Search Results - "Wakelam, Michael J.O."

Fatty Acid Uptake and Lipid Storage Induced by HIF-1α Contribute to Cell Growth and Survival after Hypoxia-Reoxygenation by Bensaad, Karim, Favaro, Elena, Lewis, Caroline A., Peck, Barrie, Lord, Simon, Collins, Jennifer M., Pinnick, Katherine E., Wigfield, Simon, Buffa, Francesca M., Li, Ji-Liang, Zhang, Qifeng, Wakelam, Michael J.O., Karpe, Fredrik, Schulze, Almut, Harris, Adrian L.

“…An in vivo model of antiangiogenic therapy allowed us to identify genes upregulated by bevacizumab treatment, including Fatty Acid Binding Protein 3 (FABP3)…”
Get full text

Update of the LIPID MAPS comprehensive classification system for lipids by Fahy, Eoin, Subramaniam, Shankar, Murphy, Robert C, Nishijima, Masahiro, Raetz, Christian R H, Shimizu, Takao, Spener, Friedrich, van Meer, Gerrit, Wakelam, Michael J O, Dennis, Edward A

“…In 2005, the International Lipid Classification and Nomenclature Committee under the sponsorship of the LIPID MAPS Consortium developed and established a…”
Get more information

PTEN Mutations as a Cause of Constitutive Insulin Sensitivity and Obesity by Pal, Aparna, Barber, Thomas M, Van de Bunt, Martijn, Rudge, Simon A, Zhang, Qifeng, Lachlan, Katherine L, Cooper, Nicola S, Linden, Helen, Levy, Jonathan C, Wakelam, Michael J.O, Walker, Lisa, Karpe, Fredrik, Gloyn, Anna L

“…Evidence suggests that protection against cancer confers a risk of type 2 diabetes and vice versa. This study shows that persons susceptible to cancer owing to…”
Get full text

BioPAN: a web-based tool to explore mammalian lipidome metabolic pathways on LIPID MAPS [version 2; peer review: 3 approved] by Gaud, Caroline, C. Sousa, Bebiana, Nguyen, An, Fedorova, Maria, Ni, Zhixu, O'Donnell, Valerie B, Wakelam, Michael J.O, Andrews, Simon, Lopez-Clavijo, Andrea F

“…Lipidomics increasingly describes the quantification using mass spectrometry of all lipids present in a biological sample.  As the power of lipidomics…”
Get full text

BioPAN: a web-based tool to explore mammalian lipidome metabolic pathways on LIPID MAPS [version 1; peer review: 3 approved] by Gaud, Caroline, C. Sousa, Bebiana, Nguyen, An, Fedorova, Maria, Ni, Zhixu, O'Donnell, Valerie B, Wakelam, Michael J.O, Andrews, Simon, Lopez-Clavijo, Andrea F

“…Lipidomics increasingly describes the quantitation using mass spectrometry of all lipids present in a biological sample.  As the power of lipidomics protocols…”
Get full text

Phospholipase D by McDermott, Mark, Wakelam, Michael J.O, Morris, Andrew J

“…Phospholipase D catalyses the hydrolysis of the phosphodiester bond of glycerophospholipids to generate phosphatidic acid and a free headgroup. Phospholipase D…”
Get full text

Analysis of intact phosphoinositides in biological samples by Pettitt, Trevor R, Dove, Stephen K, Lubben, Anneke, Calaminus, Simon D J, Wakelam, Michael J O

“…It is now apparent that each of the known, naturally occurring polyphosphoinositides, the phosphatidylinositol monophosphates (PtdIns3P, PtdIns4P, PtdIns5P),…”
Get full text

Update on LIPID MAPS classification, nomenclature, and shorthand notation for MS-derived lipid structures by Liebisch, Gerhard, Fahy, Eoin, Aoki, Junken, Dennis, Edward A, Durand, Thierry, Ejsing, Christer S, Fedorova, Maria, Feussner, Ivo, Griffiths, William J, Köfeler, Harald, Merrill, Jr, Alfred H, Murphy, Robert C, O'Donnell, Valerie B, Oskolkova, Olga, Subramaniam, Shankar, Wakelam, Michael J O, Spener, Friedrich

“…A comprehensive and standardized system to report lipid structures analyzed by MS is essential for the communication and storage of lipidomics data. Herein, an…”
Get full text

Shorthand notation for lipid structures derived from mass spectrometry by Liebisch, Gerhard, Vizcaíno, Juan Antonio, Köfeler, Harald, Trötzmüller, Martin, Griffiths, William J, Schmitz, Gerd, Spener, Friedrich, Wakelam, Michael J O

“…There is a need for a standardized, practical annotation for structures of lipid species derived from mass spectrometric approaches; i.e., for high-throughput…”
Get full text

MS-based lipidomics of human blood plasma: a community-initiated position paper to develop accepted guidelines by Burla, Bo, Arita, Makoto, Arita, Masanori, Bendt, Anne K, Cazenave-Gassiot, Amaury, Dennis, Edward A, Ekroos, Kim, Han, Xianlin, Ikeda, Kazutaka, Liebisch, Gerhard, Lin, Michelle K, Loh, Tze Ping, Meikle, Peter J, Orešič, Matej, Quehenberger, Oswald, Shevchenko, Andrej, Torta, Federico, Wakelam, Michael J O, Wheelock, Craig E, Wenk, Markus R

“…Human blood is a self-regenerating lipid-rich biological fluid that is routinely collected in hospital settings. The inventory of lipid molecules found in…”
Get more information

Acetyl-CoA synthetase 2 promotes acetate utilization and maintains cancer cell growth under metabolic stress by Schug, Zachary T, Peck, Barrie, Jones, Dylan T, Zhang, Qifeng, Grosskurth, Shaun, Alam, Israt S, Goodwin, Louise M, Smethurst, Elizabeth, Mason, Susan, Blyth, Karen, McGarry, Lynn, James, Daniel, Shanks, Emma, Kalna, Gabriela, Saunders, Rebecca E, Jiang, Ming, Howell, Michael, Lassailly, Francois, Thin, May Zaw, Spencer-Dene, Bradley, Stamp, Gordon, van den Broek, Niels J F, Mackay, Gillian, Bulusu, Vinay, Kamphorst, Jurre J, Tardito, Saverio, Strachan, David, Harris, Adrian L, Aboagye, Eric O, Critchlow, Susan E, Wakelam, Michael J O, Schulze, Almut, Gottlieb, Eyal

“…A functional genomics study revealed that the activity of acetyl-CoA synthetase 2 (ACSS2) contributes to cancer cell growth under low-oxygen and lipid-depleted…”
Get more information

Diacylglycerols and phosphatidates: which molecular species are intracellular messengers? by Hodgkin, Matthew N, Pettitt, Trevor R, Martin, Ashley, Michell, Robert H, Pemberton, Anthony J, Wakelam, Michael J.O

“…In eukaryotes, many receptor agonists use phospholipase-generated lipids as intracellular messengers. Receptor occupation stimulates the production of…”
Get full text

Mosaic overgrowth with fibroadipose hyperplasia is caused by somatic activating mutations in PIK3CA by Lindhurst, Marjorie J, Parker, Victoria E R, Payne, Felicity, Sapp, Julie C, Rudge, Simon, Harris, Julie, Witkowski, Alison M, Zhang, Qifeng, Groeneveld, Matthijs P, Scott, Carol E, Daly, Allan, Huson, Susan M, Tosi, Laura L, Cunningham, Michael L, Darling, Thomas N, Geer, Joseph, Gucev, Zoran, Sutton, V Reid, Tziotzios, Christos, Dixon, Adrian K, Helliwell, Timothy, O'Rahilly, Stephen, Savage, David B, Wakelam, Michael J O, Barroso, Inês, Biesecker, Leslie G, Semple, Robert K

“…Leslie Biesecker and colleagues report an exome sequencing study identifying somatic activating mutations in PIK3CA as the cause of a new progressive segmental…”
Get full text

Phospholipid signaling in innate immune cells by O’Donnell, Valerie B., Rossjohn, Jamie, Wakelam, Michael J.O.

“…Phospholipids comprise a large body of lipids that define cells and organelles by forming membrane structures. Importantly, their complex metabolism represents…”
Get full text

Host lipidome analysis during rhinovirus replication in HBECs identifies potential therapeutic targets by Nguyen, An, Guedán, Anabel, Mousnier, Aurelie, Swieboda, Dawid, Zhang, Qifeng, Horkai, Dorottya, Le Novere, Nicolas, Solari, Roberto, Wakelam, Michael J O

“…In patients with asthma or chronic obstructive pulmonary disease, rhinovirus (RV) infections can provoke acute worsening of disease, and limited treatment…”
Get full text

Autotaxin-lysophosphatidic acid receptor signalling regulates hepatitis C virus replication by Farquhar, Michelle J., Humphreys, Isla S., Rudge, Simon A., Wilson, Garrick K., Bhattacharya, Bishnupriya, Ciaccia, Maria, Hu, Ke, Zhang, Qifeng, Mailly, Laurent, Reynolds, Gary M., Ashcroft, Margaret, Balfe, Peter, Baumert, Thomas F., Roessler, Stephanie, Wakelam, Michael J.O., McKeating, Jane A.

“…[Display omitted] Chronic hepatitis C is a global health problem with an estimated 170 million hepatitis C virus (HCV) infected individuals at risk of…”
Get full text

Phosphatidylinositolphosphate phosphatase activities and cancer by Rudge, Simon A, Wakelam, Michael J O

“…Signaling through the phosphoinositide 3-kinase pathways mediates the actions of a plethora of hormones, growth factors, cytokines, and neurotransmitters upon…”
Get full text

Modulation of triglyceride and cholesterol ester synthesis impairs assembly of infectious hepatitis C virus by Liefhebber, Jolanda M P, Hague, Charlotte V, Zhang, Qifeng, Wakelam, Michael J O, McLauchlan, John

“…In hepatitis C virus infection, replication of the viral genome and virion assembly are linked to cellular metabolic processes. In particular, lipid droplets,…”
Get more information

Methods for analyzing phosphoinositides using mass spectrometry by Wakelam, Michael J.O., Clark, Jonathan

“…The polyphosphoinositides are key signaling lipids whose levels are tightly regulated within cells. As with other cellular lipids multiple species exist with…”
Get full text

Inter-regulatory dynamics of phospholipase D and the actin cytoskeleton by Rudge, Simon A., Wakelam, Michael J.O.

“…Phospholipase D activity has been extensively implicated in the regulation of the actin cytoskeleton. Through this regulation the enzyme controls a number of…”
Get full text