Suchergebnisse - "Walker, Timothy M."

Transmission of community- and hospital-acquired SARS-CoV-2 in hospital settings in the UK: A cohort study von Mo, Yin, Eyre, David W., Lumley, Sheila F., Walker, Timothy M., Shaw, Robert H., O’Donnell, Denise, Butcher, Lisa, Jeffery, Katie, Donnelly, Christl A., Cooper, Ben S.

“… Nosocomial spread of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has been widely reported, but the transmission pathways among patients and …”
Volltext

Whole genome sequencing of Mycobacterium tuberculosis: current standards and open issues von Meehan, Conor J, Goig, Galo A, Kohl, Thomas A, Verboven, Lennert, Dippenaar, Anzaan, Ezewudo, Matthew, Farhat, Maha R, Guthrie, Jennifer L, Laukens, Kris, Miotto, Paolo, Ofori-Anyinam, Boatema, Dreyer, Viola, Supply, Philip, Suresh, Anita, Utpatel, Christian, van Soolingen, Dick, Zhou, Yang, Ashton, Philip M, Brites, Daniela, Cabibbe, Andrea M, de Jong, Bouke C, de Vos, Margaretha, Menardo, Fabrizio, Gagneux, Sebastien, Gao, Qian, Heupink, Tim H, Liu, Qingyun, Loiseau, Chloé, Rigouts, Leen, Rodwell, Timothy C, Tagliani, Elisa, Walker, Timothy M, Warren, Robin M, Zhao, Yanlin, Zignol, Matteo, Schito, Marco, Gardy, Jennifer, Cirillo, Daniela M, Niemann, Stefan, Comas, Inaki, Van Rie, Annelies

“… Whole genome sequencing (WGS) of Mycobacterium tuberculosis has rapidly progressed from a research tool to a clinical application for the diagnosis and …”
Volltext

Same-Day Diagnostic and Surveillance Data for Tuberculosis via Whole-Genome Sequencing of Direct Respiratory Samples von Votintseva, Antonina A, Bradley, Phelim, Pankhurst, Louise, Del Ojo Elias, Carlos, Loose, Matthew, Nilgiriwala, Kayzad, Chatterjee, Anirvan, Smith, E Grace, Sanderson, Nicolas, Walker, Timothy M, Morgan, Marcus R, Wyllie, David H, Walker, A Sarah, Peto, Tim E A, Crook, Derrick W, Iqbal, Zamin

“… Routine full characterization of is culture based, taking many weeks. Whole-genome sequencing (WGS) can generate antibiotic susceptibility profiles to inform …”
Weitere Angaben

Rapid antibiotic-resistance predictions from genome sequence data for Staphylococcus aureus and Mycobacterium tuberculosis von Bradley, Phelim, Gordon, N. Claire, Walker, Timothy M., Dunn, Laura, Heys, Simon, Huang, Bill, Earle, Sarah, Pankhurst, Louise J., Anson, Luke, de Cesare, Mariateresa, Piazza, Paolo, Votintseva, Antonina A., Golubchik, Tanya, Wilson, Daniel J., Wyllie, David H., Diel, Roland, Niemann, Stefan, Feuerriegel, Silke, Kohl, Thomas A., Ismail, Nazir, Omar, Shaheed V., Smith, E. Grace, Buck, David, McVean, Gil, Walker, A. Sarah, Peto, Tim E. A., Crook, Derrick W., Iqbal, Zamin

“… The rise of antibiotic-resistant bacteria has led to an urgent need for rapid detection of drug resistance in clinical samples, and improvements in global …”
Volltext

Clinical and public health utility of Mycobacterium tuberculosis whole genome sequencing von Kizny Gordon, Alice, Marais, Ben, Walker, Timothy M., Sintchenko, Vitali

“… •WGS has particular value in the diagnosis and management of TB disease.•It can give more rapid and complete information on TB drug-resistance.•The high …”
Volltext

Whole-genome sequencing to delineate Mycobacterium tuberculosis outbreaks: a retrospective observational study von Walker, Timothy M, Ip, Camilla LC, Harrell, Ruth H, Evans, Jason T, Kapatai, Georgia, Dedicoat, Martin J, Eyre, David W, Wilson, Daniel J, Hawkey, Peter M, Crook, Derrick W, Parkhill, Julian, Harris, David, Walker, A Sarah, Bowden, Rory, Monk, Philip, Smith, E Grace, Peto, Tim EA

“… Tuberculosis incidence in the UK has risen in the past decade. Disease control depends on epidemiological data, which can be difficult to obtain. Whole-genome …”
Volltext

Tuberculosis preventive therapy: scientific and ethical considerations for trials of ultra-short regimens von Walker, Timothy M, Watson, James A, Moore, David A J, Frick, Mike, Jamrozik, Euzebiusz

“… Preventive therapy remains key to the elimination of tuberculosis and is typically offered to people with presumptive Mycobacterium tuberculosis infection to …”
Volltext

Validating a 14-Drug Microtiter Plate Containing Bedaquiline and Delamanid for Large-Scale Research Susceptibility Testing of Mycobacterium tuberculosis von Rancoita, Paola M V, Cugnata, Federica, Gibertoni Cruz, Ana Luíza, Borroni, Emanuele, Hoosdally, Sarah J, Walker, Timothy M, Grazian, Clara, Davies, Timothy J, Peto, Timothy E A, Crook, Derrick W, Fowler, Philip W, Cirillo, Daniela M

“… The UKMYC5 plate is a 96-well microtiter plate designed by the CRyPTIC Consortium (Comprehensive Resistance Prediction for Tuberculosis: an International …”
Weitere Angaben

Multivariable regression models improve accuracy and sensitive grading of antibiotic resistance mutations in Mycobacterium tuberculosis von Kulkarni, Sanjana G., Laurent, Sacha, Miotto, Paolo, Walker, Timothy M., Chindelevitch, Leonid, Nathanson, Carl-Michael, Ismail, Nazir, Rodwell, Timothy C., Farhat, Maha R.

“… Rapid genotype-based drug susceptibility testing for the Mycobacterium tuberculosis complex (MTBC) relies on a comprehensive knowledgebase of the genetic …”
Volltext

Rapid, comprehensive, and affordable mycobacterial diagnosis with whole-genome sequencing: a prospective study von Pankhurst, Louise J, Del Ojo Elias, Carlos, Votintseva, Antonina A, Walker, Timothy M, Cole, Kevin, Davies, Jim, Fermont, Jilles M, Gascoyne-Binzi, Deborah M, Kohl, Thomas A, Kong, Clare, Lemaitre, Nadine, Niemann, Stefan, Paul, John, Rogers, Thomas R, Roycroft, Emma, Smith, E Grace, Supply, Philip, Tang, Patrick, Wilcox, Mark H, Wordsworth, Sarah, Wyllie, David, Xu, Li, Crook, Derrick W

“… Slow and cumbersome laboratory diagnostics for Mycobacterium tuberculosis complex (MTBC) risk delayed treatment and poor patient outcomes. Whole-genome …”
Weitere Angaben

Pathogen-based precision medicine for drug-resistant tuberculosis von Gröschel, Matthias I., Walker, Timothy M., van der Werf, Tjip S., Lange, Christoph, Niemann, Stefan, Merker, Matthias

“… [...]mutations can be used to predict different treatment outcomes. [...]by also considering phylogenetic benign mutations that do not confer resistance, a …”
Volltext

Genomic insights into anthropozoonotic tuberculosis in captive sun bears (Helarctos malayanus) and an Asiatic black bear (Ursus thibetanus) in Cambodia von Officer, Kirsty, Walker, Timothy M., Cheng, Sokleaph, Heng, Seiha, Hidé, Mallorie, Bañuls, Anne-Laure, Cracknell, Jonathan, Broadis, Nev, Thy, Nhim, Abraham, Sam, Warren, Kris, Jackson, Bethany

“… Contact between humans and wildlife presents a risk for both zoonotic and anthropozoonotic disease transmission. In this study we report the detection of human …”
Volltext

Evaluation of Nanopore sequencing for Mycobacterium tuberculosis drug susceptibility testing and outbreak investigation: a genomic analysis von Hall, Michael B, Rabodoarivelo, Marie Sylvianne, Koch, Anastasia, Dippenaar, Anzaan, George, Sophie, Grobbelaar, Melanie, Warren, Robin, Walker, Timothy M, Cox, Helen, Gagneux, Sebastien, Crook, Derrick, Peto, Tim, Rakotosamimanana, Niaina, Grandjean Lapierre, Simon, Iqbal, Zamin

“… Mycobacterium tuberculosis whole-genome sequencing (WGS) has been widely used for genotypic drug susceptibility testing (DST) and outbreak investigation. For …”
Volltext

Future-proofing tuberculosis therapy: framework for concurrent drug and resistance testing development von Saluzzo, Francesca, MD, Yerlikaya, Seda, PhD, Dorman, Susan Elizabeth, MD, Eisenach, Kathleen, PhD, Farhat, Maha Reda, MD, Ismail, Nazir, FCPath, Lienhardt, Christian, PhD, Walker, Timothy M, Prof, Jones, Fatima, PhD, Yepes, Ana, PhD, Penn-Nicholson, Adam, PhD, Ruhwald, Morten, MD, Kana, Bavesh, PhD, Denkinger, Claudia Maria, MD, Cirillo, Daniela Maria, MD

“… SummaryThe rapid emergence of resistance to novel tuberculosis drugs, such as bedaquiline, is a key threat to the long-term effectiveness of novel regimens …”
Volltext

In silico evaluation of WHO-endorsed molecular methods to detect drug resistant tuberculosis von Brankin, Alice, Seifert, Marva, Georghiou, Sophia B., Walker, Timothy M., Uplekar, Swapna, Suresh, Anita, Colman, Rebecca E.

“… Universal drug susceptibility testing (DST) for tuberculosis is a major goal of the END TB strategy. PCR-based molecular diagnostic tests have been …”
Volltext

Antibiotic resistance prediction for Mycobacterium tuberculosis from genome sequence data with Mykrobe von Hunt, Martin, Bradley, Phelim, Lapierre, Simon Grandjean, Heys, Simon, Thomsit, Mark, Hall, Michael B., Malone, Kerri M., Wintringer, Penelope, Walker, Timothy M., Cirillo, Daniela M., Comas, Iñaki, Farhat, Maha R., Fowler, Phillip, Gardy, Jennifer, Ismail, Nazir, Kohl, Thomas A., Mathys, Vanessa, Merker, Matthias, Niemann, Stefan, Omar, Shaheed Vally, Sintchenko, Vitali, Smith, Grace, Soolingen, Dick van, Supply, Philip, Tahseen, Sabira, Wilcox, Mark, Arandjelovic, Irena, Peto, Tim E. A., Crook, Derrick W., Iqbal, Zamin

“… Two billion people are infected with Mycobacterium tuberculosis , leading to 10 million new cases of active tuberculosis and 1.5 million deaths annually …”
Volltext

Mycobacterial DNA extraction for whole-genome sequencing from early positive liquid (MGIT) cultures von Votintseva, Antonina A, Pankhurst, Louise J, Anson, Luke W, Morgan, Marcus R, Gascoyne-Binzi, Deborah, Walker, Timothy M, Quan, T Phuong, Wyllie, David H, Del Ojo Elias, Carlos, Wilcox, Mark, Walker, A Sarah, Peto, Tim E A, Crook, Derrick W

“… We developed a low-cost and reliable method of DNA extraction from as little as 1 ml of early positive mycobacterial growth indicator tube (MGIT) cultures that …”
Weitere Angaben

Multi-Label Random Forest Model for Tuberculosis Drug Resistance Classification and Mutation Ranking von Kouchaki, Samaneh, Yang, Yang, Lachapelle, Alexander, Walker, Timothy M., Walker, A. Sarah, Peto, Timothy E. A., Crook, Derrick W., Clifton, David A.

“… Resistance prediction and mutation ranking are important tasks in the analysis of Tuberculosis sequence data. Due to standard regimens for the use of …”
Volltext

The use of whole-genome sequencing in cluster investigation of a multidrug-resistant tuberculosis outbreak von Lalor, Maeve K, Casali, Nicola, Walker, Timothy M, Anderson, Laura F, Davidson, Jennifer A, Ratna, Natasha, Mullarkey, Cathy, Gent, Mike, Foster, Kirsty, Brown, Tim, Magee, John, Barrett, Anne, Crook, Derrick W, Drobniewski, Francis, Thomas, H Lucy, Abubakar, Ibrahim

“… We used whole-genome sequencing (WGS) to delineate transmission networks and investigate the benefits of WGS during cluster investigation.We included clustered …”
Weitere Angaben

Assessment of Mycobacterium tuberculosis transmission in Oxfordshire, UK, 2007-12, with whole pathogen genome sequences: an observational study von Walker, Timothy M, Lalor, Maeve K, Broda, Agnieszka, Ortega, Luisa Saldana, Morgan, Marcus, Parker, Lynne, Churchill, Sheila, Bennett, Karen, Golubchik, Tanya, Giess, Adam P, Del Ojo Elias, Carlos, Jeffery, Katie J, Bowler, Ian C J W, Laurenson, Ian F, Barrett, Anne, Drobniewski, Francis, McCarthy, Noel D, Anderson, Laura F, Abubakar, Ibrahim, Thomas, H Lucy, Monk, Philip, Smith, E Grace, Walker, A Sarah, Crook, Derrick W, Peto, Tim E A, Conlon, Christopher P

“… Patients born outside the UK have contributed to a 20% rise in the UK's tuberculosis incidence since 2000, but their effect on domestic transmission is not …”
Weitere Angaben