Suchergebnisse - "Tripathi, Swarnendu"

Defining the condensate landscape of fusion oncoproteins von Tripathi, Swarnendu, Shirnekhi, Hazheen K., Gorman, Scott D., Chandra, Bappaditya, Baggett, David W., Park, Cheon-Gil, Somjee, Ramiz, Lang, Benjamin, Hosseini, Seyed Mohammad Hadi, Pioso, Brittany J., Li, Yongsheng, Iacobucci, Ilaria, Gao, Qingsong, Edmonson, Michael N., Rice, Stephen V., Zhou, Xin, Bollinger, John, Mitrea, Diana M., White, Michael R., McGrail, Daniel J., Jarosz, Daniel F., Yi, S. Stephen, Babu, M. Madan, Mullighan, Charles G., Zhang, Jinghui, Sahni, Nidhi, Kriwacki, Richard W.

“… Fusion oncoproteins (FOs) arise from chromosomal translocations in ~17% of cancers and are often oncogenic drivers. Although some FOs can promote oncogenesis …”
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Inherent flexibility determines the transition mechanisms of the EF-hands of calmodulin von Tripathi, Swarnendu, Portman, John J

“… We explore how inherent flexibility of a protein molecule influences the mechanism controlling allosteric transitions by using a variational model inspired …”
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Protein recognition and selection through conformational and mutually induced fit von Wang, Qian, Zhang, Pengzhi, Hoffman, Laurel, Tripathi, Swarnendu, Homouz, Dirar, Liu, Yin, Waxham, M Neal, Cheung, Margaret S

“… Protein-protein interactions drive most every biological process, but in many instances the domains mediating recognition are disordered. How specificity in …”
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Molecular mechanics and dynamic simulations of well-known Kabuki syndrome-associated KDM6A variants reveal putative mechanisms of dysfunction von Chi, Young-In, Stodola, Timothy J., De Assuncao, Thiago M., Leverence, Elise N., Tripathi, Swarnendu, Dsouza, Nikita R., Mathison, Angela J., Basel, Donald G., Volkman, Brian F., Smith, Brian C., Lomberk, Gwen, Zimmermann, Michael T., Urrutia, Raul

“… Background Kabuki syndrome is a genetic disorder that affects several body systems and presents with variations in symptoms and severity. The syndrome is named …”
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Enhanced interpretation of 935 hotspot and non-hotspot RAS variants using evidence-based structural bioinformatics von Tripathi, Swarnendu, Dsouza, Nikita R., Mathison, Angela J., Leverence, Elise, Urrutia, Raul, Zimmermann, Michael T.

“… [Display omitted] •RAS mutations have been non-uniformly characterized biophysically and biochemically.•We assembled the broadest-to-date resource for KRAS …”
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Correction to: Molecular mechanics and dynamic simulations of well-known Kabuki syndrome-associated KDM6A variants reveal putative mechanisms of dysfunction von Chi, Young-In, Stodola, Timothy J., De Assuncao, Thiago M., Leverence, Elise N., Tripathi, Swarnendu, Dsouza, Nikita R., Mathison, Angela J., Basel, Donald G., Volkman, Brian F., Smith, Brian C., Lomberk, Gwen, Zimmermann, Michael T., Urrutia, Raul

“… An amendment to this paper has been published and can be accessed via the original article …”
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An Image Analysis Pipeline for Quantifying the Features of Fluorescently-Labeled Biomolecular Condensates in Cells von Baggett, David W., Medyukhina, Anna, Tripathi, Swarnendu, Shirnekhi, Hazheen K., Wu, Huiyun, Pounds, Stanley B., Khairy, Khaled, Kriwacki, Richard

“… Biomolecular condensates are cellular organelles formed through liquid-liquid phase separation (LLPS) that play critical roles in cellular functions including …”
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Inherent flexibility and protein function: The open/closed conformational transition in the N-terminal domain of calmodulin von Tripathi, Swarnendu, Portman, John J

“… The key to understand a protein's function often lies in its conformational dynamics. We develop a coarse-grained variational model to investigate the …”
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Correlation between Gene Variants, Signaling Pathways, and Efficacy of Chemotherapy Drugs against Colon Cancers von Tripathi, Swarnendu, Belkacemi, Louiza, Cheung, Margaret S., Bose, Rathindra N.

“… Efficacies, toxicities, and resistance mechanisms of chemotherapy drugs, such as oxaliplatin and 5-fluorouracil (5-FU), vary widely among various categories …”
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Novel KLHL26 variant associated with a familial case of Ebstein’s anomaly and left ventricular noncompaction von Samudrala, Sai Suma K., North, Lauren M., Stamm, Karl D., Earing, Michael G., Frommelt, Michele A., Willes, Richard, Tripathi, Swarnendu, Dsouza, Nikita R., Zimmermann, Michael T., Mahnke, Donna K., Liang, Huan Ling, Lund, Michael, Lin, Chien‐Wei, Geddes, Gabrielle C., Mitchell, Michael E., Tomita‐Mitchell, Aoy

“… Background Ebstein's anomaly (EA) is a rare congenital heart disease of the tricuspid valve and right ventricle. Patients with EA often manifest with left …”
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Properties governing small-molecule partitioning into biomolecular condensates von Chandra, Bappaditya, Tripathi, Swarnendu, Kriwacki, Richard

“… Membraneless cellular assemblies termed biomolecular condensates — into which diverse biopolymers partition — mediate myriad biological processes. A study now …”
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Assessing Protein Surface-Based Scoring for Interpreting Genomic Variants von Dsouza, Nikita R., Haque, Neshatul, Tripathi, Swarnendu, Zimmermann, Michael T.

“… Clinical genomics sequencing is rapidly expanding the number of variants that need to be functionally elucidated. Interpreting genetic variants (i.e., …”
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Elucidating the role of nucleophosmin in protein quality control mechanisms inside the nucleolus von Maslanka, Carolyn, Dogra, Priyanka, Tripathi, Swarnendu, Phillips, Aaron H, Kriwacki, Richard

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Structural bioinformatics enhances mechanistic interpretation of genomic variation, demonstrated through the analyses of 935 distinct RAS family mutations von Tripathi, Swarnendu, Dsouza, Nikita R, Urrutia, Raul, Zimmermann, Michael T

“… Abstract Motivation Protein-coding genetic alterations are frequently observed in Clinical Genetics, but the high yield of variants of uncertain significance …”
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Phase Separation Mediates NUP98 Fusion Oncoprotein Leukemic Transformation von Chandra, Bappaditya, Michmerhuizen, Nicole L, Shirnekhi, Hazheen K, Tripathi, Swarnendu, Pioso, Brittany J, Baggett, David W, Mitrea, Diana M, Iacobucci, Ilaria, White, Michael R, Chen, Jingjing, Park, Cheon-Gil, Wu, Huiyun, Pounds, Stanley, Medyukhina, Anna, Khairy, Khaled, Gao, Qingsong, Qu, Chunxu, Abdelhamed, Sherif, Gorman, Scott D, Bawa, Simranjot, Maslanka, Carolyn, Kinger, Swati, Dogra, Priyanka, Ferrolino, Mylene C, Di Giacomo, Danika, Mecucci, Cristina, Klco, Jeffery M, Mullighan, Charles G, Kriwacki, Richard W

“… NUP98 fusion oncoproteins (FO) are drivers in pediatric leukemias and many transform hematopoietic cells. Most NUP98 FOs harbor an intrinsically disordered …”
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Defining the condensate landscape of fusion oncoproteins von Baggett, David W, Shirnekhi, Hazheen, Chandra, Bappaditya, Tripathi, Swarnendu, Pioso, Brittany J, Kriwacki, Richard

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Pathogenic SPTBN1 variants cause an autosomal dominant neurodevelopmental syndrome von Cousin, Margot A., Creighton, Blake A., Breau, Keith A., Spillmann, Rebecca C., Torti, Erin, Dontu, Sruthi, Tripathi, Swarnendu, Ajit, Deepa, Edwards, Reginald J., Afriyie, Simone, Bay, Julia C., Harper, Kathryn M., Beltran, Alvaro A., Munoz, Lorena J., Falcon Rodriguez, Liset, Stankewich, Michael C., Person, Richard E., Si, Yue, Normand, Elizabeth A., Blevins, Amy, May, Alison S., Bier, Louise, Aggarwal, Vimla, Mancini, Grazia M. S., van Slegtenhorst, Marjon A., Cremer, Kirsten, Becker, Jessica, Engels, Hartmut, Aretz, Stefan, MacKenzie, Jennifer J., Brilstra, Eva, van Gassen, Koen L. I., van Jaarsveld, Richard H., Oegema, Renske, Parsons, Gretchen M., Mark, Paul, Helbig, Ingo, McKeown, Sarah E., Stratton, Robert, Cogne, Benjamin, Isidor, Bertrand, Cacheiro, Pilar, Smedley, Damian, Firth, Helen V., Bierhals, Tatjana, Kloth, Katja, Weiss, Deike, Fairley, Cecilia, Shieh, Joseph T., Kritzer, Amy, Jayakar, Parul, Kurtz-Nelson, Evangeline, Bernier, Raphael A., Wang, Tianyun, Eichler, Evan E., van de Laar, Ingrid M. B. H., McConkie-Rosell, Allyn, McDonald, Marie T., Kemppainen, Jennifer, Lanpher, Brendan C., Schultz-Rogers, Laura E., Gunderson, Lauren B., Pichurin, Pavel N., Yoon, Grace, Zech, Michael, Jech, Robert, Winkelmann, Juliane, Beltran, Adriana S., Zimmermann, Michael T., Temple, Brenda, Moy, Sheryl S., Klee, Eric W., Tan, Queenie K.-G., Lorenzo, Damaris N.

“… SPTBN1 encodes βII-spectrin, the ubiquitously expressed β-spectrin that forms micrometer-scale networks associated with plasma membranes. Mice deficient in …”
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Opposing Intermolecular Tuning of Ca2+ Affinity for Calmodulin by Neurogranin and CaMKII Peptides von Zhang, Pengzhi, Tripathi, Swarnendu, Trinh, Hoa, Cheung, Margaret S

“… We investigated the impact of bound calmodulin (CaM)-target compound structure on the affinity of calcium (Ca2+) by integrating coarse-grained models and …”
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Uncovering the leukemogenic mechanism of non-canonical NUP98 fusion oncoproteins von Pioso, Brittany J, Michmerhuizen, Nicole L, Tripathi, Swarnendu, Freyaldenhoven, Toler, Phillips, Aaron H, Mullighan, Charles G, Kriwacki, Richard

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Understanding condensate formation by fusion oncoprotein-derived intrinsically disordered regions von Kinger, Swati, Pioso, Brittany J, Tripathi, Swarnendu, Phillips, Aaron H, Park, Cheon-Gil, Maiti, Snigdha, Gorman, Scott D, Asampille, Gitanjali, Wahiduzzaman, Fnu, Freyaldenhoven, Toler, Baggett, David W, Shirnekhi, Hazheen, Chandra, Bappaditya, Kriwacki, Richard

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