Výsledky vyhľadávania - "Tsukui, Tatsuya"

Collagen-producing lung cell atlas identifies multiple subsets with distinct localization and relevance to fibrosis Autor Tsukui, Tatsuya, Sun, Kai-Hui, Wetter, Joseph B., Wilson-Kanamori, John R., Hazelwood, Lisa A., Henderson, Neil C., Adams, Taylor S., Schupp, Jonas C., Poli, Sergio D., Rosas, Ivan O., Kaminski, Naftali, Matthay, Michael A., Wolters, Paul J., Sheppard, Dean

“…Collagen-producing cells maintain the complex architecture of the lung and drive pathologic scarring in pulmonary fibrosis. Here we perform single-cell…”
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Gli1 + mesenchymal stromal cells form a pathological niche to promote airway progenitor metaplasia in the fibrotic lung Autor Cassandras, Monica, Wang, Chaoqun, Kathiriya, Jaymin, Tsukui, Tatsuya, Matatia, Peri, Matthay, Michael, Wolters, Paul, Molofsky, Ari, Sheppard, Dean, Chapman, Hal, Peng, Tien

“…Aberrant epithelial reprogramming can induce metaplastic differentiation at sites of tissue injury that culminates in transformed barriers composed of scar and…”
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Tracking of intertissue migration reveals the origins of tumor-infiltrating monocytes Autor Shand, Francis H W, Ueha, Satoshi, Otsuji, Mikiya, Koid, Suang Suang, Shichino, Shigeyuki, Tsukui, Tatsuya, Kosugi-Kanaya, Mizuha, Abe, Jun, Tomura, Michio, Ziogas, James, Matsushima, Kouji

“…Myeloid cells such as monocytes and monocyte-derived macrophages promote tumor progression. Recent reports suggest that extramedullary hematopoiesis sustains a…”
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An in vivo screening platform identifies senolytic compounds that target p16INK4a+ fibroblasts in lung fibrosis Autor Lee, Jin Young, Reyes, Nabora S., Ravishankar, Supriya, Zhou, Minqi, Krasilnikov, Maria, Ringler, Christian, Pohan, Grace, Wilson, Chris, Ang, Kenny Kean-Hooi, Wolters, Paul J., Tsukui, Tatsuya, Sheppard, Dean, Arkin, Michelle R., Peng, Tien

“…The appearance of senescent cells in age-related diseases has spurred the search for compounds that can target senescent cells in tissues ("senolytics")…”
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Impaired myofibroblast proliferation is a central feature of pathologic post-natal alveolar simplification Autor Khan, Imran S, Molina, Christopher, Ren, Xin, Auyeung, Vincent C, Cohen, Max, Tsukui, Tatsuya, Atakilit, Amha, Sheppard, Dean

“…Premature infants with bronchopulmonary dysplasia (BPD) have impaired alveolar gas exchange due to alveolar simplification and dysmorphic pulmonary…”
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Intratracheal cell transfer demonstrates the profibrotic potential of resident fibroblasts in pulmonary fibrosis Autor Tsukui, Tatsuya, Ueha, Satoshi, Shichino, Shigeyuki, Inagaki, Yutaka, Matsushima, Kouji

“…Pulmonary fibrosis is a devastating disease for which there are few effective therapies. Activated fibroblasts form subepithelial clusters known as…”
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Heat Shock Protein 27 Plays a Pivotal Role in Myofibroblast Differentiation and in the Development of Bleomycin-Induced Pulmonary Fibrosis Autor Park, Ah-Mee, Kanai, Kyosuke, Itoh, Tatsuki, Sato, Takao, Tsukui, Tatsuya, Inagaki, Yutaka, Selman, Moises, Matsushima, Kouji, Yoshie, Osamu

“…Heat shock protein 27 (HSP27) is a member of the small molecular weight HSP family. Upon treatment with transforming growth factor β1 (TGF-β1), we observed…”
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Engraftment and proliferation potential of embryonic lung tissue cells in irradiated mice with emphysema Autor Shiraishi, Kazushige, Shichino, Shigeyuki, Tsukui, Tatsuya, Hashimoto, Shinichi, Ueha, Satoshi, Matsushima, Kouji

“…Recently, there has been increasing interest in stem cell transplantation therapy, to treat chronic respiratory diseases, using lung epithelial cells or…”
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Gli signaling pathway modulates fibroblast activation and facilitates scar formation in pulmonary fibrosis Autor Tsukui, Tatsuya, Ueha, Satoshi, Shichino, Shigeyuki, Hashimoto, Shinichi, Nakajima, Takuya, Shiraishi, Kazushige, Kihara, Miho, Kiyonari, Hiroshi, Inagaki, Yutaka, Matsushima, Kouji

“…Pulmonary fibrosis is characterized by progressive and irreversible scarring of alveoli, which causes reduction of surface epithelial area and eventually…”
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Unique Glycoform-Dependent Monoclonal Antibodies for Mouse Mucin 21 Autor Nishida, Jun, Shichino, Shigeyuki, Tsukui, Tatsuya, Hoshino, Mayumi, Okada, Tomoko, Okada, Kyoko, Yi, Yuri, Toraya-Brown, Seiko, Mochizuki, Miho, Koizumi, Ryouta, Ishii-Schrade, Katrin, Denda-Nagai, Kaori, Irimura, Tatsuro

“…Mucin 21(Muc21)/epiglycanin is expressed on apical surfaces of squamous epithelia and has potentially protective roles, which are thought to be associated with…”
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Qualitative rather than quantitative changes are hallmarks of fibroblasts in bleomycin-induced pulmonary fibrosis Autor Tsukui, Tatsuya, Ueha, Satoshi, Abe, Jun, Hashimoto, Shin-ichi, Shichino, Shigeyuki, Shimaoka, Takeshi, Shand, Francis H W, Arakawa, Yasuka, Oshima, Kenshiro, Hattori, Masahira, Inagaki, Yutaka, Tomura, Michio, Matsushima, Kouji

“…Pulmonary fibrosis is characterized by accumulation of activated fibroblasts that produce excessive amounts of extracellular matrix components such as collagen…”
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Macrophage Cx43 Is Necessary for Fibroblast Cytosolic Calcium and Lung Fibrosis After Injury Autor Bhattacharyya, Aritra, Torre, Paola, Yadav, Preeti, Boostanpour, Kaveh, Chen, Tian Y., Tsukui, Tatsuya, Sheppard, Dean, Muramatsu, Rieko, Seed, Robert I., Nishimura, Stephen L., Jung, James B., Tang, Xin-Zi, Allen, Christopher D. C., Bhattacharya, Mallar

“…Macrophages are paracrine signalers that regulate tissular responses to injury through interactions with parenchymal cells. Connexin hemichannels have recently…”
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Mucin 21 confers resistance to apoptosis in an O-glycosylation-dependent manner Autor Tian, Yuan, Denda-Nagai, Kaori, Tsukui, Tatsuya, Ishii-Schrade, Katrin B., Okada, Kyoko, Nishizono, Yoshihiro, Matsuzaki, Kosuke, Hafley, Margarete, Bresalier, Robert S., Irimura, Tatsuro

“…Highly glycosylated mucins protect epithelial surfaces from external insults and are related to malignant behaviors of carcinoma cells. However, the importance…”
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Reduced supply of monocyte-derived macrophages leads to a transition from nodular to diffuse lesions and tissue cell activation in silica-induced pulmonary fibrosis in mice Autor Shichino, Shigeyuki, Abe, Jun, Ueha, Satoshi, Otsuji, Mikiya, Tsukui, Tatsuya, Kosugi-Kanaya, Mizuha, Shand, Francis H W, Hashimoto, Shin-Ichi, Suzuki, Hiroshi I, Morikawa, Teppei, Inagaki, Yutaka, Matsushima, Kouji

“…Pulmonary fibrosis (PF) is an intractable disorder with a poor prognosis. Lung macrophages have been reported to regulate both progression and remission of…”
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Transcriptome network analysis identifies protective role of the LXR/SREBP-1c axis in murine pulmonary fibrosis Autor Shichino, Shigeyuki, Ueha, Satoshi, Hashimoto, Shinichi, Otsuji, Mikiya, Abe, Jun, Tsukui, Tatsuya, Deshimaru, Shungo, Nakajima, Takuya, Kosugi-Kanaya, Mizuha, Shand, Francis H.W., Inagaki, Yutaka, Shimano, Hitoshi, Matsushima, Kouji

“…Pulmonary fibrosis (PF) is an intractable disorder with a poor prognosis. Although lung fibroblasts play a central role in PF, the key regulatory molecules…”
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Stromal heterogeneity in the adult lung delineated by single-cell genomics Autor Tsukui, Tatsuya, Sheppard, Dean

“…Stromal cells in the lung provide structural support to other cells and play critical roles in inflammation, repair, and fibrosis after injury. Recent…”
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Alveolar fibroblast lineage orchestrates lung inflammation and fibrosis Autor Tsukui, Tatsuya, Wolters, Paul J., Sheppard, Dean

“…Fibroblasts are present throughout the body and function to maintain tissue homeostasis. Recent studies have identified diverse fibroblast subsets in healthy…”
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CXCR6 regulates localization of tissue-resident memory CD8 T cells to the airways Autor Wein, Alexander N, McMaster, Sean R, Takamura, Shiki, Dunbar, Paul R, Cartwright, Emily K, Hayward, Sarah L, McManus, Daniel T, Shimaoka, Takeshi, Ueha, Satoshi, Tsukui, Tatsuya, Masumoto, Tomoko, Kurachi, Makoto, Matsushima, Kouji, Kohlmeier, Jacob E

“…Resident memory T cells (T cells) are an important first-line defense against respiratory pathogens, but the unique contributions of lung T cell populations to…”
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Clonal expansion of alveolar fibroblast progeny drives pulmonary fibrosis in mouse models Autor Molina, Christopher, Tsukui, Tatsuya, Khan, Imran S., Ren, Xin, Qiu, Wenli, Matthay, Michael, Wolters, Paul, Sheppard, Dean

“…Pulmonary fibrosis (PF) has been called a fibroproliferative disease, yet the functional importance of proliferating fibroblasts to PF has not been…”
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Gene silencing by EZH2 suppresses TGF-β activity within the decidua to avert pregnancy-adverse wound healing at the maternal-fetal interface Autor Osokine, Ivan, Siewiera, Johan, Rideaux, Damon, Ma, Stephany, Tsukui, Tatsuya, Erlebacher, Adrian

“…A little-appreciated feature of early pregnancy is that embryo implantation and placental outgrowth do not evoke wound-healing responses in the decidua, the…”
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