Výsledky vyhľadávania - "Tzoulaki, Ioanna"

Risk factors for type 2 diabetes mellitus: An exposure-wide umbrella review of meta-analyses Autor Bellou, Vanesa, Belbasis, Lazaros, Tzoulaki, Ioanna, Evangelou, Evangelos

“…Type 2 diabetes mellitus (T2DM) is a global epidemic associated with increased health expenditure, and low quality of life. Many non-genetic risk factors have…”
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Neutrophil to lymphocyte ratio and cancer prognosis: an umbrella review of systematic reviews and meta-analyses of observational studies Autor Cupp, Meghan A., Cariolou, Margarita, Tzoulaki, Ioanna, Aune, Dagfinn, Evangelou, Evangelos, Berlanga-Taylor, Antonio J.

“…Background Although neutrophils have been linked to the progression of cancer, uncertainty exists around their association with cancer outcomes, depending on…”
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COVID-19 mortality in the UK Biobank cohort: revisiting and evaluating risk factors Autor Elliott, Joshua, Bodinier, Barbara, Whitaker, Matthew, Delpierre, Cyrille, Vermeulen, Roel, Tzoulaki, Ioanna, Elliott, Paul, Chadeau-Hyam, Marc

“…Most studies of severe/fatal COVID-19 risk have used routine/hospitalisation data without detailed pre-morbid characterisation. Using the community-based UK…”
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Predictive Accuracy of a Polygenic Risk Score-Enhanced Prediction Model vs a Clinical Risk Score for Coronary Artery Disease Autor Elliott, Joshua, Bodinier, Barbara, Bond, Tom A, Chadeau-Hyam, Marc, Evangelou, Evangelos, Moons, Karel G M, Dehghan, Abbas, Muller, David C, Elliott, Paul, Tzoulaki, Ioanna

“…The incremental value of polygenic risk scores in addition to well-established risk prediction models for coronary artery disease (CAD) is uncertain. To…”
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Environmental risk factors and multiple sclerosis: an umbrella review of systematic reviews and meta-analyses Autor Belbasis, Lazaros, Bellou, Vanesa, Evangelou, Evangelos, Ioannidis, John P A, Tzoulaki, Ioanna

“…The cause of multiple sclerosis is believed to involve environmental exposure and genetic susceptibility. We aimed to summarise the environmental risk factors…”
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Environmental factors and risk of multiple sclerosis: Findings from meta-analyses and Mendelian randomization studies Autor Belbasis, Lazaros, Bellou, Vanesa, Evangelou, Evangelos, Tzoulaki, Ioanna

“…Multiple sclerosis (MS) is a chronic demyelinating disease that is associated with permanent disability and low quality of life. Development of MS is…”
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Accelerated MRI-predicted brain ageing and its associations with cardiometabolic and brain disorders Autor Kolbeinsson, Arinbjörn, Filippi, Sarah, Panagakis, Yannis, Matthews, Paul M., Elliott, Paul, Dehghan, Abbas, Tzoulaki, Ioanna

“…Brain structure in later life reflects both influences of intrinsic aging and those of lifestyle, environment and disease. We developed a deep neural network…”
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Contributions of risk factors and medical care to cardiovascular mortality trends Autor Ezzati, Majid, Obermeyer, Ziad, Tzoulaki, Ioanna, Mayosi, Bongani M., Elliott, Paul, Leon, David A.

“…Key Points Death rates from ischaemic heart disease (IHD), stroke, and other cardiovascular diseases (CVDs) are decreasing in high-income and many Latin…”
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Pleiotropic genetic architecture and novel loci for C-reactive protein levels Autor Koskeridis, Fotios, Evangelou, Evangelos, Said, Saredo, Boyle, Joseph J., Elliott, Paul, Dehghan, Abbas, Tzoulaki, Ioanna

“…C-reactive protein is involved in a plethora of pathophysiological conditions. Many genetic loci associated with C-reactive protein are annotated to lipid and…”
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Genetic analysis of over half a million people characterises C-reactive protein loci Autor Said, Saredo, Pazoki, Raha, Karhunen, Ville, Võsa, Urmo, Ligthart, Symen, Bodinier, Barbara, Koskeridis, Fotios, Welsh, Paul, Alizadeh, Behrooz Z., Chasman, Daniel I., Sattar, Naveed, Chadeau-Hyam, Marc, Evangelou, Evangelos, Jarvelin, Marjo-Riitta, Elliott, Paul, Tzoulaki, Ioanna, Dehghan, Abbas

“…Chronic low-grade inflammation is linked to a multitude of chronic diseases. We report the largest genome-wide association study (GWAS) on C-reactive protein…”
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External validation of new risk prediction models is infrequent and reveals worse prognostic discrimination Autor Siontis, George C.M., Tzoulaki, Ioanna, Castaldi, Peter J., Ioannidis, John P.A.

“…To evaluate how often newly developed risk prediction models undergo external validation and how well they perform in such validations. We reviewed derivation…”
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Proteomic risk scores for predicting common diseases using linear and neural network models in the UK biobank Autor Smith, Alexander, Elliott, Paul, Mayr, Manuel, Dehghan, Abbas, Tzoulaki, Ioanna

“…Plasma proteomics provides a unique opportunity to enhance disease prediction by capturing protein expression patterns linked to diverse pathological…”
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Use of Genetic Variants Related to Antihypertensive Drugs to Inform on Efficacy and Side Effects Autor Gill, Dipender, Georgakis, Marios K, Koskeridis, Fotios, Jiang, Lan, Feng, Qiping, Wei, Wei-Qi, Theodoratou, Evropi, Elliott, Paul, Denny, Joshua C, Malik, Rainer, Evangelou, Evangelos, Dehghan, Abbas, Dichgans, Martin, Tzoulaki, Ioanna

“…Drug effects can be investigated through natural variation in the genes for their protein targets. The present study aimed to use this approach to explore the…”
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Genetically determined serum urate levels and cardiovascular and other diseases in UK Biobank cohort: A phenome-wide mendelian randomization study Autor Li, Xue, Meng, Xiangrui, He, Yazhou, Spiliopoulou, Athina, Timofeeva, Maria, Wei, Wei-Qi, Gifford, Aliya, Yang, Tian, Varley, Tim, Tzoulaki, Ioanna, Joshi, Peter, Denny, Joshua C., Mckeigue, Paul, Campbell, Harry, Theodoratou, Evropi

“…The role of urate in cardiovascular diseases (CVDs) has been extensively investigated in observational studies; however, the extent of any causal effect…”
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Associations of genetically predicted fatty acid levels across the phenome: A mendelian randomisation study Autor Zagkos, Loukas, Dib, Marie-Joe, Pinto, Rui, Gill, Dipender, Koskeridis, Fotios, Drenos, Fotios, Markozannes, Georgios, Elliott, Paul, Zuber, Verena, Tsilidis, Kostas, Dehghan, Abbas, Tzoulaki, Ioanna

“…Fatty acids are important dietary factors that have been extensively studied for their implication in health and disease. Evidence from epidemiological studies…”
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The association of depression and all-cause and cause-specific mortality: an umbrella review of systematic reviews and meta-analyses Autor Machado, Myrela O., Veronese, Nicola, Sanches, Marcos, Stubbs, Brendon, Koyanagi, Ai, Thompson, Trevor, Tzoulaki, Ioanna, Solmi, Marco, Vancampfort, Davy, Schuch, Felipe B., Maes, Michael, Fava, Giovanni A., Ioannidis, John P. A., Carvalho, André F.

“…Background Depression is a prevalent and disabling mental disorder that frequently co-occurs with a wide range of chronic conditions. Evidence has suggested…”
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Serum metabolic signatures of coronary and carotid atherosclerosis and subsequent cardiovascular disease Autor Tzoulaki, Ioanna, Castagné, Raphaële, Boulangé, Claire L, Karaman, Ibrahim, Chekmeneva, Elena, Evangelou, Evangelos, Ebbels, Timothy M D, Kaluarachchi, Manuja R, Chadeau-Hyam, Marc, Mosen, David, Dehghan, Abbas, Moayyeri, Alireza, Ferreira, Diana L Santos, Guo, Xiuqing, Rotter, Jerome I, Taylor, Kent D, Kavousi, Maryam, de Vries, Paul S, Lehne, Benjamin, Loh, Marie, Hofman, Albert, Nicholson, Jeremy K, Chambers, John, Gieger, Christian, Holmes, Elaine, Tracy, Russell, Kooner, Jaspal, Greenland, Philip, Franco, Oscar H, Herrington, David, Lindon, John C, Elliott, Paul

“…Abstract Aims To characterize serum metabolic signatures associated with atherosclerosis in the coronary or carotid arteries and subsequently their association…”
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The Effect of Increased Plant Protein Intake on the Lipid Profile of Chronic Kidney Disease Patients: A Meta-Analysis of Controlled Clinical Trials Autor Papaodyssea, Ioanna, Lagiou, Areti, Tzoulaki, Ioanna, Valanou, Elisavet, Naska, Androniki

“…Background/Objectives: Chronic kidney disease (CKD) is associated with increased mortality, with cardiovascular disease (CVD) being the primary cause of death…”
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Assessment of claims of improved prediction beyond the Framingham risk score Autor Tzoulaki, Ioanna, Liberopoulos, George, Ioannidis, John P A

“…With heightened interest in predictive medicine, many studies try to document information that can improve prediction of major clinical outcomes. To evaluate…”
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Exposure to pesticides and childhood leukemia risk: A systematic review and meta-analysis Autor Karalexi, Maria A., Tagkas, Christos F., Markozannes, Georgios, Tseretopoulou, Xanthippi, Hernández, Antonio F., Schüz, Joachim, Halldorsson, Thorhallur I., Psaltopoulou, Theodora, Petridou, Eleni Th, Tzoulaki, Ioanna, Ntzani, Evangelia E.

“…Despite the abundance of epidemiological evidence concerning the association between pesticide exposure and adverse health outcomes including acute childhood…”
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