Suchergebnisse - "Vivalda, Francesca"
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H2AX promotes replication fork degradation and chemosensitivity in BRCA-deficient tumours
ISSN: 2041-1723, 2041-1723Veröffentlicht: London Nature Publishing Group UK 24.05.2024Veröffentlicht in Nature communications (24.05.2024)“… Histone H2AX plays a key role in DNA damage signalling in the surrounding regions of DNA double-strand breaks (DSBs). In response to DNA damage, H2AX becomes …”
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PLK1 regulates CtIP and DNA2 interplay in long-range DNA end resection
ISSN: 1549-5477, 1549-5477Veröffentlicht: United States 01.02.2023Veröffentlicht in Genes & development (01.02.2023)“… DNA double-strand break (DSB) repair is initiated by DNA end resection. CtIP acts in short-range resection to stimulate MRE11-RAD50-NBS1 (MRN) to …”
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Cancer-cell-derived cGAMP limits the activity of tumor-associated CD8+ T cells
ISSN: 2211-1247, 2211-1247Veröffentlicht: United States Elsevier Inc 22.04.2025Veröffentlicht in Cell reports (Cambridge) (22.04.2025)“… Using a mouse tumor model with inducible cancer-cell-intrinsic cyclic GMP-AMP (cGAMP) synthase (cGAS) expression, we show that cancer-cell-derived cGAMP is …”
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The PIN1–p38–CtIP signalling axis protects stalled replication forks from deleterious degradation
ISSN: 0305-1048, 1362-4962, 1362-4962Veröffentlicht: England Oxford University Press 10.04.2025Veröffentlicht in Nucleic acids research (10.04.2025)“… Abstract Human CtIP plays a critical role in homologous recombination (HR) by promoting the resection of DNA double-strand breaks. Moreover, CtIP maintains …”
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The PIN1-p38-CtIP signaling axis protects stalled replication forks from deleterious degradation
ISSN: 2692-8205Veröffentlicht: Cold Spring Harbor Laboratory 26.06.2024Veröffentlicht in bioRxiv (26.06.2024)“… Human CtIP plays a critical role in homologous recombination (HR) by promoting the resection of DNA double-strand breaks. Moreover, CtIP maintains genome …”
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H2AX promotes replication fork degradation and chemosensitivity in BRCA-deficient tumours
ISSN: 2692-8205Veröffentlicht: Cold Spring Harbor Laboratory 24.05.2023Veröffentlicht in bioRxiv (24.05.2023)“… Histone H2AX plays a key role in DNA damage signalling in the surrounding regions of DNA double-strand breaks (DSBs)1,2. In response to DNA damage, H2AX …”
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