Suchergebnisse - "Toxicology letters"

Phosgene inhalation causes hemolysis and acute lung injury von Aggarwal, Saurabh, Jilling, Tamas, Doran, Stephen, Ahmad, Israr, Eagen, Jeannette E., Gu, Stephen, Gillespie, Mark, Albert, Carolyn J., Ford, David, Oh, Joo-Yeun, Patel, Rakesh P., Matalon, Sadis

“… [Display omitted] Phosgene (Carbonyl Chloride, COCl2) remains an important chemical intermediate in many industrial processes such as combustion of chlorinated …”
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Oxidative stress injury in doxorubicin-induced cardiotoxicity von Songbo, Mei, Lang, Hong, Xinyong, Cai, Bin, Xiao, Ping, Zhang, Liang, Shao

“… Doxorubicin (DOX) is widely used as a broad-spectrum anti-tumor anthracycline to treat various cancers. The serious adverse effects of DOX on cardiotoxicity …”
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Repeated-oral dose toxicity of polyethylene microplastics and the possible implications on reproduction and development of the next generation von Park, Eun-Jung, Han, Ji-Seok, Park, Eun-Jun, Seong, Eunsol, Lee, Gwang-Hee, Kim, Dong-Wan, Son, Hwa-Young, Han, Hyoung-Yun, Lee, Byoung-Seok

“… •Polyethylene microplastics (PE-MPs) are among the most produced plastics worldwide.•PE-MPs were dosed orally to the parent mice for 90 days and to dams until …”
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Fingolimod interrupts the cross talk between estrogen metabolism and sphingolipid metabolism within prostate cancer cells von Allam, Rasha M., Al-Abd, Ahmed M., Khedr, Alaa, Sharaf, Ola A., Nofal, Salwa M., Khalifa, Amani E., Mosli, Hisham A., Abdel-Naim, Ashraf B.

“… [Display omitted] •FTY720 possesses cytotoxic/antiproliferative effects in prostate cancer cells.•This might be due to its interfering with intra-prostatic …”
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An integrated view of cisplatin-induced nephrotoxicity and ototoxicity von Karasawa, Takatoshi, Steyger, Peter S.

“… •Differing mechanisms of platinum-induced cytotoxicity are introduced.•Known pathways of cisplatin-induced nephrotoxicity are discussed.•Known mechanisms and …”
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Pesticides, cognitive functions and dementia: A review von Aloizou, Athina-Maria, Siokas, Vasileios, Vogiatzi, Christina, Peristeri, Eleni, Docea, Anca Oana, Petrakis, Demetrios, Provatas, Antonios, Folia, Vasiliki, Chalkia, Charikleia, Vinceti, Marco, Wilks, Martin, Izotov, Boris N., Tsatsakis, Aristidis, Bogdanos, Dimitrios P., Dardiotis, Efthimios

“… •Pesticide exposure has been associated with cognitive decline and dementia.•The estimation of the exposure to pesticides is frequently performed without …”
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4-PBA inhibits LPS-induced inflammation through regulating ER stress and autophagy in acute lung injury models von Zeng, Meichun, Sang, Wenhua, Chen, Sha, Chen, Ran, Zhang, Hailin, Xue, Feng, Li, Zhengmao, Liu, Yu, Gong, Yongsheng, Zhang, Hongyu, Kong, Xiaoxia

“… •4-PBA protects LPS-induced acute lung injury and inflammation in mouse model.•4-PBA decreases the levels of ER stress and autophagy induced by LPS in vivo and …”
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Resveratrol attenuates oxidative damage through activating mitophagy in an in vitro model of Alzheimer’s disease von Wang, Hui, Jiang, Tianyue, Li, Wei, Gao, Na, Zhang, Tao

“… •Aβ increased apoptosis and enhanced oxidative status in PC12 cells.•Resveratrol promoted mitophagy in Aβ-induced PC12 cells.•Resveratrol alleviated neuronal …”
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Pesticides exposure as etiological factors of Parkinson's disease and other neurodegenerative diseases—A mechanistic approach von Baltazar, Maria Teresa, Dinis-Oliveira, Ricardo Jorge, de Lourdes Bastos, Maria, Tsatsakis, Aristidis M., Duarte, José Alberto, Carvalho, Félix

“… •The review provides new information regarding the neurotoxicity mechanisms of herbicides and pesticides.•New perspectives concerning chronic pesticide …”
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PGAM5 regulates PINK1/Parkin-mediated mitophagy via DRP1 in CCCP-induced mitochondrial dysfunction von Park, Yun Sun, Choi, Su Eun, Koh, Hyun Chul

“… •CCCP induces mitochondrial dysfunction.•Mitochondrial dynamics-related genes are increased.•Drp1 interacts with PGAM5 to trigger mitohpagy.•PGAM5 regulates …”
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Adverse health effects of 5G mobile networking technology under real-life conditions von Kostoff, Ronald N., Heroux, Paul, Aschner, Michael, Tsatsakis, Aristides

“… [Display omitted] •Identifies wide-spectrum of adverse health effects of non-ionizing non-visible radiation.•Most laboratory experiments were not designed to …”
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Toxicity of silver nanoparticles in biological systems: Does the complexity of biological systems matter? von Vazquez-Muñoz, Roberto, Borrego, Belen, Juárez-Moreno, Karla, García-García, Maritza, Mota Morales, Josué D., Bogdanchikova, Nina, Huerta-Saquero, Alejandro

“… This manuscript describes that biological systems of different taxonomical groups are inhibited at concentrations of silver nanoparticles within the same order …”
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Whole cigarette smoke condensates induce ferroptosis in human bronchial epithelial cells von Park, Eun-Jung, Park, Yoo-Jin, Lee, Sang Jin, Lee, Kyuhong, Yoon, Cheolho

“… Cigarette smoke is responsible for many fatal pulmonary diseases, however, the toxic mechanism is still unclear. In this study, we first confirmed that whole …”
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Effects of single and combined toxic exposures on the gut microbiome: Current knowledge and future directions von Tsiaoussis, John, Antoniou, Michael N., Koliarakis, Ioannis, Mesnage, Robin, Vardavas, Constantine I., Izotov, Boris N., Psaroulaki, Anna, Tsatsakis, Aristidis

“… [Display omitted] •Xenobiotics affect the gut microbiome influencing development of metabolic diseases•Xenobiotics have unpredictable effects on the gut …”
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Systemic toxicity eliciting metal ion levels from metallic implants and orthopedic devices – A mini review von Badhe, Ravindra V., Akinfosile, Obakanyin, Bijukumar, Divya, Barba, Mark, Mathew, Mathew T.

“… The metal/metal alloy-based implants and prostheses are in use for over a century, and the rejections, revisions, and metal particle-based toxicities were …”
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Occurrence, toxicity and endocrine disrupting potential of Bisphenol-B and Bisphenol-F: A mini-review von Usman, Afia, Ikhlas, Shoeb, Ahmad, Masood

“… Recent imposition of restriction on the use of Bisphenol-A (BPA) paved the way for entry of its analogues in the market. Bisphenol-B and Bisphenol-F are the …”
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Comprehensive analysis of transcriptomics and metabolomics to understand triptolide-induced liver injury in mice von Zhao, Jie, Xie, Cen, Wang, Kanglong, Takahashi, Shogo, Krausz, Kristopher W., Lu, Dasheng, Wang, Qiong, Luo, Yuhong, Gong, Xianqiong, Mu, Xiyan, Wang, Qiao, Su, Suwen, Gonzalez, Frank J.

“… •An integrated application of transcriptomics and metabolomics methods was conducted to reveal mechanism of triptolide-induced liver …”
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The protective effect of lithocholic acid on the intestinal epithelial barrier is mediated by the vitamin D receptor via a SIRT1/Nrf2 and NF-κB dependent mechanism in Caco-2 cells von Yao, Baiyu, He, Jingni, Yin, Xin, Shi, Yang, Wan, Jun, Tian, Zhong

“… •Lithocholic acid (LCA) attenuates the disruption of the structure and function of tight junction proteins induced by TNF-α in Caco-2 cells.•The prevention of …”
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In vitro toxicity evaluation of graphene oxide on A549 cells von Chang, Yanli, Yang, Sheng-Tao, Liu, Jia-Hui, Dong, Erya, Wang, Yanwen, Cao, Aoneng, Liu, Yuanfang, Wang, Haifang

“… Graphene and its derivatives have attracted great research interest for their potential applications in electronics, energy, materials and biomedical areas …”
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Acrylamide-induced oxidative stress and inflammatory response are alleviated by N-acetylcysteine in PC12 cells: Involvement of the crosstalk between Nrf2 and NF-κB pathways regulated by MAPKs von Pan, Xiaoqi, Wu, Xu, Yan, Dandan, Peng, Cheng, Rao, Chaolong, Yan, Hong

“… •Oxidative stress and inflammatory response induced by acrylamide in PC12 cells were revealed.•A crosstalk between Nrf2 and NF-κB signaling pathways regulated …”
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