Suchergebnisse - "The Prostate"

LuCaP Prostate Cancer Patient‐Derived Xenografts Reflect the Molecular Heterogeneity of Advanced Disease an­­d Serve as Models for Evaluating Cancer Therapeutics von Nguyen, Holly M., Vessella, Robert L., Morrissey, Colm, Brown, Lisha G., Coleman, Ilsa M., Higano, Celestia S., Mostaghel, Elahe A., Zhang, Xiaotun, True, Lawrence D., Lam, Hung‐Ming, Roudier, Martine, Lange, Paul H., Nelson, Peter S., Corey, Eva

“… BACKGROUND Metastatic prostate cancer is a common and lethal disease for which there are no therapies that produce cures or long‐term durable remissions …”
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Polyploid giant cancer cells: Unrecognized actuators of tumorigenesis, metastasis, and resistance von Amend, Sarah R., Torga, Gonzalo, Lin, Ke‐Chih, Kostecka, Laurie G., Marzo, Angelo, Austin, Robert H., Pienta, Kenneth J.

“… Cancer led to the deaths of more than 9 million people worldwide in 2018, and most of these deaths were due to metastatic tumor burden. While in most cases, we …”
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M2 macrophages and regulatory T cells in lethal prostate cancer von Erlandsson, Ann, Carlsson, Jessica, Lundholm, Marie, Fält, Anna, Andersson, Sven‐Olof, Andrén, Ove, Davidsson, Sabina

“… Background Prostate cancer (PCa) is one of the most frequently diagnosed cancers in the world. Emerging evidence suggests that inflammatory cells such as M2 …”
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Time of metastatic disease presentation and volume of disease are prognostic for metastatic hormone sensitive prostate cancer (mHSPC) von Francini, Edoardo, Gray, Kathryn P., Xie, Wanling, Shaw, Grace K., Valença, Loana, Bernard, Brandon, Albiges, Laurence, Harshman, Lauren C., Kantoff, Philip W., Taplin, Mary‐Ellen, Sweeney, Cristopher J.

“… Background Currently, there is no universally accepted prognostic classification for patients (pts) with metastatic hormone sensitive prostate cancer (mHSPC) …”
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The association of BRCA1 and BRCA2 mutations with prostate cancer risk, frequency, and mortality: A meta‐analysis von Oh, Mok, Alkhushaym, Nasser, Fallatah, Saad, Althagafi, Abdulhamid, Aljadeed, Rana, Alsowaida, Yazed, Jeter, Joanne, Martin, Jennifer R., Babiker, Hani M., McBride, Ali, Abraham, Ivo

“… Background A prior meta‐analysis found no association between BRCA1 mutation and prostate cancer (PCa). Subsequent BRCA2 mutation studies have shown an …”
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Distribution of metastatic sites in patients with prostate cancer: A population-based analysis von Gandaglia, Giorgio, Abdollah, Firas, Schiffmann, Jonas, Trudeau, Vincent, Shariat, Shahrokh F., Kim, Simon P., Perrotte, Paul, Montorsi, Francesco, Briganti, Alberto, Trinh, Quoc-Dien, Karakiewicz, Pierre I., Sun, Maxine

“… BACKGROUND There is few data on what constitutes the distribution of metastatic sites in prostate cancer (PCa). The aim of our study was to systematically …”
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PTEN‐PI3K pathway alterations in advanced prostate cancer and clinical implications von Choudhury, Atish D.

“… Background Despite significant advances in molecular characterization and therapeutic targeting of advanced prostate cancer, it remains the second most common …”
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Estrogen receptor signaling in prostate cancer: Implications for carcinogenesis and tumor progression von Bonkhoff, Helmut

“… Background The androgen receptor (AR) is the classical target for prostate cancer prevention and treatment, but more recently estrogens and their receptors …”
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GLUT1 regulates cell glycolysis and proliferation in prostate cancer von Xiao, Hengjun, Wang, Jun, Yan, Weixin, Cui, Yubin, Chen, Zheng, Gao, Xin, Wen, Xingqiao, Chen, Jun

“… Background Glucose transporter 1 (GLUT1) plays a critical role in tumorigenesis and tumor progression in multiple cancer types. However, the specific function …”
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Association between PSA density and pathologically significant prostate cancer: The impact of prostate volume von Omri, Nativ, Kamil, Malshy, Alexander, Kastin, Alexander, Kravtzov, Edmond, Sabo, Ariel, Zisman, David, Kakiashvili, Gilad, Amiel E., Azik, Hoffman

“… Background The early diagnosis of prostate cancer (PCa) is mainly based on prostate‐specific antigen (PSA) blood levels and digital rectal examination …”
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miR‐21‐5p, miR‐141‐3p, and miR‐205‐5p levels in urine—promising biomarkers for the identification of prostate and bladder cancer von Ghorbanmehr, Nassim, Gharbi, Sedigheh, Korsching, Eberhard, Tavallaei, Mahmood, Einollahi, Behzad, Mowla, Seyed Javad

“… Background Early detection of cancers improves patients’ survival and decreases the treatment cost. Unfortunately, the current methods for diagnosis of bladder …”
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Exosomal and Non‐Exosomal Urinary miRNAs in Prostate Cancer Detection and Prognosis von Foj, Laura, Ferrer, Ferran, Serra, Marta, Arévalo, Antonio, Gavagnach, Montserrat, Giménez, Nuria, Filella, Xavier

“… BACKGROUND MicroRNAs (miRNAs) are non‐coding small RNAs, involved in post‐transcriptional regulation of many target genes. METHODS Five miRNAs that have been …”
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High intratumoral CD8+ T‐cell infiltration is associated with improved survival in prostate cancer patients undergoing radical prostatectomy von Yang, Yuanquan, Attwood, Kristopher, Bshara, Wiam, Mohler, James L., Guru, Khurshid, Xu, Bo, Kalinski, Pawel, Chatta, Gurkamal

“… Background A high density of CD8+ tumor infiltrating lymphocytes (TILs) is associated with improved survival in multiple cancers, but its prognostic role in …”
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Different gDNA content in the subpopulations of prostate cancer extracellular vesicles: Apoptotic bodies, microvesicles, and exosomes von Lázaro-Ibáñez, Elisa, Sanz-Garcia, Andres, Visakorpi, Tapio, Escobedo-Lucea, Carmen, Siljander, Pia, Ayuso-Sacido, Ángel, Yliperttula, Marjo

“… BACKGROUND Extracellular vesicles (EVs) are cell‐derived membrane vesicles. EVs contain several RNAs such as mRNA, microRNAs, and ncRNAs, but less is known of …”
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The Firmicutes/Bacteroidetes ratio of the human gut microbiota is associated with prostate enlargement von Takezawa, Kentaro, Fujita, Kazutoshi, Matsushita, Makoto, Motooka, Daisuke, Hatano, Koji, Banno, Eri, Shimizu, Nobutaka, Takao, Tetsuya, Takada, Shingo, Okada, Koichi, Fukuhara, Shinichiro, Kiuchi, Hiroshi, Uemura, Hirotsugu, Nakamura, Shota, Kojima, Yoshiyuki, Nonomura, Norio

“… Background The pathophysiology of the prostate enlargement underlying lower urinary tract symptoms is unknown. Meanwhile, the gut microbiota can contribute to …”
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Intraductal/ductal histology and lymphovascular invasion are associated with germline DNA‐repair gene mutations in prostate cancer von Isaacsson Velho, Pedro, Silberstein, John L., Markowski, Mark C., Luo, Jun, Lotan, Tamara L., Isaacs, William B., Antonarakis, Emmanuel S.

“… Background Germline mutations in genes mediating DNA repair are common in men with recurrent and advanced prostate cancer, and their presence may alter …”
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ATF6α promotes prostate cancer progression by enhancing PLA2G4A‐mediated arachidonic acid metabolism and protecting tumor cells against ferroptosis von Zhao, Ru, Lv, Ye, Feng, Tingting, Zhang, Ruojia, Ge, Luna, Pan, Jihong, Han, Bo, Song, Guanhua, Wang, Lin

“… Background Despite the clinical success of androgen receptor (AR)‐targeted therapies, prostate cancer (PCa) inevitably progresses to castration‐resistant …”
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PSMA ADC monotherapy in patients with progressive metastatic castration‐resistant prostate cancer following abiraterone and/or enzalutamide: Efficacy and safety in open‐label single‐arm phase 2 study von Petrylak, Daniel P., Vogelzang, Nicholas J., Chatta, Kamal, Fleming, Mark T., Smith, David C., Appleman, Leonard J., Hussain, Arif, Modiano, Manuel, Singh, Parminder, Tagawa, Scott T., Gore, Ira, McClay, Edward F., Mega, Anthony E., Sartor, A. Oliver, Somer, Bradley, Wadlow, Raymond, Shore, Neal D., Olson, William C., Stambler, Nancy, DiPippo, Vincent A., Israel, Robert J.

“… Background Prostate‐specific membrane antigen (PSMA) is a well‐established therapeutic and diagnostic target overexpressed in both primary and metastatic …”
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Urethral luminal epithelia are castration‐insensitive cells of the proximal prostate von Joseph, Diya B., Henry, Gervaise H., Malewska, Alicia, Iqbal, Nida S., Ruetten, Hannah M., Turco, Anne E., Abler, Lisa L., Sandhu, Simran K., Cadena, Mark T., Malladi, Venkat S., Reese, Jeffrey C., Mauck, Ryan J., Gahan, Jeffrey C., Hutchinson, Ryan C., Roehrborn, Claus G., Baker, Linda A., Vezina, Chad M., Strand, Douglas W.

“… Background Castration‐insensitive epithelial progenitors capable of regenerating the prostate have been proposed to be concentrated in the proximal region …”
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Current and projected number of years of life lost due to prostate cancer: A global study von Withrow, Diana, Pilleron, Sophie, Nikita, Nikita, Ferlay, Jacques, Sharma, Swapnil, Nicholson, Brian, Rebbeck, Timothy R., Lu‐Yao, Grace

“… Background Prostate cancer is an important cause of death worldwide. The number of years of life lost (YLL) due to prostate cancer is a metric of the toll of …”
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