Výsledky vyhľadávania - "Tomonaga, Keizō"

100-My history of bornavirus infections hidden in vertebrate genomes Autor Kawasaki, Junna, Kojima, Shohei, Mukai, Yahiro, Tomonaga, Keizo, Horie, Masayuki

“…Although viruses have threatened our ancestors for millions of years, prehistoric epidemics of viruses are largely unknown. Endogenous bornavirus-like elements…”
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Reverse Genetics and Artificial Replication Systems of Borna Disease Virus 1 Autor Kanda, Takehiro, Tomonaga, Keizo

“…Borna disease virus 1 (BoDV-1) is a neurotropic RNA virus belonging to the family Bornaviridae within the order Mononegavirales. Whereas BoDV-1 causes…”
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Borna disease virus phosphoprotein triggers the organization of viral inclusion bodies by liquid-liquid phase separation Autor Hirai, Yuya, Tomonaga, Keizo, Horie, Masayuki

“…Inclusion bodies (IBs) are characteristic biomolecular condensates organized by the non-segmented negative-strand RNA viruses belonging to the order…”
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Exogenous expression of both matrix protein and glycoprotein facilitates infectious viral particle production of Borna disease virus 1 Autor Kanda, Takehiro, Sakai, Madoka, Makino, Akiko, Tomonaga, Keizo

“…Borna disease virus 1 (BoDV-1) is a non-segmented, negative-strand RNA virus that is characterized by persistent infection in the nucleus and low production of…”
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ICTV Virus Taxonomy Profile: Bornaviridae Autor Rubbenstroth, Dennis, Briese, Thomas, Dürrwald, Ralf, Horie 堀江真行, Masayuki, Hyndman, Timothy H, Kuhn, Jens H, Nowotny, Norbert, Payne, Susan, Stenglein, Mark D, Tomonaga 朝長啓造, Keizō

“…Members of the family Bornaviridae produce enveloped virions containing a linear negative-sense non-segmented RNA genome of about 9 kb. Bornaviruses are found…”
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Reverse genetics approaches of Borna disease virus: applications in development of viral vectors and preventive vaccines Autor Komatsu, Yumiko, Tomonaga, Keizo

“…The plasmid-based reverse genetics system, which involves generation of recombinant viruses from cloned cDNA, has accelerated the understanding of clinical and…”
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Comprehensive analysis of endogenous bornavirus-like elements in eukaryote genomes Autor Horie, Masayuki, Kobayashi, Yuki, Suzuki, Yoshiyuki, Tomonaga, Keizo

“…Bornaviruses are the only animal RNA viruses that establish a persistent infection in their host cell nucleus. Studies of bornaviruses have provided unique…”
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Contact-number-driven virus evolution: A multi-level modeling framework for the evolution of acute or persistent RNA virus infection Autor Sunagawa, Junya, Komorizono, Ryo, Park, Hyeongki, Hart, William S., Thompson, Robin N., Makino, Akiko, Tomonaga, Keizo, Iwami, Shingo, Yamaguchi, Ryo

“…Viruses evolve in infected host populations, and host population dynamics affect viral evolution. RNA viruses with a short duration of infection and a high…”
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Regnase-1 and Roquin Nonredundantly Regulate Th1 Differentiation Causing Cardiac Inflammation and Fibrosis Autor Cui, Xiaotong, Mino, Takashi, Yoshinaga, Masanori, Nakatsuka, Yoshinari, Hia, Fabian, Yamasoba, Daichi, Tsujimura, Tohru, Tomonaga, Keizo, Suzuki, Yutaka, Uehata, Takuya, Takeuchi, Osamu

“…Regnase-1 and Roquin are RNA binding proteins that are essential for degradation of inflammatory mRNAs and maintenance of immune homeostasis. Although…”
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In vivo biodistribution analysis of transmission competent and defective RNA virus-based episomal vector Autor Komatsu, Yumiko, Tanaka, Chiaki, Komorizono, Ryo, Tomonaga, Keizo

“…RNA virus-based episomal vector (REVec) is an emerging viral vector system that mediates long-term stable gene expression in variety of cell types in vitro …”
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Inhibition of Borna disease virus replication by an endogenous bornavirus-like element in the ground squirrel genome Autor Fujino, Kan, Horie, Masayuki, Honda, Tomoyuki, Merriman, Dana K, Tomonaga, Keizo

“…Animal genomes contain endogenous viral sequences, such as endogenous retroviruses and retrotransposons. Recently, we and others discovered that nonretroviral…”
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Antiviral activity of favipiravir (T-705) against mammalian and avian bornaviruses Autor Tokunaga, Tomoya, Yamamoto, Yusuke, Sakai, Madoka, Tomonaga, Keizo, Honda, Tomoyuki

“…Bornaviruses, non-segmented, negative-strand RNA viruses, are emerging agents with the potential for causing various types of neurological symptoms. Previous…”
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ADAR2 Is Involved in Self and Nonself Recognition of Borna Disease Virus Genomic RNA in the Nucleus Autor Yanai, Mako, Kojima, Shohei, Sakai, Madoka, Komorizono, Ryo, Tomonaga, Keizo, Makino, Akiko

“…Cells sense pathogen-derived double-stranded RNA (dsRNA) as nonself. To avoid autoimmune activation by self dsRNA, cells utilize A-to-I editing by adenosine…”
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Differential roles of two DDX17 isoforms in the formation of membraneless organelles Autor Hirai, Yuya, Domae, Eisuke, Yoshikawa, Yoshihiro, Tomonaga, Keizo

“…The RNA helicase, DDX17 is a member of the DEAD-box protein family. DDX17 has two isoforms: p72 and p82. The p82 isoform has additional amino acid sequences…”
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Large‐scale investigation of zoonotic viruses in the era of high‐throughput sequencing Autor Kawasaki, Junna, Tomonaga, Keizo, Horie, Masayuki

“…Zoonotic diseases considerably impact public health and socioeconomics. RNA viruses reportedly caused approximately 94% of zoonotic diseases documented from…”
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Hidden Viral Sequences in Public Sequencing Data and Warning for Future Emerging Diseases Autor Kawasaki, Junna, Kojima, Shohei, Tomonaga, Keizo, Horie, Masayuki

“…Monitoring the spread of viral infections and identifying novel viruses capable of infecting humans through animal reservoirs are necessary to control emerging…”
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Endogenous non-retroviral RNA virus elements in mammalian genomes Autor Horie, Masayuki, Honda, Tomoyuki, Suzuki, Yoshiyuki, Kobayashi, Yuki, Daito, Takuji, Oshida, Tatsuo, Ikuta, Kazuyoshi, Jern, Patric, Gojobori, Takashi, Coffin, John M., Tomonaga, Keizo

“…Viral 'fossils' in the genome DNA derived from endogenous retroviruses is a common ancestral feature in mammalian genomes. Until now retroviruses have been the…”
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An endogenous bornavirus‐like nucleoprotein in miniopterid bats retains the RNA‐binding properties of the original viral protein Autor Mukai, Yahiro, Horie, Masayuki, Kojima, Shohei, Kawasaki, Junna, Maeda, Ken, Tomonaga, Keizo

“…Endogenous bornavirus‐like nucleoprotein elements (EBLNs) are sequences derived from bornaviral N genes in vertebrate genomes. Some EBLNs have been suggested…”
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Production of high‐titer transmission‐defective RNA virus‐based episomal vector using tangential flow filtration Autor Komatsu, Yumiko, Kakuya, Yoji, Tomonaga, Keizo

“…In recent years, viral vector based in vivo gene delivery strategies have achieved a significant success in the treatment of genetic diseases. RNA virus‐based…”
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Endogenized viral sequences in mammals Autor Parrish, Nicholas F., Tomonaga, Keizo

“…•Endogenous retroviruses (ERVs) make up 25% of the genome of mammals yet sequenced.•Different ERVs are involved in placenta formation in different mammalian…”
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