Výsledky vyhľadávania - "Thornton, Timothy A."

Genetic association testing using the GENESIS R/Bioconductor package Autor Gogarten, Stephanie M, Sofer, Tamar, Chen, Han, Yu, Chaoyu, Brody, Jennifer A, Thornton, Timothy A, Rice, Kenneth M, Conomos, Matthew P

“…The Genomic Data Storage (GDS) format provides efficient storage and retrieval of genotypes measured by microarrays and sequencing. We developed GENESIS to…”
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Model-free Estimation of Recent Genetic Relatedness Autor Conomos, Matthew P, Reiner, Alexander P, Weir, Bruce S, Thornton, Timothy A

“…Genealogical inference from genetic data is essential for a variety of applications in human genetics. In genome-wide and sequencing association studies, for…”
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Control for Population Structure and Relatedness for Binary Traits in Genetic Association Studies via Logistic Mixed Models Autor Chen, Han, Wang, Chaolong, Conomos, Matthew P, Stilp, Adrienne M, Li, Zilin, Sofer, Tamar, Szpiro, Adam A, Chen, Wei, Brehm, John M, Celedón, Juan C, Redline, Susan, Papanicolaou, George J, Thornton, Timothy A, Laurie, Cathy C, Rice, Kenneth, Lin, Xihong

“…Linear mixed models (LMMs) are widely used in genome-wide association studies (GWASs) to account for population structure and relatedness, for both continuous…”
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Robust Inference of Population Structure for Ancestry Prediction and Correction of Stratification in the Presence of Relatedness Autor Conomos, Matthew P., Miller, Michael B., Thornton, Timothy A.

“…ABSTRACT Population structure inference with genetic data has been motivated by a variety of applications in population genetics and genetic association…”
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Generalizing polygenic risk scores from Europeans to Hispanics/Latinos Autor Grinde, Kelsey E., Qi, Qibin, Thornton, Timothy A., Liu, Simin, Shadyab, Aladdin H., Chan, Kei Hang K., Reiner, Alexander P., Sofer, Tamar

“…Polygenic risk scores (PRSs) are weighted sums of risk allele counts of single‐nucleotide polymorphisms (SNPs) associated with a disease or trait. PRSs are…”
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Improving polygenic risk prediction in admixed populations by explicitly modeling ancestral-differential effects via GAUDI Autor Sun, Quan, Rowland, Bryce T., Chen, Jiawen, Mikhaylova, Anna V., Avery, Christy, Peters, Ulrike, Lundin, Jessica, Matise, Tara, Buyske, Steve, Tao, Ran, Mathias, Rasika A., Reiner, Alexander P., Auer, Paul L., Cox, Nancy J., Kooperberg, Charles, Thornton, Timothy A., Raffield, Laura M., Li, Yun

“…Polygenic risk scores (PRS) have shown successes in clinics, but most PRS methods focus only on participants with distinct primary continental ancestry without…”
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Adjusting for principal components can induce collider bias in genome-wide association studies Autor Grinde, Kelsey E., Browning, Brian L., Reiner, Alexander P., Thornton, Timothy A., Browning, Sharon R.

“…Principal component analysis (PCA) is widely used to control for population structure in genome-wide association studies (GWAS). Top principal components (PCs)…”
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Accuracy of Gene Expression Prediction From Genotype Data With PrediXcan Varies Across and Within Continental Populations Autor Mikhaylova, Anna V., Thornton, Timothy A.

“…Using genetic data to predict gene expression has garnered significant attention in recent years. PrediXcan has become one of the most widely used gene-based…”
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Genome-wide association study identifies peanut allergy-specific loci and evidence of epigenetic mediation in US children Autor Hong, Xiumei, Hao, Ke, Ladd-Acosta, Christine, Hansen, Kasper D., Tsai, Hui-Ju, Liu, Xin, Xu, Xin, Thornton, Timothy A., Caruso, Deanna, Keet, Corinne A., Sun, Yifei, Wang, Guoying, Luo, Wei, Kumar, Rajesh, Fuleihan, Ramsay, Singh, Anne Marie, Kim, Jennifer S., Story, Rachel E., Gupta, Ruchi S., Gao, Peisong, Chen, Zhu, Walker, Sheila O., Bartell, Tami R., Beaty, Terri H., Fallin, M. Daniele, Schleimer, Robert, Holt, Patrick G., Nadeau, Kari Christine, Wood, Robert A., Pongracic, Jacqueline A., Weeks, Daniel E., Wang, Xiaobin

“…Food allergy (FA) affects 2%–10% of US children and is a growing clinical and public health problem. Here we conduct the first genome-wide association study of…”
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On the cross-population generalizability of gene expression prediction models Autor Keys, Kevin L., Mak, Angel C. Y., White, Marquitta J., Eckalbar, Walter L., Dahl, Andrew W., Mefford, Joel, Mikhaylova, Anna V., Contreras, María G., Elhawary, Jennifer R., Eng, Celeste, Hu, Donglei, Huntsman, Scott, Oh, Sam S., Salazar, Sandra, Lenoir, Michael A., Ye, Jimmie C., Thornton, Timothy A., Zaitlen, Noah, Burchard, Esteban G., Gignoux, Christopher R.

“…The genetic control of gene expression is a core component of human physiology. For the past several years, transcriptome-wide association studies have…”
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Interferon gamma-induced protein 10 (IP-10) and cardiovascular disease in African Americans Autor Leavitt, Colton, Zakai, Neil A., Auer, Paul, Cushman, Mary, Lange, Ethan M., Levitan, Emily B., Olson, Nels, Thornton, Timothy A., Tracy, Russell P., Wilson, James G., Lange, Leslie A., Reiner, Alex P., Raffield, Laura M.

“…Biomarkers of chronic inflammation (such as C-reactive protein) have long been associated with cardiovascular disease and mortality; however, biomarkers…”
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Protein prediction for trait mapping in diverse populations Autor Schubert, Ryan, Geoffroy, Elyse, Gregga, Isabelle, Mulford, Ashley J., Aguet, Francois, Ardlie, Kristin, Gerszten, Robert, Clish, Clary, Van Den Berg, David, Taylor, Kent D., Durda, Peter, Johnson, W. Craig, Cornell, Elaine, Guo, Xiuqing, Liu, Yongmei, Tracy, Russell, Conomos, Matthew, Blackwell, Tom, Papanicolaou, George, Lappalainen, Tuuli, Mikhaylova, Anna V., Thornton, Timothy A., Cho, Michael H., Gignoux, Christopher R., Lange, Leslie, Lange, Ethan, Rich, Stephen S., Rotter, Jerome I., Manichaikul, Ani, Im, Hae Kyung, Wheeler, Heather E.

“…Genetically regulated gene expression has helped elucidate the biological mechanisms underlying complex traits. Improved high-throughput technology allows…”
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Inflammatory Bowel Disease (IBD) pharmacotherapy and the risk of serious infection: a systematic review and network meta-analysis Autor Wheat, Chelle L., Ko, Cynthia W., Clark-Snustad, Kindra, Grembowski, David, Thornton, Timothy A., Devine, Beth

“…Background The magnitude of risk of serious infections due to available medical therapies of inflammatory bowel disease (IBD) remains controversial. We…”
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Polymorphic Human Sulfotransferase 2A1 Mediates the Formation of 25-Hydroxyvitamin D3-3-O-Sulfate, a Major Circulating Vitamin D Metabolite in Humans Autor Wong, Timothy, Wang, Zhican, Chapron, Brian D, Suzuki, Mizuki, Claw, Katrina G, Gao, Chunying, Foti, Robert S, Prasad, Bhagwat, Chapron, Alenka, Calamia, Justina, Chaudhry, Amarjit, Schuetz, Erin G, Horst, Ronald L, Mao, Qingcheng, de Boer, Ian H, Thornton, Timothy A, Thummel, Kenneth E

“…Metabolism of 25-hydroxyvitamin D3 (25OHD3) plays a central role in regulating the biologic effects of vitamin D in the body. Although cytochrome…”
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Detecting Heterogeneity in Population Structure Across the Genome in Admixed Populations Autor McHugh, Caitlin, Brown, Lisa, Thornton, Timothy A

“…The genetic structure of human populations is often characterized by aggregating measures of ancestry across the autosomal chromosomes. While it may be…”
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Dissecting Vancomycin-Intermediate Resistance in Staphylococcus aureus Using Genome-Wide Association Autor Alam, Md Tauqeer, Petit, Robert A., Crispell, Emily K., Thornton, Timothy A., Conneely, Karen N., Jiang, Yunxuan, Satola, Sarah W., Read, Timothy D.

“…Vancomycin-intermediate Staphylococcus aureus (VISA) is currently defined as having minimal inhibitory concentration (MIC) of 4–8 µg/ml. VISA evolves through…”
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Admixture mapping reveals the association between Native American ancestry at 3q13.11 and reduced risk of Alzheimer’s disease in Caribbean Hispanics Autor Horimoto, Andréa R. V. R., Xue, Diane, Thornton, Timothy A., Blue, Elizabeth E.

“…Background Genetic studies have primarily been conducted in European ancestry populations, identifying dozens of loci associated with late-onset Alzheimer’s…”
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Admixture mapping in the Hispanic Community Health Study/Study of Latinos reveals regions of genetic associations with blood pressure traits Autor Sofer, Tamar, Baier, Leslie J., Browning, Sharon R., Thornton, Timothy A., Talavera, Gregory A., Wassertheil-Smoller, Sylvia, Daviglus, Martha L., Hanson, Robert, Kobes, Sayuko, Cooper, Richard S., Cai, Jianwen, Levy, Daniel, Reiner, Alex P., Franceschini, Nora

“…Admixture mapping can be used to detect genetic association regions in admixed populations, such as Hispanics/Latinos, by estimating associations between local…”
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Interrogation of CYP2D6 Structural Variant Alleles Improves the Correlation Between CYP2D6 Genotype and CYP2D6‐Mediated Metabolic Activity Autor Dalton, Rachel, Lee, Seung‐been, Claw, Katrina G., Prasad, Bhagwat, Phillips, Brian R., Shen, Danny D., Wong, Lai Hong, Fade, Mitch, McDonald, Matthew G., Dunham, Maitreya J., Fowler, Douglas M., Rettie, Allan E., Schuetz, Erin, Thornton, Timothy A., Nickerson, Deborah A., Gaedigk, Andrea, Thummel, Kenneth E., Woodahl, Erica L.

“…The cytochrome P450 2D6 (CYP2D6) gene locus is challenging to accurately genotype due to numerous single nucleotide variants and complex structural variation…”
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Genetic variations and risk of placental abruption: A genome-wide association study and meta-analysis of genome-wide association studies Autor Workalemahu, Tsegaselassie, Enquobahrie, Daniel A., Gelaye, Bizu, Sanchez, Sixto E., Garcia, Pedro J., Tekola-Ayele, Fasil, Hajat, Anjum, Thornton, Timothy A., Ananth, Cande V., Williams, Michelle A.

“…Accumulating epidemiological evidence points to strong genetic susceptibility to placental abruption (PA). However, characterization of genes associated with…”
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