Suchergebnisse - "Utani, Koichi"

Generation of a recombinant Saffold Virus expressing UnaG as a marker for the visualization of viral infection von Okuwa, Takako, Himeda, Toshiki, Utani, Koichi, Higuchi, Masaya

“… Background Saffold virus (SAFV), which belongs to the genus Cardiovirus of the family Picornaviridae , is associated with acute respiratory or gastrointestinal …”
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Dynamics of replication origin over-activation von Fu, Haiqing, Redon, Christophe E., Thakur, Bhushan L., Utani, Koichi, Sebastian, Robin, Jang, Sang-Min, Gross, Jacob M., Mosavarpour, Sara, Marks, Anna B., Zhuang, Sophie Z., Lazar, Sarah B., Rao, Mishal, Mencer, Shira T., Baris, Adrian M., Pongor, Lorinc S., Aladjem, Mirit I.

“… Safeguards against excess DNA replication are often dysregulated in cancer, and driving cancer cells towards over-replication is a promising therapeutic …”
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Variation in human chromosome 21 ribosomal RNA genes characterized by TAR cloning and long-read sequencing von Kim, Jung-Hyun, Dilthey, Alexander T, Nagaraja, Ramaiah, Lee, Hee-Sheung, Koren, Sergey, Dudekula, Dawood, Wood III, William H, Piao, Yulan, Ogurtsov, Aleksey Y, Utani, Koichi, Noskov, Vladimir N, Shabalina, Svetlana A, Schlessinger, David, Phillippy, Adam M, Larionov, Vladimir

“… Abstract Despite the key role of the human ribosome in protein biosynthesis, little is known about the extent of sequence variation in ribosomal DNA (rDNA) or …”
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SIRT1 stabilizes extrachromosomal gene amplification and contributes to repeat-induced gene silencing von Taniguchi, Ryonosuke, Utani, Koichi, Thakur, Bhushan, Ishine, Kazuho, Aladjem, Mirit I., Shimizu, Noriaki

“… Sirtuin 1 (SIRT1) is a protein deacetylase that maintains genome stability by preventing the activation of latent replication origins. Amplified genes in …”
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Convergence of SIRT1 and ATR signaling to modulate replication origin dormancy von Thakur, Bhushan L, Baris, Adrian M, Fu, Haiqing, Redon, Christophe E, Pongor, Lorinc S, Mosavarpour, Sara, Gross, Jacob M, Jang, Sang-Min, Sebastian, Robin, Utani, Koichi, Jenkins, Lisa M, Indig, Fred E, Aladjem, Mirit I

“… During routine genome duplication, many potential replication origins remain inactive or ‘dormant’. Such origin dormancy is achieved, in part, by an …”
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The replication initiation determinant protein (RepID) modulates replication by recruiting CUL4 to chromatin von Jang, Sang-Min, Zhang, Ya, Utani, Koichi, Fu, Haiqing, Redon, Christophe E., Marks, Anna B., Smith, Owen K., Redmond, Catherine J., Baris, Adrian M., Tulchinsky, Danielle A., Aladjem, Mirit I.

“… Cell cycle progression in mammals is modulated by two ubiquitin ligase complexes, CRL4 and SCF, which facilitate degradation of chromatin substrates involved …”
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Extra View: Sirt1 Acts As A Gatekeeper Of Replication Initiation To Preserve Genomic Stability von Utani, Koichi, Aladjem, Mirit I.

“… Since the discovery of a yeast gene silencing modifier (Silent Information Modifier 2, SIR2) and its role in maintaining genomic stability more than two …”
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A replicator-specific binding protein essential for site-specific initiation of DNA replication in mammalian cells von Zhang, Ya, Huang, Liang, Fu, Haiqing, Smith, Owen K., Lin, Chii Mei, Utani, Koichi, Rao, Mishal, Reinhold, William C., Redon, Christophe E., Ryan, Michael, Kim, RyangGuk, You, Yang, Hanna, Harlington, Boisclair, Yves, Long, Qiaoming, Aladjem, Mirit I.

“… Mammalian chromosome replication starts from distinct sites; however, the principles governing initiation site selection are unclear because proteins essential …”
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Distinct epigenetic features of differentiation-regulated replication origins von Smith, Owen K., Kim, RyanGuk, Fu, Haiqing, Martin, Melvenia M., Lin, Chii Mei, Utani, Koichi, Zhang, Ya, Marks, Anna B., Lalande, Marc, Chamberlain, Stormy, Libbrecht, Maxwell W., Bouhassira, Eric E., Ryan, Michael C., Noble, William S., Aladjem, Mirit I.

“… Background Eukaryotic genome duplication starts at discrete sequences (replication origins) that coordinate cell cycle progression, ensure genomic stability …”
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Phosphorylated SIRT1 associates with replication origins to prevent excess replication initiation and preserve genomic stability von Utani, Koichi, Fu, Haiqing, Jang, Sang-Min, Marks, Anna B., Smith, Owen K., Zhang, Ya, Redon, Christophe E., Shimizu, Noriaki, Aladjem, Mirit I.

“… Chromatin structure affects DNA replication patterns, but the role of specific chromatin modifiers in regulating the replication process is yet unclear. We …”
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Dynamics of replication origin over-activation von Fu, Haiqing, Redon, Christophe E, Utani, Koichi, Thakur, Bhushan, Jang, Sangmin, Marks, Anna B, Zhuang, Sophie, Lazar, Sarah B, Rao, Mishal, Mencer, Shira, Gross, Jacob M, Lorinc Pongor, Aladjem, Mirit I

“… We determined replication patterns in cancer cells in which the controls that normally prevent excess replication were disrupted ("re-replicating cells") …”
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