Výsledky vyhľadávania - "Vanderwal, Christopher D"

Stereoselective Halogenation in Natural Product Synthesis Autor Chung, Won-jin, Vanderwal, Christopher D.

“…At last count, nearly 5000 halogenated natural products have been discovered. In approximately half of these compounds, the carbon atom to which the halogen is…”
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Stereocontrolled Radical Bicyclizations of Oxygenated Precursors Enable Short Syntheses of Oxidized Abietane Diterpenoids Autor Vrubliauskas, Darius, Gross, Benjamin M, Vanderwal, Christopher D

“…The power of cation-initiated cyclizations of polyenes for the synthesis of polycyclic terpenoids cannot be overstated. However, a major limitation is the…”
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A Synthesis of Alsmaphorazine B Demonstrates the Chemical Feasibility of a New Biogenetic Hypothesis Autor Hong, Allen Y., Vanderwal, Christopher D.

“…An N-oxide fragmentation/hydroxylamine oxidation/intramolecular 1,3-dipolar cycloaddition. Cascade, efficiently converted an oxidized congener of akuammicine…”
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Site-Selective Aliphatic C-H Chlorination Using N-Chloroamides Enables a Synthesis of Chlorolissoclimide Autor Quinn, Ryan K., Koenst, Zef A., Michalak, Sharon E., Schmidt, Yvonne, Szklarski, Anne R., Flores, Alex R., Nam, Sangkil, Horne, David A., Vanderwal, Christopher D., Alexanian, Erik J.

“…Methods for the practical, intermolecular functionalization of aliphatic C-H bonds remain a paramount goal of organic synthesis. Free radical alkane…”
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Hydrogen‐Atom‐Transfer‐Initiated Radical/Polar Crossover Annulation Cascade for Expedient Access to Complex Tetralins Autor Johnson, Lucas K., Barnes, Griffin L., Fernandez, Sebastian A., Vanderwal, Christopher D.

“…A radical/polar crossover annulation between allyl‐substituted arenes and electron‐deficient alkenes is described. Cobalt‐catalyzed hydrogen atom transfer…”
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Approaches to the chemical synthesis of the chlorosulfolipids Autor Chung, Won-Jin, Vanderwal, Christopher D

“…Since the initial discovery of the chlorosulfolipids in 1969, the chemical synthesis community largely ignored these compounds for nearly four decades, perhaps…”
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Evolution of a Short and Stereocontrolled Synthesis of (+)-7,20-Diisocyanoadociane Autor Roosen, Philipp C., Karns, Alexander S., Ellis, Bryan D., Vanderwal, Christopher D.

“…A full account of the development of a concise and highly stereoselective synthesis of (+)-7,20-diisocyanoadociane (DICA)-a structurally complex…”
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A Chlorine-Atom-Controlled Terminal-Epoxide-Initiated Bicyclization Cascade Enables a Synthesis of the Potent Cytotoxins Haterumaimides J and K Autor Michalak, Sharon E., Nam, Sangkil, Kwon, David M., Horne, David A., Vanderwal, Christopher D.

“…Haterumaimide J (hatJ) is reportedly the most cytotoxic member of the lissoclimide family of labdane diterpenoids. The unusual functional group arrangement of…”
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Synthesis and Potent Antimalarial Activity of Kalihinol B Autor Daub, Mary Elisabeth, Prudhomme, Jacques, Le Roch, Karine, Vanderwal, Christopher D

“…Of the 50+ kalihinane diterpenoids reported to date, only five had been tested for antimalarial activity, in spite of the fact that kalihinol A is the most…”
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General Approach to the Synthesis of the Chlorosulfolipids Danicalipin A, Mytilipin A, and Malhamensilipin A in Enantioenriched Form Autor Chung, Won-jin, Carlson, Joseph S, Vanderwal, Christopher D

“…A second-generation synthesis of three structurally related chloro­sulfolipids has been developed. Key advances include highly stereo­controlled additions to…”
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Syntheses of Strychnine, Norfluorocurarine, Dehydrodesacetylretuline, and Valparicine Enabled by Intramolecular Cycloadditions of Zincke Aldehydes Autor Martin, David B. C., Nguyen, Lucas Q., Vanderwal, Christopher D.

“…A full account of the development of the base-mediated intramolecular Diets-Alder cycloadditions of tryptamine-derived Zincke aldehydes is described. This…”
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Strategies for the Synthesis of the Halenaquinol and Xestoquinol Families of Natural Products Autor Schwarzwalder, Gregg M., Vanderwal, Christopher D.

“…The halenaquinol family of naphthoquinol natural products includes a few closely related polycyclic compounds that each feature an activated, electrophilic…”
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Dopaminergic Control of Striatal Cholinergic Interneurons Underlies Cocaine-Induced Psychostimulation Autor Lewis, Robert G., Serra, Marcello, Radl, Daniela, Gori, Michela, Tran, Catherine, Michalak, Sharon E., Vanderwal, Christopher D., Borrelli, Emiliana

“…Cocaine drastically elevates dopamine (DA) levels in the striatum, a brain region that is critical to the psychomotor and rewarding properties of the drug. DA…”
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Efficient Access to the Core of the Strychnos, Aspidosperma and Iboga Alkaloids. A Short Synthesis of Norfluorocurarine Autor Martin, David B. C., Vanderwal, Christopher D.

“…An efficient anionic bicyclization of tryptamine-derived Zincke aldehydes forms the basis for a three-step route to the tetracyclic ABCE core of many…”
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Concise Synthesis of the Antiplasmodial Isocyanoterpene 7,20‐Diisocyanoadociane Autor Karns, Alexander S., Ellis, Bryan D., Roosen, Philipp C., Chahine, Zeinab, Le Roch, Karine G., Vanderwal, Christopher D.

“…The flagship member of the antiplasmodial isocyanoterpenes, 7,20‐diisocyanoadociane (DICA), was synthesized from dehydrocryptone in 10 steps, and in 13 steps…”
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Unraveling the mechanism of cascade reactions of zincke aldehydes Autor Paton, Robert S, Steinhardt, Sarah E, Vanderwal, Christopher D, Houk, K N

“…The thermal pericyclic cascade rearrangement of Zincke aldehydes (5-(dialkylamino)-2,4-pentadienals) to afford Z-α,β,γ,δ-unsaturated amides discovered by the…”
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A Synthesis of the Chlorosulfolipid Mytilipin A via a Longest Linear Sequence of Seven Steps Autor Chung, Won-jin, Carlson, Joseph S., Bedke, D. Karl, Vanderwal, Christopher D.

“…Magnificent seven: The chlorosulfolipid mytilipin A was synthesized in racemic form in seven steps and in enantioenriched form in eight steps. Key…”
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Synthesis facilitates an understanding of the structural basis for translation inhibition by the lissoclimides Autor Könst, Zef A., Szklarski, Anne R., Pellegrino, Simone, Michalak, Sharon E., Meyer, Mélanie, Zanette, Camila, Cencic, Regina, Nam, Sangkil, Voora, Vamsee K., Horne, David A., Pelletier, Jerry, Mobley, David L., Yusupova, Gulnara, Yusupov, Marat, Vanderwal, Christopher D.

“…The lissoclimides are unusual succinimide-containing labdane diterpenoids that were reported to be potent cytotoxins. Our short semisynthesis and…”
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A Synthesis of Exiguaquinol Dessulfate Autor Schwarzwalder, Gregg M., Scott, David R., Vanderwal, Christopher D.

“…A concise and stereoselective synthesis of exiguaquinol dessulfate is described. Sequential application of a Diels–Alder cycloaddition, a desymmetrizing aldol…”
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A Novel Polyhalogenated Monoterpene Induces Cell Cycle Arrest and Apoptosis in Breast Cancer Cells Autor El Gaafary, Menna, Hafner, Susanne, Lang, Sophia J., Jin, Lu, Sabry, Omar M., Vogel, Carl V., Vanderwal, Christopher D., Syrovets, Tatiana, Simmet, Thomas

“…Breast cancer is the most common cancer type and a primary cause of cancer mortality among females worldwide. Here, we analyzed the anticancer efficacy of a…”
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