Search Results - "Toxicity"

Presumed Gadolinium Toxicity in Subjects With Normal Renal Function: A Report of 4 Cases by Semelka, Richard C, Commander, Clayton W, Jay, Michael, Burke, Lauren M B, Ramalho, Miguel

“… History taking and targeted physical examination were performed on 4 subjects who reported development of new disease features within hours to 4 weeks of having received an intravenous administration of GBCA…”
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A systematic review of cranioplasty material toxicity in human subjects by Las, David Emmanuel, Verwilghen, Denis, Mommaerts, Maurice Yves

“… However, little is reported about cranioplasty implants. Therefore, we performed a systematic review on the toxicity of different materials used for cranioplasty implants…”
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Acute toxicity is a dose-limiting factor for intravenous polymyxin B: A safety and pharmacokinetic study in healthy Chinese subjects by Liu, Xiaofen, Chen, Yuancheng, Yang, Haijing, Li, Jian, Yu, Jicheng, Yu, Zhenwei, Cao, Guoying, Wu, Xiaojie, Wang, Yu, Wu, Hailan, Fan, Yaxin, Wang, Jingjing, Wu, Jufang, Jin, Yi, Guo, Beining, Hu, Jiali, Bian, Xingchen, Li, Xin, Zhang, Jing

“…•A single-dose (at 0.75 or 1.5 mg/kg) clinical trial of polymyxin B was firstly conducted in healthy Chinese subjects.•Acute toxicity…”
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Modeled Hepatic/Plasma Exposures of Fluvastatin Prescribed Alone in Subjects with Impaired Cytochrome P450 2C93 as One of Possible Determinant Factors Likely Associated with Hepatic Toxicity Reported in a Japanese Adverse Event Database by Adachi, Koichiro, Ohyama, Katsuhiro, Tanaka, Yoichi, Saito, Yoshiro, Shimizu, Makiko, Yamazaki, Hiroshi

“… Drug interactions between a variety of P450 2C9 substrates/inhibitors and fluvastatin can increase the incidence of fluvastatin-related hepatic or skeletal muscle toxicity in vivo…”
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Short-Term Metformin Protects Against Glucocorticoid-Induced Toxicity in Healthy Subjects: A Randomized, Double-Blind, Placebo-Controlled Trial by Thierry, Susanne, Peterson, Caspar Joyce, Pfammatter, Stéphanie, Tardio, Patricia Arroyo, Meier, Christian, Delko, Tarik, Iten, Vasco, Zuern, Christine S, Kühne, Michael, Epstein, Michael, Othman, Alaa, Zamboni, Nicola, Reinisch, Isabel, Ghosh, Adhideb, Wolfrum, Christian, Seelig, Eleonora

“… We investigated whether metformin could prevent GC-related toxicity and explored the underlying…”
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Acute cannabis toxicity by Noble, Matthew J., Hedberg, Katrina, Hendrickson, Robert G.

“… dose, product manufacture source, product ownership source, initial vital signs, clinical signs and symptoms, and subject disposition…”
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NUDT15 R139C variation increases the risk of azathioprine-induced toxicity in Chinese subjects: Case report and literature review by Fei, Xiang, Shu, Qing, Hua, Bing-zhu, Wang, Shi-ying, Chen, Zhi-yong, Ge, Wei-hong, Fang, Yun

“… However, leukopenia, the most common toxicity, still restricts its clinical applications…”
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Rare ocular toxicity induced by pertuzumab/QL1209 in healthy chinese subjects: case reports and whole-exome sequencing analysis by Ma, Junlong, Chen, Wenjing, Hu, Zhanqing, Huang, Jie, Guo, Chengxian, Zou, Chan, Yang, Guoping

“… (pertuzumab biosimilar)-induced blurred vision in healthy Chinese male subjects after a single injection of 420…”
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Beyond plastisphere transfer, deep corals are subject to dysbiosis when exposed to plastics by Chapron, L., Meistertzheim, A.-L., Ghiglione, J.-F., Peru, E., Galand, P.E., Lartaud, F.

“…Plastic pollution has been identified as a major threat to marine life and ecosystems, but their biological impacts are still largely unknown. Coral reefs,…”
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Modulation of Protein Fermentation Does Not Affect Fecal Water Toxicity: A Randomized Cross-Over Study in Healthy Subjects by Windey, Karen, De Preter, Vicky, Louat, Thierry, Schuit, Frans, Herman, Jean, Vansant, Greet, Verbeke, Kristin

“… We modified protein fermentation in healthy subjects to assess the effects on colonic metabolism and parameters of gut health, and to identify metabolites associated with toxicity…”
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Air pollution exposure and lung function in highly exposed subjects in Beijing, China: a repeated-measure study by Baccarelli, Andrea A, Zheng, Yinan, Zhang, Xiao, Chang, Dou, Liu, Lei, Wolf, Katherine Rose, Zhang, Zhou, McCracken, John P, Díaz, Anaité, Bertazzi, Pier Alberto, Schwartz, Joel, Wang, Sheng, Kang, Choong-Min, Koutrakis, Petros, Hou, Lifang

“… Elemental components of PM have been suggested to have critical roles in PM toxicity, but their contribution to respiratory effects remains under-investigated…”
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A mortality study on male subjects exposed to polyfluoroalkyl acids with high internal dose of perfluorooctanoic acid by Girardi, Paolo, Merler, Enzo

“…The aim of the present study was to examine the association between exposure to polyfluoroalkyl substances (PFASs) and mortality (1970–2018) in a cohort of 462…”
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Dynamics of toxicity within different compartments of a peri-urban river subject to combined sewer overflow discharges by Becouze-Lareure, C., Thiebaud, L., Bazin, C., Namour, P., Breil, P., Perrodin, Y.

“… Improving the management of CSO discharges requires better knowledge of their dynamics and toxicity…”
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Erucin, a Natural Isothiocyanate, Prevents Polyglutamine-Induced Toxicity in Caenorhabditis elegans via aak-2/AMPK and daf-16/FOXO Signaling by Balducci, Martina, Pérez, Julia Tortajada, del Río, Cristina Trujillo, Pérez, Mar Collado, Carranza, Andrea del Valle, Gomez Escribano, Ana Pilar, Vázquez-Manrique, Rafael P., Tarozzi, Andrea

“… Natural compounds capable of alleviating polyQ-induced toxicity are currently of great interest…”
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Biogenic amines: formation, action and toxicity – a review by Wójcik, Wojciech, Łukasiewicz, Monika, Puppel, Kamila

“…Biogenic amines (BA) are organic compounds commonly found in food, plants and animals, as well as microorganisms that are attributed with the production of…”
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Effect of reducing the dose of stavudine on body composition, bone density, and markers of mitochondrial toxicity in HIV-infected subjects: a randomized, controlled study by McComsey, G A, Lo Re, 3rd, V, O'Riordan, M, Walker, U A, Lebrecht, D, Baron, E, Mounzer, K, Frank, I

“… to a lower dose can reduce these toxicities while maintaining human immunodeficiency virus (HIV) suppression. HIV-infected subjects receiving standard-dose stavudine with undetectable HIV type 1 RNA…”
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A multiscale absorption and transit model for oral delivery of hydroxychloroquine: Pharmacokinetic modeling and intestinal concentration prediction to assess toxicity and drug‐induced damage in healthy subjects by Kannan, Ravishekar, Przekwas, Andrzej

“…Hydroxychloroquine (HCQ) is commonly used in the treatment of malaria and rheumatic diseases. Recently it has also been identified as possible therapeutic…”
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Application of Artificial Intelligence in Cardio-Oncology Imaging for Cancer Therapy–Related Cardiovascular Toxicity: Systematic Review by Mushcab, Hayat, Al Ramis, Mohammed, AlRujaib, Abdulrahman, Eskandarani, Rawan, Sunbul, Tamara, AlOtaibi, Anwar, Obaidan, Mohammed, Al Harbi, Reman, Aljabri, Duaa

“…Artificial intelligence (AI) is a revolutionary upcoming tool yet to be fully integrated into several healthcare sectors, including medical imaging. AI can…”
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Worldwide Prevalence and Trends in Unintentional Drug Overdose: A Systematic Review of the Literature by Martins, Silvia S., Sampson, Laura, Cerdá, Magdalena, Galea, Sandro

“…, mortality rates, and correlates of drug overdoses. We searched different combinations of Medical Subject Headings (MeSH…”
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Non-transferrin bound iron: A key role in iron overload and iron toxicity by Brissot, Pierre, Ropert, Martine, Le Lan, Caroline, Loréal, Olivier

“…Besides transferrin iron, which represents the normal form of circulating iron, non-transferrin bound iron (NTBI) has been identified in the plasma of patients…”
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