Search Results - "Teumer, Alexander"

Common Methods for Performing Mendelian Randomization by Teumer, Alexander

“…Mendelian randomization (MR) is a framework for assessing causal inference using cross-sectional data in combination with genetic information. This paper…”
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A bidirectional Mendelian randomization study supports causal effects of kidney function on blood pressure by Yu, Zhi, Coresh, Josef, Qi, Guanghao, Grams, Morgan, Boerwinkle, Eric, Snieder, Harold, Teumer, Alexander, Pattaro, Cristian, Köttgen, Anna, Chatterjee, Nilanjan, Tin, Adrienne

“…Blood pressure and kidney function have a bidirectional relation. Hypertension has long been considered as a risk factor for kidney function decline. However,…”
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Differentially expressed genes reflect disease-induced rather than disease-causing changes in the transcriptome by Porcu, Eleonora, Sadler, Marie C., Lepik, Kaido, Auwerx, Chiara, Wood, Andrew R., Weihs, Antoine, Sleiman, Maroun S. Bou, Ribeiro, Diogo M., Bandinelli, Stefania, Tanaka, Toshiko, Nauck, Matthias, Völker, Uwe, Delaneau, Olivier, Metspalu, Andres, Teumer, Alexander, Frayling, Timothy, Santoni, Federico A., Reymond, Alexandre, Kutalik, Zoltán

“…Comparing transcript levels between healthy and diseased individuals allows the identification of differentially expressed genes, which may be causes,…”
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Imputation-powered whole-exome analysis identifies genes associated with kidney function and disease in the UK Biobank by Wuttke, Matthias, König, Eva, Katsara, Maria-Alexandra, Kirsten, Holger, Farahani, Saeed Khomeijani, Teumer, Alexander, Li, Yong, Lang, Martin, Göcmen, Burulca, Pattaro, Cristian, Günzel, Dorothee, Köttgen, Anna, Fuchsberger, Christian

“…Genome-wide association studies have discovered hundreds of associations between common genotypes and kidney function but cannot comprehensively investigate…”
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Genome-wide associations of aortic distensibility suggest causality for aortic aneurysms and brain white matter hyperintensities by Francis, Catherine M., Futschik, Matthias E., Huang, Jian, Bai, Wenjia, Sargurupremraj, Muralidharan, Teumer, Alexander, Breteler, Monique M. B., Petretto, Enrico, Ho, Amanda S. R., Amouyel, Philippe, Engelter, Stefan T., Bülow, Robin, Völker, Uwe, Völzke, Henry, Dörr, Marcus, Imtiaz, Mohammed-Aslam, Aziz, N. Ahmad, Lohner, Valerie, Ware, James S., Debette, Stephanie, Elliott, Paul, Dehghan, Abbas, Matthews, Paul M.

“…Aortic dimensions and distensibility are key risk factors for aortic aneurysms and dissections, as well as for other cardiovascular and cerebrovascular…”
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Copy number variations and cognitive phenotypes in unselected populations by Männik, Katrin, Mägi, Reedik, Macé, Aurélien, Cole, Ben, Guyatt, Anna L, Shihab, Hashem A, Maillard, Anne M, Alavere, Helene, Kolk, Anneli, Reigo, Anu, Mihailov, Evelin, Leitsalu, Liis, Ferreira, Anne-Maud, Nõukas, Margit, Teumer, Alexander, Salvi, Erika, Cusi, Daniele, McGue, Matt, Iacono, William G, Gaunt, Tom R, Beckmann, Jacques S, Jacquemont, Sébastien, Kutalik, Zoltán, Pankratz, Nathan, Timpson, Nicholas, Metspalu, Andres, Reymond, Alexandre

“…The association of copy number variations (CNVs), differing numbers of copies of genetic sequence at locations in the genome, with phenotypes such as…”
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Genome-wide association study of chronic periodontitis in a general German population by Teumer, Alexander, Holtfreter, Birte, Völker, Uwe, Petersmann, Astrid, Nauck, Matthias, Biffar, Reiner, Völzke, Henry, Kroemer, Heyo K., Meisel, Peter, Homuth, Georg, Kocher, Thomas

“…Aim To identify loci associated with chronic periodontitis through a genome‐wide association study (GWAS). Materials and Methods A GWAS was performed in 4032…”
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Moderation of Adult Depression by a Polymorphism in the FKBP5 Gene and Childhood Physical Abuse in the General Population by Appel, Katja, Schwahn, Christian, Mahler, Jessie, Schulz, Andrea, Spitzer, Carsten, Fenske, Kristin, Stender, Jan, Barnow, Sven, John, Ulrich, Teumer, Alexander, Biffar, Reiner, Nauck, Matthias, Völzke, Henry, Freyberger, Harald J, Grabe, Hans J

“…Childhood maltreatment and depressive disorders have both been associated with a dysregulation of the hypothalamic–pituitary–adrenal axis. The FKBP5 gene codes…”
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Correction: Analysis of epidemiological association patterns of serum thyrotropin by combining random forests and Bayesian networks by Becker, Ann-Kristin, Ittermann, Till, Dörr, Markus, Felix, Stephan B., Nauck, Matthias, Teumer, Alexander, Völker, Uwe, Völzke, Henry, Kaderali, Lars, Nath, Neetika

“…[This corrects the article DOI: 10.1371/journal.pone.0271610.].[This corrects the article DOI: 10.1371/journal.pone.0271610.]…”
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Integrating multiple kidney function markers to predict all-cause and cardiovascular disease mortality: prospective analysis of 366 758 UK Biobank participants by Fujii, Ryosuke, Melotti, Roberto, Köttgen, Anna, Teumer, Alexander, Giardiello, Daniele, Pattaro, Cristian

“…Background Reduced kidney function is a risk factor of cardiovascular and all-cause mortality. This association was demonstrated for several kidney function…”
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Analysis of epidemiological association patterns of serum thyrotropin by combining random forests and Bayesian networks by Becker, Ann-Kristin, Ittermann, Till, Dörr, Markus, Felix, Stephan B., Nauck, Matthias, Teumer, Alexander, Völker, Uwe, Völzke, Henry, Kaderali, Lars, Nath, Neetika

“…Background Approaching epidemiological data with flexible machine learning algorithms is of great value for understanding disease-specific association…”
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A genome-wide association study of metabolic traits in human urine by Suhre, Karsten, Wallaschofski, Henri, Raffler, Johannes, Friedrich, Nele, Haring, Robin, Michael, Kathrin, Wasner, Christina, Krebs, Alexander, Kronenberg, Florian, Chang, David, Meisinger, Christa, Wichmann, H-Erich, Hoffmann, Wolfgang, Völzke, Henry, Völker, Uwe, Teumer, Alexander, Biffar, Reiner, Kocher, Thomas, Felix, Stephan B, Illig, Thomas, Kroemer, Heyo K, Gieger, Christian, Römisch-Margl, Werner, Nauck, Matthias

“…Karsten Suhre and colleagues report a genome-wide association study of metabolic traits in human urine, using NMR spectrometry to measure 59 metabolites in…”
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Effects of Thyroid Function on Hemostasis, Coagulation, and Fibrinolysis: A Mendelian Randomization Study by Ellervik, Christina, Mora, Samia, Kuś, Aleksander, Åsvold, Bjørn, Marouli, Eirini, Deloukas, Panos, Sterenborg, Rosalie B T M, Teumer, Alexander, Burgess, Stephen, Sabater-Lleal, Maria, Huffman, Jennifer, Johnson, Andrew D, Trégouet, David-Alexandre, Smith, Nicolas L, Medici, Marco, DeVries, Paul S, Chasman, Daniel I, Kjaergaard, Alisa D

“…Untreated hypothyroidism is associated with acquired von Willebrand syndrome, and hyperthyroidism is associated with increased thrombosis risk. However, the…”
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Discovery of novel eGFR-associated multiple independent signals using a quasi-adaptive method by Ghasemi, Sahar, Becker, Tim, Grabe, Hans J., Teumer, Alexander

“…A decreased estimated glomerular filtration rate (eGFR) leading to chronic kidney disease is a significant public health problem. Kidney function is a…”
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Mendelian randomization indicates causal effects of estradiol levels on kidney function in males by Nasr, M. Kamal, Schurmann, Claudia, Böttinger, Erwin P., Teumer, Alexander

“…Chronic kidney disease (CKD) is a public health burden worldwide. Epidemiological studies observed an association between sex hormones, including estradiol,…”
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Limited evidence for blood eQTLs in human sexual dimorphism by Porcu, Eleonora, Claringbould, Annique, Weihs, Antoine, Lepik, Kaido, Richardson, Tom G., Völker, Uwe, Santoni, Federico A., Teumer, Alexander, Franke, Lude, Reymond, Alexandre, Kutalik, Zoltán

“…Background The genetic underpinning of sexual dimorphism is very poorly understood. The prevalence of many diseases differs between men and women, which could…”
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Insulin-Like Growth Factor, Inflammation, and MRI Markers of Alzheimer's Disease in Predominantly Middle-Aged Adults by Wittfeld, Katharina, Raman, Mekala R, Conner, Sarah C, Aslam, Asra, Teumer, Alexander, Nauck, Matthias, Hosten, Norbert, Habes, Mohamad, DeCarli, Charles, Vasan, Ramachandran S, Beiser, Alexa S, Himali, Jayandra J, Seshadri, Sudha, Grabe, Hans J, Satizabal, Claudia L

“…Insulin-like growth factor 1 (IGF-1) signaling has been implicated in Alzheimer's disease pathogenesis, and further evidence suggests inflammation can be a…”
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Investigation of the Interplay between Circulating Lipids and IGF-I and Relevance to Breast Cancer Risk: An Observational and Mendelian Randomization Study by Tan, Vanessa Y, Bull, Caroline J, Biernacka, Kalina M, Teumer, Alexander, Richardson, Tom G, Sanderson, Eleanor, Corbin, Laura J, Dudding, Tom, Qi, Qibin, Kaplan, Robert C, Rotter, Jerome I, Friedrich, Nele, Völker, Uwe, Mayerle, Julia, Perks, Claire M, Holly, Jeff M P, Timpson, Nicholas J

“…Circulating lipids and insulin-like growth factor 1 (IGF-I) have been reliably associated with breast cancer. Observational studies suggest an interplay…”
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Effects of Apolipoprotein E polymorphism on carotid intima-media thickness, incident myocardial infarction and incident stroke by Pitchika, Anitha, Markus, Marcello Ricardo Paulista, Schipf, Sabine, Teumer, Alexander, Van der Auwera, Sandra, Nauck, Matthias, Dörr, Marcus, Felix, Stephan, Grabe, Hans-Jörgen, Völzke, Henry, Ittermann, Till

“…The Apolipoprotein E (APOE) gene polymorphism (rs429358 and rs7412) shows a well-established association with lipid profiles, but its effect on cardiovascular…”
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Cross-sectional and longitudinal association of seven DNAm-based predictors with metabolic syndrome and type 2 diabetes by Chew, Suet Mei, Teumer, Alexander, Matías‑García, Pamela R., Gieger, Christian, Winckelmann, Juliane, Suhre, Karsten, Herder, Christian, Rathmann, Wolfgang, Peters, Annette, Waldenberger, Melanie

“…Background To date, various epigenetic clocks have been constructed to estimate biological age, most commonly using DNA methylation (DNAm). These include…”
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