Výsledky vyhľadávania - "Verrill, Clare"

Deep learning based tissue analysis predicts outcome in colorectal cancer Autor Bychkov, Dmitrii, Linder, Nina, Turkki, Riku, Nordling, Stig, Kovanen, Panu E., Verrill, Clare, Walliander, Margarita, Lundin, Mikael, Haglund, Caj, Lundin, Johan

“…Image-based machine learning and deep learning in particular has recently shown expert-level accuracy in medical image classification. In this study, we…”
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Automated quality assessment of large digitised histology cohorts by artificial intelligence Autor Haghighat, Maryam, Browning, Lisa, Sirinukunwattana, Korsuk, Malacrino, Stefano, Khalid Alham, Nasullah, Colling, Richard, Cui, Ying, Rakha, Emad, Hamdy, Freddie C., Verrill, Clare, Rittscher, Jens

“…Research using whole slide images (WSIs) of histopathology slides has increased exponentially over recent years. Glass slides from retrospective cohorts, some…”
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Artificial intelligence in digital pathology: a roadmap to routine use in clinical practice Autor Colling, Richard, Pitman, Helen, Oien, Karin, Rajpoot, Nasir, Macklin, Philip, Bachtiar, Velicia, Booth, Richard, Bryant, Alyson, Bull, Joshua, Bury, Jonathan, Carragher, Fiona, Colling, Richard, Collins, Graeme, Craig, Clare, da Silva, Maria Freitas, Gosling, Daniel, Jacobs, Jaco, Kajland‐Wilén, Lena, Karling, Johanna, Lawler, Darragh, Lee, Stephen, Macklin, Philip, Miller, Keith, Mozolowski, Guy, Nicholson, Richard, O'Connor, Daniel, Rahbek, Mikkel, Rajpoot, Nasir, Sumner, Alan, Vossen, Dirk, White, Kieron, Wing, Charlotte, Wright, Corrina, Snead, David, Sackville, Tony, Verrill, Clare

“…The use of artificial intelligence will transform clinical practice over the next decade and the early impact of this will likely be the integration of image…”
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Validation of grading of non-invasive urothelial carcinoma by digital pathology for routine diagnosis Autor Colling, Richard, Colling, Hayleigh, Browning, Lisa, Verrill, Clare

“…Background Pathological grading of non-invasive urothelial carcinoma has a direct impact upon management. This study evaluates the reproducibility of grading…”
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Tumour Seeding in the Tract of Percutaneous Renal Tumour Biopsy: A Report on Seven Cases from a UK Tertiary Referral Centre Autor Macklin, Philip S., Sullivan, Mark E., Tapping, Charles R., Cranston, David W., Webster, Guy M., Roberts, Ian S.D., Verrill, Clare L., Browning, Lisa

“…The role of percutaneous renal tumour biopsy (RTB) in the management of radiological indeterminate renal masses is long established. Patients with small renal…”
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WHO/ISUP grading of clear cell renal cell carcinoma and papillary renal cell carcinoma; validation of grading on the digital pathology platform and perspectives on reproducibility of grade Autor Browning, Lisa, Colling, Richard, Verrill, Clare

“…Background There are recognised potential pitfalls in digital diagnosis in urological pathology, including the grading of dysplasia. The World Health…”
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Inhibiting WEE1 Selectively Kills Histone H3K36me3-Deficient Cancers by dNTP Starvation Autor Pfister, Sophia X, Markkanen, Enni, Jiang, Yanyan, Sarkar, Sovan, Woodcock, Mick, Orlando, Giulia, Mavrommati, Ioanna, Pai, Chen-Chun, Zalmas, Lykourgos-Panagiotis, Drobnitzky, Neele, Dianov, Grigory L, Verrill, Clare, Macaulay, Valentine M, Ying, Songmin, La Thangue, Nicholas B, D'Angiolella, Vincenzo, Ryan, Anderson J, Humphrey, Timothy C

“…Histone H3K36 trimethylation (H3K36me3) is frequently lost in multiple cancer types, identifying it as an important therapeutic target. Here we identify a…”
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Potential quality pitfalls of digitalized whole slide image of breast pathology in routine practice Autor Atallah, Nehal M., Toss, Michael S., Verrill, Clare, Salto-Tellez, Manuel, Snead, David, Rakha, Emad A.

“…Using digitalized whole slide images (WSI) in routine histopathology practice is a revolutionary technology. This study aims to assess the clinical impacts of…”
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TET2 Drives 5hmc Marking of GATA6 and Epigenetically Defines Pancreatic Ductal Adenocarcinoma Transcriptional Subtypes Autor Eyres, Michael, Lanfredini, Simone, Xu, Haonan, Burns, Adam, Blake, Andrew, Willenbrock, Frances, Goldin, Robert, Hughes, Daniel, Hughes, Sophie, Thapa, Asmita, Vavoulis, Dimitris, Hubert, Aline, D'Costa, Zenobia, Sabbagh, Ahmad, Abraham, Aswin G, Blancher, Christine, Jones, Stephanie, Verrill, Clare, Silva, Michael, Soonawalla, Zahir, Maughan, Timothy, Schuh, Anna, Mukherjee, Somnath, O'Neill, Eric

“…Pancreatic ductal adenocarcinoma (PDAC) is characterized by advanced disease stage at presentation, aggressive disease biology, and resistance to therapy,…”
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Nuclear IGF1R Interacts with Regulatory Regions of Chromatin to Promote RNA Polymerase II Recruitment and Gene Expression Associated with Advanced Tumor Stage Autor Aleksic, Tamara, Gray, Nicki, Wu, Xiaoning, Rieunier, Guillaume, Osher, Eliot, Mills, Jack, Verrill, Clare, Bryant, Richard J, Han, Cheng, Hutchinson, Kathryn, Lambert, Adam G, Kumar, Rajeev, Hamdy, Freddie C, Weyer-Czernilofsky, Ulrike, Sanderson, Michael P, Bogenrieder, Thomas, Taylor, Stephen, Macaulay, Valentine M

“…Internalization of ligand-activated type I IGF receptor (IGF1R) is followed by recycling to the plasma membrane, degradation or nuclear translocation. Nuclear…”
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Deep learning based digital cell profiles for risk stratification of urine cytology images Autor Awan, Ruqayya, Benes, Ksenija, Azam, Ayesha, Song, Tzu‐Hsi, Shaban, Muhammad, Verrill, Clare, Tsang, Yee Wah, Snead, David, Minhas, Fayyaz, Rajpoot, Nasir

“…Urine cytology is a test for the detection of high‐grade bladder cancer. In clinical practice, the pathologist would manually scan the sample under the…”
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Lessons from a breast cell annotation competition series for school pupils Autor Lu, Wenqi, Miligy, Islam M., Minhas, Fayyaz, Park, Young Saeng, Snead, David R. J., Rakha, Emad A., Verrill, Clare, Rajpoot, Nasir

“…Due to COVID-19 outbreaks, most school pupils have had to be home-schooled for long periods of time. Two editions of a web-based competition “Beat the…”
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Artificial intelligence for advance requesting of immunohistochemistry in diagnostically uncertain prostate biopsies Autor Chatrian, Andrea, Colling, Richard T., Browning, Lisa, Alham, Nasullah Khalid, Sirinukunwattana, Korsuk, Malacrino, Stefano, Haghighat, Maryam, Aberdeen, Alan, Monks, Amelia, Moxley-Wyles, Benjamin, Rakha, Emad, Snead, David. R.J., Rittscher, Jens, Verrill, Clare

“…The use of immunohistochemistry in the reporting of prostate biopsies is an important adjunct when the diagnosis is not definite on haematoxylin and eosin…”
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Comparison of Prostate Biopsy with or without Prebiopsy Multiparametric Magnetic Resonance Imaging for Prostate Cancer Detection: An Observational Cohort Study Autor Bryant, Richard J, Hobbs, Catherine P, Eyre, Katie S, Davies, Lucy C, Sullivan, Mark E, Shields, William, Sooriakumaran, Prasanna, Verrill, Clare L, Gleeson, Fergus V, MacPherson, Ruth E, Hamdy, Freddie C, Brewster, Simon F

“…We hypothesized that 1) introducing prebiopsy multiparametric magnetic resonance imaging would increase the diagnostic yield of transrectal prostate biopsy and…”
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Hepatocyte Expression of the Senescence Marker p21 Is Linked to Fibrosis and an Adverse Liver-Related Outcome in Alcohol-Related Liver Disease Autor Aravinthan, Aloysious, Pietrosi, Giada, Hoare, Matthew, Jupp, James, Marshall, Aileen, Verrill, Clare, Davies, Susan, Bateman, Adrian, Sheron, Nick, Allison, Michael, Alexander, Graeme J. M.

“…Alcohol-related liver disease (ALD) remains a leading cause of liver-related morbidity and mortality. Age, fibrosis stage, MELD score and continued alcohol…”
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Genomic landscape of adult testicular germ cell tumours in the 100,000 Genomes Project Autor Ní Leathlobhair, Máire, Frangou, Anna, Kinnersley, Ben, Cornish, Alex J., Chubb, Daniel, Lakatos, Eszter, Arumugam, Prabhu, Gruber, Andreas J., Law, Philip, Tapinos, Avraam, Jakobsdottir, G. Maria, Peneva, Iliana, Sahli, Atef, Smyth, Evie M., Ball, Richard Y., Sylva, Rushan, Benes, Ksenija, Stark, Dan, Young, Robin J., Lee, Alexander T. J., Wolverson, Vincent, Houlston, Richard S., Sosinsky, Alona, Protheroe, Andrew, Murray, Matthew J., Wedge, David C., Verrill, Clare

“…Testicular germ cell tumours (TGCT), which comprise seminoma and non-seminoma subtypes, are the most common cancers in young men. In this study, we present a…”
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IGF-1 regulates cancer cell immune evasion in prostate cancer Autor Nandakumar, Ashwin M., Barberis, Alessandro, Kim, Jinseon, Lang, Cameron R., Mills, Jack V., Rieunier, Guillaume, Doultsinos, Dimitrios, Taylor, Avigail, Jainarayanan, Ashwin, Phyu, Su M., Campo, Leticia, Easton, Alistair, Parkes, Eileen E., James, Timothy, Hamdy, Freddie C., Verrill, Clare, Mills, Ian G., Macaulay, Valentine M.

“…Insulin-like growth factor-1 (IGF-1) is associated with prostate cancer (PCa) development and lethality and exhibits immunosuppressive properties in other…”
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Ductal variant prostate carcinoma is associated with a significantly shorter metastasis-free survival Autor Chow, Ken, Bedő, Justin, Ryan, Andrew, Agarwal, Dinesh, Bolton, Damien, Chan, Yee, Dundee, Philip, Frydenberg, Mark, Furrer, Marc A., Goad, Jeremy, Gyomber, Dennis, Hanegbi, Uri, Harewood, Laurence, King, Dennis, Lamb, Alastair D., Lawrentschuk, Nathan, Liodakis, Peter, Moon, Daniel, Murphy, Declan G., Peters, Justin S., Ruljancich, Paul, Verrill, Clare L., Webb, David, Wong, Lih-Ming, Zargar, Homayoun, Costello, Anthony J., Papenfuss, Anthony T., Hovens, Christopher M., Corcoran, Niall M.

“…Ductal adenocarcinoma is an uncommon prostate cancer variant. Previous studies suggest that ductal variant histology may be associated with worse clinical…”
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Spatial transcriptomic analysis of virtual prostate biopsy reveals confounding effect of tissue heterogeneity on genomic signatures Autor Figiel, Sandy, Yin, Wencheng, Doultsinos, Dimitrios, Erickson, Andrew, Poulose, Ninu, Singh, Reema, Magnussen, Anette, Anbarasan, Thineskrishna, Teague, Renuka, He, Mengxiao, Lundeberg, Joakim, Loda, Massimo, Verrill, Clare, Colling, Richard, Gill, Pelvender S., Bryant, Richard J., Hamdy, Freddie C., Woodcock, Dan J., Mills, Ian G., Cussenot, Olivier, Lamb, Alastair D.

“…Genetic signatures have added a molecular dimension to prognostics and therapeutic decision-making. However, tumour heterogeneity in prostate cancer and…”
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Increased EZH2 expression in prostate cancer is associated with metastatic recurrence following external beam radiotherapy Autor Wu, Xiaoning, Scott, Helen, Carlsson, Sigrid V., Sjoberg, Daniel D., Cerundolo, Lucia, Lilja, Hans, Prevo, Remko, Rieunier, Guillaume, Macaulay, Valentine, Higgins, Geoffrey S., Verrill, Clare L., Lamb, Alastair D., Cunliffe, Vincent T., Bountra, Chas, Hamdy, Freddie C., Bryant, Richard J.

“…Background Enhancer of zeste 2 (EZH2) promotes prostate cancer progression. We hypothesized that increased EZH2 expression is associated with postradiotherapy…”
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