Výsledky vyhľadávania - "Watkins, W M"

Averting a malaria disaster Autor White, NJ, Nosten, F, Looareesuwan, S, Watkins, WM, Marsh, K, Snow, RW, Kokwaro, G, Ouma, J, Hien, TT, Molyneux, ME, Taylor, TE, Newbold, CI, Ruebush, TK, Danis, M, Greenwood, BM, Anderson, RM, Olliaro, P

“…As treatments loose their effectiveness, morbidity and mortality from malaria will inevitably continue to rise. The rationale for combining drugs with…”
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Towards an understanding of the mechanism of pyrimethamine-sulfadoxine resistance in Plasmodium falciparum: genotyping of dihydrofolate reductase and dihydropteroate synthase of Kenyan parasites Autor Nzila, A M, Mberu, E K, Sulo, J, Dayo, H, Winstanley, P A, Sibley, C H, Watkins, W M

“…The antifolate combination of pyrimethamine (PM) and sulfadoxine (SD) is the last affordable drug combination available for wide-scale treatment of falciparum…”
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The ABO blood group system: historical background Autor Watkins, W. M.

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Mutations in Plasmodium falciparum dihydrofolate reductase and dihydropteroate synthase and epidemiologic patterns of pyrimethamine-sulfadoxine use and resistance Autor Plowe, C V, Cortese, J F, Djimde, A, Nwanyanwu, O C, Watkins, W M, Winstanley, P A, Estrada-Franco, J G, Mollinedo, R E, Avila, J C, Cespedes, J L, Carter, D, Doumbo, O K

“…To assess the relationship between mutations in Plasmodium falciparum dihydrofolate reductase (DHFR) and dihydropteroate synthase (DHPS) and clinical…”
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Changing home treatment of childhood fevers by training shop keepers in rural Kenya Autor Marsh, V. M., Mutemi, W. M., Muturi, J., Haaland, A., Watkins, W. M., Otieno, G., Marsh, K.

“…Summary background Malaria control in Africa relies primarily on early effective treatment for clinical disease, but most early treatments for fever occur…”
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Chlorproguanil-dapsone versus sulfadoxine-pyrimethamine for sequential episodes of uncomplicated falciparum malaria in Kenya and Malawi: a randomised clinical trial Autor Sulo, J, Chimpeni, P, Hatcher, J, Kublin, JG, Plowe, CV, Molyneux, ME, Marsh, K, Taylor, TE, Watkins, WM, Winstanley, PA

“…Chlorproguanil-dapsone exerts lower resistance pressure on Plasmodium falciparum than does sulfadoxine-pyrimethamine, but is rapidly eliminated. We aimed to…”
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Kenyan Plasmodium falciparum field isolates: correlation between pyrimethamine and chlorcycloguanil activity in vitro and point mutations in the dihydrofolate reductase domain Autor Nzila-Mounda, A, Mberu, E K, Sibley, C H, Plowe, C V, Winstanley, P A, Watkins, W M

“…Sixty-nine Kenyan Plasmodium falciparum field isolates were tested in vitro against pyrimethamine (PM), chlorcycloguanil (CCG), sulfadoxine (SD), and dapsone…”
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Potent antimalarial activity of the alkaloid nitidine, isolated from a Kenyan herbal remedy Autor Gakunju, D M, Mberu, E K, Dossaji, S F, Gray, A I, Waigh, R D, Waterman, P G, Watkins, W M

“…Bioassay-guided fractionation of extracts of Toddalia asiatica, a plant used by the Pokot tribe of Kenya to treat fevers, has yielded the alkaloid nitidine as…”
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Empirical fear profiles among American youth Autor Schaefer, B.A., Watkins, M.W., Burnham, J.J.

“…Fears among children can range from relatively innocuous fears of simple objects to significant phobias that affect youths’ everyday functioning in the home,…”
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Chlorproguanil-dapsone: effective treatment for uncomplicated falciparum malaria Autor Amukoye, E, Winstanley, P A, Watkins, W M, Snow, R W, Hatcher, J, Mosobo, M, Ngumbao, E, Lowe, B, Ton, M, Minyiri, G, Marsh, K

“…Pyrimethamine-sulfadoxine, the first choice for uncomplicated falciparum malaria in Africa, exerts strong selection pressure for resistance because of its slow…”
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Treatment of Plasmodium falciparum malaria with pyrimethamine-sulfadoxine: selective pressure for resistance is a function of long elimination half-life Autor Watkins, W M, Mosobo, M

“…In an area of continuing transmission of Plasmodium falciparum on the Kenya coast, children treated with pyrimethamine-sulfadoxine experienced rapid parasite…”
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The antimalarial triazine WR99210 and the prodrug PS-15: folate reversal of in vitro activity against Plasmodium falciparum and a non-antifolate mode of action of the prodrug Autor Kinyanjui, S M, Mberu, E K, Winstanley, P A, Jacobus, D P, Watkins, W M

“…We have studied the reversal of activity against Plasmodium falciparum of WR99210, a triazine antimalarial drug, and of the pro-drug PS-15 by folic acid (FA)…”
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Genetic diversity of Plasmodium falciparum parasites from Kenya is not affected by antifolate drug selection Autor Nzila, A.M, Mberu, E.K, Nduati, E, Ross, A, Watkins, W.M, Sibley, C.H

“…The genotypes of merozoite surface protein-1, merozoite surface protein-2 and glutamine rich protein are frequently used to distinguish recrudescence from…”
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The disposition of intramuscular artemether in children with cerebral malaria; a preliminary study Autor Murphy, S A, Mberu, E, Muhia, D, English, M, Crawley, J, Waruiru, C, Lowe, B, Newton, C R, Winstanley, P, Marsh, K, Watkins, W M

“…The disposition of intramuscular artemether (AM) was studied in 26 Kenyan children with cerebral malaria. Antimalarial activity determined by bioassay was…”
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In vitro activities of novel antifolate drug combinations against Plasmodium falciparum and human granulocyte CFUs Autor Winstanley, P A, Mberu, E K, Szwandt, I S, Breckenridge, A M, Watkins, W M

“…The potency of antimalarial dihydrofolate reductase inhibitors, alone and in synergistic combination with dihydropteroate synthetase inhibitors, against the…”
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The changing in vitro susceptibility pattern to pyrimethamine/sulfadoxine in Plasmodium falciparum field isolates from Kilifi, Kenya Autor Mberu, E K, Mosobo, M K, Nzila, A M, Kokwaro, G O, Sibley, C H, Watkins, W M

“…Two clinical trials that used Falcidin (Cosmos Ltd., Nairobi, Kenya), the antifolate combination of pyrimethamine/sulfadoxine (PM/SD), as treatment for…”
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Differential subcompartmentation of terminal glycosylation in the Golgi apparatus of intestinal absorptive and goblet cells Autor Roth, J, Taatjes, D J, Weinstein, J, Paulson, J C, Greenwell, P, Watkins, W M

“…Two terminal glycosyltransferases, a sialyltransferase and the blood group A alpha 1,3 N-acetylgalactosaminyltransferase, were found to exhibit differential…”
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Specific defect in N-acetylglucosamine incorporation in the biosynthesis of the glycosylphosphatidylinositol anchor in cloned cell lines from patients with paroxysmal nocturnal hemoglobinuria Autor Hillmen, P, Bessler, M, Mason, P J, Watkins, W M, Luzzatto, L

“…Paroxysmal nocturnal hemoglobinuria (PNH) is a clonal disorder arising in a multipotent hemopoietic stem cell. PNH manifests clinically with intravascular…”
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Regulation of the oncodevelopmental expression of type 1 chain ABH and Lewis(b) blood group antigens in human colon by alpha-2-L-fucosylation Autor Orntoft, T F, Greenwell, P, Clausen, H, Watkins, W M

“…Blood group antigen expression in the distal human colon is related to the development of the organ and is modified by malignant transformation. To elucidate…”
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The evolution of drug-resistant malaria: the role of drug elimination half-life Autor Hastings, Ian M, Watkins, William M, White, Nicholas J

“…This paper seeks to define and quantify the influence of drug elimination half-life on the evolution of antimalarial drug resistance. There are assumed to be…”
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