Search Results - "Walczak, Aleksandra M."

High-throughput immune repertoire analysis with IGoR by Marcou, Quentin, Mora, Thierry, Walczak, Aleksandra M.

“…High-throughput immune repertoire sequencing is promising to lead to new statistical diagnostic tools for medicine and biology. Successful implementations of…”
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How a well-adapted immune system is organized by Mayer, Andreas, Balasubramanian, Vijay, Mora, Thierry, Walczak, Aleksandra M

“…The repertoire of lymphocyte receptors in the adaptive immune system protects organisms from diverse pathogens. A well-adapted repertoire should be tuned to…”
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Antigenic waves of virus-immune coevolution by Marchi, Jacopo, Lässig, Michael, Walczak, Aleksandra M, Mora, Thierry

“…The evolution of many microbes and pathogens, including circulating viruses such as seasonal influenza, is driven by immune pressure from the host population…”
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Statistical mechanics for natural flocks of birds by Bialek, William, Cavagna, Andrea, Giardina, Irene, Mora, Thierry, Silvestri, Edmondo, Viale, Massimiliano, Walczak, Aleksandra M

“…Flocking is a typical example of emergent collective behavior, where interactions between individuals produce collective patterns on the large scale. Here we…”
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Genesis of the αβ T-cell receptor by Dupic, Thomas, Marcou, Quentin, Walczak, Aleksandra M., Mora, Thierry

“…The T-cell (TCR) repertoire relies on the diversity of receptors composed of two chains, called α and β, to recognize pathogens. Using results of high…”
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Live imaging of bicoid-dependent transcription in Drosophila embryos by Lucas, Tanguy, Ferraro, Teresa, Roelens, Baptiste, De Las Heras Chanes, Jose, Walczak, Aleksandra M, Coppey, Mathieu, Dostatni, Nathalie

“…The early Drosophila embryo is an ideal model to understand the transcriptional regulation of well-defined patterns of gene expression in a developing…”
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Modeling and predicting the overlap of B- and T-cell receptor repertoires in healthy and SARS-CoV-2 infected individuals by Ruiz Ortega, María, Spisak, Natanael, Mora, Thierry, Walczak, Aleksandra M.

“…Adaptive immunity’s success relies on the extraordinary diversity of protein receptors on B and T cell membranes. Despite this diversity, the existence of…”
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Fluctuating fitness shapes the clone-size distribution of immune repertoires by Desponds, Jonathan, Mora, Thierry, Walczak, Aleksandra M

“…The adaptive immune system relies on the diversity of receptors expressed on the surface of B- and T cells to protect the organism from a vast amount of…”
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Diversity of immune strategies explained by adaptation to pathogen statistics by Mayer, Andreas, Mora, Thierry, Rivoire, Olivier, Walczak, Aleksandra M

“…Biological organisms have evolved a wide range of immune mechanisms to defend themselves against pathogens. Beyond molecular details, these mechanisms differ…”
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How a well-adapting immune system remembers by Mayer, Andreas, Balasubramanian, Vijay, Walczak, Aleksandra M, Mora, Thierry

“…An adaptive agent predicting the future state of an environment must weigh trust in new observations against prior experiences. In this light, we propose a…”
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Social interactions dominate speed control in poising natural flocks near criticality by Bialek, William, Cavagna, Andrea, Giardina, Irene, Mora, Thierry, Pohl, Oliver, Silvestri, Edmondo, Viale, Massimiliano, Walczak, Aleksandra M

“…Flocks of birds exhibit a remarkable degree of coordination and collective response. It is not just that thousands of individuals fly, on average, in the same…”
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Detecting T cell receptors involved in immune responses from single repertoire snapshots by Pogorelyy, Mikhail V., Minervina, Anastasia A., Shugay, Mikhail, Chudakov, Dmitriy M., Lebedev, Yuri B., Mora, Thierry, Walczak, Aleksandra M.

“…Hypervariable T cell receptors (TCRs) play a key role in adaptive immunity, recognizing a vast diversity of pathogen-derived antigens. Our ability to extract…”
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Statistical inference of the generation probability of T-cell receptors from sequence repertoires by Murugan, Anand, Mora, Thierry, Walczak, Aleksandra M, Callan, Jr, Curtis G

“…Stochastic rearrangement of germline V-, D-, and J-genes to create variable coding sequence for certain cell surface receptors is at the origin of immune…”
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Information transmission in genetic regulatory networks: a review by Tkačik, Gašper, Walczak, Aleksandra M

“…Genetic regulatory networks enable cells to respond to changes in internal and external conditions by dynamically coordinating their gene expression profiles…”
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Inferring processes underlying B-cell repertoire diversity by Elhanati, Yuval, Sethna, Zachary, Marcou, Quentin, Callan, Jr, Curtis G, Mora, Thierry, Walczak, Aleksandra M

“…We quantify the VDJ recombination and somatic hypermutation processes in human B cells using probabilistic inference methods on high-throughput DNA sequence…”
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Quantifying selection in immune receptor repertoires by Elhanati, Yuval, Murugan, Anand, Callan, Jr, Curtis G, Mora, Thierry, Walczak, Aleksandra M

“…The efficient recognition of pathogens by the adaptive immune system relies on the diversity of receptors displayed at the surface of immune cells. T-cell…”
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Population variability in the generation and selection of T-cell repertoires by Sethna, Zachary, Isacchini, Giulio, Dupic, Thomas, Mora, Thierry, Walczak, Aleksandra M., Elhanati, Yuval

“…The diversity of T-cell receptor (TCR) repertoires is achieved by a combination of two intrinsically stochastic steps: random receptor generation by VDJ…”
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Learning the statistics and landscape of somatic mutation-induced insertions and deletions in antibodies by Lupo, Cosimo, Spisak, Natanael, Walczak, Aleksandra M., Mora, Thierry

“…Affinity maturation is crucial for improving the binding affinity of antibodies to antigens. This process is mainly driven by point substitutions caused by…”
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Inferring the immune response from repertoire sequencing by Puelma Touzel, Maximilian, Walczak, Aleksandra M., Mora, Thierry

“…High-throughput sequencing of B- and T-cell receptors makes it possible to track immune repertoires across time, in different tissues, and in acute and chronic…”
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Maximum entropy models for antibody diversity by Mora, Thierry, Walczak, Aleksandra M, Bialek, William, Callan, Jr, Curtis G

“…Recognition of pathogens relies on families of proteins showing great diversity. Here we construct maximum entropy models of the sequence repertoire, building…”
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