Suchergebnisse - "Turecki, Gustavo"

The emerging role of exosomes in mental disorders von Saeedi, Saumeh, Israel, Sonia, Nagy, Corina, Turecki, Gustavo

“… Exosomes are a class of extracellular vesicles of endocytic origin, which are released by cells and are accessible in biofluids, such as saliva, urine, and …”
Volltext

Suicide and suicidal behaviour von Turecki, Gustavo, Brent, David A

“… Suicide is a complex public health problem of global importance. Suicidal behaviour differs between sexes, age groups, geographic regions, and sociopolitical …”
Volltext

Effects of the Social Environment and Stress on Glucocorticoid Receptor Gene Methylation: A Systematic Review von Turecki, Gustavo, Meaney, Michael J.

“… The early-life social environment can induce stable changes that influence neurodevelopment and mental health. Research focused on early-life adversity …”
Volltext

The miRNome of Depression von Żurawek, Dariusz, Turecki, Gustavo

“… Depression is an effect of complex interactions between genetic, epigenetic and environmental factors. It is well established that stress responses are …”
Volltext

Single-nucleus transcriptomics of the prefrontal cortex in major depressive disorder implicates oligodendrocyte precursor cells and excitatory neurons von Nagy, Corina, Maitra, Malosree, Tanti, Arnaud, Suderman, Matthew, Théroux, Jean-Francois, Davoli, Maria Antonietta, Perlman, Kelly, Yerko, Volodymyr, Wang, Yu Chang, Tripathy, Shreejoy J, Pavlidis, Paul, Mechawar, Naguib, Ragoussis, Jiannis, Turecki, Gustavo

“… Major depressive disorder (MDD) has an enormous impact on global disease burden, affecting millions of people worldwide and ranking as a leading cause of …”
Volltext

Comparison of mental health symptoms before and during the covid-19 pandemic: evidence from a systematic review and meta-analysis of 134 cohorts von Sun, Ying, Wu, Yin, Fan, Suiqiong, Dal Santo, Tiffany, Li, Letong, Jiang, Xiaowen, Li, Kexin, Wang, Yutong, Tasleem, Amina, Krishnan, Ankur, He, Chen, Bonardi, Olivia, Boruff, Jill T, Rice, Danielle B, Markham, Sarah, Levis, Brooke, Azar, Marleine, Thombs-Vite, Ian, Neupane, Dipika, Agic, Branka, Fahim, Christine, Martin, Michael S, Sockalingam, Sanjeev, Turecki, Gustavo, Benedetti, Andrea, Thombs, Brett D

“… AbstractObjectiveTo synthesise results of mental health outcomes in cohorts before and during the covid-19 pandemic.DesignSystematic review.Data …”
Volltext

Molecular adaptations of the blood-brain barrier promote stress resilience vs. depression von Dudek, Katarzyna A, Dion-Albert, Laurence, Lebel, Manon, LeClair, Katherine, Labrecque, Simon, Tuck, Ellen, Ferrer Perez, Carmen, Golden, Sam A, Tamminga, Carol, Turecki, Gustavo, Mechawar, Naguib, Russo, Scott J, Menard, Caroline

“… Preclinical and clinical studies suggest that inflammation and vascular dysfunction contribute to the pathogenesis of major depressive disorder (MDD). Chronic …”
Weitere Angaben

Evidence for increased microglial priming and macrophage recruitment in the dorsal anterior cingulate white matter of depressed suicides von Torres-Platas, Susana G., Cruceanu, Cristiana, Chen, Gary Gang, Turecki, Gustavo, Mechawar, Naguib

“… Despite increasing evidence supporting the neuroinflammatory theory of depression, little is known about cerebral macrophages in individuals suffering from …”
Volltext

Social stress induces neurovascular pathology promoting depression von Menard, Caroline, Pfau, Madeline L., Hodes, Georgia E., Kana, Veronika, Wang, Victoria X., Bouchard, Sylvain, Takahashi, Aki, Flanigan, Meghan E., Aleyasin, Hossein, LeClair, Katherine B., Janssen, William G., Labonté, Benoit, Parise, Eric M., Lorsch, Zachary S., Golden, Sam A., Heshmati, Mitra, Tamminga, Carol, Turecki, Gustavo, Campbell, Matthew, Fayad, Zahi A., Tang, Cheuk Ying, Merad, Miriam, Russo, Scott J.

“… Studies suggest that heightened peripheral inflammation contributes to the pathogenesis of major depressive disorder. We investigated the effect of chronic …”
Volltext

Associations Between Peer Victimization and Suicidal Ideation and Suicide Attempt During Adolescence: Results From a Prospective Population-Based Birth Cohort von Geoffroy, Marie-Claude, Boivin, Michel, Arseneault, Louise, Turecki, Gustavo, Vitaro, Frank, Brendgen, Mara, Renaud, Johanne, Séguin, Jean R, Tremblay, Richard E, Côté, Sylvana M

“… To test whether adolescents who are victimized by peers are at heightened risk for suicidal ideation and suicide attempt, using both cross-sectional and …”
Weitere Angaben

Cell type specific transcriptomic differences in depression show similar patterns between males and females but implicate distinct cell types and genes von Maitra, Malosree, Mitsuhashi, Haruka, Rahimian, Reza, Chawla, Anjali, Yang, Jennie, Fiori, Laura M., Davoli, Maria Antonietta, Perlman, Kelly, Aouabed, Zahia, Mash, Deborah C., Suderman, Matthew, Mechawar, Naguib, Turecki, Gustavo, Nagy, Corina

“… Major depressive disorder (MDD) is a common, heterogenous, and potentially serious psychiatric illness. Diverse brain cell types have been implicated in MDD …”
Volltext

Neuron-derived extracellular vesicles enriched from plasma show altered size and miRNA cargo as a function of antidepressant drug response von Saeedi, Saumeh, Nagy, Corina, Ibrahim, Pascal, Théroux, Jean-Francois, Wakid, Marina, Fiori, Laura M, Yang, Jennie, Rotzinger, Susan, Foster, Jane A, Mechawar, Naguib, Kennedy, Sidney H, Turecki, Gustavo

“… Previous work has demonstrated that microRNAs (miRNAs) change as a function of antidepressant treatment (ADT) response. However, it is unclear how …”
Volltext

The relationship between plasma serotonin and kynurenine pathway metabolite levels and the treatment response to escitalopram and desvenlafaxine von Sun, Yu, Drevets, Wayne, Turecki, Gustavo, Li, Qingqin S.

“… •Response to escitalopram was associated with higher baseline serotonin levels.•Response to escitalopram was associated with lower baseline Kyn/Trp ratio and …”
Volltext

Epigenetic Mechanisms for the Early Environmental Regulation of Hippocampal Glucocorticoid Receptor Gene Expression in Rodents and Humans von Zhang, Tie Yuan, Labonté, Benoit, Wen, Xiang Lan, Turecki, Gustavo, Meaney, Michael J

“… Parental care influences development across mammals. In humans such influences include effects on phenotypes, such as stress reactivity, which determine …”
Volltext

Epigenetics and Suicidal Behavior Research Pathways von Turecki, Gustavo

“… Suicide and suicidal behaviors are complex, heterogeneous phenomena that are thought to result from the interactions among distal factors increasing …”
Volltext

Intravenous arketamine for treatment-resistant depression: open-label pilot study von Leal, Gustavo C., Bandeira, Igor D., Correia-Melo, Fernanda S., Telles, Manuela, Mello, Rodrigo P., Vieira, Flavia, Lima, Cassio S., Jesus-Nunes, Ana Paula, Guerreiro-Costa, Lívia N. F., Marback, Roberta F., Caliman-Fontes, Ana Teresa, Marques, Breno L. S., Bezerra, Marília L. O., Dias-Neto, Alberto L., Silva, Samantha S., Sampaio, Aline S., Sanacora, Gerard, Turecki, Gustavo, Loo, Colleen, Lacerda, Acioly L. T., Quarantini, Lucas C.

Volltext

Dopaminylation of histone H3 in ventral tegmental area regulates cocaine seeking von Lepack, Ashley E, Werner, Craig T, Stewart, Andrew F, Fulton, Sasha L, Zhong, Ping, Farrelly, Lorna A, Smith, Alexander C W, Ramakrishnan, Aarthi, Lyu, Yang, Bastle, Ryan M, Martin, Jennifer A, Mitra, Swarup, O'Connor, Richard M, Wang, Zi-Jun, Molina, Henrik, Turecki, Gustavo, Shen, Li, Yan, Zhen, Calipari, Erin S, Dietz, David M, Kenny, Paul J, Maze, Ian

“… Vulnerability to relapse during periods of attempted abstinence from cocaine use is hypothesized to result from the rewiring of brain reward circuitries, …”
Weitere Angaben

miR-1202 is a primate-specific and brain-enriched microRNA involved in major depression and antidepressant treatment von Lopez, Juan Pablo, Lim, Raymond, Cruceanu, Cristiana, Crapper, Liam, Fasano, Caroline, Labonte, Benoit, Maussion, Gilles, Yang, Jennie P, Yerko, Volodymyr, Vigneault, Erika, El Mestikawy, Salah, Mechawar, Naguib, Pavlidis, Paul, Turecki, Gustavo

“… Gustavo Turecki and colleagues report that miR-1202, a miRNA specific to primates, is decreased in individuals with depression and seems to be differentially …”
Volltext

Intravenous arketamine for treatment-resistant depression: open-label pilot study von Leal, Gustavo C., Bandeira, Igor D., Correia-Melo, Fernanda S., Telles, Manuela, Mello, Rodrigo P., Vieira, Flavia, Lima, Cassio S., Jesus-Nunes, Ana Paula, Guerreiro-Costa, Lívia N. F., Marback, Roberta F., Caliman-Fontes, Ana Teresa, Marques, Breno L. S., Bezerra, Marília L. O., Dias-Neto, Alberto L., Silva, Samantha S., Sampaio, Aline S., Sanacora, Gerard, Turecki, Gustavo, Loo, Colleen, Lacerda, Acioly L. T., Quarantini, Lucas C.

“… We aimed to analyze the efficacy and safety of arketamine, the R (−)-enantiomer of ketamine, for treatment-resistant depression (TRD) in humans. Open-label …”
Volltext

Mental Health Problems and Risk of Suicidal Ideation and Attempts in Adolescents von Orri, Massimiliano, Scardera, Sara, Perret, Léa C, Bolanis, Despina, Temcheff, Caroline, Séguin, Jean R, Boivin, Michel, Turecki, Gustavo, Tremblay, Richard E, Côté, Sylvana M, Geoffroy, Marie-Claude

“… Obtaining recent estimates of the prevalence of suicide-related outcomes across adolescence and its associated mental health problems (MHPs) is important for …”
Weitere Angaben