Výsledky vyhledávání - "Tullis, Iain D C"

Tissue-specific iron levels modulate lipid peroxidation and the FLASH radiotherapy effect Autor Vilaplana-Lopera, Nuria, Kim, Jiyoung, Nam, Gilyeong, Tullis, Iain D. C., Paillas, Salome, Ruan, Jia-Ling, Lee, Pei Ju, Jiang, Yanyan, Park, Sohee, Hou, Tianxu, Nasir, Ayesha, Charlesworth, Eve, Walker, Ellie, Abu-Halawa, Ammar, Hill, Mark A., Choi, Changhoon, Lee, Ik Jae, Jeong, Youngtae, Lakhal-Littleton, Samira, Then, Chee Kin, Shen, Shing-Chuan, Giaccia, Amato J., Petersson, Kristoffer, Moon, Eui Jung

“…Iron is vital to living cells, playing a key role in cellular respiration, DNA synthesis, and various metabolic functions. Importantly, cancer cells have a…”
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Intra-prostatic tumour evolution, steps in metastatic spread and histogenomic associations revealed by integration of multi-region whole-genome sequencing with histopathological features Autor Rao, Srinivasa, Verrill, Clare, Cerundolo, Lucia, Alham, Nasullah Khalid, Kaya, Zeynep, O’Hanlon, Miriam, Hayes, Alicia, Lambert, Adam, James, Martha, Tullis, Iain D. C., Niederer, Jane, Lovell, Shelagh, Omer, Altan, Lopez, Francisco, Leslie, Tom, Buffa, Francesca, Bryant, Richard J., Lamb, Alastair D., Vojnovic, Boris, Wedge, David C., Mills, Ian G., Woodcock, Dan J., Tomlinson, Ian, Hamdy, Freddie C.

“…Background Extension of prostate cancer beyond the primary site by local invasion or nodal metastasis is associated with poor prognosis. Despite significant…”
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An efficient and robust MRI-guided radiotherapy planning approach for targeting abdominal organs and tumours in the mouse Autor Kersemans, Veerle, Beech, John S., Gilchrist, Stuart, Kinchesh, Paul, Allen, Philip D., Thompson, James, Gomes, Ana L., D’Costa, Zenobia, Bird, Luke, Tullis, Iain D. C., Newman, Robert G., Corroyer-Dulmont, Aurelien, Falzone, Nadia, Azad, Abul, Vallis, Katherine A., Sansom, Owen J., Muschel, Ruth J., Vojnovic, Borivoj, Hill, Mark A., Fokas, Emmanouil, Smart, Sean C.

“…Preclinical CT-guided radiotherapy platforms are increasingly used but the CT images are characterized by poor soft tissue contrast. The aim of this study was…”
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Irradiation at Ultra-High (FLASH) Dose Rates Reduces Acute Normal Tissue Toxicity in the Mouse Gastrointestinal System Autor Ruan, Jia-Ling, Lee, Carl, Wouters, Shari, Tullis, Iain D C, Verslegers, Mieke, Mysara, Mohamed, Then, Chee Kin, Smart, Sean C, Hill, Mark A, Muschel, Ruth J, Giaccia, Amato J, Vojnovic, Borivoj, Kiltie, Anne E, Petersson, Kristoffer

“…Preclinical studies using ultra-high dose rate (FLASH) irradiation have demonstrated reduced normal tissue toxicity compared with conventional dose rate (CONV)…”
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A Multi-Functional Imaging Approach to High-Content Protein Interaction Screening Autor Matthews, Daniel R., Fruhwirth, Gilbert O., Weitsman, Gregory, Carlin, Leo M., Ofo, Enyinnaya, Keppler, Melanie, Barber, Paul R., Tullis, Iain D. C., Vojnovic, Borivoj, Ng, Tony, Ameer-Beg, Simon M.

“…Functional imaging can provide a level of quantification that is not possible in what might be termed traditional high-content screening. This is due to the…”
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First-in-man study of the PSMA Minibody IR800-IAB2M for molecularly targeted intraoperative fluorescence guidance during radical prostatectomy Autor Hamdy, Freddie C., Lamb, Alastair D., Tullis, Iain D. C., Verrill, Clare, Rombach, Ines, Rao, Srinivasa R., Colling, Richard, Barber, Paul R., Volpi, Davide, Barbera-Martin, Luis, Lopez, J Francisco, Omer, Altan, Hewitt, Aimi, Lovell, Shelagh, Niederer, Jane, Lambert, Adam, Snoeck, Joke, Thomson, Claire, Leslie, Tom, Bryant, Richard J., Mascioni, Alessandro, Jia, Fang, Torgov, Michael, Wilson, Ian, Gudas, Jean, Wu, Anna M., Olafsen, Tove, Vojnovic, Borivoj

“…Purpose Prostate-specific membrane antigen (PSMA) is increasingly used to image prostate cancer in clinical practice. We sought to develop and test a humanised…”
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Megavoltage photon FLASH for preclinical experiments Autor Taylor, Edward R. J. F., Tullis, Iain D. C., Vojnovic, Borivoj, Petersson, Kristoffer

“…Background FLASH radiotherapy using megavoltage (MV) photon beams should enable greater therapeutic efficacy, target deep seated tumors, and provide insights…”
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Monitoring electron energies during FLASH irradiations Autor Berne, Alexander, Petersson, Kristoffer, Tullis, Iain D C, Newman, Robert G, Vojnovic, Borivoj

“…When relativistic electrons are used to irradiate tissues, such as during FLASH pre-clinical irradiations, the electron beam energy is one of the critical…”
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A prospective pilot study of detection of sentinel lymph nodes in gynaecological cancers using a novel near infrared fluorescence imaging system Autor Laios, Alexandros, Volpi, Davide, Tullis, Iain D. C., Woodward, Martha, Kennedy, Stephen, Pathiraja, Pubudu N. J., Haldar, Krishnayan, Vojnovic, Borivoj, Ahmed, Ahmed A.

“…Background Sentinel Lymph Node (SLN) sampling may significantly reduce surgical morbidity by avoiding needless radical lymphadenectomy. In gynaecological…”
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HER2-HER3 Heterodimer Quantification by FRET-FLIM and Patient Subclass Analysis of the COIN Colorectal Trial Autor Barber, Paul R, Weitsman, Gregory, Lawler, Katherine, Barrett, James E, Rowley, Mark, Rodriguez-Justo, Manuel, Fisher, David, Gao, Fangfei, Tullis, Iain D C, Deng, Jinhai, Brown, Louise, Kaplan, Richard, Hochhauser, Daniel, Adams, Richard, Maughan, Timothy S., Vojnovic, Borivoj, Coolen, Anthony C C, Ng, Tony

“…Abstract Background The phase III MRC COIN trial showed no statistically significant benefit from adding the EGFR-target cetuximab to oxaliplatin-based…”
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Identifying Ureters In Situ Under Fluorescence During Laparoscopic and Open Colorectal Surgery Autor Yeung, Trevor M, Volpi, Davide, Tullis, Iain D C, Nicholson, Gary A, Buchs, Nicolas, Cunningham, Chris, Guy, Richard, Lindsey, Ian, George, Bruce, Jones, Oliver, Wang, Lai Mun, Hompes, Roel, Vojnovic, Borivoj, Hamdy, Freddie, Mortensen, Neil J

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Tumour irradiation combined with vascular-targeted photodynamic therapy enhances antitumour effects in pre-clinical prostate cancer Autor Sjoberg, Hanna T., Philippou, Yiannis, Magnussen, Anette L., Tullis, Iain D. C., Bridges, Esther, Chatrian, Andrea, Lefebvre, Joel, Tam, Ka Ho, Murphy, Emma A., Rittscher, Jens, Preise, Dina, Agemy, Lilach, Yechezkel, Tamar, Smart, Sean C., Kinchesh, Paul, Gilchrist, Stuart, Allen, Danny P., Scheiblin, David A., Lockett, Stephen J., Wink, David A., Lamb, Alastair D., Mills, Ian G., Harris, Adrian, Muschel, Ruth J., Vojnovic, Boris, Scherz, Avigdor, Hamdy, Freddie C., Bryant, Richard J.

“…Background There is a need to improve the treatment of prostate cancer (PCa) and reduce treatment side effects. Vascular-targeted photodynamic therapy (VTP) is…”
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Monitoring beam charge during FLASH irradiations Autor Vojnovic, Borivoj, Tullis, Iain D. C., Newman, Robert G., Petersson, Kristoffer

“…In recent years, FLASH irradiation has attracted significant interest in radiation research. Studies have shown that irradiation at ultra-high dose rates…”
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The p97–Ataxin 3 complex regulates homeostasis of the DNA damage response E3 ubiquitin ligase RNF8 Autor Singh, Abhay Narayan, Oehler, Judith, Torrecilla, Ignacio, Kilgas, Susan, Li, Shudong, Vaz, Bruno, Guérillon, Claire, Fielden, John, Hernandez‐Carralero, Esperanza, Cabrera, Elisa, Tullis, Iain DC, Meerang, Mayura, Barber, Paul R, Freire, Raimundo, Parsons, Jason, Vojnovic, Borivoj, Kiltie, Anne E, Mailand, Niels, Ramadan, Kristijan

“…The E3 ubiquitin ligase RNF8 (RING finger protein 8) is a pivotal enzyme for DNA repair. However, RNF8 hyper‐accumulation is tumour‐promoting and positively…”
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Quantifying the flash effect and its dependence on average dose rate in vivo for 6 MeV electron and 6 MV photon beams Autor Paillas, Salomé, Taylor, Edward R.J.F., Lövgren, Nathalie, Tullis, Iain D.C., Petersson, Kristoffer

“…•Increasing the average dose rate delays the onset, and reduces the severity, of radiation induced skin toxicity.•Similar FLASH effect following 6 MV photon…”
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Electrically tunable fluidic lens imaging system for laparoscopic fluorescence-guided surgery Autor Volpi, Davide, Tullis, Iain D C, Barber, Paul R, Augustyniak, Edyta M, Smart, Sean C, Vallis, Katherine A, Vojnovic, Borivoj

“…The addition of fluorescence guidance in laparoscopic procedures has gained significant interest in recent years, particularly through the use of near infrared…”
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Use of intraoperative fluorescence to enhance robot-assisted radical prostatectomy Autor Rajakumar, Timothy, Yassin, Musaab, Musbahi, Omar, Harris, Eli, Lopez, J Francisco, Bryant, Richard J, Tullis, Iain Dc, Vojnovic, Borivoj, Hamdy, Freddie C, Lamb, Alastair D

“…Robot-assisted radical prostatectomy has become the standard of care for the removal of localized prostate cancer. Positive outcomes depend upon the precise…”
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Stable electron-irradiated [1- 13 C]alanine radicals for metabolic imaging with dynamic nuclear polarization Autor Rooney, Catriona H. E., Lau, Justin Y. C., Hansen, Esben S. S., Christensen, Nichlas Vous, Dang, Duy A., Petersson, Kristoffer, Tullis, Iain D. C., Vojnovic, Borivoj, Smart, Sean, Myers, William, Richardson, Zoe, Lewis, Jarrod, Kennedy, Brett W. C., Bowen, Alice M., Bertelsen, Lotte Bonde, Laustsen, Christoffer, Tyler, Damian J., Miller, Jack J.

“…Dissolution dynamic nuclear polarization (dDNP) increases the sensitivity of magnetic resonance experiments by >10 4 -fold, permitting isotopically labeled…”
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Electrically tunable fluidic lens imaging system for laparoscopic fluorescence-guided surgery Autor Volpi, Davide, Tullis, Iain D. C., Barber, Paul R., Augustyniak, Edyta M., Smart, Sean C., Vallis, Katherine A., Vojnovic, Borivoj

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Imaging tumour heterogeneity of the consequences of a PKCα-substrate interaction in breast cancer patients Autor Weitsman, Gregory, Lawler, Katherine, Kelleher, Muireann T, Barrett, James E, Barber, Paul R, Shamil, Eamon, Festy, Frederic, Patel, Gargi, Fruhwirth, Gilbert O, Huang, Lufei, Tullis, Iain D C, Woodman, Natalie, Ofo, Enyinnaya, Ameer-Beg, Simon M, Irshad, Sheeba, Condeelis, John, Gillett, Cheryl E, Ellis, Paul A, Vojnovic, Borivoj, Coolen, Anthony C C, Ng, Tony

“…Breast cancer heterogeneity demands that prognostic models must be biologically driven and recent clinical evidence indicates that future prognostic signatures…”
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