Výsledky vyhľadávania - "The Journal of cell biology"

Integrins, oncogenes, and anchorage independence Autor Schwartz, M A

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Fibroblasts, myofibroblasts, and wound contraction Autor Grinnell, F

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Endosomal escape of delivered mRNA from endosomal recycling tubules visualized at the nanoscale Autor Paramasivam, Prasath, Franke, Christian, Stöter, Martin, Höijer, Andreas, Bartesaghi, Stefano, Sabirsh, Alan, Lindfors, Lennart, Arteta, Marianna Yanez, Dahlén, Anders, Bak, Annette, Andersson, Shalini, Kalaidzidis, Yannis, Bickle, Marc, Zerial, Marino

“…Delivery of exogenous mRNA using lipid nanoparticles (LNPs) is a promising strategy for therapeutics. However, a bottleneck remains in the poor understanding…”
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Atg8 family LC3/GABARAP proteins are crucial for autophagosome-lysosome fusion but not autophagosome formation during PINK1/Parkin mitophagy and starvation Autor Nguyen, Thanh Ngoc, Padman, Benjamin Scott, Usher, Joanne, Oorschot, Viola, Ramm, Georg, Lazarou, Michael

“…Members of the Atg8 family of proteins are conjugated to autophagosomal membranes, where they have been proposed to drive autophagosome formation and selective…”
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Lipid droplets in the nervous system Autor Ralhan, Isha, Chang, Chi-Lun, Lippincott-Schwartz, Jennifer, Ioannou, Maria S

“…Lipid droplets are dynamic intracellular lipid storage organelles that respond to the physiological state of cells. In addition to controlling cell metabolism,…”
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Recent insights into the cellular biology of atherosclerosis Autor Tabas, Ira, García-Cardeña, Guillermo, Owens, Gary K

“…Atherosclerosis occurs in the subendothelial space (intima) of medium-sized arteries at regions of disturbed blood flow and is triggered by an interplay…”
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G3BP-Caprin1-USP10 complexes mediate stress granule condensation and associate with 40S subunits Autor Kedersha, Nancy, Panas, Marc D, Achorn, Christopher A, Lyons, Shawn, Tisdale, Sarah, Hickman, Tyler, Thomas, Marshall, Lieberman, Judy, McInerney, Gerald M, Ivanov, Pavel, Anderson, Paul

“…Mammalian stress granules (SGs) contain stalled translation preinitiation complexes that are assembled into discrete granules by specific RNA-binding proteins…”
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Who's in control? Principles of Rab GTPase activation in endolysosomal membrane trafficking and beyond Autor Borchers, Ann-Christin, Langemeyer, Lars, Ungermann, Christian

“…The eukaryotic endomembrane system consists of multiple interconnected organelles. Rab GTPases are organelle-specific markers that give identity to these…”
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The position of lysosomes within the cell determines their luminal pH Autor Johnson, Danielle E, Ostrowski, Philip, Jaumouillé, Valentin, Grinstein, Sergio

“…We examined the luminal pH of individual lysosomes using quantitative ratiometric fluorescence microscopy and report an unappreciated heterogeneity: peripheral…”
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The RNA binding protein FMR1 controls selective exosomal miRNA cargo loading during inflammation Autor Wozniak, Ann L, Adams, Abby, King, Kayla E, Dunn, Winston, Christenson, Lane K, Hung, Wei-Ting, Weinman, Steven A

“…Cells respond to inflammatory disease states by releasing exosomes containing highly specific protein and RNA cargos, but how inflammation alters cargo…”
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Autophagosomal YKT6 is required for fusion with lysosomes independently of syntaxin 17 Autor Matsui, Takahide, Jiang, Peidu, Nakano, Saori, Sakamaki, Yuriko, Yamamoto, Hayashi, Mizushima, Noboru

“…Macroautophagy is an evolutionarily conserved catabolic mechanism that delivers intracellular constituents to lysosomes using autophagosomes. To achieve…”
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Mechanistic insights into mammalian stress granule dynamics Autor Panas, Marc D, Ivanov, Pavel, Anderson, Paul

“…The accumulation of stalled translation preinitiation complexes (PICs) mediates the condensation of stress granules (SGs). Interactions between prion-related…”
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ATG9A shapes the forming autophagosome through Arfaptin 2 and phosphatidylinositol 4-kinase IIIβ Autor Judith, Delphine, Jefferies, Harold B J, Boeing, Stefan, Frith, David, Snijders, Ambrosius P, Tooze, Sharon A

“…ATG9A is a multispanning membrane protein essential for autophagy. Normally resident in Golgi membranes and endosomes, during amino acid starvation, ATG9A…”
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ER as master regulator of membrane trafficking and organelle function Autor Wenzel, Eva Maria, Elfmark, Liv Anker, Stenmark, Harald, Raiborg, Camilla

“…The endoplasmic reticulum (ER), which occupies a large portion of the cytoplasm, is the cell's main site for the biosynthesis of lipids and carbohydrate…”
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ORP5 and ORP8 orchestrate lipid droplet biogenesis and maintenance at ER-mitochondria contact sites Autor Guyard, Valentin, Monteiro-Cardoso, Vera Filipa, Omrane, Mohyeddine, Sauvanet, Cécile, Houcine, Audrey, Boulogne, Claire, Ben Mbarek, Kalthoum, Vitale, Nicolas, Faklaris, Orestis, El Khallouki, Naima, Thiam, Abdou Rachid, Giordano, Francesca

“…Lipid droplets (LDs) are the primary organelles of lipid storage, buffering energy fluctuations of the cell. They store neutral lipids in their core that is…”
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Senescent cells suppress macrophage-mediated corpse removal via upregulation of the CD47-QPCT/L axis Autor Schloesser, Daniela, Lindenthal, Laura, Sauer, Julia, Chung, Kyoung-Jin, Chavakis, Triantafyllos, Griesser, Eva, Baskaran, Praveen, Maier-Habelsberger, Ulrike, Fundel-Clemens, Katrin, Schlotthauer, Ines, Watson, Carolin Kirsten, Swee, Lee Kim, Igney, Frederik, Park, John Edward, Huber-Lang, Markus S, Thomas, Matthew-James, El Kasmi, Karim Christian, Murray, Peter J

“…Progressive accrual of senescent cells in aging and chronic diseases is associated with detrimental effects in tissue homeostasis. We found that senescent…”
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Cancer cells educate natural killer cells to a metastasis-promoting cell state Autor Chan, Isaac S, Knútsdóttir, Hildur, Ramakrishnan, Gayathri, Padmanaban, Veena, Warrier, Manisha, Ramirez, Juan Carlos, Dunworth, Matthew, Zhang, Hao, Jaffee, Elizabeth M, Bader, Joel S, Ewald, Andrew Josef

“…Natural killer (NK) cells have potent antitumor and antimetastatic activity. It is incompletely understood how cancer cells escape NK cell surveillance. Using…”
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Autophagy and cancer: Modulation of cell death pathways and cancer cell adaptations Autor Towers, Christina G, Wodetzki, Darya, Thorburn, Andrew

“…Autophagy is intricately linked with many intracellular signaling pathways, particularly nutrient-sensing mechanisms and cell death signaling cascades. In…”
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Lactylation stabilizes TFEB to elevate autophagy and lysosomal activity Autor Huang, Yewei, Luo, Gan, Peng, Kesong, Song, Yue, Wang, Yusha, Zhang, Hongtao, Li, Jin, Qiu, Xiangmin, Pu, Maomao, Liu, Xinchang, Peng, Chao, Neculai, Dante, Sun, Qiming, Zhou, Tianhua, Huang, Pintong, Liu, Wei

“…The transcription factor TFEB is a major regulator of lysosomal biogenesis and autophagy. There is growing evidence that posttranslational modifications play a…”
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Mitochondria on the move: Horizontal mitochondrial transfer in disease and health Autor Dong, Lan-Feng, Rohlena, Jakub, Zobalova, Renata, Nahacka, Zuzana, Rodriguez, Anne-Marie, Berridge, Michael V, Neuzil, Jiri

“…Mammalian genes were long thought to be constrained within somatic cells in most cell types. This concept was challenged recently when cellular organelles…”
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