Výsledky vyhľadávania - "Walker, Brian R."

Glucocorticoids and cardiovascular disease Autor Walker, Brian R

“…Chronic excessive activation of glucocorticoid receptors induces obesity, insulin resistance, glucose intolerance, dyslipidaemia and hypertension. Subtle…”
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Glucocorticoids Acutely Increase Brown Adipose Tissue Activity in Humans, Revealing Species-Specific Differences in UCP-1 Regulation Autor Ramage, Lynne E, Akyol, Murat, Fletcher, Alison M, Forsythe, John, Nixon, Mark, Carter, Roderick N, van Beek, Edwin J R, Morton, Nicholas M, Walker, Brian R, Stimson, Roland H

“…The discovery of brown adipose tissue (BAT) in adult humans presents a new therapeutic target for metabolic disease; however, little is known about the…”
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Visceral and subcutaneous fat have different origins and evidence supports a mesothelial source Autor Chau, You-Ying, Bandiera, Roberto, Serrels, Alan, Martínez-Estrada, Ofelia M., Qing, Wei, Lee, Martin, Slight, Joan, Thornburn, Anna, Berry, Rachel, McHaffie, Sophie, Stimson, Roland H., Walker, Brian R., Chapuli, Ramon Muñoz, Schedl, Andreas, Hastie, Nick

“…Increased visceral adipose tissue has been associated with metabolic dysfunction but the origin of the progenitors that give rise to this tissue, and whether…”
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Glucocorticoids and fatty acid metabolism in humans: fuelling fat redistribution in the metabolic syndrome Autor Macfarlane, David P, Forbes, Shareen, Walker, Brian R

“…Glucocorticoid hormones constitute an integral component of the response to stress, and many of the manifestations of glucocorticoid excess (Cushing's…”
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11β-HSD1 Inhibitors for the Treatment of Type 2 Diabetes and Cardiovascular Disease Autor Anderson, Anna, Walker, Brian R.

“…Inhibition of the enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) has been proposed as a novel therapeutic target for the treatment of type 2…”
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Substantial Metabolic Activity of Human Brown Adipose Tissue during Warm Conditions and Cold-Induced Lipolysis of Local Triglycerides Autor Weir, Graeme, Ramage, Lynne E, Akyol, Murat, Rhodes, Jonathan K, Kyle, Catriona J, Fletcher, Alison M, Craven, Thomas H, Wakelin, Sonia J, Drake, Amanda J, Gregoriades, Maria-Lena, Ashton, Ceri, Weir, Nick, van Beek, Edwin J R, Karpe, Fredrik, Walker, Brian R, Stimson, Roland H

“…Current understanding of in vivo human brown adipose tissue (BAT) physiology is limited by a reliance on positron emission tomography (PET)/computed tomography…”
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Morning plasma cortisol as a cardiovascular risk factor: findings from prospective cohort and Mendelian randomization studies Autor Crawford, Andrew A, Soderberg, Stefan, Kirschbaum, Clemens, Murphy, Lee, Eliasson, Mats, Ebrahim, Shah, Davey Smith, George, Olsson, Tommy, Sattar, Naveed, Lawlor, Debbie A, Timpson, Nicolas J, Reynolds, Rebecca M, Walker, Brian R

“…The identification of new causal risk factors has the potential to improve cardiovascular disease (CVD) risk prediction and the development of new treatments…”
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Effect of metformin on maternal and fetal outcomes in obese pregnant women (EMPOWaR): a randomised, double-blind, placebo-controlled trial Autor Chiswick, Carolyn, Reynolds, Rebecca M, Denison, Fiona, Drake, Amanda J, Forbes, Shareen, Newby, David E, Walker, Brian R, Quenby, Siobhan, Wray, Susan, Weeks, Andrew, Lashen, Hany, Rodriguez, Aryelly, Murray, Gordon, Whyte, Sonia, Norman, Jane E

“…Maternal obesity is associated with increased birthweight, and obesity and premature mortality in adult offspring. The mechanism by which maternal obesity…”
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11β-HSD1 inhibition does not affect murine tumour angiogenesis but may exert a selective effect on tumour growth by modulating inflammation and fibrosis Autor Davidson, Callam T., Miller, Eileen, Muir, Morwenna, Dawson, John C., Lee, Martin, Aitken, Stuart, Serrels, Alan, Webster, Scott P., Homer, Natalie Z. M., Andrew, Ruth, Brunton, Valerie G., Hadoke, Patrick W. F., Walker, Brian R.

“…Glucocorticoids inhibit angiogenesis by activating the glucocorticoid receptor. Inhibition of the glucocorticoid-activating enzyme 11β-hydroxysteroid…”
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Mass spectrometry imaging for dissecting steroid intracrinology within target tissues Autor Cobice, Diego F, Mackay, C Logan, Goodwin, Richard J A, McBride, Andrew, Langridge-Smith, Patrick R, Webster, Scott P, Walker, Brian R, Andrew, Ruth

“…Steroid concentrations within tissues are modulated by intracellular enzymes. Such "steroid intracrinology" influences hormone-dependent cancers and obesity…”
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The NE/AAT/CBG axis regulates adipose tissue glucocorticoid exposure Autor Boyle, Luke D., Miguelez-Crespo, Allende, Paul, Mhairi, Villalobos, Elisa, Toews, Julia N. C., Ivatt, Lisa, Nagy, Boglarka, Magennis, Marisa, Homer, Natalie Z. M., Andrew, Ruth, Viau, Victor, Hammond, Geoffrey L., Stimson, Roland H., Walker, Brian R., Nixon, Mark

“…Corticosteroid binding globulin (CBG; SERPINA6 ) binds >85% of circulating glucocorticoids but its influence on their metabolic actions is unproven. Targeted…”
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5α-Reductase type 1 deficiency or inhibition predisposes to insulin resistance, hepatic steatosis, and liver fibrosis in rodents Autor Livingstone, Dawn E W, Barat, Pascal, Di Rollo, Emma M, Rees, Georgina A, Weldin, Benjamin A, Rog-Zielinska, Eva A, MacFarlane, David P, Walker, Brian R, Andrew, Ruth

“…5α-Reductase type 1 (5αR1) catalyses A-ring reduction of androgens and glucocorticoids in liver, potentially influencing hepatic manifestations of the…”
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GDF15 Is Elevated in Conditions of Glucocorticoid Deficiency and Is Modulated by Glucocorticoid Replacement Autor Melvin, Audrey, Chantzichristos, Dimitrios, Kyle, Catriona J, Mackenzie, Scott D, Walker, Brian R, Johannsson, Gudmundur, Stimson, Roland H, O’Rahilly, Stephen

“…Abstract Context GDF15 is a stress-induced hormone acting in the hindbrain that activates neural circuitry involved in establishing aversive responses and…”
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Spatial Localization and Quantitation of Androgens in Mouse Testis by Mass Spectrometry Imaging Autor Cobice, Diego F, Livingstone, Dawn E W, Mackay, C Logan, Goodwin, Richard J A, Smith, Lee B, Walker, Brian R, Andrew, Ruth

“…Androgens are essential for male development and reproductive function. They are transported to their site of action as blood-borne endocrine hormones but can…”
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Simultaneous quantification of estrogens and glucocorticoids in human adipose tissue by liquid-chromatography-tandem mass spectrometry Autor Laforest, Sofia, Pelletier, Mélissa, Denver, Nina, Poirier, Brigitte, Nguyen, Sébastien, Walker, Brian R., Durocher, Francine, Homer, Natalie Z.M., Diorio, Caroline, Tchernof, André, Andrew, Ruth

“…•Steroid analysis using LC/ESI-MS/MS is reliable and sensitive.•ESI efficiency of estrogens is limited.•Chemical derivatization of steroids improves their…”
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Deletion of the Androgen Receptor in Adipose Tissue in Male Mice Elevates Retinol Binding Protein 4 and Reveals Independent Effects on Visceral Fat Mass and on Glucose Homeostasis Autor McInnes, Kerry J., Smith, Lee B., Hunger, Nicole I., Saunders, Philippa T.K., Andrew, Ruth, Walker, Brian R.

“…Testosterone deficiency is epidemic in obese ageing males with type 2 diabetes, but the direction of causality remains unclear. Testosterone-deficient males…”
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Non-invasive in vivo assessment of 11β-hydroxysteroid dehydrogenase type 1 activity by 19F-Magnetic Resonance Spectroscopy Autor Naredo-Gonzalez, Gregorio, Upreti, Rita, Jansen, Maurits A., Semple, Scott, Sutcliffe, Oliver B., Marshall, Ian, Walker, Brian R., Andrew, Ruth

“…11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) amplifies tissue glucocorticoid levels and is a pharmaceutical target in diabetes and cognitive decline…”
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Derivatization of estrogens enhances specificity and sensitivity of analysis of human plasma and serum by liquid chromatography tandem mass spectrometry Autor Faqehi, Abdullah M.M., Cobice, Diego F., Naredo, Gregorio, Mak, Tracy C.S., Upreti, Rita, Gibb, Fraser W., Beckett, Geoffrey J., Walker, Brian R., Homer, Natalie Z.M., Andrew, Ruth

“…Estrogens circulate at concentrations less than 20pg/mL in men and postmenopausal women, presenting analytical challenges. Quantitation by immunoassay is…”
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A Choline-Deficient Diet Exacerbates Fatty Liver but Attenuates Insulin Resistance and Glucose Intolerance in Mice Fed a High-Fat Diet Autor Raubenheimer, Peter J., Nyirenda, Moffat J., Walker, Brian R.

“…A Choline-Deficient Diet Exacerbates Fatty Liver but Attenuates Insulin Resistance and Glucose Intolerance in Mice Fed a High-Fat Diet Peter J. Raubenheimer ,…”
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Intergenerational consequences of fetal programming by in utero exposure to glucocorticoids in rats Autor Drake, Amanda J, Walker, Brian R, Seckl, Jonathan R

“…Epidemiological studies linking low birth weight and subsequent cardiometabolic disease have given rise to the hypothesis that events in fetal life permanently…”
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