Suchergebnisse - "Vanhaelen, Quentin"

Web-based Tools for Drug Repurposing: Successful Examples of Collaborative Research von Vanhaelen, Quentin

“… Computational approaches have been proven to be complementary tools of interest in identifying potential candidates for drug repurposing. However, although the …”
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The cornucopia of meaningful leads: Applying deep adversarial autoencoders for new molecule development in oncology von Kadurin, Artur, Aliper, Alexander, Kazennov, Andrey, Mamoshina, Polina, Vanhaelen, Quentin, Khrabrov, Kuzma, Zhavoronkov, Alex

“… Recent advances in deep learning and specifically in generative adversarial networks have demonstrated surprising results in generating new images and videos …”
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Artificial intelligence for aging and longevity research: Recent advances and perspectives von Zhavoronkov, Alex, Mamoshina, Polina, Vanhaelen, Quentin, Scheibye-Knudsen, Morten, Moskalev, Alexey, Aliper, Alex

“… •Presentation of the most recent advances for the design of deep learned aging clocks.•Description of achievements in the development AI de novo molecular …”
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Design of efficient computational workflows for in silico drug repurposing von Vanhaelen, Quentin, Mamoshina, Polina, Aliper, Alexander M., Artemov, Artem, Lezhnina, Ksenia, Ozerov, Ivan, Labat, Ivan, Zhavoronkov, Alex

“… •Conceptual foundations of the drug repurposing paradigm are reviewed.•Description of the technological trends behind the raise of in silico repurposing.•The …”
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In silico Pathway Activation Network Decomposition Analysis (iPANDA) as a method for biomarker development von Ozerov, Ivan V., Lezhnina, Ksenia V., Izumchenko, Evgeny, Artemov, Artem V., Medintsev, Sergey, Vanhaelen, Quentin, Aliper, Alexander, Vijg, Jan, Osipov, Andreyan N., Labat, Ivan, West, Michael D., Buzdin, Anton, Cantor, Charles R., Nikolsky, Yuri, Borisov, Nikolay, Irincheeva, Irina, Khokhlovich, Edward, Sidransky, David, Camargo, Miguel Luiz, Zhavoronkov, Alex

“… Signalling pathway activation analysis is a powerful approach for extracting biologically relevant features from large-scale transcriptomic and proteomic data …”
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Forward and reverse genetics through derivation of haploid mouse embryonic stem cells von Elling, Ulrich, Taubenschmid, Jasmin, Wirnsberger, Gerald, O'Malley, Ronan, Demers, Simon-Pierre, Vanhaelen, Quentin, Shukalyuk, Andrey I, Schmauss, Gerald, Schramek, Daniel, Schnuetgen, Frank, von Melchner, Harald, Ecker, Joseph R, Stanford, William L, Zuber, Johannes, Stark, Alexander, Penninger, Josef M

“… All somatic mammalian cells carry two copies of chromosomes (diploidy), whereas organisms with a single copy of their genome, such as yeast, provide a basis …”
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Vive la radiorésistance!: converging research in radiobiology and biogerontology to enhance human radioresistance for deep space exploration and colonization von Cortese, Franco, Klokov, Dmitry, Osipov, Andreyan, Stefaniak, Jakub, Moskalev, Alexey, Schastnaya, Jane, Cantor, Charles, Aliper, Alexander, Mamoshina, Polina, Ushakov, Igor, Sapetsky, Alex, Vanhaelen, Quentin, Alchinova, Irina, Karganov, Mikhail, Kovalchuk, Olga, Wilkins, Ruth, Shtemberg, Andrey, Moreels, Marjan, Baatout, Sarah, Izumchenko, Evgeny, de Magalhães, João Pedro, Artemov, Artem V, Costes, Sylvain V, Beheshti, Afshin, Mao, Xiao Wen, Pecaut, Michael J, Kaminskiy, Dmitry, Ozerov, Ivan V, Scheibye-Knudsen, Morten, Zhavoronkov, Alex

“… While many efforts have been made to pave the way toward human space colonization, little consideration has been given to the methods of protecting spacefarers …”
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Towards AI-driven longevity research: An overview von Marino, Nicola, Putignano, Guido, Cappilli, Simone, Chersoni, Emmanuele, Santuccione, Antonella, Calabrese, Giuliana, Bischof, Evelyne, Vanhaelen, Quentin, Zhavoronkov, Alex, Scarano, Bryan, Mazzotta, Alessandro D., Santus, Enrico

“… While in the past technology has mostly been utilized to store information about the structural configuration of proteins and molecules for research and …”
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COVIDomic: A multi-modal cloud-based platform for identification of risk factors associated with COVID-19 severity von Naumov, Vladimir, Putin, Evgeny, Pushkov, Stefan, Kozlova, Ekaterina, Romantsov, Konstantin, Kalashnikov, Alexander, Galkin, Fedor, Tihonova, Nina, Shneyderman, Anastasia, Galkin, Egor, Zinkevich, Arsenii, Cope, Stephanie M., Sethuraman, Ramanathan, Oprea, Tudor I., Pearson, Alexander T., Tay, Savas, Agrawal, Nishant, Dubovenko, Alexey, Vanhaelen, Quentin, Ozerov, Ivan, Aliper, Alex, Izumchenko, Evgeny, Zhavoronkov, Alex

“… Coronavirus disease 2019 (COVID-19) is an acute infection of the respiratory tract that emerged in December 2019 in Wuhan, China. It was quickly established …”
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Some results about the structural properties of the Wnt pathway, its steady states and its non-associative commutative algebra von Vanhaelen, Quentin

“… We consider a reaction network of the Wnt pathway endowed with mass-action kinetics. Using concepts in the theory of robustness and stability within Chemical …”
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Generic algebraic conditions for the occurrence of switch-like behavior of a chemical kinetic system of the hypoxia pathway von Vanhaelen, Quentin

“… Weakly reversible chemical reaction networks with zero deficiency associated with mass-action kinetics admit, within each positive stoichiometric compatibility …”
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Thermo-capillary effects along a deformable singular interface between two immiscible fluids von Vanhaelen, Quentin

“… In this paper, we study the onset of instabilities triggered by the thermo-capillary effect along an isotropic material deformable interface between two …”
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Entropy production, thermodynamic fluxes and transport coefficients of an interface between two electromagnetic fluids with spin von Vanhaelen, Quentin

“… The purpose of this wok is to obtain a complete description of the entropy production within the framework of non equilibrium thermodynamics for the case of an …”
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Temperature and velocity profiles along a singular interface between two immiscible fluids von Vanhaelen, Quentin

“… Bedeaux, Albano, and Mazur (BAM) have developed a convenient method to derive the boundary conditions for non‐equilibrium thermodynamic systems made of two …”
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Multimodal Transformers and Their Applications in Drug Target Discovery for Aging and Age-Related Diseases von Steurer, Barbara, Vanhaelen, Quentin, Zhavoronkov, Alex

“… Abstract Given the unprecedented rate of global aging, advancing aging research and drug discovery to support healthy and productive longevity is a pressing …”
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The Advent of Generative Chemistry von Vanhaelen, Quentin, Lin, Yen-Chu, Zhavoronkov, Alex

“… Generative adversarial networks (GANs), first published in 2014, are among the most important concepts in modern artificial intelligence (AI). Bridging deep …”
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Will Artificial Intelligence for Drug Discovery Impact Clinical Pharmacology? von Zhavoronkov, Alex, Vanhaelen, Quentin, Oprea, Tudor I.

“… As the field of artificial intelligence and machine learning (AI/ML) for drug discovery is rapidly advancing, we address the question “What is the impact of …”
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Adversarial Threshold Neural Computer for Molecular de Novo Design von Putin, Evgeny, Asadulaev, Arip, Vanhaelen, Quentin, Ivanenkov, Yan, Aladinskaya, Anastasia V, Aliper, Alex, Zhavoronkov, Alex

“… In this article, we propose the deep neural network Adversarial Threshold Neural Computer (ATNC). The ATNC model is intended for the de novo design of novel …”
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Artificial intelligence, drug repurposing and peer review von Levin, Jeremy M, Oprea, Tudor I, Davidovich, Sagie, Clozel, Thomas, Overington, John P, Vanhaelen, Quentin, Cantor, Charles R, Bischof, Evelyne, Zhavoronkov, Alex

“… Can traditional computational analysis and machine learning help compensate for inadequate peer review of drug-repurposing papers in the context of an …”
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The conundrum of human immune system “senescence” von Pawelec, Graham, Bronikowski, Anne, Cunnane, Stephen C., Ferrucci, Luigi, Franceschi, Claudio, Fülöp, Tamas, Gaudreau, Pierrette, Gladyshev, Vadim N., Gonos, Efstathios S., Gorbunova, Vera, Kennedy, Brian K., Larbi, Anis, Lemaître, Jean-François, Liu, Guang-Hui, Maier, Andrea B., Morais, José A., Nóbrega, Otávio T., Moskalev, Alexey, Rikkert, Marcel Olde, Seluanov, Andrei, Senior, Alistair M., Ukraintseva, Svetlana, Vanhaelen, Quentin, Witkowski, Jacek, Cohen, Alan A.

“… •Biomarkers of human immunosenescence are discussed.•Longitudinal studies are essential.•Associations of immune markers in older adults with clinical outcome …”
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