Suchergebnisse - "Tubb, Vanessa"

Isolation of T cell receptors targeting recurrent neoantigens in hematological malignancies von Tubb, Vanessa M., Schrikkema, Deborah S., Croft, Nathan P., Purcell, Anthony W., Linnemann, Carsten, Freriks, Manon R., Chen, Frederick, Long, Heather M., Lee, Steven P., Bendle, Gavin M.

“… Mutation-derived neoantigens represent an important class of tumour-specific, tumour rejection antigens, and are attractive targets for TCR gene therapy of …”
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Metabolic engineering against the arginine microenvironment enhances CAR-T cell proliferation and therapeutic activity von Fultang, Livingstone, Booth, Sarah, Yogev, Orli, Martins da Costa, Barbara, Tubb, Vanessa, Panetti, Silvia, Stavrou, Victoria, Scarpa, Ugo, Jankevics, Andris, Lloyd, Gavin, Southam, Andrew, Lee, Steven P, Dunn, Warwick B, Chesler, Louis, Mussai, Francis, De Santo, Carmela

“… Hematological and solid cancers catabolize the semiessential amino acid arginine to drive cell proliferation. However, the resulting low arginine …”
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The arginine metabolome in acute lymphoblastic leukemia can be targeted by the pegylated‐recombinant arginase I BCT‐100 von De Santo, Carmela, Booth, Sarah, Vardon, Ashley, Cousins, Antony, Tubb, Vanessa, Perry, Tracey, Noyvert, Boris, Beggs, Andrew, Ng, Margaret, Halsey, Christina, Kearns, Pamela, Cheng, Paul, Mussai, Francis

“… Arginine is a semi‐essential amino acid that plays a key role in cell survival and proliferation in normal and malignant cells. BCT‐100, a pegylated (PEG) …”
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Promiscuous recognition of MR1 drives self-reactive mucosal-associated invariant T cell responses von Chancellor, Andrew, Alan Simmons, Robert, Khanolkar, Rahul C, Nosi, Vladimir, Beshirova, Aisha, Berloffa, Giuliano, Colombo, Rodrigo, Karuppiah, Vijaykumar, Pentier, Johanne M, Tubb, Vanessa, Ghadbane, Hemza, Suckling, Richard J, Page, Keith, Crean, Rory M, Vacchini, Alessandro, De Gregorio, Corinne, Schaefer, Verena, Constantin, Daniel, Gligoris, Thomas, Lloyd, Angharad, Hock, Miriam, Srikannathasan, Velupillai, Robinson, Ross A, Besra, Gurdyal S, van der Kamp, Marc W, Mori, Lucia, Calogero, Raffaele, Cole, David K, De Libero, Gennaro, Lepore, Marco

“… Mucosal-associated invariant T (MAIT) cells use canonical semi-invariant T cell receptors (TCR) to recognize microbial riboflavin precursors displayed by the …”
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346 Pre-clinical characterization of AZD0240, a CRISPR-engineered autologous TCR-T cell product targeting KRAS-G12D/HLA-A11:01 that is multi-armored to increase epitope sensitivity von Kok Lianne, Eshuis Sander, Kong Xiangjun, Ma, Jennifer, Mojadidi Michelle, Hall, Elizabeth, Grace Sun Ka Hei, Kroon, Paula, Tubb, Vanessa, Schumacher, Ton, Perez, Arianne, Linnemann Carsten, Cobbold, Mark, Heijst Jeroen van, Bendle Gavin

“… BackgroundKRAS is one of the most mutated genes in human cancer, with the G12D mutation having the highest frequency, occurring in 28% and 12% of pancreatic …”
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The development of novel t cell receptor, and chimeric antigen receptor, engineered t cell therapies for the treatment of cancer von Tubb, Vanessa

“… The ability to generate a tumour-reactive T cell compartment is possible through the genetic engineering of patient T cells with tumour-reactive TCRs or CARs …”
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Project 1: the role of PTPN22.6 in intermediate uveitis and Project 2: cord blood mononuclear cells as an alternative source for chimeric antigen receptor-mediated cancer immunotherapy von Tubb, Vanessa

“… Project 1. BACKGROUND: Uveitis, an inflammatory disease with a putative autoimmune component, is a major cause of visual impairment in the UK. Lyp is a protein …”
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