Suchergebnisse - "Velds, Arno"

Drug-induced histone eviction from open chromatin contributes to the chemotherapeutic effects of doxorubicin von Pang, Baoxu, Qiao, Xiaohang, Janssen, Lennert, Velds, Arno, Groothuis, Tom, Kerkhoven, Ron, Nieuwland, Marja, Ovaa, Huib, Rottenberg, Sven, van Tellingen, Olaf, Janssen, Jeroen, Huijgens, Peter, Zwart, Wilbert, Neefjes, Jacques

“… DNA topoisomerase II inhibitors are a major class of cancer chemotherapeutics, which are thought to eliminate cancer cells by inducing DNA double-strand …”
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CopywriteR: DNA copy number detection from off-target sequence data von Kuilman, Thomas, Velds, Arno, Kemper, Kristel, Ranzani, Marco, Bombardelli, Lorenzo, Hoogstraat, Marlous, Nevedomskaya, Ekaterina, Xu, Guotai, de Ruiter, Julian, Lolkema, Martijn P, Ylstra, Bauke, Jonkers, Jos, Rottenberg, Sven, Wessels, Lodewyk F, Adams, David J, Peeper, Daniel S, Krijgsman, Oscar

“… Current methods for detection of copy number variants (CNV) and aberrations (CNA) from targeted sequencing data are based on the depth of coverage of captured …”
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Deciphering the glycosylome of dystroglycanopathies using haploid screens for lassa virus entry von Jae, Lucas T, Raaben, Matthijs, Riemersma, Moniek, van Beusekom, Ellen, Blomen, Vincent A, Velds, Arno, Kerkhoven, Ron M, Carette, Jan E, Topaloglu, Haluk, Meinecke, Peter, Wessels, Marja W, Lefeber, Dirk J, Whelan, Sean P, van Bokhoven, Hans, Brummelkamp, Thijn R

“… Glycosylated α-dystroglycan (α-DG) serves as cellular entry receptor for multiple pathogens, and defects in its glycosylation cause hereditary Walker-Warburg …”
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XenofilteR: computational deconvolution of mouse and human reads in tumor xenograft sequence data von Kluin, Roelof J. C., Kemper, Kristel, Kuilman, Thomas, de Ruiter, Julian R., Iyer, Vivek, Forment, Josep V., Cornelissen-Steijger, Paulien, de Rink, Iris, ter Brugge, Petra, Song, Ji-Ying, Klarenbeek, Sjoerd, McDermott, Ultan, Jonkers, Jos, Velds, Arno, Adams, David J., Peeper, Daniel S., Krijgsman, Oscar

“… Background Mouse xenografts from (patient-derived) tumors (PDX) or tumor cell lines are widely used as models to study various biological and preclinical …”
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A genomic and functional inventory of deubiquitinating enzymes von Nijman, Sebastian M B, Luna-Vargas, Mark P A, Velds, Arno, Brummelkamp, Thijn R, Dirac, Annette M G, Sixma, Titia K, Bernards, René

“… Posttranslational modification of proteins by the small molecule ubiquitin is a key regulatory event, and the enzymes catalyzing these modifications have been …”
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Transcription Factor NFIB Is a Driver of Small Cell Lung Cancer Progression in Mice and Marks Metastatic Disease in Patients von Semenova, Ekaterina A., Kwon, Min-chul, Monkhorst, Kim, Song, Ji-Ying, Bhaskaran, Rajith, Krijgsman, Oscar, Kuilman, Thomas, Peters, Dennis, Buikhuisen, Wieneke A., Smit, Egbert F., Pritchard, Colin, Cozijnsen, Miranda, van der Vliet, Jan, Zevenhoven, John, Lambooij, Jan-Paul, Proost, Natalie, van Montfort, Erwin, Velds, Arno, Huijbers, Ivo J., Berns, Anton

“… Small cell lung cancer (SCLC) is an aggressive neuroendocrine tumor, and no effective treatment is available to date. Mouse models of SCLC based on the …”
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Indisulam synergizes with palbociclib to induce senescence through inhibition of CDK2 kinase activity von Pogacar, Ziva, Johnson, Jackie L., Krenning, Lenno, De Conti, Giulia, Jochems, Fleur, Lieftink, Cor, Velds, Arno, Wardak, Leyma, Groot, Kelvin, Schepers, Arnout, Wang, Liqin, Song, Ji-Ying, van de Ven, Marieke, van Tellingen, Olaf, Medema, Rene H., Beijersbergen, Roderick L., Bernards, Rene, Leite de Oliveira, Rodrigo

“… Inducing senescence in cancer cells is emerging as a new therapeutic strategy. In order to find ways to enhance senescence induction by palbociclib, a CDK4/6 …”
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High-throughput identification of antigen-specific TCRs by TCR gene capture von Linnemann, Carsten, Heemskerk, Bianca, Kvistborg, Pia, Kluin, Roelof J C, Bolotin, Dmitriy A, Chen, Xiaojing, Bresser, Kaspar, Nieuwland, Marja, Schotte, Remko, Michels, Samira, Gomez-Eerland, Raquel, Jahn, Lorenz, Hombrink, Pleun, Legrand, Nicolas, Shu, Chengyi Jenny, Mamedov, Ilgar Z, Velds, Arno, Blank, Christian U, Haanen, John B A G, Turchaninova, Maria A, Kerkhoven, Ron M, Spits, Hergen, Hadrup, Sine Reker, Heemskerk, Mirjam H M, Blankenstein, Thomas, Chudakov, Dmitriy M, Bendle, Gavin M, Schumacher, Ton N M

“… The lack of robust and high-throughput technologies to analyze the human TCR repertoire has been a bottleneck in the analysis of human T cell responses …”
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Somatic loss of BRCA1 and p53 in mice induces mammary tumors with features of human BRCA1-mutated basal-like breast cancer von Liu, Xiaoling, Holstege, Henne, van der Gulden, Hanneke, Treur-Mulder, Marcelle, Zevenhoven, John, Velds, Arno, Kerkhoven, Ron M, van Vliet, Martin H, Wessels, Lodewyk F A, Peterse, Johannes L, Berns, Anton, Jonkers, Jos

“… Women carrying germ-line mutations in BRCA1 are strongly predisposed to developing breast cancers with characteristic features also observed in sporadic …”
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DRAG in situ barcoding reveals an increased number of HSPCs contributing to myelopoiesis with age von Urbanus, Jos, Cosgrove, Jason, Beltman, Joost B., Elhanati, Yuval, Moral, Rafael A., Conrad, Cecile, van Heijst, Jeroen W., Tubeuf, Emilie, Velds, Arno, Kok, Lianne, Merle, Candice, Magnusson, Jens P., Guyonnet, Léa, Frisén, Jonas, Fre, Silvia, Walczak, Aleksandra M., Mora, Thierry, Jacobs, Heinz, Schumacher, Ton N., Perié, Leïla

“… Ageing is associated with changes in the cellular composition of the immune system. During ageing, hematopoietic stem and progenitor cells (HSPCs) that produce …”
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A large-scale RNAi screen in human cells identifies new components of the p53 pathway von Berns, Katrien, Hijmans, E. Marielle, Mullenders, Jasper, Brummelkamp, Thijn R., Velds, Arno, Heimerikx, Mike, Kerkhoven, Ron M., Madiredjo, Mandy, Nijkamp, Wouter, Weigelt, Britta, Agami, Reuven, Ge, Wei, Cavet, Guy, Linsley, Peter S., Beijersbergen, Roderick L., Bernards, René

“… RNA interference (RNAi) is a powerful new tool with which to perform loss-of-function genetic screens in lower organisms and can greatly facilitate the …”
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Direct screening for chromatin status on DNA barcodes in yeast delineates the regulome of H3K79 methylation by Dot1 von Vlaming, Hanneke, Molenaar, Thom M, van Welsem, Tibor, Poramba-Liyanage, Deepani W, Smith, Desiree E, Velds, Arno, Hoekman, Liesbeth, Korthout, Tessy, Hendriks, Sjoerd, Altelaar, AF Maarten, van Leeuwen, Fred

“… Given the frequent misregulation of chromatin in cancer, it is important to understand the cellular mechanisms that regulate chromatin structure. However, …”
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Patient-Derived Organoid Models of Human Neuroendocrine Carcinoma von Dijkstra, Krijn K., van den Berg, José G., Weeber, Fleur, van de Haar, Joris, Velds, Arno, Kaing, Sovann, Peters, Dennis D. G. C., Eskens, Ferry A. L. M., de Groot, Derk-Jan A., Tesselaar, Margot E. T., Voest, Emile E.

“… Gastroenteropancreatic neuroendocrine carcinoma (GEP-NEC) is a poorly understood disease with limited treatment options. A better understanding of this disease …”
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Defining chromosomal translocation risks in cancer von Hogenbirk, Marc A, Heideman, Marinus R, de Rink, Iris, Velds, Arno, Kerkhoven, Ron M, Wessels, Lodewyk F A, Jacobs, Heinz

“… Chromosomal translocations are a hallmark of cancer. Unraveling the molecular mechanism of these rare genetic events requires a clear distinction between …”
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BRCA1-mutated and basal-like breast cancers have similar aCGH profiles and a high incidence of protein truncating TP53 mutations von Holstege, Henne, Horlings, Hugo M, Velds, Arno, Langerød, Anita, Børresen-Dale, Anne-Lise, van de Vijver, Marc J, Nederlof, Petra M, Jonkers, Jos

“… Background Basal-like breast cancers (BLBC) are aggressive breast cancers for which, so far, no targeted therapy is available because they typically lack …”
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Changes in gene expression associated with response to neoadjuvant chemotherapy in breast cancer von Hannemann, Juliane, Oosterkamp, Hendrika M, Bosch, Cathy A J, Velds, Arno, Wessels, Lodewyk F A, Loo, Claudette, Rutgers, Emiel J, Rodenhuis, Sjoerd, van de Vijver, Marc J

“… At present, clinically useful markers predicting response of primary breast carcinomas to either doxorubicin-cyclophosphamide (AC) or doxorubicin-docetaxel …”
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Differential Programming of B Cells in AID Deficient Mice von Hogenbirk, Marc A., Heideman, Marinus R., Velds, Arno, van den Berk, Paul CM, Kerkhoven, Ron M., van Steensel, Bas, Jacobs, Heinz

“… The Aicda locus encodes the activation induced cytidine deaminase (AID) and is highly expressed in germinal center (GC) B cells to initiate somatic …”
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Robust BRCA1-like classification of copy number profiles of samples repeated across different datasets and platforms von Schouten, Philip C., Grigoriadis, Anita, Kuilman, Thomas, Mirza, Hasan, Watkins, Johnathan A., Cooke, Saskia A., van Dyk, Ewald, Severson, Tesa M., Rueda, Oscar M., Hoogstraat, Marlous, Verhagen, Caroline V.M., Natrajan, Rachael, Chin, Suet-Feung, Lips, Esther H., Kruizinga, Janneke, Velds, Arno, Nieuwland, Marja, Kerkhoven, Ron M., Krijgsman, Oscar, Vens, Conchita, Peeper, Daniel, Nederlof, Petra M., Caldas, Carlos, Tutt, Andrew N., Wessels, Lodewyk F., Linn, Sabine C.

“… Breast cancers with BRCA1 germline mutation have a characteristic DNA copy number (CN) pattern. We developed a test that assigns CN profiles to be ‘BRCA1-like’ …”
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Cross-species comparison of aCGH data from mouse and human BRCA1- and BRCA2-mutated breast cancers von Holstege, Henne, van Beers, Erik, Velds, Arno, Liu, Xiaoling, Joosse, Simon A, Klarenbeek, Sjoerd, Schut, Eva, Kerkhoven, Ron, Klijn, Christiaan N, Wessels, Lodewyk FA, Nederlof, Petra M, Jonkers, Jos

“… Background Genomic gains and losses are a result of genomic instability in many types of cancers. BRCA1 - and BRCA2 -mutated breast cancers are associated with …”
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The T7-Primer Is a Source of Experimental Bias and Introduces Variability between Microarray Platforms von Kerkhoven, Ron M., Sie, Daoud, Nieuwland, Marja, Heimerikx, Mike, De Ronde, Jorma, Brugman, Wim, Velds, Arno

“… Eberwine(-like) amplification of mRNA adds distinct 6-10 bp nucleotide stretches to the 5' end of amplified RNA transcripts. Analysis of over six thousand …”
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