Suchergebnisse - "Vink, A"

The impact of lentiviral vector genome size and producer cell genomic to gag-pol mRNA ratios on packaging efficiency and titre von Sweeney, Nathan P., Vink, Conrad A.

“… Lentiviral vectors are showing success in the clinic, but producing enough vector to meet the growing demand is a major challenge. Furthermore, next-generation …”
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PAM-repeat associations and spacer selection preferences in single and co-occurring CRISPR-Cas systems von Vink, Jochem N. A., Baijens, Jan H. L., Brouns, Stan J. J.

“… Background The adaptive CRISPR-Cas immune system stores sequences from past invaders as spacers in CRISPR arrays and thereby provides direct evidence that …”
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Truncating Titin (TTN) Variants in Chemotherapy-Induced Cardiomyopathy von Linschoten, M., Teske, A.J., Baas, A.F., Vink, A., Dooijes, D., Baars, H.F., Asselbergs, F.W.

“… •Truncating titin variants are found in chemotherapy-induced cardiomyopathy.•Phenotypic expression after chemotherapy illustrates a second-hit–like …”
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Manual vs. automatic assessment of the QT-interval and corrected QT von Neumann, Benjamin, Vink, A Suzanne, Hermans, Ben J M, Lieve, Krystien V V, Cömert, Didem, Beckmann, Britt-Maria, Clur, Sally-Ann B, Blom, Nico A, Delhaas, Tammo, Wilde, Arthur A M, Kääb, Stefan, Postema, Pieter G, Sinner, Moritz F

“… Abstract Aims Sudden cardiac death (SCD) is challenging to predict. Electrocardiogram (ECG)-derived heart rate-corrected QT-interval (QTc) is used for SCD-risk …”
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Visualisation of dCas9 target search in vivo using an open-microscopy framework von Martens, Koen J. A., van Beljouw, Sam P. B., van der Els, Simon, Vink, Jochem N. A., Baas, Sander, Vogelaar, George A., Brouns, Stan J. J., van Baarlen, Peter, Kleerebezem, Michiel, Hohlbein, Johannes

“… CRISPR-Cas9 is widely used in genomic editing, but the kinetics of target search and its relation to the cellular concentration of Cas9 have remained elusive …”
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Sankofa: Transcending the roots of incivility in professional nursing education in South Africa von Vink, Hildeguard J.-A., Sefotho, Maximus M.

“… Background Professional nursing started with Florence Nightingale, who opened a School of Nursing in the mid-1800s. Her traditions of cleanliness, caring, …”
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Altered effort and deconditioning are not valid explanations of myalgic encephalomyelitis/chronic fatigue syndrome von Davenport, Todd E., Scheibenbogen, Carmen, Zinn, Mark A., Dimmock, Mary, Stone, Janet, Tronstad, Karl J., Fluge, Øystein, Bergquist, Jonas, Stevens, Staci R., Tuller, David, Behrends, Uta, Van Ness, J. Mark, Vink, Mark A., Nacul, Luis

“… [...]the Institute of Medicine (IOM) cautioned that “a single CPET may be insufficient to document the abnormal response of ME/CFS patients to exercise.” …”
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The effect of music therapy compared with general recreational activities in reducing agitation in people with dementia: a randomised controlled trial von Vink, A. C., Zuidersma, M., Boersma, F., de Jonge, P., Zuidema, S. U., Slaets, J. P. J.

“… Objective This study aimed to compare the effects of music therapy with general recreational day activities in reducing agitation in people with dementia, …”
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Feasibility and safety of single-pulse ablation in 20 patients with atrial fibrillation von Loh, Peter, Groen, Marijn H A, Taha, Karim, Velthuis, Birgitta K, Fidder, Herma H, Vink, A, Wittkampf, Fred H M, Doevendans, Pieter A F M, van Es, René

“… Single-pulse ablation leads to irreversible electroporation (IRE) and has been introduced as a nonthermal ablation technology for pulmonary vein isolation …”
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Clinical progression of high-grade cervical intraepithelial neoplasia: estimating the time to preclinical cervical cancer from doubly censored national registry data von Vink, Margaretha A, Bogaards, Johannes A, van Kemenade, Folkert J, de Melker, Hester E, Meijer, Chris J L M, Berkhof, Johannes

“… Little is known about the time span of progression from high-grade cervical intraepithelial neoplasia (CIN2/3) to invasive cervical cancer. Estimation of this …”
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Efficient CRISPR-Cas13d-Based Antiviral Strategy to Combat SARS-CoV-2 von Hussein, Mouraya, Andrade dos Ramos, Zaria, Vink, Monique A., Kroon, Pascal, Yu, Zhenghao, Enjuanes, Luis, Zuñiga, Sonia, Berkhout, Ben, Herrera-Carrillo, Elena

“… The current SARS-CoV-2 pandemic forms a major global health burden. Although protective vaccines are available, concerns remain as new virus variants continue …”
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HIV-1 sequences in lentiviral vector genomes can be substantially reduced without compromising transduction efficiency von Sertkaya, Helin, Ficarelli, Mattia, Sweeney, Nathan P., Parker, Hannah, Vink, Conrad A., Swanson, Chad M.

“… Many lentiviral vectors used for gene therapy are derived from HIV-1. An optimal vector genome would include only the viral sequences required for transduction …”
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Optimizing the diagnostic yield of invasive coronary function testing von Vink, A Suzanne, Beijk, Marcel A M

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Limited destruction of renal nerves after catheter-based renal denervation: results of a human case study von Vink, Eva E, Goldschmeding, Roel, Vink, Aryan, Weggemans, Callista, Bleijs, Ronald L A W, Blankestijn, Peter J

“… Renal denervation (RDN) is a promising novel treatment for resistant hypertension. Effectiveness of treatment is, however, highly variable and unpredictable …”
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Combined brain-derived neurotrophic factor and neurotrophin-3 treatment is preferred over either one separately in the preservation of the auditory nerve in deafened guinea pigs von Vink, Henk A., Ramekers, Dyan, Thomeer, Hans G. X. M., Versnel, Huib

“… Severe hearing loss or deafness is often caused by cochlear hair cell loss and can be mitigated by a cochlear implant (CI). CIs target the auditory nerve, …”
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Growth patterns and cerebroplacental hemodynamics in fetuses with congenital heart disease von Mebius, M. J., Clur, S. A. B., Vink, A. S., Pajkrt, E., Kalteren, W. S., Kooi, E. M. W., Bos, A. F., du Marchie Sarvaas, G. J., Bilardo, C. M.

“… ABSTRACT Objectives Congenital heart disease (CHD) has been associated with reduced fetal head circumference (HC), although the underlying pathophysiology …”
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Safety and feasibility of arterial wall targeting with robot-assisted high intensity focused ultrasound: a preclinical study von Groen, M. H. A, Slieker, F. J. B, Vink, A., de Borst, G. J., Simons, M. V., Ebbini, E. S., Doevendans, P. A., Hazenberg, C. E. V. B., van Es, R.

“… High-intensity focused ultrasound (HIFU) is a potential noninvasive thermal ablation method for the treatment of peripheral artery disease. Dual-mode …”
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Single cell variability of CRISPR‐Cas interference and adaptation von McKenzie, Rebecca E, Keizer, Emma M, Vink, Jochem N A, van Lopik, Jasper, Büke, Ferhat, Kalkman, Vera, Fleck, Christian, Tans, Sander J, Brouns, Stan J J

“… While CRISPR‐Cas defence mechanisms have been studied on a population level, their temporal dynamics and variability in individual cells have remained unknown …”
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Imaging the intracranial atherosclerotic vessel wall using 7T MRI: initial comparison with histopathology von van der Kolk, A G, Zwanenburg, J J M, Denswil, N P, Vink, A, Spliet, W G M, Daemen, M J A P, Visser, F, Klomp, D W J, Luijten, P R, Hendrikse, J

“… Several studies have attempted to characterize intracranial atherosclerotic plaques by using MR imaging sequences. However, dedicated validation of these …”
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Myocardial Bridging as a Trigger in Angina With No Obstructive Coronary Artery Disease von Beijk, Marcel A.M., Woudstra, Janneke, Vink, A. Suzanne, Bijsterveld, Nick R., de Lind van Wijngaarden, Robert A.F., Klautz, Robert J.M.

“… We present 2 patients with angina with no obstructive coronary artery disease and concomitant myocardial bridging. Despite maximal tolerated pharmacotherapy, …”
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