackie, Brown, Morris J

“… In the PATHWAY-2 study of resistant hypertension, spironolactone reduced blood pressure substantially more than conventional antihypertensive drugs. We did …”
Weitere Angaben

Circulating microRNAs as potential markers of human drug‐induced liver injury von Starkey Lewis, Philip J., Dear, James, Platt, Vivien, Simpson, Kenneth J., Craig, Darren G.N., Antoine, Daniel J., French, Neil S., Dhaun, Neeraj, Webb, David J., Costello, Eithne M., Neoptolemos, John P., Moggs, Jonathan, Goldring, Chris E., Park, B. Kevin

“… New biomarkers of liver injury are required in the clinic and in preclinical pharmaceutical evaluation. Previous studies demonstrate that two liver‐enriched …”
Volltext