Výsledky vyhledávání - "Translational Therapeutics"

TRLS-11. A PHASE 1 STUDY OF SAVOLITINIB IN RECURRENT, PROGRESSIVE, OR REFRACTORY MEDULLOBLASTOMA, HIGH-GRADE GLIOMA, DIFFUSE INTRINSIC PONTINE GLIOMA, AND CENTRAL NERVOUS SYSTEM (CNS) TUMORS HARBORING MET ABERRATIONS: A PEDIATRIC BRAIN TUMOR CONSORTIUM TRIAL Autor Salloum, Ralph, Huang, Jie, Stewart, Clinton F, Fuller, Christine, Smolarek, Teresa, Lenzen, Alicia, Waanders, Angela J, Baxter, Patiricia, Lindsay, Holly, Robison, Nathan, Pillay-Smiley, Natasha, Partap, Sonia, Fangusaro, Jason, Onar-Thomas, Arzu, Fouladi, Maryam, Dunkel, Ira J

“…Abstract Aberrant mesenchymal epithelial transition receptor (MET) activation leads to neoplasia, promotes invasive tumor growth, angiogenesis, and metastasis…”
Získat plný text

Predicting breast cancer response to neoadjuvant chemotherapy using pretreatment diffuse optical spectroscopic texture analysis Autor Tran, William T, Gangeh, Mehrdad J, Sannachi, Lakshmanan, Chin, Lee, Watkins, Elyse, Bruni, Silvio G, Rastegar, Rashin Fallah, Curpen, Belinda, Trudeau, Maureen, Gandhi, Sonal, Yaffe, Martin, Slodkowska, Elzbieta, Childs, Charmaine, Sadeghi-Naini, Ali, Czarnota, Gregory J

“…Background: Diffuse optical spectroscopy (DOS) has been demonstrated capable of monitoring response to neoadjuvant chemotherapy (NAC) in locally advanced…”
Získat plný text

Comparing desferrioxamine and light fractionation enhancement of ALA-PpIX photodynamic therapy in skin cancer Autor de Souza, Ana Luiza Ribeiro, Marra, Kayla, Gunn, Jason, Samkoe, Kimberley S, Kanick, Stephen Chad, Davis, Scott C, Chapman, M Shane, Maytin, Edward V, Hasan, Tayyaba, Pogue, Brian W

“…Background: Aminolevulinic acid (ALA)-based photodynamic therapy (PDT) provides selective uptake and conversion of ALA into protoporphyrin IX (PpIX) in actinic…”
Získat plný text

Carbogen breathing increases prostate cancer oxygenation: a translational MRI study in murine xenografts and humans Autor Alonzi, R, Padhani, A R, Maxwell, R J, Taylor, N J, Stirling, J J, Wilson, J I, d′Arcy, J A, Collins, D J, Saunders, M I, Hoskin, P J

“… There was a mean reduction in R 2 * of 6.4% ( P =0.003) for DU145 xenografts and 5.8% ( P =0.007) for PC3 xenografts. In all, 14 human subjects were evaluable…”
Získat plný text

CYP2C19 pharmacogenetics in advanced cancer: compromised function independent of genotype Autor Helsby, N A, Lo, W-Y, Sharples, K, Riley, G, Murray, M, Spells, K, Dzhelai, M, Simpson, A, Findlay, M

“…). In healthy subjects PM can be identified through homozygous variant genotype. However, a discordance between CYP2C19 genotype and phenotype has been reported previously in a small study of cancer patients…”
Získat plný text

Interleukin-6 trans signalling enhances photodynamic therapy by modulating cell cycling Autor Wei, L-H, Baumann, H, Tracy, E, Wang, Y, Hutson, A, Rose-John, S, Henderson, B W

“…). We have previously reported that PDT-treated cells lose responsiveness to IL-6 cytokines. Therefore, it is unclear whether PDT surviving tumour cells are subject to regulation by IL-6 and whether this regulation could contribute to tumour control by PDT…”
Získat plný text

Complement C1q essential for aeroallergen sensitization via CSF1R+ conventional dendritic cells type 2 Autor Moon, Hyung-Geun, Eccles, Jacob D., Kim, Seung-jae, Kim, Ki-Hyun, Kim, Young-Mee, Rehman, Jalees, Lee, Hyun, Kanabar, Pinal, Christman, John W., Ackerman, Steven J., Ascoli, Christian, Kang, Homan, Choi, Hak Soo, Kim, Minhyung, You, Sungyong, Park, Gye Young

“…Dendritic cells (DCs) are heterogeneous, comprising multiple subsets with unique functional specifications. Our previous work has demonstrated that the…”
Získat plný text

The transition from enthesis physiological responses in health to aberrant responses that underpin spondyloarthritis mechanisms Autor Aydin, Sibel Zehra, Bridgewood, Charles, Zabotti, Alen, Girolimetto, Nicolò, McGonagle, Dennis

“…Despite immunology and translational therapeutics advances in inflammatory arthritis over the past two decades, the enthesis, which is the epicentric of the spondyloarthritis family pathological…”
Zjistit podrobnosti o přístupu

The Role of Neutrophils and Neutrophil Extracellular Traps in Vascular Damage in Systemic Lupus Erythematosus Autor O’Neil, Liam J., Kaplan, Mariana J., Carmona-Rivera, Carmelo

“… Enhanced neutrophil extracellular trap (NET) formation was linked to vasculopathy in both SLE and non-SLE subjects and may promote enhanced coronary plaque formation and lipoprotein dysregulation…”
Získat plný text

mRNA vaccines induce durable immune memory to SARS-CoV-2 and variants of concern Autor Goel, Rishi R, Painter, Mark M, Apostolidis, Sokratis A, Mathew, Divij, Meng, Wenzhao, Rosenfeld, Aaron M, Lundgreen, Kendall A, Reynaldi, Arnold, Khoury, David S, Pattekar, Ajinkya, Gouma, Sigrid, Kuri-Cervantes, Leticia, Hicks, Philip, Dysinger, Sarah, Hicks, Amanda, Sharma, Harsh, Herring, Sarah, Korte, Scott, Baxter, Amy E, Oldridge, Derek A, Giles, Josephine R, Weirick, Madison E, McAllister, Christopher M, Awofolaju, Moses, Tanenbaum, Nicole, Drapeau, Elizabeth M, Dougherty, Jeanette, Long, Sherea, D'Andrea, Kurt, Hamilton, Jacob T, McLaughlin, Maura, Williams, Justine C, Adamski, Sharon, Kuthuru, Oliva, Frank, Ian, Betts, Michael R, Vella, Laura A, Grifoni, Alba, Weiskopf, Daniela, Sette, Alessandro, Hensley, Scott E, Davenport, Miles P, Bates, Paul, Luning Prak, Eline T, Greenplate, Allison R, Wherry, E John

“… and –recovered individuals for 6 months after vaccination. Antibodies declined from peak levels but remained detectable in most subjects at 6 months…”
Zjistit podrobnosti o přístupu

Common variable immunodeficiency–associated endotoxemia promotes early commitment to the T follicular lineage Autor Le Coz, Carole, Bengsch, Bertram, Khanna, Caroline, Trofa, Melissa, Ohtani, Takuya, Nolan, Brian E., Henrickson, Sarah E., Lambert, Michele P., Kim, Taylor Olmsted, Despotovic, Jenny M., Feldman, Scott, Fadugba, Olajumoke O., Takach, Patricia, Ruffner, Melanie, Jyonouchi, Soma, Heimall, Jennifer, Sullivan, Kathleen E., Wherry, E. John, Romberg, Neil

“…) subjects with numeric and/or functional TH cell alterations. The causes, interrelationships, and consequences of CVID-associated CD4…”
Získat plný text

Phase I Trial of Autologous RNA-electroporated cMET-directed CAR T Cells Administered Intravenously in Patients with Melanoma and Breast Carcinoma Autor Shah, Payal D., Huang, Alexander C., Xu, Xiaowei, Orlowski, Robert, Amaravadi, Ravi K., Schuchter, Lynn M., Zhang, Paul, Tchou, Julia, Matlawski, Tina, Cervini, Amanda, Shea, Joanne, Gilmore, Joan, Lledo, Lester, Dengel, Karen, Marshall, Amy, Wherry, E. John, Linette, Gerald P., Brennan, Andrea, Gonzalez, Vanessa, Kulikovskaya, Irina, Lacey, Simon F., Plesa, Gabriela, June, Carl H., Vonderheide, Robert H., Mitchell, Tara C.

“…) T cells targeting the cell-surface antigen cMET. Metastatic melanoma or mTNBC subjects had at least 30…”
Získat plný text

Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease Autor Tebay, Lauren E., Robertson, Holly, Durant, Stephen T., Vitale, Steven R., Penning, Trevor M., Dinkova-Kostova, Albena T., Hayes, John D.

“…Nuclear factor-erythroid 2 p45-related factor 2 (Nrf2) regulates the basal and stress-inducible expression of a battery of genes encoding key components of the…”
Získat plný text

Controlled Co-delivery of pPDGF-B and pBMP-2 from intraoperatively bioprinted bone constructs improves the repair of calvarial defects in rats Autor Moncal, Kazim K., Tigli Aydın, R. Seda, Godzik, Kevin P., Acri, Timothy M., Heo, Dong N., Rizk, Elias, Wee, Hwabok, Lewis, Gregory S., Salem, Aliasger K., Ozbolat, Ibrahim T.

“…Intraoperative bioprinting (IOB), which refers to the bioprinting process performed on a live subject in a surgical setting, has made it feasible to directly deliver gene-activated matrices into craniomaxillofacial (CMF) defect sites…”
Získat plný text

Mechanical strain stimulates COPII‐dependent secretory trafficking via Rac1 Autor Phuyal, Santosh, Djaerff, Elena, Le Roux, Anabel‐Lise, Baker, Martin J, Fankhauser, Daniela, Mahdizadeh, Sayyed Jalil, Reiterer, Veronika, Parizadeh, Amirabbas, Felder, Edward, Kahlhofer, Jennifer C, Teis, David, Kazanietz, Marcelo G, Geley, Stephan, Eriksson, Leif, Roca‐Cusachs, Pere, Farhan, Hesso

“…), much less is known about whether and how this trafficking is subject to regulation by mechanical signals…”
Získat plný text

Obesity diminishes response to PD-1-based immunotherapies in renal cancer Autor Boi, Shannon K, Orlandella, Rachael M, Gibson, Justin Tyler, Turbitt, William James, Wald, Gal, Thomas, Lewis, Buchta Rosean, Claire, Norris, Katlyn E, Bing, Megan, Bertrand, Laura, Gross, Brett P, Makkouk, Amani, Starenki, Dmytro, Farag, Kristine I, Sorge, Robert E, Brown, James A, Gordetsky, Jennifer, Yasin, Hesham, Garje, Rohan, Nandagopal, Lakshminarayanan, Weiner, George J, Lubaroff, David M, Arend, Rebecca C, Li, Peng, Zakharia, Yousef, Yang, Eddy, Salem, Aliasger K, Nepple, Kenneth, Marquez-Lago, Tatiana T, Norian, Lyse A

“…)-based outcomes in both renal cell carcinoma (RCC) subjects and orthotopic murine renal tumors. Overall survival (OS…”
Získat plný text

Characterization and Quantification of Oxidized High Mobility Group Box 1 Proteoforms Secreted from Hepatocytes by Toxic Levels of Acetaminophen Autor Pirnie, Ross, Gillespie, Kevin P, Weng, Liwei, Mesaros, Clementina, Blair, Ian A

“… The redox behavior of HMGB1 and the proteoforms of HMGB1 present in oxidative environments has been the subject of a number of confusing and contradictory studies…”
Zjistit podrobnosti o přístupu

Melatonin directly binds and inhibits death‐associated protein kinase 1 function in Alzheimer’s disease Autor Chen, Dongmei, Mei, Yingxue, Kim, Nami, Lan, Guihua, Gan, Chen‐Ling, Fan, Fei, Zhang, Tao, Xia, Yongfang, Wang, Long, Lin, Chun, Ke, Fang, Zhou, Xiao Zhen, Lu, Kun Ping, Lee, Tae Ho

“…) patients compared with normal subjects, and aberrant DAPK1 regulation is implicated in the development of AD. However…”
Získat plný text

Quantification of Serum High Mobility Group Box 1 by Liquid Chromatography/High-Resolution Mass Spectrometry: Implications for Its Role in Immunity, Inflammation, and Cancer Autor Weng, Liwei, Guo, Lili, Vachani, Anil, Mesaros, Clementina, Blair, Ian A

“… However, these studies used immunoassay-based methods to analyze serum HMGB1. Autoantibodies to HMGB1 in serum are found in healthy control subjects as well as in patients with different diseases…”
Zjistit podrobnosti o přístupu

Frataxin analysis using triple quadrupole mass spectrometry: application to a large heterogeneous clinical cohort Autor Lynch, David R., Rojsajjakul, Teerapat, Subramony, S. H., Perlman, Susan L., Keita, Medina, Mesaros, Clementina, Blair, Ian A.

“…Background Friedreich ataxia is a progressive multisystem disorder caused by deficiency of the protein frataxin; a small mitochondrial protein involved in iron…”
Získat plný text