Výsledky vyhľadávania - "Transcriptomes"

Developing a ‘personalome’ for precision medicine: emerging methods that compute interpretable effect sizes from single-subject transcriptomes Autor Vitali, Francesca, Li, Qike, Schissler, A Grant, Berghout, Joanne, Kenost, Colleen, Lussier, Yves A

“… from single-subject -omics remain underdeveloped, particularly for quantitative non-sequence measurements, including complete transcriptome…”
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Intracoronary Imaging, Cholesterol Efflux, and Transcriptomes After Intensive Statin Treatment: The YELLOW II Study Autor Kini, Annapoorna S, Vengrenyuk, Yuliya, Shameer, Khader, Maehara, Akiko, Purushothaman, Meerarani, Yoshimura, Takahiro, Matsumura, Mitsuaki, Aquino, Melissa, Haider, Nezam, Johnson, Kipp W, Readhead, Ben, Kidd, Brian A, Feig, Jonathan E, Krishnan, Prakash, Sweeny, Joseph, Milind, Mahajan, Moreno, Pedro, Mehran, Roxana, Kovacic, Jason C, Baber, Usman, Dudley, Joel T, Narula, Jagat, Sharma, Samin

“… optical coherence tomography (OCT) of an obstructive nonculprit lesion. All subjects received 40 mg of rosuvastatin daily for 8 to 12 weeks, when the nonculprit lesion was reimaged and intervention performed…”
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Endogenous retroviruses drive species-specific germline transcriptomes in mammals Autor Sakashita, Akihiko, Maezawa, So, Takahashi, Kazuki, Alavattam, Kris G, Yukawa, Masashi, Hu, Yueh-Chiang, Kojima, Shohei, Parrish, Nicholas F, Barski, Artem, Pavlicev, Mihaela, Namekawa, Satoshi H

“… Male germline transcriptomes undergo dynamic changes after the mitosis-to-meiosis transition and have been subject to evolutionary divergence among mammals…”
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RNA Sequencing Reveals Small and Variable Contributions of Infectious Agents to Transcriptomes of Postmortem Nervous Tissues From Amyotrophic Lateral Sclerosis, Alzheimer’s Disease and Parkinson’s Disease Subjects, and Increased Expression of Genes From Disease-Activated Microglia Autor Bennett, James P., Keeney, Paula M., Brohawn, David G.

“… gray matter ribbons of AD and CTL subjects, and ventral midbrains of PD and CTL subjects. Trimmed PE reads were aligned against the hg38 human transcriptome using Tophat2/Bowtie2…”
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Single cell transcriptomes and multiscale networks from persons with and without Alzheimer’s disease Autor Wang, Qi, Antone, Jerry, Alsop, Eric, Reiman, Rebecca, Funk, Cory, Bendl, Jaroslav, Dudley, Joel T., Liang, Winnie S., Karr, Timothy L., Roussos, Panos, Bennett, David A., De Jager, Philip L., Serrano, Geidy E., Beach, Thomas G., Van Keuren-Jensen, Kendall, Mastroeni, Diego, Reiman, Eric M., Readhead, Benjamin P.

“… We report snRNA-seq profiles from superior frontal gyrus samples from 101 well characterized subjects from the Banner Brain and Body Donation Program in combination with whole genome sequences…”
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Charting Extracellular Transcriptomes in The Human Biofluid RNA Atlas Autor Hulstaert, Eva, Morlion, Annelien, Avila Cobos, Francisco, Verniers, Kimberly, Nuytens, Justine, Vanden Eynde, Eveline, Yigit, Nurten, Anckaert, Jasper, Geerts, Anja, Hindryckx, Pieter, Jacques, Peggy, Brusselle, Guy, Bracke, Ken R., Maes, Tania, Malfait, Thomas, Derveaux, Thierry, Ninclaus, Virginie, Van Cauwenbergh, Caroline, Roelens, Kristien, Roets, Ellen, Hemelsoet, Dimitri, Tilleman, Kelly, Brochez, Lieve, Kuersten, Scott, Simon, Lukas M., Karg, Sebastian, Kautzky-Willers, Alexandra, Leutner, Michael, Nöhammer, Christa, Slaby, Ondrej, Prins, Roméo Willinge, Koster, Jan, Lefever, Steve, Schroth, Gary P., Vandesompele, Jo, Mestdagh, Pieter

“… Where most studies focus on blood-derived fluids, other biofluids may be more informative. We present an atlas of messenger, circular, and small RNA transcriptomes of a comprehensive collection of 20 human biofluids…”
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Temporal changes in postprandial blood transcriptomes reveal subject-specific pattern of expression of innate immunity genes after a high-fat meal Autor Lemay, Danielle G, Huang, Shurong, Huang, Liping, Alkan, Zeynep, Kirschke, Catherine, Burnett, Dustin J, Wang, Yining E, Hwang, Daniel H

“… A total of 45 fasting and postprandial (3-h and 6-h) whole blood transcriptomes from 5 subjects in a crossover intervention trial of a high-fat meal supplemented with placebo, blueberry powder or docosahexaenoic acid (DHA…”
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Integration and transfer learning of single-cell transcriptomes via cFIT Autor Peng, Minshi, Li, Yue, Wamsley, Brie, Wei, Yuting, Roeder, Kathryn

“…) for capturing various batch effects across experiments, technologies, subjects, and even species…”
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Interpretation of 'Omics dynamics in a single subject using local estimates of dispersion between two transcriptomes Autor Li, Qike, Zaim, Samir Rachid, Aberasturi, Dillon, Berghout, Joanne, Li, Haiquan, Vitali, Francesca, Kenost, Colleen, Zhang, Helen Hao, Lussier, Yves A

“… By imposing restrictive transcriptome-wide assumptions limiting inferential opportunities of conventional methods…”
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N-of-1-pathways MixEnrich: advancing precision medicine via single-subject analysis in discovering dynamic changes of transcriptomes Autor Li, Qike, Schissler, A. Grant, Gardeux, Vincent, Achour, Ikbel, Kenost, Colleen, Berghout, Joanne, Li, Haiquan, Zhang, Hao Helen, Lussier, Yves A.

“…Background Transcriptome analytic tools are commonly used across patient cohorts to develop drugs and predict clinical outcomes…”
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A metaanalysis of bat phylogenetics and positive selection based on genomes and transcriptomes from 18 species Autor Hawkins, John A, Kaczmarek, Maria E, Müller, Marcel A, Drosten, Christian, Press, William H, Sawyer, Sara L

“… We generated a transcriptome sequence of , the African hammer-headed bat, and additional transcriptome sequence for , the Egyptian fruit bat…”
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Combining human platelet proteomes and transcriptomes: possibilities and challenges Autor Huang, Jingnan, Heemskerk, Johan W.M., Swieringa, Frauke

“… A comparison of the classified platelet transcriptome (17.6k transcripts) with the identified platelet proteome (5.2k proteins…”
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ARDS Molecular Phenotypes Have Distinct Lower Respiratory Tract Transcriptomes Autor Sarma, Aartik, Christenson, Stephanie A, Zha, Beth Shoshana, Pisco, Angela Oliveira, Neyton, Lucile P A, Mick, Eran, Sinha, Pratik S, Wilson, Jennifer G, Moazed, Farzad, Leligdowicz, Aleksandra, Maddali, Manoj V, Siegel, Emily R, Lyon, Zoe M, Carillo Haller, Sidney, Zhuo, Hanjing, Jauregui, Alejandra, Ghale, Rajani, Caldera, Saharai, Serpa, Paula Hayakawa, Deiss, Thomas, Love, Christina, Byrne, Ashley, Kalantar, Katrina L, DeRisi, Joseph L, Erle, David J, Krummel, Matthew F, Kangelaris, Kirsten N, Hendrickson, Carolyn M, Woodruff, Prescott G, Matthay, Michael A, Bos, Lieuwe D J, Langelier, Charles R, Calfee, Carolyn S

“…Two molecular phenotypes of the acute respiratory distress syndrome (ARDS) with divergent clinical trajectories and responses to therapy have been identified…”
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Sex-dependent neuro-deconvolution analysis of Alzheimer's disease brain transcriptomes according to CHI3L1 expression levels Autor Sanfilippo, Cristina, Castrogiovanni, Paola, Imbesi, Rosa, Musumeci, Giuseppe, Vecchio, Michele, Li Volti, Giovanni, Tibullo, Daniele, Broggi, Giuseppe, Caltabiano, Rosario, Ulivieri, Martina, Kazakova, Maria, Parenti, Rosalba, Vicario, Nunzio, Fazio, Francesco, Di Rosa, Michelino

“…Glial activation and related neuroinflammatory processes play a key role in the aging and progression of Alzheimer's disease (AD). CHI3L1/ YKL40 is a widely…”
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Species delimitation in Amana (Liliaceae): transcriptomes battle with evolutionary complexity Autor Wang, Mei‐Zhen, Wu, Jing, Zhang, Sheng‐Lu, Mao, Li‐Mi, Ohi‐Toma, Tetsuo, Takano, Atsuko, Zhang, Yong‐Hua, Cameron, Kenneth M., Li, Pan

“…Species delimitation has long been a subject of controversy, and there are many alternative concepts and approaches used to define species in plants. The genus Amana (Liliaceae), known as ”East Asian tulips…”
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Impact of BRAF kinase inhibitors on the miRNomes and transcriptomes of melanoma cells Autor Kozar, Ines, Cesi, Giulia, Margue, Christiane, Philippidou, Demetra, Kreis, Stephanie

“… To investigate the impact of BRAF inhibitors on miRNomes and transcriptomes, we used in vitro melanoma models consisting of BRAF inhibitor-sensitive and -resistant cell lines generated in our laboratory…”
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Species-Specific Exon Loss in Human Transcriptomes Autor Wang, Jinkai, Lu, Zhi-xiang, Tokheim, Collin J., Miller, Sara E., Xing, Yi

“… Historically, transcriptome data and exon annotations are significantly biased toward humans over nonhuman primates…”
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Prefrontal cortex interneurons display dynamic sex-specific stress-induced transcriptomes Autor Girgenti, Matthew J., Wohleb, Eric S., Mehta, Sameet, Ghosal, Sriparna, Fogaca, Manoela V., Duman, Ronald S.

“… Abnormalities of GABA interneurons, particularly the somatostatin (human, SST; mouse, Sst) subtype, have been reported in postmortem brains of depressed subjects and include…”
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Impact of APOL1 kidney risk variants on glomerular transcriptomes Autor Kopp, Jeffrey B, Heymann, Jurgen

“…McNulty and colleagues describe the glomerular transcriptional landscape of subjects with APOL1…”
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Matching of oligoclonal immunoglobulin transcriptomes and proteomes of cerebrospinal fluid in multiple sclerosis Autor Obermeier, Birgit, Mentele, Reinhard, Malotka, Joachim, Kellermann, Josef, Kümpfel, Tania, Wekerle, Hartmut, Lottspeich, Friedrich, Hohlfeld, Reinhard, Dornmair, Klaus

“…) are diagnostic hallmarks of multiple sclerosis. Here we compared the Ig transcriptomes of B cells with the corresponding Ig proteomes in CSF samples from four subjects with multiple sclerosis…”
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