Search Results - "Vrijland, Kim"

Therapeutic targeting of macrophages enhances chemotherapy efficacy by unleashing type I interferon response by Salvagno, Camilla, Ciampricotti, Metamia, Tuit, Sander, Hau, Cheei-Sing, van Weverwijk, Antoinette, Coffelt, Seth B., Kersten, Kelly, Vrijland, Kim, Kos, Kevin, Ulas, Thomas, Song, Ji-Ying, Ooi, Chia-Huey, Rüttinger, Dominik, Cassier, Philippe A., Jonkers, Jos, Schultze, Joachim L., Ries, Carola H., de Visser, Karin E.

“…Recent studies have revealed a role for macrophages and neutrophils in limiting chemotherapy efficacy; however, the mechanisms underlying the therapeutic…”
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Tumor-educated Tregs drive organ-specific metastasis in breast cancer by impairing NK cells in the lymph node niche by Kos, Kevin, Aslam, Muhammad A., van de Ven, Rieneke, Wellenstein, Max D., Pieters, Wietske, van Weverwijk, Antoinette, Duits, Danique E.M., van Pul, Kim, Hau, Cheei-Sing, Vrijland, Kim, Kaldenbach, Daphne, Raeven, Elisabeth A.M., Quezada, Sergio A., Beyaert, Rudi, Jacobs, Heinz, de Gruijl, Tanja D., de Visser, Karin E.

“…Breast cancer is accompanied by systemic immunosuppression, which facilitates metastasis formation, but how this shapes organotropism of metastasis is poorly…”
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Mammary tumor-derived CCL2 enhances pro-metastatic systemic inflammation through upregulation of IL1β in tumor-associated macrophages by Kersten, Kelly, Coffelt, Seth B., Hoogstraat, Marlous, Verstegen, Niels J.M., Vrijland, Kim, Ciampricotti, Metamia, Doornebal, Chris W., Hau, Cheei-Sing, Wellenstein, Max D., Salvagno, Camilla, Doshi, Parul, Lips, Esther H., Wessels, Lodewyk F.A., de Visser, Karin E.

“…Patients with primary solid malignancies frequently exhibit signs of systemic inflammation. Notably, elevated levels of neutrophils and their associated…”
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Tumor-associated macrophages promote intratumoral conversion of conventional CD4+ T cells into regulatory T cells via PD-1 signalling by Kos, Kevin, Salvagno, Camilla, Wellenstein, Max D., Aslam, Muhammad A., Meijer, Denize A., Hau, Cheei-Sing, Vrijland, Kim, Kaldenbach, Daphne, Raeven, Elisabeth A.M., Schmittnaegel, Martina, Ries, Carola H., de Visser, Karin E.

“…While regulatory T cells (T regs ) and macrophages have been recognized as key orchestrators of cancer-associated immunosuppression, their cellular crosstalk…”
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Neoadjuvant immune checkpoint blockade triggers persistent and systemic Treg activation which blunts therapeutic efficacy against metastatic spread of breast tumors by Blomberg, Olga S., Kos, Kevin, Spagnuolo, Lorenzo, Isaeva, Olga I., Garner, Hannah, Wellenstein, Max D., Bakker, Noor, Duits, Danique E.M., Kersten, Kelly, Klarenbeek, Sjoerd, Hau, Cheei-Sing, Kaldenbach, Daphne, Raeven, Elisabeth A.M., Vrijland, Kim, Kok, Marleen, de Visser, Karin E.

“…The clinical successes of immune checkpoint blockade (ICB) in advanced cancer patients have recently spurred the clinical implementation of ICB in the…”
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The identification and developmental requirements of colonic CD169+ macrophages by Hiemstra, Ida H., Beijer, Marieke R., Veninga, Henrike, Vrijland, Kim, Borg, Ellen G. F., Olivier, Brenda J., Mebius, Reina E., Kraal, Georg, Haan, Joke M. M.

“…Summary CD169‐positive macrophages in the marginal zone of the spleen and subcapsular sinus of lymph nodes play an important role as gatekeepers, strategically…”
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Radiolabeled Monoclonal Antibody Against Colony-Stimulating Factor 1 Receptor Specifically Distributes to the Spleen and Liver in Immunocompetent Mice by Waaijer, Stijn J. H., Suurs, Frans V., Hau, Cheei-Sing, Vrijland, Kim, de Visser, Karin E., de Groot, Derk Jan A., de Vries, Elisabeth G. E., Lub-de Hooge, Marjolijn N., Schröder, Carolina P.

“…Macrophages can promote tumor development. Preclinically, targeting macrophages by colony-stimulating factor 1 (CSF1)/CSF1 receptor (CSF1R) monoclonal…”
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hMRP8-ATTAC Mice: A New Model for Conditional and Reversible Neutrophil Ablation by Duits, Danique E. M., Salvagno, Camilla, Raeven, Elisabeth A. M., Vrijland, Kim, Stip, Marjolein C., Hau, Cheei-Sing, Kaldenbach, Daphne, de Visser, Karin E.

“…Neutrophils are not only crucial immune cells for the neutralization of pathogens during infections, but they are also key players in tissue repair and cancer…”
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Intestinal epithelial cell transported TLR2 ligand stimulates Ly6C+ monocyte differentiation in a G-CSF dependent manner by Hiemstra, Ida H., Vrijland, Kim, Hogenboom, Marye M., Bouma, Gerd, Kraal, Georg, den Haan, Joke M.M.

“…Microflora-induced TLR signaling in the intestinal epithelium is essential for a proper intestinal barrier function. Because of the close interactions of this…”
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IL-17-producing γδ T cells and neutrophils conspire to promote breast cancer metastasis by Coffelt, Seth B., Kersten, Kelly, Doornebal, Chris W., Weiden, Jorieke, Vrijland, Kim, Hau, Cheei-Sing, Verstegen, Niels J. M., Ciampricotti, Metamia, Hawinkels, Lukas J. A. C., Jonkers, Jos, de Visser, Karin E.

“…Tumours maximize their chance of metastasizing by evoking a systemic inflammatory cascade in mouse models of spontaneous breast cancer metastasis. A novel…”
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IL-5-producing CD4 + T cells and eosinophils cooperate to enhance response to immune checkpoint blockade in breast cancer by Blomberg, Olga S, Spagnuolo, Lorenzo, Garner, Hannah, Voorwerk, Leonie, Isaeva, Olga I, van Dyk, Ewald, Bakker, Noor, Chalabi, Myriam, Klaver, Chris, Duijst, Maxime, Kersten, Kelly, Brüggemann, Marieke, Pastoors, Dorien, Hau, Cheei-Sing, Vrijland, Kim, Raeven, Elisabeth A M, Kaldenbach, Daphne, Kos, Kevin, Afonina, Inna S, Kaptein, Paulien, Hoes, Louisa, Theelen, Willemijn S M E, Baas, Paul, Voest, Emile E, Beyaert, Rudi, Thommen, Daniela S, Wessels, Lodewyk F A, de Visser, Karin E, Kok, Marleen

“…Immune checkpoint blockade (ICB) has heralded a new era in cancer therapy. Research into the mechanisms underlying response to ICB has predominantly focused on…”
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Understanding and reversing mammary tumor-driven reprogramming of myelopoiesis to reduce metastatic spread by Garner, Hannah, Martinovic, Moreno, Liu, Ning Qing, Bakker, Noor A M, Velilla, Irene Querol, Hau, Cheei-Sing, Vrijland, Kim, Kaldenbach, Daphne, Kok, Marleen, de Wit, Elzo, de Visser, Karin E

“…Tumor-induced systemic accumulation and polarization of neutrophils to an immunosuppressive phenotype is a potent driver of metastasis formation. Yet, how…”
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Tumor-educated T regs drive organ-specific metastasis in breast cancer by impairing NK cells in the lymph node niche by Kos, Kevin, Aslam, Muhammad A, van de Ven, Rieneke, Wellenstein, Max D, Pieters, Wietske, van Weverwijk, Antoinette, Duits, Danique E M, van Pul, Kim, Hau, Cheei-Sing, Vrijland, Kim, Kaldenbach, Daphne, Raeven, Elisabeth A M, Quezada, Sergio A, Beyaert, Rudi, Jacobs, Heinz, de Gruijl, Tanja D, de Visser, Karin E

“…Breast cancer is accompanied by systemic immunosuppression, which facilitates metastasis formation, but how this shapes organotropism of metastasis is poorly…”
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Loss of p53 triggers WNT-dependent systemic inflammation to drive breast cancer metastasis by Wellenstein, Max D., Coffelt, Seth B., Duits, Danique E. M., van Miltenburg, Martine H., Slagter, Maarten, de Rink, Iris, Henneman, Linda, Kas, Sjors M., Prekovic, Stefan, Hau, Cheei-Sing, Vrijland, Kim, Drenth, Anne Paulien, de Korte-Grimmerink, Renske, Schut, Eva, van der Heijden, Ingrid, Zwart, Wilbert, Wessels, Lodewyk F. A., Schumacher, Ton N., Jonkers, Jos, de Visser, Karin E.

“…Cancer-associated systemic inflammation is strongly linked to poor disease outcome in patients with cancer 1 , 2 . For most human epithelial tumour types, high…”
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Morphine does not facilitate breast cancer progression in two preclinical mouse models for human invasive lobular and HER2⁺ breast cancer by Doornebal, Chris W, Vrijland, Kim, Hau, Cheei-Sing, Coffelt, Seth B, Ciampricotti, Metamia, Jonkers, Jos, de Visser, Karin E, Hollmann, Markus W

“…Morphine and other opioid analgesics are potent pain-relieving agents routinely used for pain management in patients with cancer. However, these drugs have…”
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Rational design of DNA vaccines for the induction of human papillomavirus type 16 E6- and E7-specific cytotoxic T-cell responses by Oosterhuis, Koen, Aleyd, Esil, Vrijland, Kim, Schumacher, Ton N, Haanen, John B

“…Many DNA vaccine candidates have been developed for the treatment of human papillomavirus type 16 (HPV16)-induced malignancies. Most of these vaccines consist…”
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Neoadjuvant immune checkpoint blockade triggers persistent and systemic T reg activation which blunts therapeutic efficacy against metastatic spread of breast tumors by Blomberg, Olga S., Kos, Kevin, Spagnuolo, Lorenzo, Isaeva, Olga I., Garner, Hannah, Wellenstein, Max D., Bakker, Noor, Duits, Danique E.M., Kersten, Kelly, Klarenbeek, Sjoerd, Hau, Cheei-Sing, Kaldenbach, Daphne, Raeven, Elisabeth A.M., Vrijland, Kim, Kok, Marleen, de Visser, Karin E.

“…The clinical successes of immune checkpoint blockade (ICB) in advanced cancer patients have recently spurred the clinical implementation of ICB in the…”
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IL-17-producing [gamma][delta] T cells and neutrophils conspire to promote breast cancer metastasis by Coffelt, Seth B, Kersten, Kelly, Doornebal, Chris W, Weiden, Jorieke, Vrijland, Kim, Hau, Cheei-Sing, Verstegen, Niels J. M, Ciampricotti, Metamia, Hawinkels, Lukas J. A. C, Jonkers, Jos, de Visser, Karin E

“…Metastatic disease remains the primary cause of death for patients with breast cancer. The different steps of the metastatic cascade rely on reciprocal…”
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IL17-producing γδ T cells and neutrophils conspire to promote breast cancer metastasis by Coffelt, Seth B., Kersten, Kelly, Doornebal, Chris W., Weiden, Jorieke, Vrijland, Kim, Hau, Cheei-Sing, Verstegen, Niels J.M., Ciampricotti, Metamia, Hawinkels, Lukas J.A.C., Jonkers, Jos, de Visser, Karin E.

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Development of metastatic HER2+ breast cancer is independent of the adaptive immune system by Ciampricotti, Metamia, Vrijland, Kim, Hau, Cheei-Sing, Pemovska, Tea, Doornebal, Chris W, Speksnijder, Ewoud N, Wartha, Katharina, Jonkers, Jos, de Visser, Karin E

“…The tumour‐modulating effects of the endogenous adaptive immune system are rather paradoxical. Whereas some clinical and experimental observations offer…”
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