Výsledky vyhľadávania - "Timpson, Nicholas"

Apparent latent structure within the UK Biobank sample has implications for epidemiological analysis Autor Haworth, Simon, Mitchell, Ruth, Corbin, Laura, Wade, Kaitlin H., Dudding, Tom, Budu-Aggrey, Ashley, Carslake, David, Hemani, Gibran, Paternoster, Lavinia, Smith, George Davey, Davies, Neil, Lawson, Daniel J., J. Timpson, Nicholas

“…Large studies use genotype data to discover genetic contributions to complex traits and infer relationships between those traits. Co-incident geographical…”
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Obesity and Multiple Sclerosis: A Mendelian Randomization Study Autor Mokry, Lauren E., Ross, Stephanie, Timpson, Nicholas J., Sawcer, Stephen, Davey Smith, George, Richards, J. Brent

“…Observational studies have reported an association between obesity, as measured by elevated body mass index (BMI), in early adulthood and risk of multiple…”
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Therapeutic potential of IL6R blockade for the treatment of sepsis and sepsis-related death: A Mendelian randomisation study Autor Hamilton, Fergus W., Thomas, Matt, Arnold, David, Palmer, Tom, Moran, Ed, Mentzer, Alexander J., Maskell, Nick, Baillie, Kenneth, Summers, Charlotte, Hingorani, Aroon, MacGowan, Alasdair, Khandaker, Golam M., Mitchell, Ruth, Davey Smith, George, Ghazal, Peter, Timpson, Nicholas J.

“…Sepsis is characterised by dysregulated, life-threatening immune responses, which are thought to be driven by cytokines such as interleukin 6 (IL-6). Genetic…”
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Vitamin D levels and risk of type 1 diabetes: A Mendelian randomization study Autor Manousaki, Despoina, Harroud, Adil, Mitchell, Ruth E., Ross, Stephanie, Forgetta, Vince, Timpson, Nicholas J., Smith, George Davey, Polychronakos, Constantin, Richards, J Brent

“…Vitamin D deficiency has been associated with type 1 diabetes in observational studies, but evidence from randomized controlled trials (RCTs) is lacking. The…”
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Mendelian randomization studies of periodontitis: Understanding benefits and natural limitations in an applied context Autor Haworth, Simon, Timpson, Nicholas J., Divaris, Kimon

“…Mendelian randomization (MR) is a flexible analytical tool that has been widely applied to strengthen causal inference in observational epidemiology and is now…”
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Genetic architecture: the shape of the genetic contribution to human traits and disease Autor Timpson, Nicholas J, Greenwood, Celia M T, Soranzo, Nicole, Lawson, Daniel J, Richards, J Brent

“…Genetic architecture describes the characteristics of genetic variation that are responsible for heritable phenotypic variability. It depends on the number of…”
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Assessing Causality in the Association between Child Adiposity and Physical Activity Levels: A Mendelian Randomization Analysis Autor Richmond, Rebecca C., Davey Smith, George, Ness, Andy R., den Hoed, Marcel, McMahon, George, Timpson, Nicholas J.

“…Cross-sectional studies have shown that objectively measured physical activity is associated with childhood adiposity, and a strong inverse dose-response…”
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Using published data in Mendelian randomization: a blueprint for efficient identification of causal risk factors Autor Burgess, Stephen, Scott, Robert A., Timpson, Nicholas J., Smith, George Davey, Thompson, Simon G.

“…Finding individual-level data for adequatelypowered Mendelian randomization analyses may be problematic. As publicly-available summarized data on genetic…”
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Mental health before and during the COVID-19 pandemic in two longitudinal UK population cohorts Autor Kwong, Alex S. F., Pearson, Rebecca M., Adams, Mark J., Northstone, Kate, Tilling, Kate, Smith, Daniel, Fawns-Ritchie, Chloe, Bould, Helen, Warne, Naomi, Zammit, Stanley, Gunnell, David J., Moran, Paul A., Micali, Nadia, Reichenberg, Abraham, Hickman, Matthew, Rai, Dheeraj, Haworth, Simon, Campbell, Archie, Altschul, Drew, Flaig, Robin, McIntosh, Andrew M., Lawlor, Deborah A., Porteous, David, Timpson, Nicholas J.

“…The COVID-19 pandemic and mitigation measures are likely to have a marked effect on mental health. It is important to use longitudinal data to improve…”
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Genome-wide Association Study for Vitamin D Levels Reveals 69 Independent Loci Autor Manousaki, Despoina, Mitchell, Ruth, Dudding, Tom, Haworth, Simon, Harroud, Adil, Forgetta, Vincenzo, Shah, Rupal L, Luan, Jian'an, Langenberg, Claudia, Timpson, Nicholas J, Richards, J Brent

“…We aimed to increase our understanding of the genetic determinants of vitamin D levels by undertaking a large-scale genome-wide association study (GWAS) of…”
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Polygenic Prediction of Weight and Obesity Trajectories from Birth to Adulthood Autor Khera, Amit V, Chaffin, Mark, Wade, Kaitlin H, Zahid, Sohail, Brancale, Joseph, Xia, Rui, Distefano, Marina, Senol-Cosar, Ozlem, Haas, Mary E, Bick, Alexander, Aragam, Krishna G, Lander, Eric S, Smith, George Davey, Mason-Suares, Heather, Fornage, Myriam, Lebo, Matthew, Timpson, Nicholas J, Kaplan, Lee M, Kathiresan, Sekar

“…Severe obesity is a rapidly growing global health threat. Although often attributed to unhealthy lifestyle choices or environmental factors, obesity is known…”
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Strengthening the Reporting of Observational Studies in Epidemiology Using Mendelian Randomization: The STROBE-MR Statement Autor Skrivankova, Veronika W, Richmond, Rebecca C, Woolf, Benjamin A R, Yarmolinsky, James, Davies, Neil M, Swanson, Sonja A, VanderWeele, Tyler J, Higgins, Julian P T, Timpson, Nicholas J, Dimou, Niki, Langenberg, Claudia, Golub, Robert M, Loder, Elizabeth W, Gallo, Valentina, Tybjaerg-Hansen, Anne, Davey Smith, George, Egger, Matthias, Richards, J Brent

“…Mendelian randomization (MR) studies use genetic variation associated with modifiable exposures to assess their possible causal relationship with outcomes and…”
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Strengthening the reporting of observational studies in epidemiology using mendelian randomisation (STROBE-MR): explanation and elaboration Autor Skrivankova, Veronika W, Richmond, Rebecca C, Woolf, Benjamin A R, Davies, Neil M, Swanson, Sonja A, VanderWeele, Tyler J, Timpson, Nicholas J, Higgins, Julian P T, Dimou, Niki, Langenberg, Claudia, Loder, Elizabeth W, Golub, Robert M, Egger, Matthias, Davey Smith, George, Richards, J Brent

“…Mendelian randomisation (MR) studies allow a better understanding of the causal effects of modifiable exposures on health outcomes, but the published evidence…”
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The MR-Base platform supports systematic causal inference across the human phenome Autor Hemani, Gibran, Zheng, Jie, Elsworth, Benjamin, Wade, Kaitlin H, Haberland, Valeriia, Baird, Denis, Laurin, Charles, Burgess, Stephen, Bowden, Jack, Langdon, Ryan, Tan, Vanessa Y, Yarmolinsky, James, Shihab, Hashem A, Timpson, Nicholas J, Evans, David M, Relton, Caroline, Martin, Richard M, Davey Smith, George, Gaunt, Tom R, Haycock, Philip C

“…Results from genome-wide association studies (GWAS) can be used to infer causal relationships between phenotypes, using a strategy known as 2-sample Mendelian…”
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Influence of puberty timing on adiposity and cardiometabolic traits: A Mendelian randomisation study Autor Bell, Joshua A., Carslake, David, Wade, Kaitlin H., Richmond, Rebecca C., Langdon, Ryan J., Vincent, Emma E., Holmes, Michael V., Timpson, Nicholas J., Davey Smith, George

“…Earlier puberty is widely linked with future obesity and cardiometabolic disease. We examined whether age at puberty onset likely influences adiposity and…”
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The Avon Longitudinal Study of Parents and Children (ALSPAC): an update on the enrolled sample of index children in 2019 Autor Northstone, Kate, Lewcock, Melanie, Groom, Alix, Boyd, Andy, Macleod, John, Timpson, Nicholas, Wells, Nicholas

“…The Avon Longitudinal Study of Parents and Children (ALSPAC) is a prospective population-based study. Initial recruitment of pregnant women took place in…”
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Challenges in undertaking nonlinear Mendelian randomization Autor Wade, Kaitlin H., Hamilton, Fergus W., Carslake, David, Sattar, Naveed, Davey Smith, George, Timpson, Nicholas J.

“…Mendelian randomization (MR) is a widely used method that exploits the unique properties of germline genetic variation to strengthen causal inference in…”
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The Effect of Elevated Body Mass Index on Ischemic Heart Disease Risk: Causal Estimates from a Mendelian Randomisation Approach Autor Nordestgaard, Børge G., Palmer, Tom M., Benn, Marianne, Zacho, Jeppe, Tybjærg-Hansen, Anne, Davey Smith, George, Timpson, Nicholas J.

“…Adiposity, assessed as elevated body mass index (BMI), is associated with increased risk of ischemic heart disease (IHD); however, whether this is causal is…”
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BMI and Mortality in UK Biobank: Revised Estimates Using Mendelian Randomization Autor Wade, Kaitlin H., Carslake, David, Sattar, Naveed, Davey Smith, George, Timpson, Nicholas J.

“…Objective The aim of this study was to obtain estimates of the causal relationship between BMI and mortality. Methods Mendelian randomization (MR) with…”
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BMI as a Modifiable Risk Factor for Type 2 Diabetes: Refining and Understanding Causal Estimates Using Mendelian Randomization Autor Corbin, Laura J, Richmond, Rebecca C, Wade, Kaitlin H, Burgess, Stephen, Bowden, Jack, Smith, George Davey, Timpson, Nicholas J

“…This study focused on resolving the relationship between BMI and type 2 diabetes. The availability of multiple variants associated with BMI offers a new chance…”
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