Suchergebnisse - "Tin, Adrienne"

Mapping the pathways underlying the associations of albuminuria with cognitive decline and dementia von Tin, Adrienne

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A bidirectional Mendelian randomization study supports causal effects of kidney function on blood pressure von Yu, Zhi, Coresh, Josef, Qi, Guanghao, Grams, Morgan, Boerwinkle, Eric, Snieder, Harold, Teumer, Alexander, Pattaro, Cristian, Köttgen, Anna, Chatterjee, Nilanjan, Tin, Adrienne

“… Blood pressure and kidney function have a bidirectional relation. Hypertension has long been considered as a risk factor for kidney function decline. However, …”
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Proteomics analysis of plasma from middle-aged adults identifies protein markers of dementia risk in later life von Walker, Keenan A, Chen, Jingsha, Shi, Liu, Yang, Yunju, Fornage, Myriam, Zhou, Linda, Schlosser, Pascal, Surapaneni, Aditya, Grams, Morgan E, Duggan, Michael R, Peng, Zhongsheng, Gomez, Gabriela T, Tin, Adrienne, Hoogeveen, Ron C, Sullivan, Kevin J, Ganz, Peter, Lindbohm, Joni V, Kivimaki, Mika, Nevado-Holgado, Alejo J, Buckley, Noel, Gottesman, Rebecca F, Mosley, Thomas H, Boerwinkle, Eric, Ballantyne, Christie M, Coresh, Josef

“… A diverse set of biological processes have been implicated in the pathophysiology of Alzheimer's disease (AD) and related dementias. However, there is limited …”
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Epigenome-wide association studies identify DNA methylation associated with kidney function von Chu, Audrey Y., Tin, Adrienne, Schlosser, Pascal, Ko, Yi-An, Qiu, Chengxiang, Yao, Chen, Joehanes, Roby, Grams, Morgan E., Liang, Liming, Gluck, Caroline A., Liu, Chunyu, Coresh, Josef, Hwang, Shih-Jen, Levy, Daniel, Boerwinkle, Eric, Pankow, James S., Yang, Qiong, Fornage, Myriam, Fox, Caroline S., Susztak, Katalin, Köttgen, Anna

“… Chronic kidney disease (CKD) is defined by reduced estimated glomerular filtration rate (eGFR). Previous genetic studies have implicated regulatory mechanisms …”
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Large scale plasma proteomics identifies novel proteins and protein networks associated with heart failure development von Shah, Amil M., Myhre, Peder L., Arthur, Victoria, Dorbala, Pranav, Rasheed, Humaira, Buckley, Leo F., Claggett, Brian, Liu, Guning, Ma, Jianzhong, Nguyen, Ngoc Quynh, Matsushita, Kunihiro, Ndumele, Chiadi, Tin, Adrienne, Hveem, Kristian, Jonasson, Christian, Dalen, Håvard, Boerwinkle, Eric, Hoogeveen, Ron C., Ballantyne, Christie, Coresh, Josef, Omland, Torbjørn, Yu, Bing

“… Heart failure (HF) causes substantial morbidity and mortality but its pathobiology is incompletely understood. The proteome is a promising intermediate …”
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Association between Mitochondrial DNA Copy Number in Peripheral Blood and Incident CKD in the Atherosclerosis Risk in Communities Study von Tin, Adrienne, Grams, Morgan E, Ashar, Foram N, Lane, John A, Rosenberg, Avi Z, Grove, Megan L, Boerwinkle, Eric, Selvin, Elizabeth, Coresh, Josef, Pankratz, Nathan, Arking, Dan E

“… Mitochondrial dysfunction in kidney cells has been implicated in the pathogenesis of CKD. Mitochondrial DNA (mtDNA) copy number is a surrogate measure of …”
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MicroRNAs in the miR-17 and miR-15 families are downregulated in chronic kidney disease with hypertension von Nandakumar, Priyanka, Tin, Adrienne, Grove, Megan L., Ma, Jianzhong, Boerwinkle, Eric, Coresh, Josef, Chakravarti, Aravinda

“… In older adults (aged 70-74 years), African-Americans have 4-fold higher risk of developing hypertension-attributed end-stage renal disease (ESRD) than …”
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Mitochondrial DNA copy number can influence mortality and cardiovascular disease via methylation of nuclear DNA CpGs von Castellani, Christina A., Longchamps, Ryan J., Sumpter, Jason A., Newcomb, Charles E., Lane, John A., Grove, Megan L., Bressler, Jan, Brody, Jennifer A., Floyd, James S., Bartz, Traci M., Taylor, Kent D., Wang, Penglong, Tin, Adrienne, Coresh, Josef, Pankow, James S., Fornage, Myriam, Guallar, Eliseo, O’Rourke, Brian, Pankratz, Nathan, Liu, Chunyu, Levy, Daniel, Sotoodehnia, Nona, Boerwinkle, Eric, Arking, Dan E.

“… Background Mitochondrial DNA copy number (mtDNA-CN) has been associated with a variety of aging-related diseases, including all-cause mortality. However, the …”
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Using Genetic Technologies To Reduce, Rather Than Widen, Health Disparities von Smith, Caren E, Fullerton, Stephanie M, Dookeran, Keith A, Hampel, Heather, Tin, Adrienne, Maruthur, Nisa M, Schisler, Jonathan C, Henderson, Jeffrey A, Tucker, Katherine L, Ordovás, José M

“… Evidence shows that both biological and nonbiological factors contribute to health disparities. Genetics, in particular, plays a part in how common diseases …”
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Discovery and prioritization of genetic determinants of kidney function in 297,355 individuals from Taiwan and Japan von Chen, Hung-Lin, Chiang, Hsiu-Yin, Chang, David Ray, Cheng, Chi-Fung, Wang, Charles C. N., Lu, Tzu-Pin, Lee, Chien-Yueh, Chattopadhyay, Amrita, Lin, Yu-Ting, Lin, Che-Chen, Yu, Pei-Tzu, Huang, Chien-Fong, Lin, Chieh-Hua, Yeh, Hung-Chieh, Ting, I-Wen, Tsai, Huai-Kuang, Chuang, Eric Y., Tin, Adrienne, Tsai, Fuu-Jen, Kuo, Chin-Chi

“… Current genome-wide association studies (GWAS) for kidney function lack ancestral diversity, limiting the applicability to broader populations. The East-Asian …”
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Large-scale whole-exome sequencing association studies identify rare functional variants influencing serum urate levels von Tin, Adrienne, Li, Yong, Brody, Jennifer A., Nutile, Teresa, Chu, Audrey Y., Huffman, Jennifer E., Yang, Qiong, Chen, Ming-Huei, Robinson-Cohen, Cassianne, Macé, Aurélien, Liu, Jun, Demirkan, Ayşe, Sorice, Rossella, Sedaghat, Sanaz, Swen, Melody, Yu, Bing, Ghasemi, Sahar, Teumer, Alexanda, Vollenweider, Peter, Ciullo, Marina, Li, Meng, Uitterlinden, André G., Kraaij, Robert, Amin, Najaf, van Rooij, Jeroen, Kutalik, Zoltán, Dehghan, Abbas, McKnight, Barbara, van Duijn, Cornelia M., Morrison, Alanna, Psaty, Bruce M., Boerwinkle, Eric, Fox, Caroline S., Woodward, Owen M., Köttgen, Anna

“… Elevated serum urate levels can cause gout, an excruciating disease with suboptimal treatment. Previous GWAS identified common variants with modest effects on …”
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Higher Serotonin 1A Binding in a Second Major Depression Cohort: Modeling and Reference Region Considerations von Parsey, Ramin V., Ogden, R. Todd, Miller, Jeffrey M., Tin, Adrienne, Hesselgrave, Natalie, Goldstein, Ellen, Mikhno, Arthur, Milak, Matthew, Zanderigo, Francesca, Sullivan, Gregory M., Oquendo, Maria A., Mann, J. John

“… Serotonin 1A receptors (5-HT 1A) are implicated in major depressive disorder (MDD). We previously reported higher 5-HT 1A binding potential (BP F) in …”
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Race, Serum Potassium, and Associations With ESRD and Mortality von Chen, Yan, Sang, Yingying, Ballew, Shoshana H, Tin, Adrienne, Chang, Alex R, Matsushita, Kunihiro, Coresh, Josef, Kalantar-Zadeh, Kamyar, Molnar, Miklos Z, Grams, Morgan E

“… Recent studies suggest that potassium levels may differ by race. The basis for these differences and whether associations between potassium levels and adverse …”
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Polygenic Risk, Midlife Life's Simple 7, and Lifetime Risk of Stroke von Thomas, Emy A., Enduru, Nitesh, Tin, Adrienne, Boerwinkle, Eric, Griswold, Michael E., Mosley, Thomas H., Gottesman, Rebecca F., Fornage, Myriam

“… Background Recent genetic discoveries in stroke have unleashed the potential of using genetic information for risk prediction and health interventions aimed at …”
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Estimating time to ESRD using kidney failure risk equations: results from the African American Study of Kidney Disease and Hypertension (AASK) von Grams, Morgan E, Li, Liang, Greene, Tom H, Tin, Adrienne, Sang, Yingying, Kao, W H Linda, Lipkowitz, Michael S, Wright, Jackson T, Chang, Alex R, Astor, Brad C, Appel, Lawrence J

“… Planning for renal replacement therapy, such as referral for arteriovenous fistula placement and transplantation, often is guided by level of estimated …”
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Genome-wide association study meta-analysis uncovers novel genetic variants associated with olfactory dysfunction von Imtiaz, Mohammed Aslam, Melas, Konstantinos, Tin, Adrienne, Talevi, Valentina, Chen, Honglei, Fornage, Myriam, Shrestha, Srishti, Gögele, Martin, Emmert, David, Pattaro, Cristian, Pramstaller, Peter, Förster, Franz, Horn, Katrin, Mosley, Thomas H., Fuchsberger, Christian, Scholz, Markus, Breteler, Monique M.B., Aziz, N. Ahmad

“… Background Olfactory dysfunction is among the earliest signs of many age-related neurodegenerative diseases and has been associated with increased mortality in …”
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Association of a cystatin C gene variant with cystatin C levels, CKD, and risk of incident cardiovascular disease and mortality von O'Seaghdha, Conall M, Tin, Adrienne, Yang, Qiong, Katz, Ronit, Liu, Yongmei, Harris, Tamara, Astor, Brad, Coresh, Josef, Fox, Caroline S, Kao, W H Linda, Shlipak, Michael G

“… Carriers of the T allele of the single-nucleotide polymorphism rs13038305 tend to have lower cystatin C levels and higher cystatin C-based estimated glomerular …”
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GSTM1 Copy Number Is Not Associated With Risk of Kidney Failure in a Large Cohort von Zhang, Yanfei, Zafar, Waleed, Hartzel, Dustin N., Williams, Marc S., Tin, Adrienne, Chang, Alex R., Lee, Ming Ta Michael

“… Deletion of glutathione S-transferase µ1 (GSTM1) is common in populations and has been asserted to associate with chronic kidney disease progression in some …”
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38 Plasma proteomic signature of motoric cognitive risk syndrome von Gomez, Gabriela T., Sathyan, Sanish, Chen, Jingsha, Fornage, Myriam, Schlosser, Pascal, Peng, Zhongsheng, Cordon, Jenifer, Palta, Priya, Sullivan, Kevin J., Tin, Adrienne, Windham, B. Gwen, Gottesman, Rebecca F., Coresh, Josef, Barzilai, Nir, Milman, Sofiya, Verghese, Joe, Walker, Keenan A.

“… OBJECTIVES/GOALS: Motoric cognitive risk (MCR) is a pre-dementia syndrome characterized by slow gait and subjective cognitive complaints. In the …”
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Validation of a Novel Modified Aptamer-Based Array Proteomic Platform in Patients with End-Stage Renal Disease von Han, Zhongji, Xiao, Zhousheng, Kalantar-Zadeh, Kamyar, Moradi, Hamid, Shafi, Tariq, Waikar, Sushrut S., Quarles, L. Darryl, Yu, Zhi, Tin, Adrienne, Coresh, Josef, Kovesdy, Csaba P.

“… End stage renal disease (ESRD) is characterized by complex metabolic abnormalities, yet the clinical relevance of specific biomarkers remains unclear. The …”
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