Suchergebnisse - "Thomas, David M"

Topological barrier to Cas12a activation by circular DNA nanostructures facilitates autocatalysis and transforms DNA/RNA sensing von Deng, Fei, Li, Yi, Yang, Biyao, Sang, Rui, Deng, Wei, Kansara, Maya, Lin, Frank, Thavaneswaran, Subotheni, Thomas, David M., Goldys, Ewa M.

“… Control of CRISPR/Cas12a trans -cleavage is crucial for biosensor development. Here, we show that small circular DNA nanostructures which partially match guide …”
Volltext

Locally Aggressive Connective Tissue Tumors von Gounder, Mrinal M, Thomas, David M, Tap, William D

“… In this review, we highlight the complexities of the natural history, biology, and clinical management of three intermediate connective tissue tumors: desmoid …”
Weitere Angaben

Diagnosis of fusion genes using targeted RNA sequencing von Heyer, Erin E., Deveson, Ira W., Wooi, Danson, Selinger, Christina I., Lyons, Ruth J., Hayes, Vanessa M., O’Toole, Sandra A., Ballinger, Mandy L., Gill, Devinder, Thomas, David M., Mercer, Tim R., Blackburn, James

“… Fusion genes are a major cause of cancer. Their rapid and accurate diagnosis can inform clinical action, but current molecular diagnostic assays are restricted …”
Volltext

IFN-γ is required for cytotoxic T cell-dependent cancer genome immunoediting von Takeda, Kazuyoshi, Nakayama, Masafumi, Hayakawa, Yoshihiro, Kojima, Yuko, Ikeda, Hiroaki, Imai, Naoko, Ogasawara, Kouetsu, Okumura, Ko, Thomas, David M., Smyth, Mark J.

“… Genetic evolution that occurs during cancer progression enables tumour heterogeneity, thereby fostering tumour adaptation, therapeutic resistance and …”
Volltext

Tumor-associated macrophages and macrophage-related immune checkpoint expression in sarcomas von Dancsok, Amanda R., Gao, Dongxia, Lee, Anna F., Steigen, Sonja Eriksson, Blay, Jean-Yves, Thomas, David M., Maki, Robert G., Nielsen, Torsten O., Demicco, Elizabeth G.

“… Early trials for immune checkpoint inhibitors in sarcomas have delivered mixed results, and efforts to improve outcomes now look to combinatorial strategies …”
Volltext

MTOR signaling orchestrates stress-induced mutagenesis, facilitating adaptive evolution in cancer von Cipponi, Arcadi, Goode, David L, Bedo, Justin, McCabe, Mark J, Pajic, Marina, Croucher, David R, Rajal, Alvaro Gonzalez, Junankar, Simon R, Saunders, Darren N, Lobachevsky, Pavel, Papenfuss, Anthony T, Nessem, Danielle, Nobis, Max, Warren, Sean C, Timpson, Paul, Cowley, Mark, Vargas, Ana C, Qiu, Min R, Generali, Daniele G, Keerthikumar, Shivakumar, Nguyen, Uyen, Corcoran, Niall M, Long, Georgina V, Blay, Jean-Yves, Thomas, David M

“… In microorganisms, evolutionarily conserved mechanisms facilitate adaptation to harsh conditions through stress-induced mutagenesis (SIM). Analogous processes …”
Weitere Angaben

Precision medicine: affording the successes of science von Lu, Christine Y., Terry, Vera, Thomas, David M.

“… Science has made remarkable advances in understanding the molecular basis of disease, generating new and effective rationally-designed treatments at an …”
Volltext

Author Correction: IFN-γ is required for cytotoxic T cell-dependent cancer genome immunoediting von Takeda, Kazuyoshi, Nakayama, Masafumi, Hayakawa, Yoshihiro, Kojima, Yuko, Ikeda, Hiroaki, Imai, Naoko, Ogasawara, Kouetsu, Okumura, Ko, Thomas, David M., Smyth, Mark J.

Volltext

Benefits and adverse events in younger versus older patients receiving neoadjuvant chemotherapy for osteosarcoma: findings from a meta-analysis von Collins, Marnie, Wilhelm, Miriam, Conyers, Rachel, Herschtal, Alan, Whelan, Jeremy, Bielack, Stefan, Kager, Leo, Kühne, Thomas, Sydes, Matthew, Gelderblom, Hans, Ferrari, Stefano, Picci, Piero, Smeland, Sigbjørn, Eriksson, Mikael, Petrilli, Antonio Sérgio, Bleyer, Archie, Thomas, David M

“… The LIVESTRONG Young Adult Alliance has conducted a meta-analysis of individual patient data from prospective neoadjuvant chemotherapy osteosarcoma studies and …”
Weitere Angaben

ClinSV: clinical grade structural and copy number variant detection from whole genome sequencing data von Minoche, Andre E., Lundie, Ben, Peters, Greg B., Ohnesorg, Thomas, Pinese, Mark, Thomas, David M., Zankl, Andreas, Roscioli, Tony, Schonrock, Nicole, Kummerfeld, Sarah, Burnett, Leslie, Dinger, Marcel E., Cowley, Mark J.

“… Whole genome sequencing (WGS) has the potential to outperform clinical microarrays for the detection of structural variants (SV) including copy number variants …”
Volltext

FGFR genetic alterations predict for sensitivity to NVP-BGJ398, a selective pan-FGFR inhibitor von Guagnano, Vito, Kauffmann, Audrey, Wöhrle, Simon, Stamm, Christelle, Ito, Moriko, Barys, Louise, Pornon, Astrid, Yao, Yao, Li, Fang, Zhang, Yun, Chen, Zhi, Wilson, Christopher J, Bordas, Vincent, Le Douget, Mickaël, Gaither, L Alex, Borawski, Jason, Monahan, John E, Venkatesan, Kavitha, Brümmendorf, Thomas, Thomas, David M, Garcia-Echeverria, Carlos, Hofmann, Francesco, Sellers, William R, Graus-Porta, Diana

“… Patient stratification biomarkers that enable the translation of cancer genetic knowledge into clinical use are essential for the successful and rapid …”
Weitere Angaben

Optical mapping reveals a higher level of genomic architecture of chained fusions in cancer von Chan, Eva K F, Cameron, Daniel L, Petersen, Desiree C, Lyons, Ruth J, Baldi, Benedetta F, Papenfuss, Anthony T, Thomas, David M, Hayes, Vanessa M

“… Genomic rearrangements are common in cancer, with demonstrated links to disease progression and treatment response. These rearrangements can be complex, …”
Weitere Angaben

The architecture and evolution of cancer neochromosomes von Garsed, Dale W, Marshall, Owen J, Corbin, Vincent D A, Hsu, Arthur, Di Stefano, Leon, Schröder, Jan, Li, Jason, Feng, Zhi-Ping, Kim, Bo W, Kowarsky, Mark, Lansdell, Ben, Brookwell, Ross, Myklebost, Ola, Meza-Zepeda, Leonardo, Holloway, Andrew J, Pedeutour, Florence, Choo, K H Andy, Damore, Michael A, Deans, Andrew J, Papenfuss, Anthony T, Thomas, David M

“… We isolated and analyzed, at single-nucleotide resolution, cancer-associated neochromosomes from well- and/or dedifferentiated liposarcomas. Neochromosomes, …”
Weitere Angaben

A Qualitative Analysis on the Effectiveness of Peer Feedback in Team-Based Learning von Lerchenfeldt, Sarah, Kamel-ElSayed, Suzan, Patino, Gustavo, Loftus, Stephen, Thomas, David M.

“… Introduction There is limited information on medical students’ perceptions of peer feedback in team-based learning (TBL), both in terms of its value and how it …”
Volltext

Liposarcoma: Molecular Genetics and Therapeutics von Conyers, Rachel, Young, Sophie, Thomas, David M.

“… Sarcomas are a group of heterogeneous tumours with varying genetic basis. Cytogenetic abnormalities range from distinct genomic rearrangements such as …”
Volltext

High resolution melting analysis for the rapid and sensitive detection of mutations in clinical samples: KRAS codon 12 and 13 mutations in non-small cell lung cancer von Krypuy, Michael, Newnham, Genni M, Thomas, David M, Conron, Matthew, Dobrovic, Alexander

“… The development of targeted therapies has created a pressing clinical need for the rapid and robust molecular characterisation of cancers. We describe here the …”
Volltext

Implementation of precision medicine in treating non-communicable diseases: a systematic review von Liang, Shuang, Kennedy, Elizabeth, Gale, Nyree, Watson, Paul, Ramanathan, Mahitha, Shinde, Arya, McKay, Skye, Torres-Robles, Andrea, Li, Zhicheng, Chan, Jeffery, Jones, Helen, Ballinger, Mandy L., Butow, Phyllis, Goldstein, David, Leaney, Kathryn, Middleton, Sandy, Morrow, April, Thomas, David M., Tucker, Kathy M., Zaheed, Milita, Parkinson, Bonny, Lin, Frank, Taylor, Natalie

“… Background Non-communicable diseases (NCDs) are a major global health and economic burden. Precision medicine has merged as a promising approach for treating …”
Volltext

ASPiRATION: Australian observational cohort study of comprehensive genomic profiling in metastatic lung cancer tissue von Mersiades, Antony J, Solomon, Benjamin J, Thomas, David M, Lee, Chee K, Cummins, Michelle M, Sebastian, Lucille, Ballinger, Mandy L, Collignon, Emily, Turnbull, Olivia Mh, Yip, Sonia, Morton, Rachael L, Brown, Chris, Wheeler, Patrick J, Itchins, Malinda, Simes, R John, Pavlakis, Nick

“… ASPiRATION is a national prospective observational cohort study assessing the feasibility, clinical and economic value of up-front tissue-based comprehensive …”
Weitere Angaben

Psychological outcomes in advanced cancer patients after receiving genomic tumor profiling results von Vatter, Sabina, Schlub, Timothy E, Napier, Christine E, Best, Megan C, Bartley, Nicci, Juraskova, Ilona, Meiser, Bettina, Ballinger, Mandy L, Biesecker, Barbara B, Goldstein, David, Thomas, David M, Butow, Phyllis

“… Comprehensive tumor genomic profiling (CGP) offers hope for personalized treatment for cancer patients when other treatment options have been exhausted …”
Weitere Angaben

Wnt inhibitory factor 1 is epigenetically silenced in human osteosarcoma, and targeted disruption accelerates osteosarcomagenesis in mice von Kansara, Maya, Tsang, Michael, Kodjabachian, Laurent, Sims, Natalie A., Trivett, Melanie K., Ehrich, Mathias, Dobrovic, Alexander, Slavin, John, Choong, Peter F.M., Simmons, Paul J., Dawid, Igor B., Thomas, David M.

“… Wnt signaling increases bone mass by stimulating osteoblast lineage commitment and expansion and forms the basis for novel anabolic therapeutic strategies …”
Volltext