Výsledky vyhledávání - "Tissue Array Analysis/*methods"

Life on Magnets: Stem Cell Networking on Micro-Magnet Arrays Autor Zablotskii, Vitalii, Dejneka, Alexandr, Kubinová, Šárka, Le-Roy, Damien, Dumas-Bouchiat, Frédéric, Givord, Dominique, Dempsey, Nora M., Syková, Eva

“…Interactions between a micro-magnet array and living cells may guide the establishment of cell networks due to the cellular response to a magnetic field. To…”
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A Multi-Modality CMOS Sensor Array for Cell-Based Assay and Drug Screening Autor Taiyun Chi, Jong Seok Park, Butts, Jessica C., Hookway, Tracy A., Su, Amy, Chengjie Zhu, Styczynski, Mark P., McDevitt, Todd C., Hua Wang

“…In this paper, we present a fully integrated multi-modality CMOS cellular sensor array with four sensing modalities to characterize different cell…”
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TTF-1 expression in primary ovarian epithelial neoplasia Autor Graham, A D, Williams, A R, Salter, D M

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Simultaneous epitope and transcriptome measurement in single cells Autor Stoeckius, Marlon, Hafemeister, Christoph, Stephenson, William, Houck-Loomis, Brian, Chattopadhyay, Pratip K, Swerdlow, Harold, Satija, Rahul, Smibert, Peter

“…Using established high-throughput single-cell RNA-seq platforms, CITE-seq combines highly multiplexed, antibody-based protein marker quantification with…”
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Automated Gleason grading of prostate cancer tissue microarrays via deep learning Autor Arvaniti, Eirini, Fricker, Kim S., Moret, Michael, Rupp, Niels, Hermanns, Thomas, Fankhauser, Christian, Wey, Norbert, Wild, Peter J., Rüschoff, Jan H., Claassen, Manfred

“…The Gleason grading system remains the most powerful prognostic predictor for patients with prostate cancer since the 1960s. Its application requires…”
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Data-analysis strategies for image-based cell profiling Autor Caicedo, Juan C, Cooper, Sam, Heigwer, Florian, Warchal, Scott, Qiu, Peng, Molnar, Csaba, Vasilevich, Aliaksei S, Barry, Joseph D, Bansal, Harmanjit Singh, Kraus, Oren, Wawer, Mathias, Paavolainen, Lassi, Herrmann, Markus D, Rohban, Mohammad, Hung, Jane, Hennig, Holger, Concannon, John, Smith, Ian, Clemons, Paul A, Singh, Shantanu, Rees, Paul, Horvath, Peter, Linington, Roger G, Carpenter, Anne E

“…This Review covers the steps required to create high-quality image-based profiles from high-throughput microscopy images. Image-based cell profiling is a…”
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histoCAT: analysis of cell phenotypes and interactions in multiplex image cytometry data Autor Schapiro, Denis, Jackson, Hartland W, Raghuraman, Swetha, Fischer, Jana R, Zanotelli, Vito R T, Schulz, Daniel, Giesen, Charlotte, Catena, Raúl, Varga, Zsuzsanna, Bodenmiller, Bernd

“…The histology topography cytometry analysis toolbox (histoCAT) enables quantitative analysis and exploration of highly multiplexed imaging data for better…”
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Probing the binding specificities of human Siglecs by cell-based glycan arrays Autor Büll, Christian, Nason, Rebecca, Sun, Lingbo, Van Coillie, Julie, Madriz Sørensen, Daniel, Moons, Sam J, Yang, Zhang, Arbitman, Steven, Fernandes, Steve M, Furukawa, Sanae, McBride, Ryan, Nycholat, Corwin M, Adema, Gosse J, Paulson, James C, Schnaar, Ronald L, Boltje, Thomas J, Clausen, Henrik, Narimatsu, Yoshiki

“…Siglecs are a family of sialic acid-binding receptors expressed by cells of the immune system and a few other cell types capable of modulating immune cell…”
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Microfluidic blood–brain barrier model provides in vivo‐like barrier properties for drug permeability screening Autor Wang, Ying I., Abaci, Hasan Erbil, Shuler, Michael L.

“…Efficient delivery of therapeutics across the neuroprotective blood–brain barrier (BBB) remains a formidable challenge for central nervous system drug…”
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Multi-tissue interactions in an integrated three-tissue organ-on-a-chip platform Autor Skardal, Aleksander, Murphy, Sean V., Devarasetty, Mahesh, Mead, Ivy, Kang, Hyun-Wook, Seol, Young-Joon, Shrike Zhang, Yu, Shin, Su-Ryon, Zhao, Liang, Aleman, Julio, Hall, Adam R., Shupe, Thomas D., Kleensang, Andre, Dokmeci, Mehmet R., Jin Lee, Sang, Jackson, John D., Yoo, James J., Hartung, Thomas, Khademhosseini, Ali, Soker, Shay, Bishop, Colin E., Atala, Anthony

“…Many drugs have progressed through preclinical and clinical trials and have been available – for years in some cases – before being recalled by the FDA for…”
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A vascularized and perfused organ-on-a-chip platform for large-scale drug screening applications Autor Phan, Duc T T, Wang, Xiaolin, Craver, Brianna M, Sobrino, Agua, Zhao, Da, Chen, Jerry C, Lee, Lilian Y N, George, Steven C, Lee, Abraham P, Hughes, Christopher C W

“…There is a growing awareness that complex 3-dimensional (3D) organs are not well represented by monolayers of a single cell type - the standard format for many…”
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A lung/liver-on-a-chip platform for acute and chronic toxicity studies Autor Bovard, David, Sandoz, Antonin, Luettich, Karsta, Frentzel, Stefan, Iskandar, Anita, Marescotti, Diego, Trivedi, Keyur, Guedj, Emmanuel, Dutertre, Quentin, Peitsch, Manuel C, Hoeng, Julia

“…The merging of three-dimensional in vitro models with multi-organ-on-a-chip (MOC) technology has taken in vitro assessment of chemicals to an unprecedented…”
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Claudin-18 expression in oesophagogastric adenocarcinomas: a tissue microarray study of 523 molecularly profiled cases Autor Coati, Irene, Lotz, Gábor, Fanelli, Giuseppe Nicolò, Brignola, Stefano, Lanza, Cristiano, Cappellesso, Rocco, Pellino, Antonio, Pucciarelli, Salvatore, Spolverato, Gaya, Guzzardo, Vincenza, Munari, Giada, Zaninotto, Giovanni, Scarpa, Marco, Mastracci, Luca, Farinati, Fabio, Realdon, Stefano, Pilati, Pierluigi, Lonardi, Sara, Valeri, Nicola, Rugge, Massimo, Kiss, Andras, Loupakis, Fotios, Fassan, Matteo

“…Background Claudin-18 (CLDN18) is a highly specific tight junction protein of the gastric mucosa. An isoform of CLDN18, the Claudin 18.2, has recently emerged…”
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A reductionist metastasis-on-a-chip platform for in vitro tumor progression modeling and drug screening Autor Skardal, Aleksander, Devarasetty, Mahesh, Forsythe, Steven, Atala, Anthony, Soker, Shay

“…Current animal and 2‐D cell culture models employed in metastasis research and drug discovery remain poor mimics of human cancer physiology. Here we describe a…”
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3D niche microarrays for systems-level analyses of cell fate Autor Ranga, A., Gobaa, S., Okawa, Y., Mosiewicz, K., Negro, A., Lutolf, M. P.

“…The behaviour of mammalian cells in a tissue is governed by the three-dimensional (3D) microenvironment and involves a dynamic interplay between biochemical…”
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Statistical characterization and classification of colon microarray gene expression data using multiple machine learning paradigms Autor Maniruzzaman, Md, Jahanur Rahman, Md, Ahammed, Benojir, Abedin, Md. Menhazul, Suri, Harman S., Biswas, Mainak, El-Baz, Ayman, Bangeas, Petros, Tsoulfas, Georgios, Suri, Jasjit S.

“…•Identification of high risk differential gene expression using statistical tests.•Development of a machine learning strategy for predicting the cancerous…”
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Pre-arrayed Pan-AAV Peptide Display Libraries for Rapid Single-Round Screening Autor Börner, Kathleen, Kienle, Eike, Huang, Lin-Ya, Weinmann, Jonas, Sacher, Anna, Bayer, Philipp, Stüllein, Christian, Fakhiri, Julia, Zimmermann, Laura, Westhaus, Adrian, Beneke, Jürgen, Beil, Nina, Wiedtke, Ellen, Schmelas, Carolin, Miltner, Dominik, Rau, Alexander, Erfle, Holger, Kräusslich, Hans-Georg, Müller, Martin, Agbandje-McKenna, Mavis, Grimm, Dirk

“…Display of short peptides on the surface of adeno-associated viruses (AAVs) is a powerful technology for the generation of gene therapy vectors with altered…”
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Transcriptomic analysis of probable asymptomatic and symptomatic alzheimer brains Autor Patel, Hamel, Hodges, Angela K., Curtis, Charles, Lee, Sang Hyuck, Troakes, Claire, Dobson, Richard J.B., Newhouse, Stephen J.

“…•Asymptomatic AD subjects show increased transcriptomic activity in frontal cortex.•Disruption in brain energy pathway detected in Asymptomatic AD…”
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Centromere and kinetochore gene misexpression predicts cancer patient survival and response to radiotherapy and chemotherapy Autor Zhang, Weiguo, Mao, Jian-Hua, Zhu, Wei, Jain, Anshu K., Liu, Ke, Brown, James B., Karpen, Gary H.

“…Chromosomal instability (CIN) is a hallmark of cancer that contributes to tumour heterogeneity and other malignant properties. Aberrant centromere and…”
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Pooled CRISPR screens with imaging on microraft arrays reveals stress granule-regulatory factors Autor Wheeler, Emily C., Vu, Anthony Q., Einstein, Jaclyn M., DiSalvo, Matthew, Ahmed, Noorsher, Van Nostrand, Eric L., Shishkin, Alexander A., Jin, Wenhao, Allbritton, Nancy L., Yeo, Gene W.

“…Genetic screens using pooled CRISPR-based approaches are scalable and inexpensive, but restricted to standard readouts, including survival, proliferation and…”
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