Výsledky vyhľadávania - "Vanderhyden, Barbara C"

Context specificity of the EMT transcriptional response Autor Cook, David P., Vanderhyden, Barbara C.

“…Epithelial–mesenchymal plasticity contributes to many biological processes, including tumor progression. Various epithelial–mesenchymal transition (EMT)…”
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Single cell transcriptomic analysis of murine lung development on hyperoxia-induced damage Autor Hurskainen, Maria, Mižíková, Ivana, Cook, David P., Andersson, Noora, Cyr-Depauw, Chanèle, Lesage, Flore, Helle, Emmi, Renesme, Laurent, Jankov, Robert P., Heikinheimo, Markku, Vanderhyden, Barbara C., Thébaud, Bernard

“…During late lung development, alveolar and microvascular development is finalized to enable sufficient gas exchange. Impaired late lung development manifests…”
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Epithelial ovarian cancer stem cells: underlying complexity of a simple paradigm Autor Garson, Kenneth, Vanderhyden, Barbara C

“…The lack of significant progress in the treatment of epithelial ovarian cancer (EOC) underscores the need to gain a better understanding of the processes that…”
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Bidirectional communication between oocytes and follicle cells: ensuring oocyte developmental competence Autor Kidder, Gerald M, Vanderhyden, Barbara C

“…Female fertility is determined to a large extent by the quality (developmental competence) of the oocyte as reflected in its ability to undergo meiosis, be…”
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miR-590-3p Promotes Ovarian Cancer Growth and Metastasis via a Novel FOXA2-Versican Pathway Autor Salem, Mohamed, O'Brien, Jacob A, Bernaudo, Stefanie, Shawer, Heba, Ye, Gang, Brkić, Jelena, Amleh, Asma, Vanderhyden, Barbara C, Refky, Basel, Yang, Burton B, Krylov, Sergey N, Peng, Chun

“…miRNAs play important roles in gene regulation, and their dysregulation is associated with many diseases, including epithelial ovarian cancer (EOC). In this…”
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Metformin prevents age-associated ovarian fibrosis by modulating the immune landscape in female mice Autor Landry, David A., Yakubovich, Edward, Cook, David P., Fasih, Sijyl, Upham, Jeremy, Vanderhyden, Barbara C.

“…Ovarian fibrosis is a pathological condition associated with aging and is responsible for a variety of ovarian dysfunctions. Given the known contributions of…”
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Transcriptional census of epithelial-mesenchymal plasticity in cancer Autor Cook, David P., Vanderhyden, Barbara C.

“…Epithelial-mesenchymal plasticity is a prevalent source of intratumoral heterogeneity, driven by diverse molecular programs. Epithelial-mesenchymal plasticity…”
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Metformin Abrogates Age-Associated Ovarian Fibrosis Autor McCloskey, Curtis W, Cook, David P, Kelly, Brendan S, Azzi, Feryel, Allen, Christian H, Forsyth, Amanda, Upham, Jeremy, Rayner, Katey J, Gray, Douglas A, Boyd, Robert W, Murugkar, Sangeeta, Lo, Bryan, Trudel, Dominique, Senterman, Mary K, Vanderhyden, Barbara C

“…The ovarian cancer risk factors of age and ovulation are curious because ovarian cancer incidence increases in postmenopausal women, long after ovulations have…”
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Transcriptional regulation of the postnatal cardiac conduction system heterogeneity Autor Oh, Yena, Abid, Rimshah, Dababneh, Saif, Bakr, Marwan, Aslani, Termeh, Cook, David P., Vanderhyden, Barbara C., Park, Jin G., Munshi, Nikhil V., Hui, Chi-Chung, Kim, Kyoung-Han

“…The cardiac conduction system (CCS) is a network of specialized cardiomyocytes that coordinates electrical impulse generation and propagation for synchronized…”
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The Oncolytic Poxvirus JX-594 Selectively Replicates in and Destroys Cancer Cells Driven by Genetic Pathways Commonly Activated in Cancers Autor Parato, Kelley A, Breitbach, Caroline J, Le Boeuf, Fabrice, Wang, Jiahu, Storbeck, Chris, Ilkow, Carolina, Diallo, Jean-Simon, Falls, Theresa, Burns, Joseph, Garcia, Vanessa, Kanji, Femina, Evgin, Laura, Hu, Kang, Paradis, Francois, Knowles, Shane, Hwang, Tae-Ho, Vanderhyden, Barbara C, Auer, Rebecca, Kirn, David H, Bell, John C

“…Oncolytic viruses are generally designed to be cancer selective on the basis of a single genetic mutation. JX-594 is a thymidine kinase (TK) gene-inactivated…”
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FGL2 promotes tumour growth and attenuates infiltration of activated immune cells in melanoma and ovarian cancer models Autor Galpin, Kristianne J. C., Rodriguez, Galaxia M., Maranda, Vincent, Cook, David P., Macdonald, Elizabeth, Murshed, Humaira, Zhao, Shan, McCloskey, Curtis W., Chruscinski, Andrzej, Levy, Gary A., Ardolino, Michele, Vanderhyden, Barbara C.

“…The tumour microenvironment is infiltrated by immunosuppressive cells, such as regulatory T cells (Tregs), which contribute to tumour escape and impede…”
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Mesenchymal ovarian cancer cells promote CD8+ T cell exhaustion through the LGALS3-LAG3 axis Autor Yakubovich, Edward, Cook, David P., Rodriguez, Galaxia M., Vanderhyden, Barbara C.

“…Cancer cells often metastasize by undergoing an epithelial-mesenchymal transition (EMT). Although abundance of CD8 + T-cells in the tumor microenvironment…”
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17β‐estradiol upregulates GREB1 and accelerates ovarian tumor progression in vivo Autor Laviolette, Laura A., Hodgkinson, Kendra M., Minhas, Neha, Perez‐Iratxeta, Carol, Vanderhyden, Barbara C.

“…Exogenous 17β‐estradiol (E2) accelerates the progression of ovarian cancer in the transgenic tgCAG‐LS‐TAg mouse model of the disease. We hypothesized that E2…”
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Transglutaminase 2 regulates ovarian cancer metastasis by modulating the immune microenvironment Autor Ibrahim, Dalia, Grondin, Melanie, Galpin, Kristianne, Asif, Sara, Thompson, Emily, Nersesian, Sarah, Abou-Hamad, John, Echaibi, Maryam, Rodriguez, Galaxia M., Navals, Pauline, Macdonald, Elizabeth, Ryan, Brianna, Cook, David P., Keillor, Jeffrey W., Vanderhyden, Barbara C.

“…Ovarian cancer is the most lethal gynecological malignancy. Deepening our knowledge of the interactions within the tumor microenvironment (TME) is important…”
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Oocyte-granulosa cell interactions during mouse follicular development: regulation of kit ligand expression and its role in oocyte growth Autor Thomas, Fiona H, Vanderhyden, Barbara C

“…Ovarian folliculogenesis is regulated by both endocrine and intraovarian mechanisms that coordinate the processes of oocyte growth and somatic cell…”
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Genetic determinants of FOXM1 overexpression in epithelial ovarian cancer and functional contribution to cell cycle progression Autor Barger, Carter J, Zhang, Wa, Hillman, Joanna, Stablewski, Aimee B, Higgins, Michael J, Vanderhyden, Barbara C, Odunsi, Kunle, Karpf, Adam R

“…The FOXM1 transcription factor network is frequently activated in high-grade serous ovarian cancer (HGSOC), the most common and lethal subtype of epithelial…”
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NLRC5 overexpression in ovarian tumors remodels the tumor microenvironment and increases T-cell reactivity toward autologous tumor-associated antigens Autor Rodriguez, Galaxia M., Yakubovich, Edward, Murshed, Humaira, Maranda, Vincent, Galpin, Kristianne J.C., Cudmore, Alison, Hanna, Andrew M. R., Macdonald, Elizabeth, Ramesh, Shashankan, Garson, Kenneth, Vanderhyden, Barbara C.

“…Epithelial ovarian cancer (OC) stands as one of the deadliest gynecologic malignancies, urgently necessitating novel therapeutic strategies. Approximately 60%…”
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17β-Estradiol sensitizes ovarian surface epithelium to transformation by suppressing Disabled-2 expression Autor Vuong, Nhung H., Salah Salah, Omar, Vanderhyden, Barbara C.

“…Estrogen replacement therapy increases the risk of human ovarian cancer and exogenous estradiol accelerates the onset of ovarian cancer in mouse models. This…”
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BRCA1 and BRCA2 deficient tumour models generate distinct ovarian tumour microenvironments and differential responses to therapy Autor Farokhi Boroujeni, Salar, Rodriguez, Galaxia, Galpin, Kristianne, Yakubovich, Edward, Murshed, Humaira, Ibrahim, Dalia, Asif, Sara, Vanderhyden, Barbara C.

“…Clinical trials are currently exploring combinations of PARP inhibitors and immunotherapies for the treatment of ovarian cancer, but their effects on the…”
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Activating Transcription Factor 3 as a Novel Regulator of Chemotherapy Response in Breast Cancer Autor Hasim, Mohamed S., Nessim, Carolyn, Villeneuve, Patrick J., Vanderhyden, Barbara C., Dimitroulakos, Jim

“…Anthracyclines, such as doxorubicin, are used as first-line chemotherapeutics, usually in combination therapies, for the treatment of advanced breast cancer…”
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