Search Results - "The EMBO journal"

Autophagy in major human diseases by Klionsky, Daniel J, Petroni, Giulia, Amaravadi, Ravi K, Baehrecke, Eric H, Ballabio, Andrea, Boya, Patricia, Bravo‐San Pedro, José Manuel, Cadwell, Ken, Cecconi, Francesco, Choi, Augustine M K, Choi, Mary E, Chu, Charleen T, Codogno, Patrice, Colombo, Maria Isabel, Cuervo, Ana Maria, Deretic, Vojo, Dikic, Ivan, Elazar, Zvulun, Eskelinen, Eeva‐Liisa, Fimia, Gian Maria, Gewirtz, David A, Green, Douglas R, Hansen, Malene, Jäättelä, Marja, Johansen, Terje, Juhász, Gábor, Karantza, Vassiliki, Kraft, Claudine, Kroemer, Guido, Ktistakis, Nicholas T, Kumar, Sharad, Lopez‐Otin, Carlos, Macleod, Kay F, Madeo, Frank, Martinez, Jennifer, Meléndez, Alicia, Mizushima, Noboru, Münz, Christian, Penninger, Josef M, Perera, Rushika M, Piacentini, Mauro, Reggiori, Fulvio, Rubinsztein, David C, Ryan, Kevin M, Sadoshima, Junichi, Santambrogio, Laura, Scorrano, Luca, Simon, Hans‐Uwe, Simon, Anna Katharina, Simonsen, Anne, Stolz, Alexandra, Tavernarakis, Nektarios, Tooze, Sharon A, Yoshimori, Tamotsu, Yuan, Junying, Yue, Zhenyu, Zhong, Qing, Galluzzi, Lorenzo, Pietrocola, Federico

“…Autophagy is a core molecular pathway for the preservation of cellular and organismal homeostasis. Pharmacological and genetic interventions impairing…”
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Molecular mechanisms and physiological functions of mitophagy by Onishi, Mashun, Yamano, Koji, Sato, Miyuki, Matsuda, Noriyuki, Okamoto, Koji

“…Degradation of mitochondria via a selective form of autophagy, named mitophagy, is a fundamental mechanism conserved from yeast to humans that regulates…”
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Dynamic EMT: a multi‐tool for tumor progression by Brabletz, Simone, Schuhwerk, Harald, Brabletz, Thomas, Stemmler, Marc P.

“…The process of epithelial–mesenchymal transition (EMT) is fundamental for embryonic morphogenesis. Cells undergoing it lose epithelial characteristics and…”
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SARS‐CoV‐2 receptor ACE2 and TMPRSS2 are primarily expressed in bronchial transient secretory cells by Lukassen, Soeren, Chua, Robert Lorenz, Trefzer, Timo, Kahn, Nicolas C, Schneider, Marc A, Muley, Thomas, Winter, Hauke, Meister, Michael, Veith, Carmen, Boots, Agnes W, Hennig, Bianca P, Kreuter, Michael, Conrad, Christian, Eils, Roland

“…The SARS‐CoV‐2 pandemic affecting the human respiratory system severely challenges public health and urgently demands for increasing our understanding of…”
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m6A RNA methylation: from mechanisms to therapeutic potential by He, P Cody, He, Chuan

“…RNA carries a diverse array of chemical modifications that play important roles in the regulation of gene expression. N 6 ‐methyladenosine (m 6 A), installed…”
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Past, present, and future of circRNAs by Patop, Ines Lucia, Wüst, Stas, Kadener, Sebastian

“…Exonic circular RNAs (circRNAs) are covalently closed RNA molecules generated by a process named back‐splicing. circRNAs are highly abundant in eukaryotes, and…”
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SARS‐CoV‐2 targets neurons of 3D human brain organoids by Ramani, Anand, Müller, Lisa, Ostermann, Philipp N, Gabriel, Elke, Abida‐Islam, Pranty, Müller‐Schiffmann, Andreas, Mariappan, Aruljothi, Goureau, Olivier, Gruell, Henning, Walker, Andreas, Andrée, Marcel, Hauka, Sandra, Houwaart, Torsten, Dilthey, Alexander, Wohlgemuth, Kai, Omran, Heymut, Klein, Florian, Wieczorek, Dagmar, Adams, Ortwin, Timm, Jörg, Korth, Carsten, Schaal, Heiner, Gopalakrishnan, Jay

“…COVID‐19 pandemic caused by SARS‐CoV‐2 infection is a public health emergency. COVID‐19 typically exhibits respiratory illness. Unexpectedly, emerging clinical…”
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Long‐term expanding human airway organoids for disease modeling by Sachs, Norman, Papaspyropoulos, Angelos, Zomer‐van Ommen, Domenique D, Heo, Inha, Böttinger, Lena, Klay, Dymph, Weeber, Fleur, Huelsz‐Prince, Guizela, Iakobachvili, Nino, Amatngalim, Gimano D, de Ligt, Joep, van Hoeck, Arne, Proost, Natalie, Viveen, Marco C, Lyubimova, Anna, Teeven, Luc, Derakhshan, Sepideh, Korving, Jeroen, Begthel, Harry, Dekkers, Johanna F, Kumawat, Kuldeep, Ramos, Emilio, van Oosterhout, Matthijs FM, Offerhaus, G Johan, Wiener, Dominique J, Olimpio, Eduardo P, Dijkstra, Krijn K, Smit, Egbert F, van der Linden, Maarten, Jaksani, Sridevi, van de Ven, Marieke, Jonkers, Jos, Rios, Anne C, Voest, Emile E, van Moorsel, Coline HM, van der Ent, Cornelis K, Cuppen, Edwin, van Oudenaarden, Alexander, Coenjaerts, Frank E, Meyaard, Linde, Bont, Louis J, Peters, Peter J, Tans, Sander J, van Zon, Jeroen S, Boj, Sylvia F, Vries, Robert G, Beekman, Jeffrey M, Clevers, Hans

“…Organoids are self‐organizing 3D structures grown from stem cells that recapitulate essential aspects of organ structure and function. Here, we describe a…”
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Mechanism and inhibition of the papain‐like protease, PLpro, of SARS‐CoV‐2 by Klemm, Theresa, Ebert, Gregor, Calleja, Dale J, Allison, Cody C, Richardson, Lachlan W, Bernardini, Jonathan P, Lu, Bernadine GC, Kuchel, Nathan W, Grohmann, Christoph, Shibata, Yuri, Gan, Zhong Yan, Cooney, James P, Doerflinger, Marcel, Au, Amanda E, Blackmore, Timothy R, van der Heden van Noort, Gerbrand J, Geurink, Paul P, Ovaa, Huib, Newman, Janet, Riboldi‐Tunnicliffe, Alan, Czabotar, Peter E, Mitchell, Jeffrey P, Feltham, Rebecca, Lechtenberg, Bernhard C, Lowes, Kym N, Dewson, Grant, Pellegrini, Marc, Lessene, Guillaume, Komander, David

“…The SARS‐CoV‐2 coronavirus encodes an essential papain‐like protease domain as part of its non‐structural protein (nsp)‐3, namely SARS2 PLpro, that cleaves the…”
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Syncytia formation by SARS‐CoV‐2‐infected cells by Buchrieser, Julian, Dufloo, Jérémy, Hubert, Mathieu, Monel, Blandine, Planas, Delphine, Rajah, Maaran Michael, Planchais, Cyril, Porrot, Françoise, Guivel‐Benhassine, Florence, Van der Werf, Sylvie, Casartelli, Nicoletta, Mouquet, Hugo, Bruel, Timothée, Schwartz, Olivier

“…Severe cases of COVID‐19 are associated with extensive lung damage and the presence of infected multinucleated syncytial pneumocytes. The viral and cellular…”
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A single‐cell RNA expression atlas of normal, preneoplastic and tumorigenic states in the human breast by Pal, Bhupinder, Chen, Yunshun, Vaillant, François, Capaldo, Bianca D, Joyce, Rachel, Song, Xiaoyu, Bryant, Vanessa L, Penington, Jocelyn S, Di Stefano, Leon, Tubau Ribera, Nina, Wilcox, Stephen, Mann, Gregory B, Papenfuss, Anthony T, Lindeman, Geoffrey J, Smyth, Gordon K, Visvader, Jane E

“…To examine global changes in breast heterogeneity across different states, we determined the single‐cell transcriptomes of > 340,000 cells encompassing normal…”
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RNA m6A methylation regulates sorafenib resistance in liver cancer through FOXO3‐mediated autophagy by Lin, Ziyou, Niu, Yi, Wan, Arabella, Chen, Dongshi, Liang, Heng, Chen, Xijun, Sun, Lei, Zhan, Siyue, Chen, Liutao, Cheng, Chao, Zhang, Xiaolei, Bu, Xianzhang, He, Weiling, Wan, Guohui

“…N6‐methyladenosine (m 6 A) is an abundant nucleotide modification in mRNA, known to regulate mRNA stability, splicing, and translation, but it is unclear…”
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Stromal cell diversity associated with immune evasion in human triple‐negative breast cancer by Wu, Sunny Z, Roden, Daniel L, Wang, Chenfei, Holliday, Holly, Harvey, Kate, Cazet, Aurélie S, Murphy, Kendelle J, Pereira, Brooke, Al‐Eryani, Ghamdan, Bartonicek, Nenad, Hou, Rui, Torpy, James R, Junankar, Simon, Chan, Chia‐Ling, Lam, Chuan En, Hui, Mun N, Gluch, Laurence, Beith, Jane, Parker, Andrew, Robbins, Elizabeth, Segara, Davendra, Mak, Cindy, Cooper, Caroline, Warrier, Sanjay, Forrest, Alistair, Powell, Joseph, O'Toole, Sandra, Cox, Thomas R, Timpson, Paul, Lim, Elgene, Liu, X Shirley, Swarbrick, Alexander

“…The tumour stroma regulates nearly all stages of carcinogenesis. Stromal heterogeneity in human triple‐negative breast cancers (TNBCs) remains poorly…”
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TMPRSS2 expression dictates the entry route used by SARS‐CoV‐2 to infect host cells by Koch, Jana, Uckeley, Zina M, Doldan, Patricio, Stanifer, Megan, Boulant, Steeve, Lozach, Pierre‐Yves

“…SARS‐CoV‐2 is a newly emerged coronavirus that caused the global COVID‐19 outbreak in early 2020. COVID‐19 is primarily associated with lung injury, but many…”
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Tau protein liquid–liquid phase separation can initiate tau aggregation by Wegmann, Susanne, Eftekharzadeh, Bahareh, Tepper, Katharina, Zoltowska, Katarzyna M, Bennett, Rachel E, Dujardin, Simon, Laskowski, Pawel R, MacKenzie, Danny, Kamath, Tarun, Commins, Caitlin, Vanderburg, Charles, Roe, Allyson D, Fan, Zhanyun, Molliex, Amandine M, Hernandez‐Vega, Amayra, Muller, Daniel, Hyman, Anthony A, Mandelkow, Eckhard, Taylor, J Paul, Hyman, Bradley T

“…The transition between soluble intrinsically disordered tau protein and aggregated tau in neurofibrillary tangles in Alzheimer's disease is unknown. Here, we…”
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Microglial subtypes: diversity within the microglial community by Stratoulias, Vassilis, Venero, Jose Luis, Tremblay, Marie‐Ève, Joseph, Bertrand

“…Microglia are brain‐resident macrophages forming the first active immune barrier in the central nervous system. They fulfill multiple functions across…”
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Local externalization of phosphatidylserine mediates developmental synaptic pruning by microglia by Scott‐Hewitt, Nicole, Perrucci, Fabio, Morini, Raffaella, Erreni, Marco, Mahoney, Matthew, Witkowska, Agata, Carey, Alanna, Faggiani, Elisa, Schuetz, Lisa Theresia, Mason, Sydney, Tamborini, Matteo, Bizzotto, Matteo, Passoni, Lorena, Filipello, Fabia, Jahn, Reinhard, Stevens, Beth, Matteoli, Michela

“…Neuronal circuit assembly requires the fine balance between synapse formation and elimination. Microglia, through the elimination of supernumerary synapses,…”
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Structures of the SARS‐CoV‐2 nucleocapsid and their perspectives for drug design by Peng, Ya, Du, Ning, Lei, Yuqing, Dorje, Sonam, Qi, Jianxun, Luo, Tingrong, Gao, George F, Song, Hao

“…COVID‐19, caused by SARS‐CoV‐2, has resulted in severe and unprecedented economic and social disruptions in the world. Nucleocapsid (N) protein, which is the…”
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Cell death pathways: intricate connections and disease implications by Kist, Matthias, Vucic, Domagoj

“…Various forms of cell death have been identified over the last decades with each relying on a different subset of proteins for the activation and execution of…”
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Length‐independent telomere damage drives post‐mitotic cardiomyocyte senescence by Anderson, Rhys, Lagnado, Anthony, Maggiorani, Damien, Walaszczyk, Anna, Dookun, Emily, Chapman, James, Birch, Jodie, Salmonowicz, Hanna, Ogrodnik, Mikolaj, Jurk, Diana, Proctor, Carole, Correia‐Melo, Clara, Victorelli, Stella, Fielder, Edward, Berlinguer‐Palmini, Rolando, Owens, Andrew, Greaves, Laura C, Kolsky, Kathy L, Parini, Angelo, Douin‐Echinard, Victorine, LeBrasseur, Nathan K, Arthur, Helen M, Tual‐Chalot, Simon, Schafer, Marissa J, Roos, Carolyn M, Miller, Jordan D, Robertson, Neil, Mann, Jelena, Adams, Peter D, Tchkonia, Tamara, Kirkland, James L, Mialet‐Perez, Jeanne, Richardson, Gavin D, Passos, João F

“…Ageing is the biggest risk factor for cardiovascular disease. Cellular senescence, a process driven in part by telomere shortening, has been implicated in…”
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