Výsledky vyhľadávania - "Tumor cell lines"

Loss of DUSP3 activity radiosensitizes human tumor cell lines via attenuation of DNA repair pathways Autor Torres, Thompson E.P., Russo, Lilian C., Santos, Alexsandro, Marques, Gabriela R., Magalhaes, Yuli T., Tabassum, Sartaj, Forti, Fabio L.

“…; however, whether DUSP3 affects these processes remains unknown. Tumor cell lines in which DUSP3 activity was suppressed by pharmacological inhibitors or a targeted…”
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A novel microfluidic liposomal formulation for the delivery of the SN-38 camptothecin: characterization and in vitro assessment of its cytotoxic effect on two tumor cell lines Autor Casado, Ana, M. Sagrista, Lluisa, Mora, Margarita

“…) has been considered a subject of unquestionable medical interest. This article focuses on the development of an alternative protocol to the classical lipid-film hydration procedures to obtain a pharmaceutical formulation for SN-38…”
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Cytotoxicity of polybia paulista wasp crude venom on the tumor cell lines HeLa, HRT-18, jurkat, and K562 Autor Thomassewski, Ana Carla, Quadros, Thaline, Lima, Gabriel Ramos, Kanunfre, Carla Cristine, Paludo, Katia, De Oliveira, Marcia Paes

“…The social wasp Polybia paulista is an animal that produces venom for defense, which has been the subject of numerous studies in recent decades…”
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Proteomic analyses of brain tumor cell lines amidst the unfolded protein response Autor Redzic, Jasmina S, Gomez, Joe D, Hellwinkel, Justin E, Anchordoquy, Thomas J, Graner, Michael W

“… The tumor environment is subject to a number of cellular stressors such as hypoxia and glucose deprivation…”
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Suppression of 5-lipoxygenase gene is involved in triptolide-induced apoptosis in pancreatic tumor cell lines Autor Zhou, G.X., Ding, X.L., Huang, J.F., Zhang, H., Wu, S.B.

“…Pancreatic adenocarcinoma is characterized by a poor prognosis and lack of response to conventional therapy. The purpose of this study was to investigate the…”
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Claudin18.2-Specific Chimeric Antigen Receptor Engineered T Cells for the Treatment of Gastric Cancer Autor Jiang, Hua, Shi, Zhimin, Wang, Peng, Wang, Cong, Yang, Linlin, Du, Guoxiu, Zhang, Honghong, Shi, Bizhi, Jia, Jie, Li, Qixiang, Wang, Huamao, Li, Zonghai

“…Claudin18.2 (CLDN18.2), a gastric-specific membrane protein, has been regarded as a potential therapeutic target for gastric cancer and other cancer types. The…”
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Plasma cell deficiency in human subjects with heterozygous mutations in Sec61 translocon alpha 1 subunit (SEC61A1) Autor Schubert, Desirée, Klein, Marie-Christine, Hassdenteufel, Sarah, Caballero-Oteyza, Andrés, Yang, Linlin, Proietti, Michele, Bulashevska, Alla, Kemming, Janine, Kühn, Johannes, Winzer, Sandra, Rusch, Stephan, Fliegauf, Manfred, Schäffer, Alejandro A., Pfeffer, Stefan, Geiger, Roger, Cavalié, Adolfo, Cao, Hongzhi, Yang, Fang, Li, Yong, Rizzi, Marta, Eibel, Hermann, Kobbe, Robin, Marks, Amy L., Peppers, Brian P., Hostoffer, Robert W., Puck, Jennifer M., Zimmermann, Richard, Grimbacher, Bodo

“…Primary antibody deficiencies (PADs) are the most frequent primary immunodeficiencies in human subjects…”
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Extensive protein dosage compensation in aneuploid human cancers Autor Schukken, Klaske M, Sheltzer, Jason M

“…Aneuploidy is a hallmark of human cancers, but the effects of aneuploidy on protein expression remain poorly understood. To uncover how chromosome copy number…”
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Chemoproteomic discovery of a covalent allosteric inhibitor of WRN helicase Autor Baltgalvis, Kristen A., Lamb, Kelsey N., Symons, Kent T., Wu, Chu-Chiao, Hoffman, Melissa A., Snead, Aaron N., Song, Xiaodan, Glaza, Thomas, Kikuchi, Shota, Green, Jason C., Rogness, Donald C., Lam, Betty, Rodriguez-Aguirre, Maria E., Woody, David R., Eissler, Christie L., Rodiles, Socorro, Negron, Seth M., Bernard, Steffen M., Tran, Eileen, Pollock, Jonathan, Tabatabaei, Ali, Contreras, Victor, Williams, Heather N., Pastuszka, Martha K., Sigler, John J., Pettazzoni, Piergiorgio, Rudolph, Markus G., Classen, Moritz, Brugger, Doris, Claiborne, Christopher, Plancher, Jean-Marc, Cuartas, Isabel, Seoane, Joan, Burgess, Laurence E., Abraham, Robert T., Weinstein, David S., Simon, Gabriel M., Patricelli, Matthew P., Kinsella, Todd M.

“… This compound selectively engages a cysteine (C727) located in a region of the helicase domain subject to interdomain movement during DNA unwinding…”
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Histidine catabolism is a major determinant of methotrexate sensitivity Autor Kanarek, Naama, Keys, Heather R., Cantor, Jason R., Lewis, Caroline A., Chan, Sze Ham, Kunchok, Tenzin, Abu-Remaileh, Monther, Freinkman, Elizaveta, Schweitzer, Lawrence D., Sabatini, David M.

“… . Depletion of tetrahydrofolate causes cell death by suppressing DNA and RNA production 3 . Although methotrexate is widely used as an anticancer agent and is the subject…”
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DNA in extracellular vesicles: biological and clinical aspects Autor Elzanowska, Julia, Semira, Christine, Costa‐Silva, Bruno

“…The presence of DNA in EVs, including exosomes and microvesicles, remains contentious as this field of study is still evolving. This review explores what is…”
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Complement Activation via a C3a Receptor Pathway Alters CD4 + T Lymphocytes and Mediates Lung Cancer Progression Autor Kwak, Jeff W, Laskowski, Jennifer, Li, Howard Y, McSharry, Maria V, Sippel, Trisha R, Bullock, Bonnie L, Johnson, Amber M, Poczobutt, Joanna M, Neuwelt, Alexander J, Malkoski, Stephen P, Weiser-Evans, Mary C, Lambris, John D, Clambey, Eric T, Thurman, Joshua M, Nemenoff, Raphael A

“…), with tumors undetectable in many subjects. Growth inhibition was associated with increased numbers of IFNγ /TNFα…”
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Centrosome amplification is a frequent event in circulating tumor cells from subjects with metastatic breast cancer Autor Singh, Ashok, Denu, Ryan A., Wolfe, Serena K., Sperger, Jamie M., Schehr, Jennifer, Witkowsky, Tessa, Esbona, Karla, Chappell, Richard J., Weaver, Beth A., Burkard, Mark E., Lang, Joshua M.

“… Here, we surveyed CA in CTCs from human subjects with metastatic breast cancer. CTCs were captured by CD45 exclusion and selection of EpCAM…”
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Potential Role of Curcumin and Its Nanoformulations to Treat Various Types of Cancers Autor Kabir, Md. Tanvir, Rahman, Md. Habibur, Akter, Rokeya, Behl, Tapan, Kaushik, Deepak, Mittal, Vineet, Pandey, Parijat, Akhtar, Muhammad Furqan, Saleem, Ammara, Albadrani, Ghadeer M., Kamel, Mohamed, Khalifa, Shaden A.M., El-Seedi, Hesham R., Abdel-Daim, Mohamed M.

“…Cancer is a major burden of disease globally. Each year, tens of millions of people are diagnosed with cancer worldwide, and more than half of the patients…”
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Cell-Membrane-Localizing, Two-Photon Probe for Ratiometric Imaging of γ-Glutamyl Transpeptidase in Cancerous Cells and Tissues Autor Reo, Ye Jin, Dai, Mingchong, Yang, Yun Jae, Ahn, Kyo Han

“… The detection of the enzyme activity is an important subject, leading to about 40 activatable fluorescent probes so far…”
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IFT proteins interact with HSET to promote supernumerary centrosome clustering in mitosis Autor Vitre, Benjamin, Taulet, Nicolas, Guesdon, Audrey, Douanier, Audrey, Dosdane, Aurelie, Cisneros, Melanie, Maurin, Justine, Hettinger, Sabrina, Anguille, Christelle, Taschner, Michael, Lorentzen, Esben, Delaval, Benedicte

“…Centrosome amplification is a hallmark of cancer, and centrosome clustering is essential for cancer cell survival. The mitotic kinesin HSET is an essential…”
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Arnicolide D: a multi-targeted anticancer sesquiterpene lactone—preclinical efficacy and mechanistic insights Autor Mangalpady, Shivaprasad Shetty, Peña-Corona, Sheila I., Borbolla-Jiménez, Fabiola, Kaverikana, Rajesh, Shetty, Shobhitha, Shet, Vinayaka Babu, Almarhoon, Zainab M., Calina, Daniela, Leyva-Gómez, Gerardo, Sharifi-Rad, Javad

“…Arnicolide D, a potent sesquiterpene lactone from Centipeda minima , has emerged as a promising anticancer candidate, demonstrating significant efficacy in…”
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Glycosides from Medicinal Plants as Potential Anticancer Agents: Emerging Trends Towards Future Drugs Autor Khan, Haroon, Saeedi, Mina, Nabavi, Seyed Mohammad, Mubarak, Mohammad S, Bishayee, Anupam

“…Cancer continues to be a global burden, despite the advancement of various technological and pharmaceutical improvements over the past two decades. Methods for…”
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Single Cell Profiling of Circulating Tumor Cells: Transcriptional Heterogeneity and Diversity from Breast Cancer Cell Lines Autor Powell, Ashley A., Talasaz, AmirAli H., Zhang, Haiyu, Coram, Marc A., Reddy, Anupama, Deng, Glenn, Telli, Melinda L., Advani, Ranjana H., Carlson, Robert W., Mollick, Joseph A., Sheth, Shruti, Kurian, Allison W., Ford, James M., Stockdale, Frank E., Quake, Stephen R., Pease, R. Fabian, Mindrinos, Michael N., Bhanot, Gyan, Dairkee, Shanaz H., Davis, Ronald W., Jeffrey, Stefanie S.

“…To improve cancer therapy, it is critical to target metastasizing cells. Circulating tumor cells (CTCs) are rare cells found in the blood of patients with…”
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Quercetin - Mediated Apoptosis and Cellular Senescence in Human Colon Cancer Autor Özsoy, Serpil, Becer, Eda, Kabadayı, Hilal, Vatansever, Hafize S, Yücecan, Sevinç

“… The effects of phenolic compounds, including quercetin, on programmed cell death and cellular senescence have been the subject of research in recent years…”
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