Suchergebnisse - "The Journal of experimental medicine"

Serum proteomics reveals systemic dysregulation of innate immunity in type 1 diabetes von Zhang, Qibin, Fillmore, Thomas L, Schepmoes, Athena A, Clauss, Therese R W, Gritsenko, Marina A, Mueller, Patricia W, Rewers, Marian, Atkinson, Mark A, Smith, Richard D, Metz, Thomas O

“… Using global liquid chromatography-mass spectrometry (LC-MS)-based proteomics analyses, we identified 24 serum proteins that were significantly variant between …”
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Dendritic cells as adjuvants for class I major histocompatibility complex-restricted antitumor immunity von Young, J W, Inaba, K

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Altered immune responses in interleukin 10 transgenic mice von Hagenbaugh, A, Sharma, S, Dubinett, S M, Wei, S H, Aranda, R, Cheroutre, H, Fowell, D J, Binder, S, Tsao, B, Locksley, R M, Moore, K W, Kronenberg, M

“… Interleukin (IL)-10 is a pleiotropic cytokine which inhibits a broad array of immune parameters including T helper cell type 1 (Th1) cytokine production, …”
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Inflammasomes are activated in response to SARS-CoV-2 infection and are associated with COVID-19 severity in patients von Rodrigues, Tamara S, de Sá, Keyla S G, Ishimoto, Adriene Y, Becerra, Amanda, Oliveira, Samuel, Almeida, Leticia, Gonçalves, Augusto V, Perucello, Debora B, Andrade, Warrison A, Castro, Ricardo, Veras, Flavio P, Toller-Kawahisa, Juliana E, Nascimento, Daniele C, de Lima, Mikhael H F, Silva, Camila M S, Caetite, Diego B, Martins, Ronaldo B, Castro, Italo A, Pontelli, Marjorie C, de Barros, Fabio C, do Amaral, Natália B, Giannini, Marcela C, Bonjorno, Letícia P, Lopes, Maria Isabel F, Santana, Rodrigo C, Vilar, Fernando C, Auxiliadora-Martins, Maria, Luppino-Assad, Rodrigo, de Almeida, Sergio C L, de Oliveira, Fabiola R, Batah, Sabrina S, Siyuan, Li, Benatti, Maira N, Cunha, Thiago M, Alves-Filho, José C, Cunha, Fernando Q, Cunha, Larissa D, Frantz, Fabiani G, Kohlsdorf, Tiana, Fabro, Alexandre T, Arruda, Eurico, de Oliveira, Renê D R, Louzada-Junior, Paulo, Zamboni, Dario S

“… Severe cases of COVID-19 are characterized by a strong inflammatory process that may ultimately lead to organ failure and patient death. The NLRP3 inflammasome …”
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Transforming growth factor-β in tissue fibrosis von Frangogiannis, Nikolaos

“… TGF-β is extensively implicated in the pathogenesis of fibrosis. In fibrotic lesions, spatially restricted generation of bioactive TGF-β from latent stores …”
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CD36, a signaling receptor and fatty acid transporter that regulates immune cell metabolism and fate von Chen, Yiliang, Zhang, Jue, Cui, Weiguo, Silverstein, Roy L

“… CD36 is a type 2 cell surface scavenger receptor widely expressed in many immune and non-immune cells. It functions as both a signaling receptor responding to …”
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The gut microbiome: Relationships with disease and opportunities for therapy von Durack, Juliana, Lynch, Susan V

“… Over the past decade, our view of human-associated microbes has expanded beyond that of a few species toward an appreciation of the diverse and …”
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Microglia in Alzheimer's disease at single-cell level. Are there common patterns in humans and mice? von Chen, Yun, Colonna, Marco

“… Alzheimer's disease (AD) is characterized by extracellular aggregates of amyloid β peptides, intraneuronal tau aggregates, and neuronal death. This pathology …”
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CAR-T cell manufacturing: Major process parameters and next-generation strategies von Ayala Ceja, Melanie, Khericha, Mobina, Harris, Caitlin M, Puig-Saus, Cristina, Chen, Yvonne Y

“… Chimeric antigen receptor (CAR)-T cell therapies have demonstrated strong curative potential and become a critical component in the array of B-cell malignancy …”
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Accumulation of long-chain fatty acids in the tumor microenvironment drives dysfunction in intrapancreatic CD8+ T cells von Manzo, Teresa, Prentice, Boone M, Anderson, Kristin G, Raman, Ayush, Schalck, Aislyn, Codreanu, Gabriela S, Nava Lauson, Carina B, Tiberti, Silvia, Raimondi, Andrea, Jones, Marissa A, Reyzer, Michelle, Bates, Breanna M, Spraggins, Jeffrey M, Patterson, Nathan H, McLean, John A, Rai, Kunal, Tacchetti, Carlo, Tucci, Sara, Wargo, Jennifer A, Rodighiero, Simona, Clise-Dwyer, Karen, Sherrod, Stacy D, Kim, Michael, Navin, Nicholas E, Caprioli, Richard M, Greenberg, Philip D, Draetta, Giulio, Nezi, Luigi

“… CD8+ T cells are master effectors of antitumor immunity, and their presence at tumor sites correlates with favorable outcomes. However, metabolic constraints …”
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PD-L1 on tumor cells is sufficient for immune evasion in immunogenic tumors and inhibits CD8 T cell cytotoxicity von Juneja, Vikram R, McGuire, Kathleen A, Manguso, Robert T, LaFleur, Martin W, Collins, Natalie, Haining, W Nicholas, Freeman, Gordon J, Sharpe, Arlene H

“… It is unclear whether PD-L1 on tumor cells is sufficient for tumor immune evasion or simply correlates with an inflamed tumor microenvironment. We used three …”
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Nucleoside-modified mRNA vaccines induce potent T follicular helper and germinal center B cell responses von Pardi, Norbert, Hogan, Michael J, Naradikian, Martin S, Parkhouse, Kaela, Cain, Derek W, Jones, Letitia, Moody, M Anthony, Verkerke, Hans P, Myles, Arpita, Willis, Elinor, LaBranche, Celia C, Montefiori, David C, Lobby, Jenna L, Saunders, Kevin O, Liao, Hua-Xin, Korber, Bette T, Sutherland, Laura L, Scearce, Richard M, Hraber, Peter T, Tombácz, István, Muramatsu, Hiromi, Ni, Houping, Balikov, Daniel A, Li, Charles, Mui, Barbara L, Tam, Ying K, Krammer, Florian, Karikó, Katalin, Polacino, Patricia, Eisenlohr, Laurence C, Madden, Thomas D, Hope, Michael J, Lewis, Mark G, Lee, Kelly K, Hu, Shiu-Lok, Hensley, Scott E, Cancro, Michael P, Haynes, Barton F, Weissman, Drew

“… T follicular helper (Tfh) cells are required to develop germinal center (GC) responses and drive immunoglobulin class switch, affinity maturation, and …”
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Growth of Mycobacterium tuberculosis in vivo segregates with host macrophage metabolism and ontogeny von Huang, Lu, Nazarova, Evgeniya V, Tan, Shumin, Liu, Yancheng, Russell, David G

“… To understand how infection by (Mtb) is modulated by host cell phenotype, we characterized those host phagocytes that controlled or supported bacterial growth …”
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Analysis of classical neutrophils and polymorphonuclear myeloid-derived suppressor cells in cancer patients and tumor-bearing mice von Veglia, Filippo, Hashimoto, Ayumi, Dweep, Harsh, Sanseviero, Emilio, De Leo, Alessandra, Tcyganov, Evgenii, Kossenkov, Andrew, Mulligan, Charles, Nam, Brian, Masters, Gregory, Patel, Jaymala, Bhargava, Vipul, Wilkinson, Patrick, Smirnov, Denis, Sepulveda, Manuel A, Singhal, Sunil, Eruslanov, Evgeniy B, Cristescu, Razvan, Loboda, Andrey, Nefedova, Yulia, Gabrilovich, Dmitry I

“… In this study, using single-cell RNA-seq, cell mass spectrometry, flow cytometry, and functional analysis, we characterized the heterogeneity of …”
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CXCR6 regulates localization of tissue-resident memory CD8 T cells to the airways von Wein, Alexander N, McMaster, Sean R, Takamura, Shiki, Dunbar, Paul R, Cartwright, Emily K, Hayward, Sarah L, McManus, Daniel T, Shimaoka, Takeshi, Ueha, Satoshi, Tsukui, Tatsuya, Masumoto, Tomoko, Kurachi, Makoto, Matsushima, Kouji, Kohlmeier, Jacob E

“… Resident memory T cells (T cells) are an important first-line defense against respiratory pathogens, but the unique contributions of lung T cell populations to …”
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A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules von Aspelund, Aleksanteri, Antila, Salli, Proulx, Steven T, Karlsen, Tine Veronica, Karaman, Sinem, Detmar, Michael, Wiig, Helge, Alitalo, Kari

“… The central nervous system (CNS) is considered an organ devoid of lymphatic vasculature. Yet, part of the cerebrospinal fluid (CSF) drains into the cervical …”
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Gasdermins and their role in immunity and inflammation von Orning, Pontus, Lien, Egil, Fitzgerald, Katherine A

“… The gasdermins are a family of pore-forming proteins recently implicated in the immune response. One of these proteins, gasdermin D (GSDMD), has been …”
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PD-1 restraint of regulatory T cell suppressive activity is critical for immune tolerance von Tan, Catherine L, Kuchroo, Juhi R, Sage, Peter T, Liang, Dan, Francisco, Loise M, Buck, Jessica, Thaker, Youg Raj, Zhang, Qianxia, McArdel, Shannon L, Juneja, Vikram R, Lee, Sun Jung, Lovitch, Scott B, Lian, Christine, Murphy, George F, Blazar, Bruce R, Vignali, Dario A A, Freeman, Gordon J, Sharpe, Arlene H

“… Inhibitory signals through the PD-1 pathway regulate T cell activation, T cell tolerance, and T cell exhaustion. Studies of PD-1 function have focused …”
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Multi-omic profiling reveals widespread dysregulation of innate immunity and hematopoiesis in COVID-19 von Wilk, Aaron J, Lee, Madeline J, Wei, Bei, Parks, Benjamin, Pi, Ruoxi, Martínez-Colón, Giovanny J, Ranganath, Thanmayi, Zhao, Nancy Q, Taylor, Shalina, Becker, Winston, Jimenez-Morales, David, Blomkalns, Andra L, O'Hara, Ruth, Ashley, Euan A, Nadeau, Kari C, Yang, Samuel, Holmes, Susan, Rabinovitch, Marlene, Rogers, Angela J, Greenleaf, William J, Blish, Catherine A

“… Our understanding of protective versus pathological immune responses to SARS-CoV-2, the virus that causes coronavirus disease 2019 (COVID-19), is limited by …”
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Dynamic innate immune response determines susceptibility to SARS-CoV-2 infection and early replication kinetics von Cheemarla, Nagarjuna R, Watkins, Timothy A, Mihaylova, Valia T, Wang, Bao, Zhao, Dejian, Wang, Guilin, Landry, Marie L, Foxman, Ellen F

“… Initial replication of SARS-CoV-2 in the upper respiratory tract is required to establish infection, and the replication level correlates with the likelihood …”
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