Výsledky vyhľadávania - "Turley, Helen"

Glucose utilization via glycogen phosphorylase sustains proliferation and prevents premature senescence in cancer cells Autor Favaro, Elena, Bensaad, Karim, Chong, Mei G, Tennant, Daniel A, Ferguson, David J P, Snell, Cameron, Steers, Graham, Turley, Helen, Li, Ji-Liang, Günther, Ulrich L, Buffa, Francesca M, McIntyre, Alan, Harris, Adrian L

“…Metabolic reprogramming of cancer cells provides energy and multiple intermediates critical for cell growth. Hypoxia in tumors represents a hostile environment…”
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DLL4-Notch signaling mediates tumor resistance to anti-VEGF therapy in vivo Autor Li, Ji-Liang, Sainson, Richard C A, Oon, Chern Ein, Turley, Helen, Leek, Russell, Sheldon, Helen, Bridges, Esther, Shi, Wen, Snell, Cameron, Bowden, Emma T, Wu, Herren, Chowdhury, Partha S, Russell, Angela J, Montgomery, Craig P, Poulsom, Richard, Harris, Adrian L

“…Resistance to VEGF inhibitors is emerging as a major clinical problem. Notch signaling has been implicated in tumor angiogenesis. Therefore, to investigate…”
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Targeting p21-activated kinase 1 (PAK1) to induce apoptosis of tumor cells Autor Ong, Christy C, Jubb, Adrian M, Haverty, Peter M, Zhou, Wei, Tran, Victoria, Truong, Tom, Turley, Helen, O'Brien, Tom, Vucic, Domagoj, Harris, Adrian L, Belvin, Marcia, Friedman, Lori S, Blackwood, Elizabeth M, Koeppen, Hartmut, Hoeflich, Klaus P

“…p21-activated kinases (PAKs) are serine/threonine protein kinases that serve as important mediators of Rac and Cdc42 GTPase function as well as pathways…”
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Differential function of the prolyl hydroxylases PHD1, PHD2, and PHD3 in the regulation of hypoxia-inducible factor Autor Appelhoff, Rebecca J, Tian, Ya-Min, Raval, Raju R, Turley, Helen, Harris, Adrian L, Pugh, Christopher W, Ratcliffe, Peter J, Gleadle, Jonathan M

“…Hypoxia-inducible factor (HIF) is a transcriptional regulator that plays a key role in many aspects of oxygen homeostasis. The heterodimeric HIF complex is…”
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Corrigendum to “Low cytoplasmic NUB1 protein exerts hypoxic cell death with poorer prognosis in oestrogen receptor negative breast cancer patients” [Translational Oncology, volume 49 (2024), 102106] Autor Tan, Ka-Liong, Haider, Syed, Zois, Christos E., Hu, Jianting, Turley, Helen, Leek, Russell, Buffa, Francesca, Acuto, Oreste, Harris, Adrian L., Pezzella, Francesco

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Delta-like 4 Notch ligand regulates tumor angiogenesis, improves tumor vascular function, and promotes tumor growth in vivo Autor Li, Ji-Liang, Sainson, Richard C A, Shi, Wen, Leek, Russell, Harrington, Laura S, Preusser, Matthias, Biswas, Swethajit, Turley, Helen, Heikamp, Emily, Hainfellner, Johannes A, Harris, Adrian L

“…The vascular endothelial growth factor (VEGF) plays a key role in tumor angiogenesis. However, clinical trials targeting the VEGF pathway are often…”
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Low cytoplasmic NUB1 protein exerts hypoxic cell death with poorer prognosis in oestrogen receptor negative breast cancer patients Autor Tan, Ka-Liong, Haider, Syed, Zois, Christos E., Hu, Jianting, Turley, Helen, Leek, Russell, Buffa, Francesca, Acuto, Oreste, Harris, Adrian L., Pezzella, Francesco

“…•1) The study identified that downregulated AIPL1 leads to the deactivation of NUB1 under hypoxic conditions, resulting in cell cycle arrest in breast cancer…”
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Relation of a hypoxia metagene derived from head and neck cancer to prognosis of multiple cancers Autor Winter, Stuart C, Buffa, Francesca M, Silva, Priyamal, Miller, Crispin, Valentine, Helen R, Turley, Helen, Shah, Ketan A, Cox, Graham J, Corbridge, Rogan J, Homer, Jarrod J, Musgrove, Brian, Slevin, Nick, Sloan, Philip, Price, Pat, West, Catharine M L, Harris, Adrian L

“…Affymetrix U133plus2 GeneChips were used to profile 59 head and neck squamous cell cancers. A hypoxia metagene was obtained by analysis of genes whose in vivo…”
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TRAP1 regulates proliferation, mitochondrial function, and has prognostic significance in NSCLC Autor Agorreta, Jackeline, Hu, Jianting, Liu, Dongxia, Delia, Domenico, Turley, Helen, Ferguson, David J P, Iborra, Francisco, Pajares, María J, Larrayoz, Marta, Zudaire, Isabel, Pio, Ruben, Montuenga, Luis M, Harris, Adrian L, Gatter, Kevin, Pezzella, Francesco

“…The TNF receptor-associated protein 1 (TRAP1) is a mitochondrial HSP that has been related to drug resistance and protection from apoptosis in colorectal and…”
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Proline-Hydroxylated Hypoxia-Inducible Factor 1α (HIF-1α) Upregulation in Human Tumours Autor Snell, Cameron E., Turley, Helen, McIntyre, Alan, Li, Demin, Masiero, Massimo, Schofield, Christopher J., Gatter, Kevin C., Harris, Adrian L., Pezzella, Francesco

“…The stabilisation of HIF-α is central to the transcriptional response of animals to hypoxia, regulating the expression of hundreds of genes including those…”
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Expression of vascular notch ligand delta-like 4 and inflammatory markers in breast cancer Autor Jubb, Adrian M, Soilleux, Elizabeth J, Turley, Helen, Steers, Graham, Parker, Andrew, Low, Irene, Blades, Jennifer, Li, Ji-Liang, Allen, Paul, Leek, Russell, Noguera-Troise, Irene, Gatter, Kevin C, Thurston, Gavin, Harris, Adrian L

“…Delta-like ligand 4 (Dll4) is a Notch ligand that is predominantly expressed in the endothelium. Evidence from xenografts suggests that inhibiting Dll4 may…”
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Role of Hypoxia-Inducible Factors in Epigenetic Regulation via Histone Demethylases Autor Yang, Jun, Ledaki, Ioanna, Turley, Helen, Gatter, Kevin C., Montero, Juan-Carlos Martinez, Li, Ji-Liang, Harris, Adrian L.

“…Eukaryotic chromatin is subject to multiple posttranslational histone modifications such as acetylation, methylation, phosphorylation, and ubiquitination…”
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Immunohistological recognition of cyclin D1 expression by non-lymphoid cells among lymphoid neoplastic cells Autor Abdulla, Zainalabideen, Turley, Helen, Gatter, Kevin, Pezzella, Francesco

“…Cyclin D1 immunostaining of non‐neoplastic cells has been a source of diagnostic confusion especially in lymphoproliferative lesions. This study has reviewed…”
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Gastrointestinal differentiation marker Cytokeratin 20 is regulated by homeobox gene CDX1 Autor Chan, Carol W M, Wong, Newton A, Liu, Ying, Bicknell, David, Turley, Helen, Hollins, Laura, Miller, Crispin J, Wilding, Jennifer L, Bodmer, Walter F

“…CDX1 is a transcription factor that plays a key role in intestinal development and differentiation. However, the downstream targets of CDX1 are less well…”
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Expression of vascular Notch ligands Delta-like 4 and Jagged-1 in glioblastoma Autor Jubb, Adrian M, Browning, Lisa, Campo, Leticia, Turley, Helen, Steers, Graham, Thurston, Gavin, Harris, Adrian L, Ansorge, Olaf

“…Jubb A M, Browning L, Campo L, Turley H, Steers G, Thurston G, Harris A L & Ansorge O 
(2012) Histopathology 60, 740–747
Expression of vascular Notch ligands…”
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The androgen receptor is significantly associated with vascular endothelial growth factor and hypoxia sensing via hypoxia-inducible factors HIF-1a, HIF-2a, and the prolyl hydroxylases in human prostate cancer Autor Boddy, Jane L, Fox, Stephen B, Han, Cheng, Campo, Leticia, Turley, Helen, Kanga, Suresh, Malone, Peter R, Harris, Adrian L

“…Hypoxia regulates key biological processes including angiogenesis via the transcription factor, hypoxia-inducible factor (HIF). In prostate cancer,…”
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Hypoxia-inducible factor (HIF1A and HIF2A), angiogenesis, and chemoradiotherapy outcome of squamous cell head-and-neck cancer Autor Koukourakis, Michael I, Giatromanolaki, Alexandra, Sivridis, Efthimios, Simopoulos, Constantinos, Turley, Helen, Talks, Kate, Gatter, Kevin C, Harris, Adrian L

“…Hypoxia-inducible factors HIF1alpha and HIF2alpha (HIFalphas) regulate the expression of a variety of genes encoding proteins related to angiogenesis and to…”
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Increased angiogenesis and lymphangiogenesis in inflammatory versus noninflammatory breast cancer by real-time reverse transcriptase-PCR gene expression quantification Autor Van der Auwera, Ilse, Van Laere, Steven J, Van den Eynden, Gert G, Benoy, Ina, van Dam, Peter, Colpaert, Cecile G, Fox, Stephen B, Turley, Helen, Harris, Adrian L, Van Marck, Eric A, Vermeulen, Peter B, Dirix, Luc Y

“…Inflammatory breast cancer is a distinct and aggressive form of locally advanced breast cancer with unique clinical and pathological features. Recently,…”
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Carbonic anhydrase IX expression, a novel surrogate marker of tumor hypoxia, is associated with a poor prognosis in non-small-cell lung cancer Autor Swinson, Daniel E B, Jones, J Louise, Richardson, Donna, Wykoff, Charles, Turley, Helen, Pastorek, Jaromir, Taub, Nick, Harris, Adrian L, O'Byrne, Kenneth J

“…To evaluate carbonic anhydrase (CA) IX as a surrogate marker of hypoxia and investigate the prognostic significance of different patterns of expression in…”
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BNIP3 as a progression marker in primary human breast cancer; opposing functions in in situ versus invasive cancer Autor Tan, Ern Yu, Campo, Leticia, Han, Cheng, Turley, Helen, Pezzella, Francesco, Gatter, Kevin C, Harris, Adrian L, Fox, Stephen B

“…BNIP3 is involved in cell death and cell survival via autophagy. Its perinecrotic localization within ductal carcinoma in situ (DCIS) suggests an involvement…”
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