Suchergebnisse - "Walwyn, Rebecca"

Optimising error rates in programmes of pilot and definitive trials using Bayesian statistical decision theory von Wilson, Duncan T, Hall, Andrew, Brown, Julia M, Walwyn, Rebecca Ea

“… Pilot trials are often conducted in advance of definitive trials to assess their feasibility and to inform their design. Although pilot trials typically …”
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Factors associated with physical activity in individuals with metastatic cancer: a UK cross-sectional survey von Haider, Zainab Faatimah, Smith, Samuel George, Walwyn, Rebecca E. A., Lally, Phillippa, Fisher, Abigail, Beeken, Rebecca J.

“… Physical activity is safe and feasible for individuals with metastatic cancer and may support symptom management. We investigated the extent to which …”
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A hypothesis test of feasibility for external pilot trials assessing recruitment, follow‐up, and adherence rates von Wilson, Duncan T., Brown, Julia, Farrin, Amanda J., Walwyn, Rebecca E. A.

“… The power of a large clinical trial can be adversely affected by low recruitment, follow‐up, and adherence rates. External pilot trials estimate these rates …”
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Efficient and flexible simulation-based sample size determination for clinical trials with multiple design parameters von Wilson, Duncan T, Hooper, Richard, Brown, Julia, Farrin, Amanda J, Walwyn, Rebecca Ea

“… Simulation offers a simple and flexible way to estimate the power of a clinical trial when analytic formulae are not available. The computational burden of …”
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Surgical trial design for incorporating the effects of learning: what is the current methodological guidance, and is it sufficient? von Corrigan, Neil, Brown, Julia M., Emsley, Richard, Jayne, David G., Walwyn, Rebecca E. A.

“… Background Surgical interventions are complex. Key elements of this complexity are the surgeon and their learning curve. They pose methodological challenges in …”
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Bayesian design and analysis of external pilot trials for complex interventions von Wilson, Duncan T., Wason, James M. S., Brown, Julia, Farrin, Amanda J., Walwyn, Rebecca E. A.

“… External pilot trials of complex interventions are used to help determine if and how a confirmatory trial should be undertaken, providing estimates of …”
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Dementia Care Mapping™ to reduce agitation in care home residents with dementia: the EPIC cluster RCT von Surr, Claire A, Holloway, Ivana, Walwyn, Rebecca Ea, Griffiths, Alys W, Meads, David, Kelley, Rachael, Martin, Adam, McLellan, Vicki, Ballard, Clive, Fossey, Jane, Burnley, Natasha, Chenoweth, Lynn, Creese, Byron, Downs, Murna, Garrod, Lucy, Graham, Elizabeth H, Lilley-Kelley, Amanda, McDermid, Joanne, Millard, Holly, Perfect, Devon, Robinson, Louise, Robinson, Olivia, Shoesmith, Emily, Siddiqi, Najma, Stokes, Graham, Wallace, Daphne, Farrin, Amanda J

“… The quality of care for people with dementia in care homes is of concern. Interventions that can improve care outcomes are required. To investigate the …”
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Improving audit and feedback: A user-centred approach to designing feedback techniques for an online experiment von Seymour, Valentine, Willis, Thomas A., Weller, Ana, Althaf, Mohamed, Francis, Jill J., Lorencatto, Fabiana, Wright-Hughes, Alexandra, Walwyn, Rebecca E. A., Alderson, Sarah L., Brown, Benjamin C., Brehaut, Jamie, Colquhoun, Heather, Ivers, Noah, Presseau, Justin, Farrin, Amanda J., Foy, Robbie, Wilson, Stephanie

“… Objective: Audit and feedback (A&F) programmes aim to improve patient care by providing summary data on performance to clinicians. They generally have modest, …”
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The evaluation of enhanced feedback interventions to reduce unnecessary blood transfusions (AFFINITIE): protocol for two linked cluster randomised factorial controlled trials von Hartley, Suzanne, Foy, Robbie, Walwyn, Rebecca E. A., Cicero, Robert, Farrin, Amanda J., Francis, Jill J., Lorencatto, Fabiana, Gould, Natalie J., Grant-Casey, John, Grimshaw, Jeremy M., Glidewell, Liz, Michie, Susan, Morris, Stephen, Stanworth, Simon J.

“… Background Blood for transfusion is a frequently used clinical intervention, and is also a costly and limited resource with risks. Many transfusions are given …”
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A systematic review and narrative synthesis of footwear and orthotic devices used in the management of ankle haemarthrosis and haemarthropathy in haemophilia von Wilkins, Richard A., Chapman, Lara S., Emmel, Jenny C., Flannery, Thuvia, Chapman, Graham J., Walwyn, Rebecca E. A., Redmond, Anthony C., Siddle, Heidi J.

“… Introduction Haemarthrosis is a clinical feature of haemophilia leading to haemarthropathy. The ankle joint is most commonly affected, resulting in significant …”
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Sertraline or mirtazapine for depression in dementia (HTA-SADD): a randomised, multicentre, double-blind, placebo-controlled trial von Banerjee, Sube, Hellier, Jennifer, Dewey, Michael, Romeo, Renee, Ballard, Clive, Baldwin, Robert, Bentham, Peter, Fox, Chris, Holmes, Clive, Katona, Cornelius, Knapp, Martin, Lawton, Claire, Lindesay, James, Livingston, Gill, McCrae, Niall, Moniz-Cook, Esme, Murray, Joanna, Nurock, Shirley, Orrell, Martin, O'Brien, John, Poppe, Michaela, Thomas, Alan, Walwyn, Rebecca, Wilson, Kenneth, Burns, Alistair

“… Depression is common in dementia but the evidence base for appropriate drug treatment is sparse and equivocal. We aimed to assess efficacy and safety of two of …”
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Researchers’ experiences of the design and conduct challenges associated with parallel-group cluster-randomised trials and views on a novel open-cohort design von Surr, Claire, Marsden, Laura, Griffiths, Alys, Cox, Sharon, Fossey, Jane, Martin, Adam, Prevost, A. Toby, Walshe, Catherine, Walwyn, Rebecca

“… Two accepted designs exist for parallel-group cluster-randomised trials (CRTs). Closed-cohort designs follow the same individuals over time with a single …”
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Effectiveness of Dementia Care Mapping™ to reduce agitation in care home residents with dementia: an open-cohort cluster randomised controlled trial von Surr, Claire A., Holloway, Ivana, Walwyn, Rebecca E. A., Griffiths, Alys W., Meads, David, Martin, Adam, Kelley, Rachael, Ballard, Clive, Fossey, Jane, Burnley, Natasha, Chenoweth, Lynn, Creese, Byron, Downs, Murna, Garrod, Lucy, Graham, Elizabeth H., Lilley-Kelly, Amanda, McDermid, Joanne, McLellan, Vicki, Millard, Holly, Perfect, Devon, Robinson, Louise, Robinson, Olivia, Shoesmith, Emily, Siddiqi, Najma, Stokes, Graham, Wallace, Daphne, Farrin, Amanda J.

“… Agitation is common and problematic in care home residents with dementia. This study investigated the (cost)effectiveness of Dementia Care Mapping™ (DCM) for …”
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Systematic Review and Individual Participant Data Meta-Analysis: Reducing Self-Harm in Adolescents: Pooled Treatment Effects, Study, Treatment, and Participant Moderators von Wright-Hughes, Alex, Farrin, Amanda J, Fonagy, Peter, Ougrin, Dennis, Stahl, Daniel, Wright, Judy, Irving, Donna, Mughal, Faraz, Truscott, Alex, Diggins, Emma, Chanen, Andrew, Cooney, Emily, Carter, Greg, Clover, Kerrie, Dadds, Mark, Diamond, Guy, Esposito-Smythers, Christianne, Green, Jonathan, Griffiths, Helen, Hassanian-Moghaddam, Hossein, Hatcher, Simon, Hazell, Philip, Husain, Nusrat, Kaess, Michael, King, Cheryl, Morthorst, Britt, O'Connor, Rory C, Santamarina-Perez, Pilar, Tyrer, Peter, Walwyn, Rebecca, Cottrell, David

“… Self-harm is common in adolescents and a major public health concern. Evidence for effective interventions that stop repetition is lacking. This individual …”
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Statistical challenges in assessing potential efficacy of complex interventions in pilot or feasibility studies von Wilson, Duncan T, Walwyn, Rebecca Ea, Brown, Julia, Farrin, Amanda J, Brown, Sarah R

“… Early phase trials of complex interventions currently focus on assessing the feasibility of a large randomised control trial and on conducting pilot work …”
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Reducing self-harm in adolescents: the RISA-IPD individual patient data meta-analysis and systematic review von Cottrell, David, Wright-Hughes, Alex, Farrin, Amanda, Walwyn, Rebecca, Mughal, Faraz, Truscott, Alex, Diggins, Emma, Irving, Donna, Fonagy, Peter, Ougrin, Dennis, Stahl, Daniel, Wright, Judy

“… Self-harm is common in adolescents and a major public health concern. Evidence for effective interventions is lacking. An individual patient data meta-analysis …”
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The Implementation of Dementia Care Mapping in a Randomized Controlled Trial in Long-Term Care: Results of a Process Evaluation von Surr, Claire A, Griffiths, Alys W, Kelley, Rachael, Holloway, Ivana, Walwyn, Rebecca E A, Martin, Adam, McDermid, Joanne, Chenoweth, Lynn, Farrin, Amanda J

“… This study explored intervention implementation within a pragmatic, cluster randomized controlled trial of Dementia Care Mapping™ (DCM) in UK care homes. DCM …”
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Evaluating the effectiveness and cost-effectiveness of Dementia Care Mapping™ to enable person-centred care for people with dementia and their carers (DCM-EPIC) in care homes: study protocol for a randomised controlled trial von Surr, Claire A., Walwyn, Rebecca E. A., Lilley-Kelly, Amanda, Cicero, Robert, Meads, David, Ballard, Clive, Burton, Kayleigh, Chenoweth, Lynn, Corbett, Anne, Creese, Byron, Downs, Murna, Farrin, Amanda J., Fossey, Jane, Garrod, Lucy, Graham, Elizabeth H., Griffiths, Alys, Holloway, Ivana, Jones, Sharon, Malik, Baber, Siddiqi, Najma, Robinson, Louise, Stokes, Graham, Wallace, Daphne

“… Background Up to 90 % of people living with dementia in care homes experience one or more behaviours that staff may describe as challenging to support (BSC) …”
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Twelve-month prevalence of haemarthrosis and joint disease using the Haemophilia Joint Health score: evaluation of the UK National Haemophilia Database and Haemtrack patient reported data: an observational study von Wilkins, Richard A, Stephensen, David, Siddle, Heidi, Scott, Martin J, Xiang, Hua, Horn, Elizabeth, Palmer, Ben, Chapman, Graham J, Richards, Michael, Walwyn, Rebecca, Redmond, Anthony

“… ObjectivesTo report the 12-month prevalence of joint bleeds from the National Haemophilia Database (NHD) and Haemtrack, a patient-reported online treatment …”
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The detection and management of attempted fraud during an online randomised trial von Willis, Thomas A., Wright-Hughes, Alexandra, Skinner, Clare, Farrin, Amanda J., Hartley, Suzanne, Walwyn, Rebecca, Weller, Ana, Althaf, Mohamed, Wilson, Stephanie, Gale, Chris P., Foy, Robbie

“… Background Online studies offer an efficient method of recruiting participants and collecting data. Whilst delivering an online randomised trial, we detected …”
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